IIMCB

 

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The Laboratory of Protein structure headed dr hab. Marcin Nowotny is looking for highly motivated and talented:

- PhD students
- postdoctoral fellows

for the TEAM grant awarded by Foundation for Polish Science (FNP) entitled: “Structural and biochemical studies of the mechanism of LINE-1 retrotransposition and hepadnaviral replication”. The project combines molecular and structural biology. It aims to determine the structures of  reverse transcriptases and to elucidate their  functional mechanism.  The experimental work will involve production of protein using different expression systems, purification of proteins,  crystallization and structure determination as well as biochemical studies on reverse transcription and retrotransposition mechanism . The project will start on June 1st  2017 and will last for 3 year. PhD students will be awarded a stipend of 4500 PLN net/month. The employment contract for postdocs will amount to 6000-8000 PLN net/month depending on experience.

Requirements for candidates:

-          Solid knowledge and documented laboratory experience in at least one of the following disciplines: structural biology, molecular biology, biochemistry

-          Very good command of English (oral and written)

-          Motivation and passion for experimental work

Additionally for postdoc candidates: PhD degree in biological sciences or related fields, obtained not earlier than in 2012.

Required documents for prospective PhD students:

-          Motivation letter (in English)

-          CV (in English)

-          Subjects studied and grades obtained (in English or in Polish)

-          Contact details of the scientific supervisor and if available other personal referees

Required documents for postdoc candidates:

-          Motivation letter (in English)

-          CV and the list of publications (in English)

-          Scan of the PhD diploma

-          Contact details of two personal referees

Please submit the application documents to: praca@iimcb.gov.pl titled PhD student_TEAM or postdoc_TEAM, respectively.

 

Application deadline: 10 April 2017. Selected candidates will be invited for an interview.

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

 

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Laboratory of Neurodegeneration headed by Prof. Jacek Kuznicki

is looking for a highly motivated, talented and enthusiastic PhD student

who is interested in working with the zebrafish model in the OPUS project awarded by the National Science Centre. The aim of the project, led by Prof. Vladimir Korzh is to investigate the role of K channel Kv2.1 (Kcnb1) in the development of the brain ventricular system, to establish zebrafish transgenics expressing fluorescent proteins in the developing brain ventricular system and to study developmental factors involved.

The successful candidate will be performing molecular biology experiments including PCR, Western blot, in situ hybridization and microscopy techniques. Moreover, he/she will become familiar with gene editing technology using the CRISPR/Cas9 system. In the course of work with zebrafish the student will assist in animal handling, crossing fish, renewing lines and fish genotyping.

The ideal candidate should be:

  • a graduate of biology, biochemistry, biotechnology or related fields,
  • prepared to develop work experience in an international lab setting under guidance of one of the world experts in zebrafish biology,
  • interested in experimental work and learning new molecular techniques/methods,
  • able to communicate in English and possess good teamwork skills.

Previous experience in working with animal models is highly desirable.

Remuneration will be offered according to the NCN regulations.

Please submit the application documents to: vkorzh@iimcb.gov.pl with the reference “student_OPUS” before 15th March 2017. The application in English should include a CV and a brief cover letter. Only selected candidates will be contacted regarding further selection procedures.

Please include in your application the following statement:

“In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”

 

 

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Laboratory of Cell Biology headed by Prof. Marta Miączyńska 

is looking for a highly motivated, talented and enthusiastic undergraduate student

who is interested in working with the zebrafish model in the SONATA project awarded by the National Science Centre. The aim of the project, led by Dr. Lidia Wolińska-Nizioł is to investigate the role of Tollip protein in the early zebrafish development and to establish its potential function in protein homeostasis.

The successful candidate will be performing molecular biology experiments including PCR, Western blot, in situ hybridization and microscopy techniques. Moreover, he/she will become familiar with gene editing technology using the CRISPR/Cas9 system. In the course of work with zebrafish the student will assist in animal handling, crossing fish, renewing lines and fish genotyping.

