News

“CePT - a development platform for innovative medicine” conference,
February 27, 2017, Medical University of Warsaw

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On February 27, 2017 over 300 representatives of science, business and government administration met at the Didactic Centre of the Medical University of Warsaw, attending the conference entitled “CePT  a development platform for innovative medicine”. The purpose of the event, conceived  by the Centre for Preclinical Research and Technology (CePT), was to initiate a substantive discussion on the cooperation of science, business and government, in the area of bioinnovation.

Even though spending on innovation has doubled over the past 10 years, Poland is still among the ten European countries where it represents less than 1 per cent of GDP. The first Innovation Act, signed in November 2016, is to bring the level of R&D expenditure to 1.7% of GDP in 2020, thanks to incentives in the form of tax credits, stabilizing financing for commercialization of the results of scientific research and streamlined procedures. Today Polish scientists run research projects that would put to shame even the largest R&D centers in the world, however, few of these projects stand the chance of being implemented, due to the lack of funds and strategic science support programs. For example, in the past 30 years no innovative drugsdeveloped in Poland have appeared on the market.

Possible actions which could speed up the development of innovativeness in Poland were discussed during the conference.  Representatives from both the science and business sectors emphasized that innovativeness should receive governmental support, and that appropriate legal and tax regulations can contribute towards the integration of the two worlds. According to CePT conference participants, what’s important is that the proposed legislative solutions should address the real needs of enterprises and research institutes. Piotr Ziółkowski, who attended the conference on behalf of the Minister of Science and Higher Education, Jarosław Gowin, invited the attending representatives of the scientific community and investors to issue an open letter addressed to the Minister. The letter should provide their comments and suggestions that would be helpful in legislative work with regard to an Act of Parliament intended to introduce a number of modifications to the existing laws and certain tax credits that would encourage entrepreneurs to invest in R&D. As emphasized by conference participants, the challenge for Polish biotechnology lies in going beyond the preliminary research and prototyping phase. This applies to the scientific sector and pharmaceutical companies alike. The estimated cost of a market launch for a new innovative drug, means a budget of at least USD 1 bn. These costs are so high because nowadays the development of new advanced drugs requires the use of sophisticated biotechnology. According to the data quoted by Jerzy Pieczykolan, PhD of Celon Pharma S.A., the costs of developing new therapies have increased more than forty times over the past 40 years. In the 1970s and 1980s, costs were about USD 179 m – today they reach over USD 2.5 bn. There are no entities in Poland that would be able to bear this financial burden on their own – that’s why it is so important to strengthen the cooperation between pharmaceutical companies and research institutes. And, in order to turn this into an effective relationship, the cooperation must be based on mutual understanding of the needs of each side of the deal. Marcin Szumowski, PhD of OncoArendi Therapeutics S.A. expressed his opinion that another essential issue which would have to be addressed, for an efficient and effective transfer of technology between research institutes and the business sector, are scientific teams. The members of which would  no longer be proficient only in academic terms, but would also have experience in the industry – and that might be a factor instrumental in adaptation to the industry needs.

According to popular thinking there is a “Death Valley” between the realms of business and science. Slowly, this gap is filling, thanks to initiatives taken by both scientists, and entrepreneurs. The cooperation between these two worlds is essential for building a knowledge-based economy, and the commercialization process cannot work without top-level science. According to the representatives of the business sphere, the science sector is increasingly opening up to business. During the second part of the conference scientists from CePT presented innovative projects carried out in collaboration with the business sector and currently conducted research which can have a huge impact on improving the quality of patients' lives, for example a personal hemodialysis monitor, a bionic pancreas, new methods of immunotherapy for cancer, non-invasive methods in oncology or a substance that protects against allergy to nickel. The event was accompanied by an exhibition of research projects carried out by the institutions which form the CePT research centre, and companies from the Life Sciences sector.

