IIMCB

 

 

tl_files/Institute/Logo/IIMCB_CMYK.png

The Laboratory of Cell Biology headed by Professor Marta Miączyńska Is looking for highly motivated and talented Master student

Position in the project: Master student

Scientific discipline: cell biology, cancer biology

Job type (employment contract/stipend): stipend

Number of job offers: 1

Remuneration/stipend amount/month: 1500-2500 PLN (depending on experience and time commitment)

Position starts on: 2 October 2017 (or later to be discussed)

Maximum  period of contract/stipend agreement: 12 – 18 months

Institution: Laboratory of Cell Biology, International Institute of Molecular and Cell Biology (IIMCB) in Warsaw

Project leader:  Prof. Marta Miączyńska

Project title: Cellular consequences of endosomal dysfunction for proteostasis, metabolism and cancer biology (TEAM grant funded by Foundation for Polish Science)

Project description: The project combines molecular cell biology and cancer biology. It aims to elucidate the consequences of endosomal dysfunction in mammalian cells and their contribution to tumorigenesis.

Key responsibilities include: Experimental studies using biochemical, microscopy and transcriptomic techniques, performed independently and in collaboration with other team members. Investigation of metabolic processes, membrane transport and signal transduction in mammalian cells.

Profile of candidates/requirements:
1.    Solid knowledge and familiarity with laboratory techniques in at least one of the following disciplines: cell biology, molecular biology, biochemistry, cancer biology, genomics/transcriptomics
2.    Very good command of English (oral and written)
3.    Motivation and passion for experimental work

Required documents:
1.    Motivation letter (in English)
2.    CV (in English)
3.    Subjects studied and grades obtained (in English or in Polish)
4.    Contact details of the scientific supervisor and if available other personal referees

Please submit the application documents to: team-recruitment@iimcb.gov.pl

Application deadline: 22 September 2017

For more details about the position please visit: http://www.iimcb.gov.pl/jobs.html; http://www.iimcb.gov.pl/Miaczynska-Laboratory-research-focus.html

Please include in your application:
“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”



 

tl_files/Institute/Logo/IIMCB_CMYK.png

International Institute of Molecular and Cell Biology in WarsawLaboratory of Neurodegeneration headed by Professor Jacek Kuznickiis seeking a talented
Postdoctoral fellow
(NCN OPUS)

Position in the project:
Postdoctoral researcher

Number of job offers:
1

Institution:
International Institute of Molecular and Cell Biology in Warsaw, Laboratory of Neurodegeneration (www.iimcb.gov.pl)


Requirements:
- doctoral degree (not earlier than in January 2010) in molecular, cell or developmental biology and/or bioinformatics (with experience in the wet lab);
- substantial research experience and publication record with at least one first author paper in international recognized journals
- prior research experience in cell biology, fish biology or bioimaging or all of these;
- ability to work independently but also as a part of a team;
- interest in and knowledge of neurobiology;
- written and spoken fluency in English;
- creative and independent approach, motivation to work in research, analytical thinking.
- Experience in calcium imaging and protein biochemistry will be a plus.

Description of tasks:
- Analysis of calcium homeostasis in zebrafish and the role of Stim protein (using in situ hybridization and immunohistochemistry, imaging of calcium signaling in vivo in the brain of 5-day-old zebrafish and in primary neuronal cultures from zebrafish)  
- Identification of Stim-dependent calcium channels by immunoprecipitation and subsequent mass spectrometry, co-localization of selected Stim targets on fixed primary cell cultures from zebrafish larvae and/or whole-mount zebrafish larvae.
- Analysis of behavior of Stim-/- lines.

Appllication deadline:
25th of August 2017.

Job type:
full-time position, contract of employment, ca. 7083 gross/month for 3 years


How to apply:
Please send your application including CV, motivation letter, the list of publications, candidate’s research achievements, and names of three referees to the e-mail address: rekrutacja-LN@iimcb.gov.pl until 25th of August 2017. Thanking all applicants for their interest, we will contact only selected candidates for an interview. In case no suitable candidates are found, we will continue collecting applications.

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

International Institute of Molecular and Cell Biology in WarsawLaboratory of Neurodegeneration headed by Professor Jacek Kuznickiis seeking a talented
PhD Student
(NCN OPUS)

Position in the project:
PhD student - scholarship position

Number of job offers:
2

Institution:
International Institute of Molecular and Cell Biology in Warsaw, Laboratory of Neurodegeneration (www.iimcb.gov.pl)

Requirements:
- master's degree in biology or related field;
- good knowledge of cell and molecular biology;
- experience in laboratory work, including fish biology;
- research experience abroad;
- interest in neurobiology research;
- written and spoken fluency in English;
- creative and independent approach, motivation to work in research, analytical thinking.
- Experience in calcium imaging and protein biochemistry will be a plus.