The ideal candidate should be

  • an undergraduate student of biology, biochemistry, biotechnology or related fields,
  • prepared to balance his/her other coursework at the university with a challenging work experience in a lab setting,
  • interested in experimental work and learning new molecular techniques/methods,
  • able to communicate in English and possess good teamwork skills.

Previous experience in working with animal models is highly desirable.

Remuneration will be offered depending on the level of experience and time commitment of the successful candidate.

Please submit the application documents to: lwolinska@iimcb.gov.pl with the reference “student_Sonata” before 10th March 2017. The application in English should include a CV and a brief cover letter. Only selected candidates will be contacted regarding further selection procedures.

Please include in your application the following statement:

“In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

 


 


 

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International Institute of Molecular and Cell Biology (IIMCB), Warsaw, Poland

invites applications for the position of

Director

The IIMCB seeks a Director to provide scientific and operational leadership for one of Poland’s leading institutions in molecular and cell biology. The successful candidate will be appointed for 4 years, with a possibility of further extension. Candidates should hold a Ph.D, M.D./Ph.D, or equivalent degree in a relevant field of biology or medicine, have senior level scientific experience, an outstanding scientific record, and proven leadership in a major research unit. Salary and research support will be commensurate with the experience of the candidate. The position will be available from February 1, 2018. 

The IIMCB is an independent, state of the art research facility located in a center of a large academic campus. IIMCB’s working language is English. The primary objective of the new director is to lead further development of the institute so that the IIMCB will continue to meet the highest scientific standards in forthcoming years. The successful candidate will be supported by an outstanding administrative staff, three deputy directors, and significant laboratory space and research funding. Preference will be given to applicants with research interests focused on problems in modern molecular biomedicine.

For more information see: www.iimcb.gov.pl. For informal inquiries contact Professor Walter J. Chazin, Chair of the IIMCB International Advisory Board (walter.j.chazin@vanderbilt.edu) and/or Dr. Urszula Wyrzykowska, Deputy Director for Development of IIMCB (ulawyrzykowska@iimcb.gov.pl).

Applications should include a cover letter, CV, and statement of research interests, along with a concise description of the candidate’s vision for the future development and management of the IIMCB. Documents should be sent electronically to: director-competition@iimcb.gov.pl.

A short list of top candidates will be invited for a presentation at IIMCB during the annual meeting of the International Advisory Board on June 3, 2017. The deadline for applications is May 1, 2017.

 

 


 

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The Laboratory of Cell Biology headed by Prof. Marta Miączyńska

is seeking for a PhD student

for the OPUS grant (National Science Centre) entitled: “The impact of intracellular distribution and endocytic transport of lymphotoxin β receptor (LTβR) on its signaling”. The project, led by Dr. Magdalena Banach-Orłowska, aims to elucidate the endocytic routes responsible for lymphotoxin β receptor internalization and intracellular trafficking as well as to determine a relationship between endocytosis and LTβR mediated signaling. The experimental work planned for the PhD student will involve mostly microscopy, biochemical, and molecular biology techniques.

The project will start on March 31st 2017 and will last for 3 years. The PhD student will be awarded a stipend of 3000 PLN net/month.

Requirements for candidates:

  1. Master degree in biology or biotechnology
  2. Experience in laboratory work in cell biology, molecular biology, biochemistry (at least one of the listed fields)
  3. High motivation and passion for experimental work
  4. Teamwork skills
  5. Good command of English

Required documents for prospective PhD students:

  1. Motivation letter (in English)
  2. CV (in English)
  3. Subjects studied and grades obtained (in English or in Polish)
  4. Contact details of the scientific supervisor and if available other personal referees

 

Please submit the application documents to: praca@iimcb.gov.pl with the reference “PhD student_LCB_OPUS”.

