JACEK JAWORSKI, PhD

Affiliation:
2005 - Postdoctoral associate, Howard Hughes Medical Institute & Picower Center for Learning and Memory, Massachusetts Institute of Technology
E18-215, 77 Massachusetts Ave.
Cambridge, MA 02139,USA
Ph. 617 452 2987
Fax 617-452-3692
E-mail: jaworski@mit.edu

Previous Employment:
2002 – 2005 Postdoctoral associate
Picower Center for Learning and Memory, Massachusetts Institute of Technology
1996 – 2002 Research associate , Laboratory of Molecular Neurobiology, Department of Molecular and Cellular Neurobiology, Nencki Institute, Warsaw, Poland

Education:
2001 – Ph.D. in molecular neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland
1996 - M.Sc. in Biology, Department of Genetics, Warsaw University, Poland

Trainings and Practices:
2000 - ARL Division of Neural Systems, Memory and Aging, University of Arizona, Dr. J. Guzowski, Tucson, USA
1997-2001 - Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs (L.G.N.), Prof. J. Mallet, UMR 9923 C.N.R.S., Paris, France (seven months in total)
1995/6 - Department of Genetics, Prof. P. Weglenski, Warsaw University, Poland
1994 - Department of Microbial Biochemistry, Laboratory of Dr. P. Ceglowski, Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw, Poland (4 weeks).

Scholarships, grants and awards:
2002 - Polish Prime Minister Award for the PhD thesis
2001 - Nencki Institute Award for the PhD thesis
2001 - State Committee for Scientific Research grant no. 6P04B02421 “Application of high resolution in situ fluorescent hybridization (catFISH) for studying regulation of immediate early genes expression in cells of CNS”. 1 year grant
2001 - Foundation for Polish Science National Scholarship for Young Investigators, 1 year scholarship
2000 - EMBO Short Term Fellowship; to visit in 2000 Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs (L.G.N.) in Paris, France
2000 - Polish Network for Cell and Molecular Biology UNESCO/PAN Scholarship -
to visit in 2000 ARL Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, USA.
1998 - State Committee for Scientific Research grant no. 4 P05A00715: “Involvement of AP-1 transcription factor in apoptosis of granular cells of the dentate gyrus in cell culture”. 3 years grant.
1997 - Bourse de stage du Gouvernement Francaise (French Government Scholarship), 2 months travel scholarship to visit Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs (L.G.N.) in Paris, France
1997-2005 -Travel scholarship from ISN, German Neuroscience Society, Deutsche Forschungsgemeinschaft, FEBS, SFN/IBRO, Foundation of St. Batory, Polish Foundation of Experimental and Clinical Oncology.