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The members of the CePT consortium are among the leading academic and research institutions in Poland, and their activities largely contribute to  to the overall perception and role of Polish science, both domestically and abroad. They are: the Medical University of Warsaw, the University of Warsaw, the Warsaw University of Technology, the International Institute of Molecular and Cell Biology in Warsaw, as well as several institutes of the Polish Academy of Sciences: the Nencki Institute of Experimental Biology, the Institute of Biochemistry and Biophysics, the Mossakowski Medical Research Centre, the Institute of Fundamental Technological Research, the Institute of High Pressure Physics, and the Nałęcz Institute of Biocybernetics and Biomedical Engineering. Currently CePT represents the largest domestic investment in science. Nearly 1000 eminent scientists from Poland and abroad, can use 10 new specialized research centers provided with  world-class equipment. This results in a unique synergy between the potential of excellent scientific teams and the capacity of the laboratory network, thanks to which, CePT researchers can reach new levels of excellence in medicine and solve problems much more complex than before, pushing out the barriers which, until now, limited the capabilities of individual departments, universities and institutes.

 

                                                                                                                                                                               

WORKSHOP FOR THE HYDRODYNAMIC AND THERMODYNAMIC ANALYSIS OF BIOLOGICAL MACROMOLECULES AND THEIR INTERACTIONS WITH SEDFIT AND SEDPHAT

19-23 September 2016, Warsaw, IIMCB

 

                                                                                                                                                                               

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International Institute of Molecular and Cell Biology in Warsaw, 

Poland


19 – 23 September 2016    

 

Workshop for the hydrodynamic and thermodynamic analysis of

biological macromolecules and their interactions with

SEDFIT and SEDPHAT

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Aims and Topics

This workshop will review strategies for hydrodynamic and thermodynamic analysis of:

  •  Analytical Ultracentrifugation (AUC)
  •  Dynamic Light Scattering (DLS)
  •  Isothermal Titration Calorimetry (ITC)
  •  Fluorescence Spectroscopy (anisotropy and quenching isotherms)
  •  Fluorescence (AUC
  •  Optical Biosensing (SPR)
  •  Small Angle X-Ray Scattering

for the characterization of biological macromolecules and their interactions in solution. 

Practical data analysis will be demonstrated using the computational tools: SEDFIT, SEDPHAT, EVILFIT and NITPIC.

The workshop is aimed at researchers with at least limited experience in experimental biophysical methods.  An integral part of the workshop is the presentation by the participants of their systems of interest and informal discussion of data

 

Find here the Workshop Schedule and Registration Form

Instructors: 

Christine Ebel (IBS Grenoble), Rodolfo Ghirlando (NIH Bethesda), Marcin Nowotny (IIMCB Warsaw), Tomáš Obšil (Charles University Prague),  Grzegorz Piszczek (NIH Bethesda), Peter Schuck (NIH Bethesda), Roman Szczepanowski (IIMCB Warsaw), Huaying Zhao (NIH Bethesda)

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 For detailed information, please contact Roman Szczepanowski (roman@iimcb.gov.pl)

 

 
                                                                                                                                                                               

HEART OF EUROPE: ZEBRAFISH MEETING

17-19 September 2014, Warsaw, IIMCB

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The International Institute of Molecular and Cell Biology organized an academic event “Heart of Europe: Zebrafish Meeting”, which was held in Warsaw on September 17-19, 2014. Research carried out with an extensive use of zebrafish (Danio rerio) model in many fields of science, such as: modelling of human diseases, developmental biology, neurology, bioinformatics, toxicology, etc. have been presented by: Stephan Neuhauss, Peter Aleström, Claire Allen, Oliver Bandmann, Petr Bartůněk, Ilse Bollaerts, Michael Brand, Martina Burczyk, Elisabeth Busch-Nentwich, Catarina Certal, Yann  Chomis, Jan  de Soneville, Thomas Dickmeis, Éva Fetter, Marta Gajewska, Carl-Philipp Heisenberg, Corinne Houart, Ekaterina Kondakova, Ivan Mihaljević, Ralf Mikut, Jean-Philippe Mocho, Markus Ojanen, Franziska Rönicke, Steven Rudeck, Thomas Sala, Steffen Scholpp, Stefan Schulte-Merker, B. Ewa Snaar-Jagalska, Lynne U. Sneddon Smijin Soman, Herman P. Spaink Didier Stainier, Ondřej Svoboda, Béla Urbányi, Cecilia L. Winata and Áron Zsigmond.