Application deadline: 15 March 2017. The shortlisted candidates will be contacted regarding further selection procedures. 

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.


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PhD student position in software development for molecular modeling

in the Bujnicki group in IIMCB, Warsaw, Poland

 

We are looking for junior scientists with energy and passion, interested in bioinformatics, software development and molecular simulations, and motivated to develop a career in an interdisciplinary and international research team.

We are one of the most successful RNA modeling teams in the world: check out the rankings of RNA Puzzles and our results at http://ahsoka.u-strasbg.fr/rnapuzzles/problems_past.php

We offer you a chance to be a part of this success.

PhD-software-modeling: You will develop computer software for RNA 3D structure prediction and modeling, building on our successful tools, in particular ModeRNA and SimRNA.
Our big goal is to model RNA-protein and RNA-ligand interactions towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry.
You must have skills in programming: C/C++ or Python (you will need to learn and use both).
Experience in bioinformatics, molecular modeling, computational biophysics, computational chemistry, structural biology and related areas will be an advantage, but is not essential.

 

About us:

• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.

• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015, Matelska et al. Genome Biol Evol 2016. We also develop databases that are widely used, such as the MODOMICS database of RNA modification pathways. We are also involved in efforts towards commercialization of our results.

• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

• Check out http://genesilico.pl for details

 

We offer:

• Focused scientific projects with well-defined goals that balance safety (high chance to generate publishable results quickly) and big challenges (high risk and high gain).

• Flexible PhD studies with 100% focus on research (no teaching obligations).

• Unique environment for junior scientists to work in a top research center, develop skills in bioinformatics, and gain experience in analyzing real biological data.

• A chance to collaborate with and learn from extraordinary, exceptional, and eccentric ;-) experts.

• Participation in courses, scientific training, support from peers, and academic mentoring

• Individual thesis advisory committee, with top international experts.

• Basic funding (3000 PLN/month, initially as a contract for specific work /umowa o dzieło/ during a trial period, then a PhD fellowship starting October 2017). The work can start as soon as possible.

• Opportunity and support to compete for additional funding from grants and fellowships.

 

How to apply:

• We will collect applications until February 15th or until suitable candidates are found

Apply now (or ask any questions you may have) to employment@genesilico.pl  

• In the subject include "PhD-software-modeling" and your first and last name.

• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), and contacts to at least two potential referees, including at least one former or current direct supervisor.

• The application must contain the following statement to allow us to process your data: "I hereby give consent for my personal data included in the job offer to be processed for the purposed of recruitment under the Data Protection Act 1997 (Dz. U. 2002 no. 101, item 926 with subs. changes)." / "Wyrażam zgodę na przetwarzanie danych osobowych w celach rekrutacji zgodnie z ustawą z dnia 29 sierpnia 1997 r. o ochronie danych osobowych (tekst jedn.: Dz U. z 2002 r. Nr 101, poz 926 z późn. zm.)."

• Best candidates will be given additional questions and tasks before the final interview.

 


 

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The Bochtler laboratory at the
International Institute of Molecular and Cell Biology (IIMCB)

is looking for a postdoc to work on an NCN funded project on the mixed lineage leukemia (MLL) proteins

The project in collaboration with Prof. Albert Jeltsch aims for a better understanding of MLL recruitment to its target loci in chromatin, and for a characterization in the specificity switch caused by the COMPASS complex binding partners of MLL.

Experience in biochemistry and/or structural biology is required, additional expertise with high-throughput sequencing (particularly CHIP-Seq) would be an asset.

Funding is either for one postdoc for 24 months or for two postdocs for 12 months each.

Applications until February 28th to pokafor@iimcb.gov.pl



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PhD STUDENT POSITION AVAILABLE

at the Laboratory of Protein Structure of
INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY

Post

Laboratory of Protein Structure seeks  PhD Student to study biochemical and structural evolution of reverse transcriptases.   PhD fellowship is funded in frame of National Science Centre OPUS grant. High motivation, analytical skills and independent thinking, experience with molecular biology and protein purification or protein crystallography (preferred)  as well as fluent English are required.

