International Institute of Molecular and Cell Biology

home

site map

International Institute of Molecular and Cell Biology

News

About IIMCB

2010-02-05

International Institute

of Molecular and Cell Biology in Warsaw

invites to a seminar of

Jean-Philippe Borges, PhD

Laboratory of Structural Biology, IIMCB

Max-Planck/PAN Junior Research Group

"Porins of Campylobacter: more than a simple channel in the membrane"

It will be held on February 11th (Thursday) 2010,

at 9:15 a.m.
at the Institute of Biocybernetics and Biomedical Engineering
in Warsaw

ul. Ks. Trojdena 4

the lecture hall 90

News:

New vacancies at IIMCB:

Matthias Bochtler, Head of the Laboratory of Structural Biology MPG/PAN received a Professorial title from the President of Poland

Poland Regional Report (Nature, 3 December issue) describes IIMCB as a precursor of modernization of Polish science - see section "INSTITUTIONALIZING INNOVATION", page3.

Agnieszka Chacińska, Head of the Laboratory of the Mitochondrial Biogenesis in IIMCB received grant "Biogenesis and turnover of mitochondrial intermembrane space proteins" funded by Foundation for Polish Science in the frame of the II edition of WELCOME Programme.
She is one of two recipients of this award. The recruitment of the new members of the group will start soon.

Janusz M. Bujnicki, Head of the Laboratory of Bioinformatics and Protein Engineering received a Professorial title from the President of Poland

At the Inauguration of the Academic Year 2009/2010 of Biocentrum Ochota, Drs. Magdalena Błażejczyk and Adam Sobczak from the Laboratory of Neurodegeneration in IIMCB received awards for their PhD theses distinguished by the Scientific Council of the Nencki Institute in the year 2008. Awards were presented by the president of PAN, prof. Michal Kleiber, the president of Biocentrum Ochota, prof. Adama Szewczyk, and the president of the Scientific Council at the Nencki Institute, Prof. Leszek Kaczmarek.
Promotor of both awarded theses was Dr. hab. Urszula Wojda.

Emilia Bialopiotrowicz from the Laboratory of Neurodegeneration in IIMCB received the Mozolowski Award presented by the Polish Biochemical Society for outstanding young biochemists in 2009 for her project and presentation titled: Disturbances of the cell cycle in lymphocytes from Alzheimers dementia patients, promotor: Dr hab. Urszula Wojda. 39 young researchers took part in the competition, including finalists of the Youth Forum.

Bozena Kuzniewska from the Laboratory of Neurodegeneration in IIMCB received the main award at the 5th Conference of International Natural Sciences Students in Wilno for the presentation of her MSc research on apoptosis and the cell cycle of lymphocytes in Alzheimers disease patients; promotor: Dr. hab. Urszula Wojda.

"The Polish Science Voice" (July 2009) features an interview with Prof. Michal Witt as a Special Guest. The topis is legislative aspects of molecular genetic testing and biobanking.

"wiat Nauki" (June 2009), in the article on silent mutations by J. Chamary and L. Hurst, extensively refers to results and publications of Grzegorz Kudła, a former PhD student of Maciej Żylicz.

On June 3 a conference Challenges of molecular genetic testing in Poland the proposal for regulations was coorganized by IIMCB at the Ministry of Science and Higher Education. The conference was formally open by Prof. Witold Jurek, Undersecretary at the Ministry of Science and Higher Education, Ric Todd, UK's Ambassador to Poland and Prof. Andrzej Górski, Vice-President of the Polish Academy of Sciences. Among the speakers were: Prof. Jean-Jacques Cassiman (Univ. of Leuven), Dr. Mark Bale (UKs Department of Health, Dr. Laurence Lwoff (Council of Europe), Prof. Milan Macek (Charles Univ. Prague), Prof. Michal Witt (IIMCB), Prof. Helena Zakowska-Henzler (Institute of Law Studies) and Prof. Jerzy Bal (Institute of Mother and Child). Sessions were chaired by Micha³ Witt and Janusz Limon. On June 1, the meeting was organized by Prof. Jerzy Duszynski, Undersecretary at the Ministry of Science and Higher Education, devoted to problems of biobanking in which Prof. Jacek Kuznicki participated. The meeting was followed by a workshop on biobanking (June 2).