Description of tasks:
- Analysis of calcium homeostasis in zebrafish and the role of Stim protein (using in situ hybridization and immunohistochemistry, imaging of calcium signaling in vivo in the brain zebrafish larvae and in primary neuronal cultures from zebrafish); 
- Identification of Stim-dependent calcium channels by immunoprecipitation and subsequent mass spectrometry, co-localization of selected Stim targets on fixed primary cell cultures from zebrafish larvae and/or whole-mount zebrafish larvae;
- Analysis of behavior of Stim-/- lines.

Application deadline:
25th of August, 2017

Job type:
Scholarship agreement, 3000 PLN net/month for 3 years


How to apply:
Please send your application to the e-mail address: rekrutacja-LN@iimcb.gov.pl until 25th of August 2017. The application should include cover letter, CV including candidate’s research achievements, the list of publications, and names of two referees. Thanking all applicants for their interest, we will contact only selected candidates for an interview. In case no suitable candidates are found, we will continue collecting applications.


Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

In case of resignation of the selected candidate, the scholarship will be awarded to the next person on the ranking list.

The recruitment procedure fulfills the National Science Centre’s regulations on granting the scholarships to young scientists.

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

The laboratory of Zebrafish Developmental Genomics headed by Cecilia L. Winata is
looking for highly a motivated and talented PhD student

The Laboratory of Zebrafish Developmental Genomics headed by Cecilia L. Winata was established in partnership with the Max Planck Institute for Heart and Lung Research (MPI-HLR). The focus of our research is to elucidate the gene regulatory networks and epigenetic mechanisms regulating various aspects of developmental biology as the initial step towards understanding human genetic diseases. Our research employs state of the art methodology based on Next-Generation Sequencing as well as CRISPR/Cas9 genome editing technology.

We invite application from motivated and talented individuals for a PhD student position in bioinformatics within the project titled “Bioinformatics discovery of novel elements of the zebrafish transcriptome”.  The biological part of the project aims to discover novel transcriptome elements in zebrafish. In particular, but not limited to, novel noncoding RNA species expressed in cardiomiocytes at early developmental stages. In addition, the project will also involve the development of methods that will improve the process of novel transcriptome elements discovery using diverse set of NGS data.

The ideal candidate should be able to communicate in English language and possess good communication skills. A good understanding of any of the following subjects is essential: bioinformatics, molecular biology, biochemistry, and/or genetics principles.

We offer stipend depending on the candidates’ qualifications and the chance to work in a team of young and friendly scientists with interests in developmental biology, regulatory genomics, epigenetics, and biochemistry.

Please forward your complete application including a CV, a motivation letter, university scores, and the contact of at least one referee to rekrutacjazdg@iimcb.gov.pl with the subject line “Bioinformatics – PhD student” until the 28th of July 2017. Thanking all applicants for their interest, only selected candidates will be invited for an interview.

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.
 

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

JOB OFFER

Position in the project:
postdoc (researcher)

Scientific discipline:
protein biochemistry, structural biology

Job type (employment contract/stipend):
employment contract

Number of job offers:
1

Remuneration /month:
ca. 9000 PLN gross (6000 PLN net)/month plus annual bonus and thirteenth salary

Position starts on:
01.12.2017

Maximum period of contract/stipend agreement:
36 months

Institution:
International Institute of Molecular and Cell Biology in Warsaw (IIMCB, www.iimcb.gov.pl) is ranked in the top 3% of research institutions in Poland, producing world class publications and providing outstanding environment for basic research and applied biotechnology.

Project leader:
Dr. Izabela Sabała

Project title:
INFECTLESS New generation of antibacterial wound dressing

Project is carried out within the TeamTech programme of the Foundation for Polish Science

Project description:
Dr Sabala’s team is focused on investigating of new antimicrobial proteins, their activity and potential applications as antimicrobial agents in various areas of industry. It requires involvement of experts in biochemistry (protein engineering, structural biology) nanomaterials, regenerative medicine and industrial biotechnology. The successful candidate will be involved in an exciting multidisciplinary research programme which aims to develop new generation of effective, antimicrobial wound dressings.