The meeting was attended by nearly 170 people from 25 countries: Austria (4), Belgium (5), Croatia (5), Czech Republic (6), Denmark (1), Finland (4), France (4), Germany (15), Greece (4), Hungary (9), Ireland (1), Italy (7), The Netherlands (7), Norway (2), Poland (68), Portugal (2), Russian Federation (1), Singapore (1), Slovenia (2), Spain (2), Sweden (1), Switzerland (1), Ukraine (2), United Kingdom (13) and USA (4).

The intention of the conference organisers was also to create national and international network group(s) that would gather zebrafish researcher in Eastern and Central Europe. As first, the aquatic section of the Polish Laboratory Animals Science Association has been constituted and now it accepts new members.

The meeting was held under the patronage of:

  • Prof. Hanna Gronkiewicz-Waltz, Mayor of  Warsaw,
  • Prof. Maciej Żylicz, President of the Foundation for Polish Science,
  • Prof. Michał Kleiber, President of Polish Academy of Sciences,
  • Polish Laboratory Animals Science Association (PolLASA).

 

 
                                                                                                                                                                               

Opening of the Academic Year 2014/2015 at Biocentrum Ochota

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On October 17th the Opening of the Academic Year 2014/2015 was held at Biocentrum Ochota. The PhD students of IIMCB, IBB and the Nencki Instiute organized the ceremony with the invited keynote speakers, Prof. Andrzej Udalski and Prof. Virginijus Siksnys.

The event started with the awards ceremony for the best PhD dissertations of year 2013. The opening lecture ‘’Extrasolar Planetary Systems’’ was delivered by prof. Andrzej Udalski  from the Warsaw University Poland. The next lecture ‘’CRISPR - Cas craze: from microbial antiviral defense system to genome editing’’ was presented by prof. Virginijus Siksnys from the Vilnius University, Lithuania. There was a poster session with a competition for the best poster. The ceremony was honored by the presence of Prof. Michał Kleiber, the President of the Polish Academy of  Sciences and directors of all individual institutes of Biocentrum Ochota. More than 150 PhD students of Biocentrum Ochota participated in the event. Furthermore, PhD students from Institute of Molecular Biology and Genetics (Ukraine) accepted the invitation and joined the Opening.

The event was supported by all institutes of Biocentrum Ochota. Moreover, IIMCB supported prof. Siksnys’ visit and VitaInSilica, Bio-Rad, Eppendorf were the sponsors of the awards.

For more information and the abstract book please visit the official page of the event: http://www.biocentrumochota.pan.pl/OpeningAcademicYear

 

 

 
                                                                                                                                                                               
 
COMBIOM
 
Practical Training on IPR, Project Management and Equipment
22 - 26 September 2014, IIMCB, Warsaw
 

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Training experts:

  • Magdalena Powierża, IPR Manager, Head of BioTech-IP
  • Dr. Piotr Kamiński, European Patent Attorney
  • Adam Głuszuk, Bogna Hryniszyn, Monika Kornacka, NCP Experts on Horizon2020
  • Prof. Jacek Kuźnicki, IIMCB Director and Dorota Libiszowska, Marcin Ogonowski, Dr. Urszula Wyrzykowska, IIMCB Project Managers
  • Dr. Krzysztof Skowronek, Expert on Mass Spectrometry
  • Dr. Tomasz Węgierski, Expert on Fluorescence microscopy 
  • Dr. Agnieszka Chołuj, Head of Centre for Innovative Bioscience Education (BIoCEN)

Course trainees:

  • Scientists from IMBG: Valeriia Dotsenko, Dmytro Gerasymchuk, Viktoriia Kosach, Iryna Khomenko, Veronika Kushniruk, Oleksandr Kondratov, Zarina Nidoieva, Volodymyr Rushchak, Oleksandr Savytskyi,  Oleksandr Skorokhod, Liudmyla Shkotova, Olena Zinchenko, Yanina Mishchuk

Practical Training on IPR, Project Management and Equipment for a group of junior scientists from the Institute of Molecular Biology and Genetics in Kiev, Ukraine, took place in the framework of the COMBIOM project titled: ’’Strengthening Cooperation in Molecular Biomedicine between EU and Ukraine”, co-financed from the European Union 7th Framework Programme. This complex training gave trainees a thorough insight into the following subject:  IPR, patenting and commercialization of scientific results; funding opportunities under the current EU Framework Programme - Horizon 2020, and projects management; principles and on-site training of Mass Spectrometry and Fluorescence microscopy;  BioCEN good practices in popularization of science.  