On May 14 a Polish-Ukrainian research collaboration meeting in a form of poster session was organized, with 18 posters from the Institute of Molecular Biology and Genetics in Kiev and 18 posters from IIMCB. Our Institute hosted a group of 23 Ukrainian scientists.

On May 15 IAB members participated in a kick-off meeting of the HealthProt project and in the International Research Symposium in celebration of the 10th anniversary of IIMCB presenting the HealthProt project partners and potential partners of other European projects. Lectures were delivered by: Wolfgang Zachariae, Vincenza Andrisano, Saulius Klimasauskas, Ted Hupp, Anita Becker, Samantha Spangler, Oleg Krishtal.

On May 16 the 11th Annual Meeting of the International Advisory Board of IIMCB took place. Positive evaluations were granted for two lab leaders: Marta Miaczynska and Maciej Zylicz. Jacek Kuznicki got reelected as the Institute's Director for the term 2010-2013. This was the last meeting of IAB within the current term of office.

On May 7, Prof. Jacek Kuznicki was a moderator of the session " EU-funded Health research collaboration in FP7" at a major event on EU research programmes "Research Connection 2009".
Objective of the session were: To highlight current priorities and forhtcoming calls in the health sector, challenges, difficulties and benefits, in particular for new Member States. New avenues to stimulate further participation of new Member States in EU research programmes. Prof. Kuznicki presented a lecture "Good, better, best - use of EC Framework Programmes" (please download).

Agnieszka Obarska-Kosinska, MSc and Elzbieta Purta, MSc were awarded with START Fellowship for young scientists for 2009 by Foundation for Polish Science (FNP)

On April 22, 2009 the delegation of Vietnam Academy of Science and Technology (VAST) with Pham Van Quy, Vice President and Chu Chi Thang, Director of International Cooperation Department, visited IIMCB. They met with J. Kunicki and M. Witt and discussed perspectives for further research cooperation.

On April 2, Prof. Jacek Kuznicki and Prof. Michał Witt visited the Headquarters of the Max-Planck Society in Munich. They met with the President of MPG Prof. Peter Gruss, the former Vice-President Prof. Klaus Halhbrock and the Head of Division of International Relations Dr. Berthold Neizert. Discussions were focused on forms of continuation of mutual collaboration.

On March 26, 2009 a delegation of German Cancer Research Center (DKFZ) and the Helmholtz Association with Prof. Otmar Wiestler visited IIMCB. Prof. Wiestler is the Chairman of the Management Board and Scientific Director of DKFZ and the Vice-President for Health Research of the Helmholtz Association. The delegation was hosted by Prof. Michal Witt and discussion focused on possibilities of future cooperation of IIMCB with both institutions.

The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) is one of the most modern country´s research institutes in its field. The IIMCB´s research topics cover the wide area of cancer biology, molecular immunology, neurobiology, protein structural biology, bioinformatics/computer modelling, etc. The International Advisory Board, the rules of recruitment of all faculty members through international competition and lack of tenure employment make it unique among Polish research institutions.
more...

Latest publications:

Spooren A, Rondou P, Debowska K, Lintermans B, Vermeulen L, Samyn B, Skieterska K, Debyser G, Devreese B, Vanhoenacker P, Wojda U, Haegeman G, Van Craenenbroeck K. Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation. Cellular Signalling 2009 Nov 20. [Epub ahead of print]

Khan F, Furuta Y, Kawai M, Kaminska KH, Ishikawa K, Bujnicki JM, Kobayashi I. A mobile genetic element of a novel type carrying a Type IIF restriction-modification system (PluTI). Nucleic Acids Res 2010 (in press)

Zhou X, Khiang TC, Tkaczuk KL, Bujnicki JM, Sivaraman J. Crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate binding pocket J Struct Biol 2010 [Epub ahead of print 2010]. doi:10.1016/j.jsb.2009.12.024

Pukancsik M, Bekesi A, Klement Eva, Hunyadi-Gulyas E, Medzihradszky K, Kosinski J, Bujnicki JM, Alfonso C, Rivas G, Vertessy B. Physiological truncation and domain organization of a novel uracil-DNA degrading factor. FEBS J 2010 (in press)