Key responsibilities include:
1.     Production and purification of recombinant proteins
2.     Protein engineering
3.      Biochemical, biophysical and structural characterization of proteins
4.     Supervision of postgraduate students

Profile of candidates/requirements:
1.      PhD degree in biological sciences or related fields, obtained not earlier than in 2013
2.      Solid knowledge and experience in protein biochemistry and/or molecular biology. Experience in structural biology (crystallography) would be an asset.
3.      Good publication record
4.     Very good oral and written command of English

Required documents:
1.      Motivation letter
2.     CV including the list of publications
3.     Scan of the PhD diploma
4.     Contact details for at least two referees including at least one former or current direct supervisor

We offer:
·      Opportunities to get training in IP protection, technology transfer and soft skills
·       Access to state-of-the-art equipment and excellent research facilities at IIMCB
·      Ongoing support and mentoring from experienced researchers
·      Reduced-rate for individual medical care packages
·      Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/

Please submit the following documents to:
aurezyna@iimcb.gov.pl

Only selected candidates will be contacted and invited for an interview that will take place at IIMCB in October

Application deadline:
15.09.2017

For more details about the position please and the project visit:
www.auresine.com

http://www.iimcb.gov.pl/aurezyna.html

Euraxess job offer:
-

 

Please include in your offer:
“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

 

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

JOB OFFER

Position in the project:
PhD student

Scientific discipline:
protein biochemistry

Job type (employment contract/stipend):
stipend

Number of job offers:
2

Remuneration /month:
4000 PLN/month

Position starts on:
01.12.2017 or earlier

Maximum period of contract/stipend agreement:
36 months (with possible extension)

Institution:
International Institute of Molecular and Cell Biology in Warsaw (IIMCB, www.iimcb.gov.pl) is ranked in the top 3% of research institutions in Poland, producing world class publications and providing outstanding environment for basic research and applied biotechnology.

Project leader:
Dr. Izabela Sabała

Project title:
INFECTLESS New generation of antibacterial wound dressing

Project is carried out within the TeamTech programme of the Foundation for Polish Science

Project description:
Dr Sabala’s team is focused on investigating of new antimicrobial proteins, their activity and potential applications as antimicrobial agents in various areas of industry. It requires involvement of experts in biochemistry (protein engineering, structural biology) nanomaterials, regenerative medicine and industrial biotechnology. The successful candidate will be involved in an exciting multidisciplinary research programme which aims to develop new generation of effective, antimicrobial wound dressings.

Key responsibilities include:
1.     Production and purification of recombinant proteins
2.     Protein engineering
3.      Biochemical and biophysical characterization of proteins

Profile of candidates/requirements:
1.      MSc degree in biological sciences or related fields
2.      Solid knowledge in protein biochemistry and/or molecular biology
3.      Laboratory experience in protein biochemistry
4.     Very good oral and written command of English

Required documents:
1.      Motivation letter
2.     CV including the list of publications
3.     Scan of the MSc diploma
4.     Contact details for at least two referees including at least one former or current direct supervisor

We offer:
·      Opportunity to transfer skills and technology from basic research to industry
·       Access to state-of-the-art equipment  and excellent research facilities at IIMCB
·      Ongoing support and mentoring from experienced researchers Reduced-rate for individual medical care packages
·      Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)

Please submit the following documents to:
aurezyna@iimcb.gov.pl

Only selected candidates will be contacted and invited for an interview that will take place at IIMCB in October

Application deadline:
15.09.2017

For more details about the position please and the project visit:
www.auresine.com

http://www.iimcb.gov.pl/aurezyna.html

Euraxess job offer:
-

 

Please include in your offer:
“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

 

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

JOB OFFER

Position in the project:
MSc Student

Scientific discipline:
protein biochemistry

Job type (employment contract/stipend):
stipend

Number of job offers:
1

Remuneration /month:
1500 PLN/month

Position starts on:
01.12.2017 or earlier

Maximum period of contract/stipend agreement:
10 months

Institution:
International Institute of Molecular and Cell Biology in Warsaw (IIMCB, www.iimcb.gov.pl) is ranked in the top 3% of research institutions in Poland, producing world class publications and providing outstanding environment for basic research and applied biotechnology.