Program of the Training

 
                                                                                                                                                                               

BRAINSTORMING SESSION on TALEN and CRISPR/Cas9 based methods
for genome modification
 

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The International Institute of Molecular and Cell Biology patronizes
the 10th Warsaw International Medical Congress

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 The 10th Warsaw International Medical Congress will take place on May 15-18, 2014 at the Didactic Center of Medical University of Warsaw, Poland.

The Warsaw International Medical Congress (WIMC) is one of the most significant medical student scientific gatherings in Central Europe. Every year WIMC hosts over 400 participants from all around the world. Last year more than 300 presentations were given in 27 sessions.


                                                                                                                                                                               

Launch of the International Year of Crystallography (IYCr2014)
20-21 January 2014, Paris

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On January 20-21, 2014 Dr. Marcin Nowotny and Prof. Jacek Kuźnicki participated in the IYCr2014 Opening Ceremony in Paris, France. Dr. Nowotny was representing Eastern Europe and took part in a session ’’Young talented crystallographers of the World’’.

2014 was chosen as the year to celebrate crystallography as it is close to the anniversaries of two major landmarks in the field’s history. Just over a hundred years ago, father-and-son team William Henry and William Lawrence Bragg first showed that diffracted x-rays can be used to map the positions of atoms within a crystal and determine its three-dimensional structure. It is also around 400 years since one of the earliest studies of crystal structures: astronomer Johannes Kepler’s observations of ice crystals in snowflakes. This year also commemorates the 50th anniversary of another Nobel Prize, awarded to Dorothy Hodgkin for her work on vitamin B12 and penicillin.

The year-long celebration aims to strengthen international collaboration and increase public awareness of crystallography with a series of conferences, exhibitions and educational activities taking place throughout 2014.


                                                                                                                                                                               

Opening of the Academic Year 2013/2014 at Biocentrum Ochota

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On October 25 the Opening of the Academic Year 2013/2014 was held at Biocentrum Ochota. The PhD students of IIMCB organized the ceremony with the invited keynote speakers, prof. Gottfried Schatz, prof. Ineke Braakman and a special guest, the co-recipient of the 2012 Nobel Prize in Chemistry, prof. Brian Kobilka.

The event started with the awards ceremony for the best PhD dissertations of year 2012. The opening lecture ‘’Science and the modern university’’ was delivered by prof. Gottfried Schatz,  Professor emeritus of University of Basel, Switzerland. The next lecture ‘’From Pharmacy to Molecular Cell Biology’’ was presented by prof. Ineke Braakman from the Utrecht University, the Netherlands. The ceremony was honored by the presence of prof. Michał Kleiber, the President of the Polish Academy of  Sciences and directors of all individual institutes of Biocentrum Ochota. More than 150 PhD students of Biocentrum Ochota participated in the event. Furthermore, PhD students from Institute of Molecular Biology and Genetics (Ukraine), Utrecht University (the Netherlands) and Friedrich Miescher Institute for Biomedical Research (Switzerland) accepted the invitation and joined the Opening.

There was a competition for the best PhD student talks. The check for 600 euro was handed over to the best speaker, Magdalena Richter from the Institute of Biochemistry and Biophysics, PAS. During the coffee break, there were three speakers' corners where PhD students could ask questions to prof. Schatz, prof. Braakman and prof. Kobilka. There was a poster session with a competition for the best poster. The best poster was presented by Agnieszka Mamińska, PhD student of the International Institute of Molecuar and Cell Biology. Next there was a time to discuss science during a dinner with a string quartet. The event ended with a dance party.

The event was supported by all institutes of Biocentrum Ochota. Moreover, EMBO supported prof. Schatz's lecture and VitaInSilica, Life Technologies, Eppendorf and Sigma-Aldrich were the sponsors of the awards.