List of publications (original publications):
- Jaworski J., Spangler S., Seeburg DP., Hoogenraad CC., Sheng M:Control of dendritic arborization by the PI3-kinase – Akt - mTOR pathway, submitted.
- Nolan EM., Jaworski J., Okamoto K., Hayashi Y., Sheng M., and Lippard SJ. QZ1 and QZ2, quinoline-derivatized fluoresceins for sensing biological Zn(II) with rapid reversible binding, submitted
- Dunah AW., Hueske E., Wyszynski M., Hoogenraad CC., Jaworski J., Pak DT., Simonetta A., Liu G., Sheng M. (2005) LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses in hippocampal neurons. Nat. Neurosci., in press.
- Konopka W., Duniec K., Mioduszewska B., Proszynski T., Jaworski J., Kaczmarek L. (2005) hCMV and Tet promoters for the inducible gene expression in rat neurons in vitro and in vivo. Neurobiol. Dis., in press
- Chang CJ., Nolan EM., Jaworski J., Okamoto K., Hayashi Y., Sheng M., Lippard SJ. (2004) ZP8, an improved neuronal zinc sensor of the ZP family: Application to imaging zinc in hippocampal slices with two-photon microscopy. Inorganic Chemistry, 43:6774-6779.
- Kowalczyk A., Filipkowski RK., Rylski M., Wilczynski GM., Konopacki FA., Jaworski J., Maria A. Ciemerych MA., Sicinski P., Kaczmarek L. (2004) The critical role of cyclin D2 in adult neurogenesis. J. Cell. Biol., 167: 209-213.
- Chang CJ., Nolan EM., Jaworski J., Burdette SC., Sheng M., Lippard SJ. (2004) Novel fluorescent chemosensor platforms for imaging endogenous pools of neuronal zinc. Chemistry&Biology, 11: 203-210
- Chang CJ., Jaworski J., Nolan EM., Sheng M., Lippard SJ. (2004) A tautomeric zinc sensor for ratiometric fluorescence imaging: Application to nitric oxide-induced release of intracellular zinc. Proc Natl Acad Sci U S A., 101: 1129-1134
- Gozdz A., Habas A., Jaworski J., Zielinska M., Albrecht J., Chlystun M., Jalili A., Hetman M. (2003) Role of N-methyl-D-aspartate receptors in the neuroprotective activation of Extracellular Signal Regulated Kinase1/2 by Cisplatin. J. Biol. Chem., 278: 43663-71
- Mioduszewska B., Jaworski J., Kaczmarek L. (2003) Inducible cAMP early repressor (ICER) in the nervous system - a transcriptional regulator of neuronal plasticity and programmed cell death. J. Neurochem., 87: 1313-1320
- Jaworski J., Mioduszewska B., Sanchez-Capelo A., Figiel I., Habas A., Gozdz A, Proszynki T., Hetman H., Mallet J., Kaczmarek L. (2003) Inducible cAMP Early Repressor (ICER), an endogenous antagonist of cAMP responsive element binding protein (CREB) evokes neuronal apoptosis in vitro. J. Neurosci., 23: 4519-4526.
- Jaworski J., Savonenko A., Lukasiuk K., Werka T., Rydz M., Nikolaev E., Zielinski K., Kaczmarek L. (2002) AP-1 transcription factor in acqusition of two-way avoidance behavior. Memory and Emotion (Calabrese P., Neugenauer A., red.), World Scientific, New Jersey, London, Singaprore, Hong Kong, pp. 65-69
- Jaworski J., Figiel I., Proszynski T., Kaczmarek L. (2000) Efficient expression of tetracycline-responsive gene following transfection of dentate gyrus neurons in vitro. J. Neurosci. Res., 60: 754-760.
- Jaworski J., Biederman I., Lapinska J., Szklarczyk A.W., Figiel I., Konopka D., Nowicka D., Filipkowski R.K., Hetman M., Kowalczyk A., Kaczmarek L. (1999) Neuronal excitation-driven and AP-1-dependent activation of timp1 gene expression in rodent hippocampus. J. Biol. Chem., 274: 28106-28112
- Figiel I., Jaworski J., Kaczmarek L (1998) Hippocampal cells in culture as a model to study neuronal apoptosis. w: Merten O-W, Perrin P., Griffiths B. (eds.) New Developments and New Applications in Animal Cell Technology, Kulwer Academic Publishers, 255-259.

Other publications:
- Kaczmarek L., Kamińska-Kaczmarek B., Savonenko A., Łukasiuk K., Jaworski J., Biedermann I., Zieliński K., Werka T., Nikolaev E., Szklarczyk A., Dzwonek J., Kowalczyk A., Konopka D., Nowicka D., Rydz M., Filipkowski R., Figiel-Ożóg I. (2000) Involvement of regulation of gene expression in processes of integration of information in neurons. PAN Działalnoœć naukowa, wybrane zagadnienia, 9: 46-48. – in Polish.
- Jaworski J. (1998) Controlled expression of exogenous genes in mammalian cells. Postępy Biochemii, 44 (1): 40-48. – in Polish.