Project leader:
Dr. Izabela Sabała

Project title:
INFECTLESS New generation of antibacterial wound dressing

Project is carried out within the TeamTech programme of the Foundation for Polish Science

Project description:
Dr Sabala’s team is focused on investigating of new antimicrobial proteins, their activity and potential applications as antimicrobial agents in various areas of industry. It requires involvement of experts in biochemistry (protein engineering, structural biology) nanomaterials, regenerative medicine and industrial biotechnology. The successful candidate will be involved in an exciting multidisciplinary research programme which aims to develop new generation of effective, antimicrobial wound dressings.

Key responsibilities include:
1.     Production and purification of recombinant proteins
2.      Biochemical and biophysical characterization of proteins

Profile of candidates/requirements:
1.      BSc degree in biological sciences or related fields
2.      Solid knowledge in protein biochemistry and/or molecular biology
3.      Laboratory experience in protein biochemistry and/or molecular biology
4.     Good oral and written command of English

Required documents:
1.      Motivation letter
2.     CV
3.     Contact details and/or reference letter form former or current supervisor

We offer:
·      Participation in challenging, interdisciplinary project  which combines basic research with advanced applications
·       Access to state-of-the-art equipment and excellent facilities at IIMCB
·      Ongoing mentoring and support of experienced researchers

Please submit the following documents to:
aurezyna@iimcb.gov.pl

Only selected candidates will be contacted and invited for an interview that will take place in October

Application deadline:
15.09.2017

For more details about the position please and the project visit:
www.auresine.com

http://www.iimcb.gov.pl/aurezyna.html

Euraxess job offer:
-

 

Please include in your offer:
“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

 

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

The Laboratory of Protein Structure headed by dr hab. Marcin Nowotny is looking for highly motivated and talented:

postdoctoral fellows


for the TEAM grant awarded by Foundation for Polish Science (FNP) entitled: “Structural and biochemical studies of the mechanism of LINE-1 retrotransposition and hepadnaviral replication”. The project combines molecular and structural biology. It aims to determine the structures of reverse transcriptases and to elucidate their functional mechanism. The experimental work will involve production of protein using different expression systems, purification of proteins, crystallization and structure determination as well as biochemical studies on reverse transcription and retrotransposition mechanism. The project started on June 1-st 2017 and will last for 3 year. The employment contract for postdocs will amount to 6000-8000 PLN net/month depending on experience. 

Requirements for candidates:
- Solid knowledge and documented laboratory experience in at least one of the following disciplines: structural biology, molecular biology, biochemistry
- Very good command of English (oral and written)
- Motivation and passion for experimental work
- PhD degree in biological sciences or related fields, obtained not earlier than in 2012
 

Required documents for postdoc candidates:
- Motivation letter (in English)
- CV and the list of publications (in English)
- Scan of the PhD diploma
- Contact details of two personal referees
 


Please submit the application documents to: praca@iimcb.gov.pl titled postdoc_TEAM.  

 
Application deadline: 25th of August 2017. Selected candidates will be invited for an interview.

 
Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

Job Offer: PhD student

(NCN founded scholarship, grant OPUS-ST6), development of simulation methods for RNA 3D structure prediction

Description of the project:
The title of the project is: "A coarse-grained method for RNA 3D structure modeling, with emphasis on non-canonical base pairing". This will be further development of SimRNA. SimRNA is successful, already implemented and published method for RNA folding simulations and 3D structure prediction. (just google "SimRNA"). The main goal will be development towards better recapitulation of non-canonical base pairing, also improving overall prediction ability. The project also includes studies of folding RNA with restraints. Selected candidate will work together with PI (Michał Boniecki) (optionally with other lab members) on further development of SimRNA as well as investigate folding of RNA molecules. Typical tasks are (optionally, only some of them will be done by selected candidate):
• development (programming) and testing of SimRNA and also other scripts or programs
• running/setting up simulations, making structure predictions (of RNA molecules
• studies of folding with restraints
• processing results, making statistics
• deriving statistical potentials (also preparing/filtering data sets of experimentally solved structures PDB)
• optimization of parameters (at various levels/stages)
• development of web server that runs SimRNA (in web server mode)
• preparing conference materials (seminars, posters ...)
• sharing of knowledge and experience
The project will be executed in prof. Janusz Bujnicki lab (www.genesilico.pl), Principle Investigator of the project will be dr Michał Boniecki.