Laboratory Interest

Research of Laboratory of Protein Structure focuses on structural and biochemical studies of nucleic acid enzymes using protein crystallography as a primary method. More information can be found at http://www.iimcb.gov.pl/Nowotny-Laboratory-research-focus.html.

Selected publication

Nowak E, Miller JT, Bona MK, Studnicka J, Szczepanowski RH, Jurkowski J, Le Grice SFJ, Nowotny M. Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. 2014. Nature Structural & Molecular Biology, 21(4) 389-96.

Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M. Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid. 2013. Nucleic Acids Res, 41(6) 3874-87.

Gaur V, Wyatt HDM, Komorowska W, Szczepanowski RH, de Sanctis D, Gorecka KM, West SC, Nowotny M. Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease. 2015. Cell Reports, 10 .

Miętus M, Nowak E, Jaciuk M, Kustosz P, Studnicka J, Nowotny M. Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. 2014. Nucleic Acids Res, 42(16) 10762-75.

 

Interested candidates are kindly asked to provide short motivation letter, CV and the name of a referee by February 15-th . Application should be submitted to praca@iimcb.gov.pl titled  PhD student_OPUS_LSB. The shortlisted candidates will be contacted regarding further selection procedures.



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The Laboratory of Cell Biology headed by Prof. Marta Miączyńska is looking for highly motivated and talented:

- PhD students
- postdoctoral fellows

for the TEAM grant awarded by Foundation for Polish Science (FNP) entitled: “Cellular consequences of endosomal dysfunction for proteostasis, metabolism and cancer biology”.  The project combines molecular cell biology and cancer biology. It aims to elucidate the consequences of endosomal dysfunction in mammalian cells and their contribution to tumorigenesis. The experimental work will involve biochemical, microscopy and transcriptomic techniques to investigate metabolic processes, membrane transport and signal transduction in mammalian cells. The project will start on June 1st  2017 and will last for 3 years, with a possibility of extension. PhD students will be awarded a stipend of 4500 PLN net/month. The employment contract for postdocs will amount to 6000-8000 PLN net/month depending on experience.

Requirements for candidates:

  1. Solid knowledge and documented laboratory experience in at least one of the following disciplines: cell biology, molecular biology, biochemistry, cancer biology, genomics/transcriptomics
  2. Very good command of English (oral and written)
  3. Motivation and passion for experimental work

Additionally for postdoc candidates: PhD degree in biological sciences or related fields, obtained not earlier than in 2012.

Required documents for prospective PhD students:

  1. Motivation letter (in English)
  2. CV (in English)
  3. Subjects studied and grades obtained (in English or in Polish)
  4. Contact details of the scientific supervisor and if available other personal referees

Required documents for postdoc candidates:

  1. Motivation letter (in English)
  2. CV and the list of publications (in English)
  3. Scan of the PhD diploma
  4. Contact details of two personal referees

 

Please submit the application documents to: recruitment-lcb@iimcb.gov.pl

Application deadline: 24 February 2017. Selected candidates will be invited for an interview. 

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.




    

TWO FULL-TIME POSITIONS FOR PH.D. CANDIDATES

Laboratory of Biomolecular Interactions and Transport (www.labbit.eu)

 

We are seeking motivated colleagues to fill in two vacant positions of Ph.D. student at newly formed Laboratory of Biomolecular Interactions and Transport (www.labbit.eu). Successful candidates will study mechanisms of action of biomedically and biotechnologically interesting proteins and their interactions with a host of small molecules by using the state-of-the-art computational methods. The laboratory is located in Poznan, Poland, and is jointly affiliated to the International Institute of Molecular and Cell Biology in Warsaw and the Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznan – both rank among the top research institutes in Poland.

