Research

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Aurezyna logo

Head: Izabela Sabała, PhD

Postdoctoral Fellow: Elżbieta Jagielska, PhD

Research Assistant: Paweł Mitkowski, MSc

 

The “Biotechnological applications of bacteriolytic protein (Aurezyna)” project is financed by the National Center for Research and Development under the Applied Research Program. The funding was awarded to a consortium that was established by IIMCB (project leader) and A&A Biotechnology (commercial partner). The project develops commercial applications of enzyme for diagnostic tests, as bacteriostatic and bacteriolytic agent (e.g., to eliminate staphylococci from food and the hospital environment). In parallel, basic research focuses on further structural and biochemical characterization of the protein to broaden our knowledge on the regulation of activity and determination of enzyme specificity.

Main achievements in 2015:

(1) The patent “Method of peptide hydrolysis, peptidase, the composition for use as a bacteriostatic and bactericidal agent, a kit and the uses of the active form of LytM from S. aureus or derivatives thereof” was granted by the European Patent Office (2699254) and Australian Patent Office (2012246763). The patent has already been validated in several European countries. Patent procedures are pending in the United States, Canada, India, and Japan.

(2) We continue to develop our network of internal (Bochtler Lab, Bujnicki Lab) and external collaborations in Poland (Warsaw University, Warsaw Medical University, Warsaw university of Life Sciences) and abroad (Nottingham University, UK; Fritz Lipmann Institute, Germany; Sheffield University, UK; ITQB-UNL, Portugal).

(3) We have presented our results at prestigious international meetings (Gordon Conference, ECM, “The Great Wall” symposium).

(4) We completed a 12-month grant related to a prize that was received  the IMPULS competition of the SKILLS program organized by FNP (Foundation for Polish Science) for work on chimeric enzymes designed based on our previous work on bacteriolytic enzymes.

(5) We have signed a first patent license for our enzyme.

(6) We also started collaboration with a business partner to test the implementation of our enzyme in industry.

(7) Our results have been published in Scientific Reports: Grabowska M, Jagielska E, Czapinska H, Bochtler M, Sabala I. High resolution structure of an M23 peptidase with a substrate analogue. Scientific Reports 2015 Oct 6;5:14833.

 

Publications: http://www.iimcb.gov.pl/aurezyna-project.html

More information on webpage: aurezyna.com

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