Requirements:
Candidates with skills listed below will be preferred:
• MSc in science or engineering (physics, chemistry, computer science, bioinformatics, biology or related)
• understanding of basic concepts of dealing with / programming geometry 3D
• programming/designing in languages: C/C++ (python will be an advantage)
• understanding or/and experience in deriving statistical potentials (machine learning issues)
• understanding or/and experience in optimization issues (in practice)
• understanding of issues of folding of biomolecules (especially RNA)
• understanding or/and Django framework
• English, fluent spoken and written
• creativity and dedication towards work and learning
• good interpersonal skills, sharing knowledge and experience

Benefits:
We are an interdisciplinary team (www.genesilico.pl) that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases.
Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics/
Scholarship agreement, 3000 PLN per month netto.

How to apply:
Please send your CV and motivation letter (preferably as one PDF) to mboni@genesilico.pl (please do not send files bigger than 5 MB). Application should include a short statement of research interests, a brief description of scientific achievements (if applicable), and, if possible, contact information for one or two  references.
Questions about the position can be send to mboni@genesilico.pl or employment@genesilico.pl
Applications will be collected until 31 of July 2017.

 In case no suitable candidates are found, we will continue collecting applications
Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.
The recruitment procedure fulfills the National Science Centre’s regulations on granting the scholarships to young scientists.

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

International Institute of Molecular and Cell Biology in Warsaw
Laboratory of Protein Metabolism in Development and Aging

is seeking PhD student

Location: Warsaw, a vibrant city with an international academic research environment. International Institute of Molecular and Cell Biology (www.iimcb.gov.pl) - one of the most dynamic and top ranked Polish research institutes.

Job description: Laboratory of Protein Metabolism in Development and Aging, which will be opening on August 2017, is seeking highly motivated PhD candidates to join our young team investigating the protein homeostasis in development and aging. We use both genetic, molecular and biochemical approaches, primarily in the C. elegans, to study proteolytic networks. PhD fellowship is funded in frame of National Science Centre OPUS grant.

Summary: Organismal development or environmental stimuli challenge the homeostatic protein balance (proteostasis) of individual cells, tissues or the entire organism. The ubiquitin proteasome system (UPS) is a key determinant of proteostasis as it regulates the turnover of damaged proteins supporting cellular protein homeostasis and thereby maintains the proteome during stress and aging. Our long-term objective is to understand the mechanistic and developmental aspects of protein degradation pathways defined by combinations of particular ubiquitin ligases (E3). The identification of stress and aging-induced signals that coordinate the interplay between specific E3s will offer intriguingly new mechanistic insights how proteolytic networks are fine-tuned to maintain the cellular proteome and support development and longevity.

Qualifications:
• master degree in any field related to biological sciences obtained within the last two years;
• general laboratory experience;
• expertise in either of the following areas will be preferred: cell biology, molecular biology, genetics,  biochemistry, fluorescence microscopy
• analytical and creative thinking;
• ability to communicate knowledge in English (written and spoken);
• motivation and passion for experimental work;
• excellent interpersonal skills. 

How to apply:
Please send your application to the e-mail address: wpokrzywa@iimcb.gov.pl, until 6th August 2017. The application should include cover letter, CV including candidate’s research achievements, university scores, and marks for candidate’s master degree. Thanking all applicants for their interest, we will contact only selected candidates for an interview.
Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.
The recruitment procedure fulfills the National Science Centre’s regulations on granting the scholarships to young scientists.

Selected publications:
Riga T*, Pokrzywa W*, Kevei E, Akyuz M, Vishnu Balaji, Svenja Adrian, Hoehfeld J, Hoppe T. (2017). The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover. Cell. 169: 470-482.

 Ackermann L., Schell M., Pokrzywa W., Gartner A., Schumacher B., Hoppe T. (2016). E4 ubiquitin ligase specific degradation hubs coordinate DNA double strand break repair and apoptosis. Nat Struct Mol Biol. 23: 995-1002

 Kaushik S, and Cuervo AM (2015). Proteostasis and aging.  Nat Med. 21, 1406-15

 Frumkin A, Dror S, Pokrzywa W, Bar-Lavan Y, Karady I, Hoppe T, Ben-Zvi A. (2014). Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans. Front Mol Biosci., doi: 10.3389

 van Oosten-Hawle P, and Morimoto RI (2014). Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling. Genes & Dev. 28: 1533-43

 Segref A, Kevei E, Pokrzywa W, Mansfeld J, Schmeisser K, Livnat-Levanon N, Ensenauer R,  Glickman M.H, Ristow M, Hoppe T. (2014). Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome-system. Cell Metab. 4:642-652

 Pokrzywa W. and Hoppe T. (2013). Chaperoning myosin assembly in muscle formation and aging. Worm. 2:e25644

 Gazda L*, Pokrzywa W*, Hellerschmied D, Loewe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T. (2013). The myosin chaperone UNC-45 is organized in tandem modules to support myofilaments formation in C. elegans. Cell. 1, 183-195.