Examples of available research topics

  • modeling of molecular mechanisms in function of proteins
  • study of effects of mutations on protein function
  • discovery of novel inhibitors of enzymes
  • projects driven by your own ideas

Requirements

  • master´s degree in biophysics, bioinformatics, biochemistry, computational chemistry or related field; candidates expected to receive their degrees this year will also be considered.
  • good knowledge of Linux OS 
  • hands-on experience in molecular modeling, bioinformatics or computational chemistry–highly desirable
  • high motivation and enthusiasm
  • basic scripting/programming  skills, e.g., Python, BASH, JAVA, etc.
  • fluency in English

Our offer

  • friendly, dynamic and supportive environment
  • training in advanced computational methods
  • opportunity to participate in international courses and conferences
  • fully funded position – net fellowship 3,000 PLN / month
  • help with applications for additional funding during your studies

How to apply

Please send your applications or additional questions to jbrezovsky@iimcb.gov.pl or janbre@amu.edu.pl by March 31, 2017. The selected candidates will be invited for an interview. The starting date is May 1, 2017.

The application should be prepared in English and contain:

  • Curriculum Vitae
  • one-page cover letter describing your motivation and previous experience
  • two letters of recommendation - at least one should be from your direct supervisor
  • please include the following statement in your application: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

Selected publications

  • ACS Catalysis 6: 7597-7610, 2016
  • Nucleic Acids Research 44: W479-487, 2016
  • Nature Chemical Biology 10: 428-430, 2014
  • Journal of the American Chemical Society 137: 4988-4992, 2015
  • PLoS Computational Biology 12: e1004962, 2016
  • Journal of Chemical Information and Modeling 55: 54-62, 2015.

 




  

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Technician POSITION AVAILABLE

Laboratory of Zebrafish Developmental Genomics

 

We are looking for a technician to prepare and conduct laboratory experiments in the POLONEZ-1 project ‘Deciphering the role of RNA editing in zebrafish development'.

Requirements:
- Master degree (or equivalent) in biology or related discipline
- Good knowledge of molecular biology techniques and experience in lab work is essential
- Good command of English language
- Previous animal handling experience


Conditions:
Work contract (umowa o pracę) from 1 Feb 2017 till 31 Dec 2018 (23 months) with possibility of extension.
Competitive salary and possibility of professional training.


Required documents:
- CV covering contact details, previous scientific activities, publication list, participation in scientific projects, conferences, workshops, scholarship programmes, and contact details for two previous supervisors
- motivation letter


Deadline: 23rd Jan 2017, 12:00

Applications entitled ‘[technician position] RNA editing’ should be directed to lpryszcz [at] iimcb.gov.pl

Selected candidates will be invited for an interview in the last week of January 2017.

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.


 

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Research technician position available jointly at the

Laboratory of Zebrafish Developmental Genomics and the Laboratory of Mitochondrial Biogenesis headed by Agnieszka Chacinska

 

The Laboratory of Zebrafish Developmental Genomics headed by Cecilia L. Winata and the Laboratory of Mitochondrial Biogenesis headed by Agnieszka Chacinska at the  International Institute for Molecular and Cell Biology ,Warsaw jointly invite application from motivated and talented individuals for the position of ‘Research technician’. The selected candidate will be working on the project titled “localized translation on the surface of mitochondria” .

The ideal candidate should have previous laboratory experience in basic Biochemistry and Molecular biology techniques and a thorough understanding of the principles. Additionally, candidate should be able to communicate fluently in English.

We offer the chance to work in a team of young and friendly scientists with interests in biochemistry, mitochondrial biology, developmental biology, and regulatory genomics. The successful candidate will have the opportunity to work with the zebrafish model animal and learn and apply next generation sequencing methods.