Kaminska KH, Purta E, Hansen LH, Bujnicki JM, Vester B, Long KS. Insights into the structure, function, and evolution of the Radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria. Nucleic Acids Res 2010 [Epub ahead of print 2009] doi:10.1093/nar/gkp1142

Tuszynska I, Bujnicki JM. Predicting atomic details of the unfolding pathway for YibK, a knotted protein from the SPOUT superfamily J Biomol Struct Dyn 2010; Feb;27(4):511-520

Gentsch M, Kaczmarczyk A, van Leeuwen K, de Boer M, Kaus-Drobek M, Dagher MC, Kaiser P, Arkwright PD, Gahr M, Rösen-Wolff A, Bochtler M, Secord E, Britto-Williams P, Saifi GM, Maddalena A, Dbaibo G, Bustamante J, Casanova JL, Roos D, Roesler J. Alu-repeat-induced deletions within the NCF2 gene causing p67-phox deficient chronic granulomatous disease (CGD), Human Mutation, 2009, epub ahead of print

Chojnowski G, Breer K, Narczyk M, Wielgus-Kutrowska B, Czapinska H, Hashimoto M, Hikishima S, Yokomatsu T, Bochtler M, Girstun A, Staron K, Bzowska A. 1.45 Å resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state, Biochem Biophys Res Commun 2010, 391, 703-8

Skibinska-Kijek A, Wisniewska MB, Gruszczynska-Biegala J, Methner A, Kuznicki J. Immunolocalization of STIM1 in the mouse brain. Acta Neurobiol Exp (Wars). 2009;69(4):413-28

Walerych D, Olszewski MB, Gutkowska M, Helwak A, Zylicz M, Zylicz A. Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions. Oncogene, 2009, 28(48):4284-94

Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M. Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. Biochem J. 2009, 423:389400

Narayan V, Eckert M, Zylicz A, Zylicz M, Ball LK. Cooperative regulation of the IRF-1 tumour suppressor protein by core components of the molecular chaperone machinery. J Biol Chem. 2009, 284(38):25889-99

Wawrzynow B, Pettersson S, Zylicz A, Bramham J, Worral E, Hupp TR, Ball K. A function for the RING finger domain in the allosteric control of MDM2 conformation and activity. J Biol Chem, 2009, 284, 11517-11530

Szymanska Z, Zylicz M. Mathematical modeling of heat shock proteins synthesis in response to temperature change. J Math Biol, 2009, 58: 819-844

Fink G, Hajdo L, Skowronek KJ, Reuther C, Kasprzak AA, Diez S. The mitotic kinesin-14 Ncd drives directional microtubule-microtubule sliding. Nat Cell Biol. 2009 Jun;11(6):717-23

Pyrzynska B, Pilecka I, Miaczynska M. Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis. Mol. Oncol. 3, 321-338. Review

Ohya T, Miaczynska M, Coskun U, Lommer B, Runge A, Drechsel D, Kalaidzidis Y, Zerial M. Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes. Nature. 2009, 459(7250):1091-7

Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. J Biol Chem. 2009 Jul 3;284(27):18115-28

Nowotny M. Retroviral integrase superfamily: the structural perspective. EMBO Rep. 2009 Feb;10(2):144-51

Jaworski J, Kapitein LC, Montenegro Gouveia S, Dortland BR, Wulf PS, Grigoriev I, Camera P, Spangler SA, di Stefano P, Demmers J, Krugers H, Defilippi P, Akhmanova A, Hoogenraad CC. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron. 2009 Jan 15;61(1):85-100.

Tinevez JY, Schulze U, Salbreux G, Roensch J, Joanny JF, Paluch E. Role of cortical tension in bleb growth. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18581-6

NEW BOOK
"Hematologia molekularna - patogeneza, patomechanizmy
i metody badawcze"

Editors: Michał Witt, Tomasz Szczepański, Małgorzata Dawidowska
Orodek Wydanictw Naukowych

Spis treci

This is a new book edited at IIMCB by Michal Witt, being the first Polish language monography devoted to molecular aspects of hematooncological diseases and modern treatment and diagnostic procedures. A separate section deals with application of molecular biology methods for diagnosis of hematological disorders.

4 Ks. Trojdena Street, 02-109 Warsaw, Poland
Telephone: (+48 22) 597 07 00
Fax: (+48 22) 597 07 15
e-mail: secretariat@iimcb.gov.pl

design by VENTI