 Kuhlbrodt K, Janiesch PC, Kevei E, Segref A, Barikbin R, and Hoppe T (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol. 13, 273-81


tl_files/HR_EX.png

http://www.iimcb.gov.pl/hr-excellence-in-research.html

 


 

tl_files/Institute/Logo/IIMCB_CMYK.png

International Institute of Molecular and Cell Biology in Warsaw
Laboratory of Protein Metabolism in Development and Aging

is seeking a talented Postdoctoral fellow


Location:
Warsaw, a vibrant city with an international academic research environment. International Institute of Molecular and Cell Biology (www.iimcb.gov.pl) - one of the most dynamic and top ranked Polish research institutes.

Job description: Laboratory of Protein Metabolism in Development and Aging, which will be opening on August 2017, is seeking highly motivated and talented Postdoc to join young team investigating the protein homeostasis in development and aging. We use both genetic, molecular and biochemical approaches, primarily in the C. elegans, to study proteolytic networks. Postdoc fellowship is funded in frame of National Science Centre OPUS grant.

Summary: Organismal development or environmental stimuli challenge the homeostatic protein balance (proteostasis) of individual cells, tissues or the entire organism. The ubiquitin proteasome system (UPS) is a key determinant of proteostasis as it regulates the turnover of damaged proteins supporting cellular protein homeostasis and thereby maintains the proteome during stress and aging. Our long-term objective is to understand the mechanistic and developmental aspects of protein degradation pathways defined by combinations of particular ubiquitin ligases (E3). The identification of stress and aging-induced signals that coordinate the interplay between specific E3s will offer intriguingly new mechanistic insights how proteolytic networks are fine-tuned to maintain the cellular proteome and support development and longevity.

Qualifications:
• PhD (or be close to completion) in Molecular Biology, Cell Biology, Protein Chemistry, Genetics or a related discipline;
• experience in C. elegans or cell culture is an advantage;
• experience in Next Generation Sequencing techniques (RNA-Seq, ChIP-Seq) and genomic engineering is an advantage;
• good writing and oral communication skills in English, and competence in scientific writing.

How to apply:
Please send your application including CV, motivation letter and the list of publications to the e-mail address: wpokrzywa@iimcb.gov.pl, until 6th August 2017. Thanking all applicants for their interest, we will contact only selected candidates for an interview.
Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.
The recruitment procedure fulfills the National Science Centre’s regulations on granting the scholarships to young scientists.

Selected publications:

Riga T*, Pokrzywa W*, Kevei E, Akyuz M, Vishnu Balaji, Svenja Adrian, Hoehfeld J, Hoppe T. (2017). The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover. Cell. 169: 470-482.

Ackermann L., Schell M., Pokrzywa W., Gartner A., Schumacher B., Hoppe T. (2016). E4 ubiquitin ligase specific degradation hubs coordinate DNA double strand break repair and apoptosis. Nat Struct Mol Biol. 23: 995-1002

 Kaushik S, and Cuervo AM (2015). Proteostasis and aging.  Nat Med. 21, 1406-15

 Frumkin A, Dror S, Pokrzywa W, Bar-Lavan Y, Karady I, Hoppe T, Ben-Zvi A. (2014). Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans. Front Mol Biosci., doi: 10.3389

 van Oosten-Hawle P, and Morimoto RI (2014). Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling. Genes & Dev. 28: 1533-43

 Segref A, Kevei E, Pokrzywa W, Mansfeld J, Schmeisser K, Livnat-Levanon N, Ensenauer R,  Glickman M.H, Ristow M, Hoppe T. (2014). Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome-system. Cell Metab. 4:642-652

 Pokrzywa W. and Hoppe T. (2013). Chaperoning myosin assembly in muscle formation and aging. Worm. 2:e25644

 Gazda L*, Pokrzywa W*, Hellerschmied D, Loewe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T. (2013). The myosin chaperone UNC-45 is organized in tandem modules to support myofilaments formation in C. elegans. Cell. 1, 183-195.

 Kuhlbrodt K, Janiesch PC, Kevei E, Segref A, Barikbin R, and Hoppe T (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol. 13, 273-81

 

tl_files/HR_EX.png

http://www.iimcb.gov.pl/hr-excellence-in-research.html