Please forward your complete application including a CV, a motivation letter, university scores, and the contact of at least one referee to rekrutacjazdg[at]iimcb.gov.pl with the subject line “Research Technician - Mitochondria”. The position is open immediately and will remain open until a suitable candidate is found. Only selected candidates will be invited for an interview.

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.


 

 

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PhD STUDENT POSITION AVAILABLE

at the Laboratory of Molecular and Cellular Neurobiology of

INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY

 

Post

Laboratory of Molecular and Cell Neurobiology seeks 2 PhD Students to study various aspects of mTOR contribution to regulation motor protein functions in neuronal development and neurodevelopmental diseases. These 2 PhD fellowships are funded in frame of National Science Centre OPUS grant. High motivation, analytical skills and independent thinking, experience with molecular and cell biology or neurobiology, and microscopy techniques as well as fluent English are required.

Laboratory interest

Research of Laboratory of Molecular and Cell Neurobiology focuses on molecular aspects of development of neurons. We are especially interested in role of mTOR kinase regulated processes (e.g., cytoskeleton dynamics, protein translation, membrane trafficking) in neurogenesis starting from neural stem cells to the end of circuitry formation. More info can be found at IIMCB Annual Reports (http://www.iimcb.gov.pl/annual_reports.php).

Selected publications

Lipka J., Kapitein LC., Jaworski J., Hoogenraad CC. (2016) Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO J. 35:302-18.

Malik AR., Liszewska E., Skalecka A., Urbanska M., Iyer AM., Swiech LJ., Perycz M., Parobczak K., Pietruszka P., Zarebska MM., Macias M., Kotulska K., Borkowska J., Grajkowska W., Tyburczy ME., Jozwiak S., Kwiatkowski DJ., Aronica E., Jaworski J. (2015) Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. Acta Neuropathol. Commun. 3(1):48.

Malik AR., Urbanska M., Gozdz A, Swiech LJ., Nagalski A., Perycz M., Blazejczyk M., Jaworski J. (2013) Cyr61, a matricellular protein, is needed for dendritic arborization of hippocampal neurons. J Biol Chem., 288: 8544-59.

Urbanska M, Gozdz A, Swiech LJ, Jaworski J. (2012) Mammalian target of rapamycin complex 1 (MTORC1) and 2 (MTORC2) control the dendritic arbor morphology of hippocampal neurons. J Biol Chem., 287: 30240-56

Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B., Malik A., Wulf P., Hoogenraad CC., Jaworski J. (2011) CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci., 31:4555-4568.

Jaworski J., Kapitein LC., Montenegro Gouveia S., Dortland BR., Wulf PS., Grigoriev I., Camera P., Spangler SA., di Stefano P., Demmers J., Krugers H., Defilippi P., Akhmanova A. and Hoogenraad CC. (2009) Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron, 61:85-100.

 

Interested candidates are kindly asked to contact Dr. Jaworski by e-mail only (jaworski@iimcb.gov.pl) and provide short motivation letter, CV and the name of a referee by February 1st. The shortlisted candidates will be contacted regarding further selection procedures.  

 


 

 
 

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The laboratory of Zebrafish Developmental Genomics headed by Cecilia L. Winata is

looking for highly motivated and talented undergraduate students

 

The Laboratory of Zebrafish Developmental Genomics headed by Cecilia L. Winata was established in partnership with the Max Planck Institute for Heart and Lung Research (MPIHLR). The focus of our research is to elucidate the gene regulatory networks and epigenetic mechanisms regulating various aspects of developmental biology as the initial step towards understanding human genetic diseases. Our research employs state of the art methodology
based on Next-Generation Sequencing as well as CRISPR/Cas9 genome editing technology.

We invite application from motivated and talented students to perform the research part of their Master thesis in the study of heart pacemaker development using zebrafish as a model. The project titled “Genomics dissection of the heart pacemaker in Zebrafish” will be funded by the First-TEAM grant from the Foundation for Polish Science (FNP) starting from January 2017 for 18 months. The ideal candidate should be able to communicate in English language and possess good communication skills. A good understanding of any of the following subjects is essential: molecular biology, biochemistry, and/or genetics principles. Prior experience in lab work is highly desired.