For more information and the abstract book please visit the official page of the event: http://www.biocentrumochota.pan.pl/OpeningAcademicYear

 

 
                                                                                                                                                                               
 
COMBIOM
 
Course on Research Integrity and Responsible Conduct of Research
30 September - 3 October 2013, IIMCB, Warsaw
 
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Course expert: Prof. Nils Axelsen, Ombudsman for Research Integrity at Statens Serum Institut in Copenhagen and the co-founder of the Danish Committees on Scientific Dishonesty.
Course trainees: Young scientists from IMBG and IIMCB: Liliia Andriichuk, Dmytro Gerasymchuk, Oleksandr Korolov, Viktoriia Kosach, Kateryna Kotsarenko, Ihor Kravchuk, Olga Maliuta, Larysa Matsevych, Viacheslav Shalak, Oleksandr Skorokhod, Olexii Stepanenko, Sam Dinesh Stephen (IIMCB), Anna Tyutyunnykova.
Course co-teachers: Anna Bartosik, Agnieszka Chacińska, Prof. Jacek Kuźnicki, Michał Wasilewski.
 
The first such Course performed at IIMCB took place in the framework of the COMBIOM project titled: „Strengthening Cooperation in Molecular Biomedicine between EU and Ukraine” co-financed from the European Union 7th Framework Programme. It was organised in a very practical way where trainees presented and discussed different relevant cases and regulations, as well as played roles in a dramatic play on authorship.  This complex training gave trainees a thorough insight into the subject of responsible conduct or research, its importance and consequences of scientific misconduct.
 
The Course covered the following topics:
  • The international history of scientific dishonesty including the political turbulence and the heart searching of the scientific communities in USA and Europe. 
  • The nature and (high) prevalence of misconduct; whistleblowing; handling of allegations for scientific misconduct in different countries; ORI’s interactive movie: The Lab; the full reports on the Sudbø case and the Stapel-case; IIMCB’s Ordinance No.3/2006.
  • Questionable Research Practices and it’s possible reasons.
  • A case for authorship (dramatic play); the ICMJE guidelines for authorship; how to prevent, and solve authorship disputes; cases of authorship disputes; importance of agreements in research.
  • The Singapore Statement on Research Integrity; The European Code of Conduct for Research Integrity; The Polish Academy of Science: Good Manners in Science; IIMCB’s Ordinance No.2/2006. NSteneck: ORI Introduction to the responsible conduct of research.
  • Strength, weaknesses and complexity of peer review; 14 golden rules for editors; the Committee for Publication Ethics; how to avoid plagiarism; retractions; new forms for publication; conflict of interests.
  • The ten most important things to know about research ethics.
  • Round table discussion: How can each of us implement Responsible Conduct of Research in daily life? How to find information and help?
 
 
                                                                                                                                                                               
 
HEALTH‑PROT Workshop

„Summary of scientific results of the project and domestic actions beyond”
26 March 2012, Sopot, Poland

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Speakers:
Jacek Kuźnicki HEALTH‑PROT project at the IIMCB and its international and domestic extension
Ewa Łojkowska Intercollegiate Faculty of Biotechnology UG and MUG – a unique example of the interaction between two universities
MacieJ Żylicz MDM2’s dilemma: to be an oncogene or tumour suppressor
Janusz M. Bujnicki From bioinformatics to protein engineering
Matthias Bochtler A new CG methyltransferase
Marta Miączyńska Multiple roles of endocytic proteins in the regulation of signal transduction
Jacek Jaworski Neuronal dendritic arbor, a playground for understanding non‑canonical functions of mTOR
Michał Witt Cilia biology, a key to multiple pathologies
Agnieszka Chacińska Redox‑driven protein import into mitochondria – nothing by chance
Marcin Nowotny Structural studies of a monomeric reverse transcriptase
Roman Szczepanowski Presentation of principal scientific equipment available at IIMCB
Jacek Kuźnicki Calcium and beta‑catenin signaling in the brain
 
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[                                                                                                                                                                               
 
International Institute of Molecular and Cell Biology in Warsaw

invites to the seminar and equipment presentation:
 
Stephen Blanke, PhD
 NanoTemper Technologies GmbH, Munich, Germany

Some like it hot  -  Biomolecule Analytics using Microscale Thermophoresis (MST)
 
