Publications

  • 2017
  • Charbonnel C, Niazi AK, Elvira-Matelot E, Nowak E, Zytnicki M, de Bures A, Jobet E, Opsomer A, Shamandi N, Nowotny M, Carapito C, Reichheld J-P, Vaucheret H, Saez-Vasquez J. The siRNA suppressor RTL1 is redox-regulated through glutathionylation of a conserved cysteine in the double-stranded-RNA-binding domain. 2017. Nucleic Acids Res., Epub ahead of print . details
  • Rydzik AM, Warminski M, Sikorski PJ, Baranowski MR, Walczak S, Kowalska J, Zuberek J, Lukaszewicz M, Nowak E, W Claridge TD, Darzynkiewicz E, Nowotny M, Jemielity J. mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. 2017. Nucleic Acids Res., 45(15) 8661-8675. details
  • Figiel M, Nowotny M. Chapter Six - Structural Studies of RNases H2 as an Example of Crystal Structure Determination of Protein–Nucleic Acid Complexes. 2017. Methods in Enzymology, 592:123-143 . details
  • Figiel M, Krepl M, Poznanski J, Golab A, Šponer J, Nowotny M. Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase. 2017. Nucleic Acids Res., 45(6):3341-3352 . details
  • 2016
  • Kalisiak K, Kuliński TM, Tomecki R, Cysewski D, Pietras Z, Chlebowski A, Kowalska K, Dziembowski A . A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. 2016. Nucleic Acids Res, pii: gkw862 . details
  • Stracy M, Jaciuk M, Uphoff S, Kapanidis AN, Nowotny M, Sherratt DJ, Zawadzki P. Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli. 2016. Nat Commun., Aug 26;7:12568 . details
  • Nowotny M, Gaur V. Structure and mechanism of nucleases regulated by SLX4. 2016. Curr Opin Struct Biol, 36 97-105. details
  • 2015
  • Bocian-Ostrzycka KM, Łasica AM, Dunin-Horkawicz S, Grzeszczuk MJ, Drabik K, Dobosz AM, Godlewska R, Nowak E, Collet J-F, Jagusztyn-Krynicka EK. Functional and evolutionary analyses of Helicobacter pylori HP0231 (DsbK) protein with strong oxidative and chaperone activity characterized by a highly diverged dimerization domain. 2015. Frontiers in Microbiology, 6:1065 . details
  • Roszczenko P, Grzeszczuk M, Kobierecka P, Wywial E, Urbanowicz P, Wincek P, Nowak E, Jagusztyn-Krynicka EK . Helicobacter pylori HP0377, a member of the Dsb family, is an untypical multifunctional CcmG that cooperates with dimeric thioldisulfide oxidase HP0231. 2015. BMC Microbiol., 15 135. details
  • Gaur V, Wyatt HDM, Komorowska W, Szczepanowski RH, de Sanctis D, Gorecka KM, West SC, Nowotny M. Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease. 2015. Cell Reports, 10 . details
  • 2014
  • Miętus M, Nowak E, Jaciuk M, Kustosz P, Studnicka J, Nowotny M. Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. 2014. Nucleic Acids Res, 42(16) 10762-75. details
  • Majorek KA, Dunin-Horkawicz S, Steczkiewicz K, Muszewska A, Nowotny M, Ginalski K, Bujnicki JM. The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification. 2014. Nucleic Acids Res., 42(7) 4160-79. details
  • Tomecki R, Drazkowska K, Kucinski I, Stodus K, Szczesny RJ, Gruchota J, Owczarek EP, Kalisiak K, Dziembowski A . Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target. 2014. Nucleic Acids Res., 42(2) 1270-90. details
  • Nowak E, Miller JT, Bona MK, Studnicka J, Szczepanowski RH, Jurkowski J, Le Grice SFJ, Nowotny M. Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. 2014. Nature Structural & Molecular Biology, 21(4) 389-96. details
  • Smietanski M, Werner M, Purta E, Kaminska KH, Stepinski J, Darzynkiewicz E, Nowotny M, Bujnicki JM. Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation. 2014. Nat Commun, 5 3004. details
  • 2013
  • Górecka KM, Komorowska W, Nowotny M. Crystal structure of RuvC resolvase in complex with Holliday junction substrate. 2013. Nucleic Acids Res, 41(21) 9945-55. details
  • Chon H, Sparks JL, Rychlik M, Nowotny M, Burgers PM, Crouch RJ, Cerritelli SM. RNase H2 roles in genome integrity revealed by unlinking its activities. 2013. Nucleic Acids Res, 41(5) 3130-43. details
  • Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M. Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid. 2013. Nucleic Acids Res, 41(6) 3874-87. details
  • 2012
  • Sulej AA, Tuszynska I, Skowronek KJ, Nowotny M, Bujnicki JM. Sequence-specific cleavage of the RNA strand in DNA-RNA hybrids by the fusion of ribonuclease H with a zinc finger. 2012. Nucleic Acids Res, 40(22) 11563-70. details
  • 2011
  • Figiel M, Chon H, Cerritelli SM, Cybulska M, Crouch RJ, Nowotny M. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects. 2011. J Biol Chem, 286(12) 10540-10550. details
  • Rosta E, Nowotny M, Yang W, Hummer G. Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations. 2011. J Am Chem Soc., 133(23) 8934-8941. details
  • Jaciuk M, Nowak E, Skowronek K, Tańska A, Nowotny M. Structure of UvrA nucleotide excision repair protein in complex with modified DNA.. 2011. Nat Struct Mol Biol, 18 191-7. details
  • 2010
  • Rychlik MP, Chon H, Cerritelli SM, Klimek P, Crouch RJ, Nowotny M. Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage.. 2010. Mol Cell, 40 658-70. details
  • 2009
  • Nowotny M, Yang W. Structural and functional modules in RNA interference. 2009. Curr Opin Struct Biol, 19 286-93. details
  • Nowotny M. Retroviral integrase superfamily: the structural perspective.. 2009. EMBO Rep, 10 144-51. details
  • 2004
  • Lee YT, Jacob J, Michowski W, Nowotny M, Kuznicki J, Chazin WJ. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain.. 2004. J Biol Chem, 279 16511-7. details
  • Lee YT, Jacob J, Michowski W, Nowotny M, Kuznicki J, Chazin WJ. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain.. 2004. J Biol Chem, 279 16511-7. details
  • 2003
  • Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J. Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. 2003. J Biol Chem., 278(29) 26923-8. details
  • 2002
  • Billing-Marczak K, Buzanska L, Winsky L, Nowotny M, Rudka T, Isaacs K, Belin MF, Kuznicki J. AP2-like cis element is required for calretinin gene promoter activity in cells of neuronal phenotype differentiated from multipotent human cell line DEV.. 2002. Biochim Biophys Acta, 1577 412-20. details
  • Filipek A, Jastrzebska B, Nowotny M, Kuznicki J. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. 2002. J Biol Chem, 277 28848-52. details
  • Filipek A, Jastrzebska B, Nowotny M, Kwiatkowska K, Hetman M, Surmacz L, Wyroba E, Kuznicki J. Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells.. 2002. J Biol Chem, 277 21103-9. details
  • Filipek A, Jastrzebska B, Nowotny M, Kuznicki J. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. 2002. J Biol Chem, 277 28848-52. details
  • Billing-Marczak K, Buzanska L, Winsky L, Nowotny M, Rudka T, Isaacs K, Belin MF, Kuznicki J. AP2-like cis element is required for calretinin gene promoter activity in cells of neuronal phenotype differentiated from multipotent human cell line DEV.. 2002. Biochim Biophys Acta, 1577 412-20. details