We offer stipend in the range of 1500 - 2500 PLN/month depending on the candidates’ qualifications and time commitment, and the chance to work in a team of young and friendly scientists with interests in developmental biology, regulatory genomics, epigenetics, and biochemistry. The successful candidate will have the opportunity to work with the zebrafish model animal and learn and apply state of the art microscopy techniques on in vivo imaging
of the heart, as well as other methods in zebrafish developmental biology.

Please forward your complete application including a CV, a motivation letter, university scores, and the contact of at least one referee to rekrutacjazdg@iimcb.gov.pl with the subject line “First-TEAM” until the 28th of February 2017. Thanking all applicants for their interest, only selected candidates will be invited for an interview.

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

 

 

 


 

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POSTDOCTORAL POSITION AVAILABLE

at INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY

Post

Laboratory of Molecular and Cell Neurobiology seeks a highly motivated

Postdoctoral Fellow

to study effects of mTOR on molecular motors. This National Science Centre-funded position is available for a period of up to 3 years (starting March 2017), and requires practical skills in cell biology and live imaging techniques (e.g. spinning disc microscopy). Experience with zebrafish model and molecular biology, or biochemistry will be an additional asset.

Laboratory interest

Research of Laboratory of Molecular and Cell Neurobiology focuses on molecular and cell biology aspects of development of neurons. We are especially interested in role of mTOR kinase in neurodevelopment and neurodevelopmental diseases More info can be found at IIMCB Annual Reports (http://www.iimcb.gov.pl/annual_reports.php)

Selected publications

Blazejczyk M., Macias M., Korostynski M., Pieprzyk M., Piechota M., Skalecka A., Tempes A., Koscielny A., Przewlocki R., Jaworski J. (2016) Kainic acid induces mTORC1-dependent expression of Elmo1 in hippocampal neurons. Mol. Neurobiol., in press

Lipka J., Kapitein LC., Jaworski J., Hoogenraad CC. (2016) Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO J. 35:302-18.

Malik AR., Liszewska E., Skalecka A., Urbanska M., Iyer AM., Swiech LJ., Perycz M., Parobczak K., Pietruszka P., Zarebska MM., Macias M., Kotulska K., Borkowska J., Grajkowska W., Tyburczy ME., Jozwiak S., Kwiatkowski DJ., Aronica E., Jaworski J. (2015) Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. Acta Neuropathol. Commun. 3(1):48.

Urbanska M., Gozdz A., Swiech LJ., Jaworski J. (2012) Mammalian target of rapamycin complex 1 (MTORC1) and 2 (MTORC2) control the dendritic arbor morphology of hippocampal neurons. J. Biol. Chem., 287: 30240-56.

Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B., Malik A., Wulf P., Hoogenraad CC., Jaworski J. (2011) CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci., 31:4555-4568

Jaworski J., Kapitein LC., Montenegro Gouveia S., Dortland BR., Wulf PS., Grigoriev I., Camera P., Spangler SA., di Stefano P., Demmers J., Krugers H., Defilippi P., Akhmanova A. and Hoogenraad CC. (2009) Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron, 61:85-100.

 

Interested candidates are kindly asked to contact Dr. Jaworski (jaworski@iimcb.gov.pl ) and provide short motivation letter, CV and the names of two referees. 


 

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POSTDOCTORAL POSITION AVAILABLE

at INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY

 

Post

Laboratory of Molecular and Cell Neurobiology seeks a highly motivated Postdoctoral Fellow to use iPS technology to model development of mTOR-dependent epilepsy. This STRATEGMED-funded position is available for a period of up to 3 years (starting April. 1st 2017), and requires previous experience in iPS and stem cells technology. Experience with either neural stem cells, molecular biology techniques, imaging or electrophysiology will be an additional asset.