Wednesday, 15.02.2012,  9:15 AM
IIMCB, Ks. Trojdena 4 the lecture hall 0-12
The presentation gives an overview of Microscale Thermophoresis (MST), a new technology for the measurement of biomolecule interactions. The term Microscale Thermophoresis refers to the directed movement of molecules in optically generated microscopic temperature gradients. This thermophoretic movement is determined by the entropy of the hydration shell around the molecules. Almost all interactions between molecules and virtually any biochemical process are linked to a change in size, charge and/or conformation of molecules which alter this hydration shell and therefore can be detected and quantified by MST.
Microscale Thermophoresis allows quantification of binding affinities of proteins, nucleic acids and small molecules as well as measurement of enzymatic activities. In addition also functional studies of small molecule inhibitors are possible. The steep microscopic temperature gradient is generated by an IR-Laser, which is strongly absorbed by water. The readout method of the interaction analysis is based on fluorescence: fluorescently labeled proteins/peptides/nucleic acids can be used as well as intrinsic tryptophane fluorescence or proteins expressed with GFP/YFP/RFP.
The presentation will cover: 1) Technical details and benefits of the Microscale Thermophoresis technology platform and 2) Examples of interaction measurements ranging from protein – ribosome, protein – protein, small molecule – receptor down to protein – ion binding studies to experiments where the interactions between receptors incorporated in vesicles and soluble proteins are analyzed.
 
 
 
                                                                                                                                                                                
 
PhD Report Session #2
The International Institute of Molecular and Cell Biology in Warsaw (IIMCB)
January 12th (Thursday) 2012, the lecture hall 012,
ground floor
chair: Agnieszka Górnicka (Laboratory of Mitochondrial Biogenesis)
14:55 – 15:00 Welcome!

15:00 – 16:00 Session I: 4 x presentation (10min + 5min)
   
15:00 – 15:15
Protein import into mitochondria: Changes in the rodox state of the Mia40 receptor upon the precursor binding.
Tomasz Czerwik (Laboratory of Mitochondrial Biogenesis)
15:15 – 15:30
Detection of DNA modification in bacterial nucleotide excision repair system.  
Marcin Jaciuk  (Laboratory of Protein Structure)
15:30 – 15:45
Mapping interactions between DNA repair enzymes MLH1 and MBD4.
Katarzyna Poleszak (Laboratory of Bioinformatics and Protein Engineering)
15:45 – 16:00
MetaDisorder – integrated platform for predicting intrinsic disorder in proteins.  
Łukasz Kozłowski (Laboratory of Bioinformatics and Protein Engineering)
   
16:00 - 16:15 coffee break (15min)

16:15 – 17:00 Session II: 3 x presentation (10min + 5min)
16:15 – 16:30
New regulators of cell signaling among endocytic proteins.  
Agnieszka Mamińska (Laboratory of Cell Biology)
16:30 – 16:45
TCF7L2 is a candidate for terminal selector of thalamic neurons.  
Andrzej Nagalski (Laboratory of Neurodegeneration)
16:45 – 17:00
What can one find in PDB?  
Juliusz Stasiewicz (Laboratory of Bioinformatics and Protein Engineering)
   
                                                                                                                                                                               
 
International Institute of Molecular and Cell Biology in Warsaw

invites to a panel discussion*:
 
Silicon’s tales:
TOP500 Innovators Program discussed by its participants
   
Ryszard Buczyński        Warsaw University 
Marek Bury                     Warsaw University of Technology 
Magdalena Powierża      IIMCB
Jarosław Sarnecki          Air Force Institute of Technology 
Mateusz Śmietana          Warsaw University of Technology 
Adam Sobczak              IIMCB
Marta Wachowicz          Space Research Center PAS 
 
Moderator: 
Iwona Cymerman          IIMCB  
 
TOP500 Innovators “Science-Management-Commercialization” program is organized by Ministry of Science and Higher Education.
In 2011 we have visited Stanford University and now we would like to share with you our experiences, impressions and answer your questions.
discussion will be held *in Polish on January 17th (Tuesday) 2012, at 11:00 a.m.
at the International Institute of Molecular and Cell Biology in Warsaw
ul. Ks. Trojdena 4, the lecture hall 0-12, ground floor