Laboratory interest

Research of Laboratory of Molecular and Cell Neurobiology focuses on molecular and cell biology aspects of development of neurons. We are especially interested in role of mTOR kinase in neurodevelopment and neurodevelopmental diseases More info can be found at IIMCB Annual Reports (http://www.iimcb.gov.pl/annual_reports.php)

Selected publications

Blazejczyk M., Macias M., Korostynski M., Pieprzyk M., Piechota M., Skalecka A., Tempes A., Koscielny A., Urbanska M., Przewlocki R., Jaworski J. (2016) Kainic acid induces mTORC1-dependent expression of Elmo1 in hippocampal neurons. Mol. Neurobiol., in press

Malik AR., Liszewska E., Skalecka A., Urbanska M., Iyer AM., Swiech LJ., Perycz M., Parobczak K., Pietruszka P., Zarebska MM., Macias M., Kotulska K., Borkowska J., Grajkowska W., Tyburczy ME., Jozwiak S., Kwiatkowski DJ., Aronica E., Jaworski J. (2015) Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. Acta Neuropathol. Commun. 3(1):48.

Urbanska M., Gozdz A., Swiech LJ., Jaworski J. (2012) Mammalian target of rapamycin complex 1 (MTORC1) and 2 (MTORC2) control the dendritic arbor morphology of hippocampal neurons. J. Biol. Chem., 287: 30240-56.

Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B., Malik A., Wulf P., Hoogenraad CC., Jaworski J. (2011) CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci., 31:4555-4568

Jaworski J., Kapitein LC., Montenegro Gouveia S., Dortland BR., Wulf PS., Grigoriev I., Camera P., Spangler SA., di Stefano P., Demmers J., Krugers H., Defilippi P., Akhmanova A. and Hoogenraad CC. (2009) Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron, 61:85-100.

 

Interested candidates are kindly asked to contact Dr. Jaworski (jaworski@iimcb.gov.pl ) and provide short motivation letter, CV and the names of two referees.

 


 

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Laboratory of Mitochondrial BiogenesisInternational

Institute of Molecular and Cell Biology in Warsaw

offers research position for PhD student

Prof. Agnieszka Chacinska’s Laboratory is seeking for highly motivated and talented individual who will be recruited for a PhD student position to investigate fundamental biological processes involved in mitochondrial biogenesis within the project awarded by the National Science Centre within the OPUS Programme. The laboratory is located in the International Institute of Molecular and Cell Biology in Warsaw (www.iimcb.gov.pl) – one of the top ranked Polish research institutes.

We offer the opportunity to work in the international team of young and open-minded scientists with multiple domestic and international collaborations. Our research interests concern mechanisms of protein sorting in mitochondria, cytoplasmic systems caring for precursors of mitochondrial proteins and a crosstalk between the transport of mitochondrial proteins, oxidative stress and cellular protein homeostasis. We use diverse model systems such as yeast, human cells, fish Danio rerio and worm Caenorhabditis elegans. We are interested in fundamental cellular mechanisms in physiology as well as in pathology and ageing. Our recent achievements include papers published in Nature and PNAS.

Please send your application by e-mail as soon as possible, but not later than 16th December 2016, to the following address: mito-recruitment@iimcb.gov.pl. The application should include cover letter, CV with candidate’s research achievements, university scores, average overall mark and marks for candidate’s master degree (thesis and defense), contact information to at least one referee. We thank all applicants for their interest, however, only selected candidates will be invited for an interview.

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

The recruitment procedure fulfills the National Science Centre’s regulations on granting the scholarships to young scientists.

To learn about our research, please search PubMed and visit our Institute’s website:

http://www.iimcb.gov.pl/Chacinska-Laboratory-research-focus.html.

If you have any questions, please contact Maria Łepkowska: mlepkowska@iimcb.gov.pl