Michal Witt

b. 1956; M. Sc. biochemistry Adam Mickiewicz University Poznan 1979; M.D. University of Medical Sciences Poznan 1986; Ph. D. natural sciences 1982; Dr hab. 1995; postdoctoral training, University of Michigan Medical School Ann Arbor, MI, 1987-90; Full Professor 2002.

At present:

Professor, head of the Division of Molecular and Clinical Genetics, Intitute of Human Genetics, Polish Academy of Sciences in Poznan; deputy director of this Institute 1992-1998. In 1994 and 1996 visiting professor, NIH, Bethesda, USA, since 1993 member of the Board of Directors of Polish Working Group for Cystic Fibrosis; 1996-2002 member of Scientific/Medical Advisory Council (SMAC) of the International Cystic Fibrosis (Mucoviscidosis) Association (ICFMA). Since 1999 deputy director for scientific matters of the International Institute of Molecular and Cell Biology in Warsaw.
Editor of the Human Genetics section of the Journal of Applied Genetics since 2001.
Board Member of the Postgraduate School of Molecular Medicine, of the Board of Directors of the Polish Genetics Society and the Polish Society of Human Genetics.

Main scientific interests:

molecular genetics of inherited diseases of respiratory tract (cystic fibrosis, immotile cilia syndrome) and of sex determination; genetics of longevity; molecular aspects of hematooncologic diseases and of bone marrow transplantation; genetics of the attention deficit hyperactivity disorder (ADHD). Involved in genetic counseling; specialist in clinical genetics. Author of original papers, reviews, and book chapters published in: Hum Genet, Am J Reprod Immunol, Biochem Biophys Res Commun, J Immunol, Am J Med Genet, Ann Hum Genet, Clin Genet, J Med Genet, Pediatric Pulmonol, J Gerontol, etc.

Selected recent publications:

Geremek M, Schoenmaker F, Zietkiewicz E, Pogorzelski A, Diehl S, Wijmenga C, Witt M.
Sequence analysis of 21 genes located in the Kartagener syndrome linkage region on chromosome 15q.
Eur J Hum Genet. 2008 Jun, 16(6):668-695

Wojda A, Zietkiewicz E, Witt M.
Effects of age and gender on micronucleus and chromosome nondisjunction frequencies in centenarians and younger subjects.
Mutagenesis 2007, 22: 195-200. Epub 2007 Feb 6

Wojda A, Zietkiewicz E, Mossakowska M, Pawlowski W, Skrzypczak K, Witt M.
Correlation between the level of cytogenetic aberrations in cultured human lymphocytes and the age and gender of donors.
J Gerontol Biol Sci 2006, Aug;61(8): 763-772

Dawidowska M, Derwich K, Szczepański T, Jółkowska J, van der Velden VHJ, van Dongen JJM, Wachowiak J, Witt M.
Pattern of immunoglobulin and T-cell receptor (Ig/TCR) gene rearrangements in Polish pediatric acute lymphoblastic leukemia patients--implications for RQ-PCR-based assessment of minimal residual disease.
Leukemia Res, 2006, 30, 1119-25

Wiktor-Jedrzejczak W, Rokicka M, Urbanowska E, Torosian T, Graczyk-Pol E, Tomaszewska A, Król M, Paluszewska M, Grodkowska A, Ziarkiewicz-Wróblewska B, Jólkowska J, Witt M.
Simultaneous transplantation of two allogeneic units of cord blood in an adult patient with acute myeloblastic leukemia. A case report.
Arch Immunol Ther Exp 2005, 53, 364-368.

Geremek M, Zietkiewicz E, Diehl S.R , Alizadeh B.Z, Wijmenga C, Witt M.
Linkage analysis localizes a Kartagener syndrome gene to a 3.5 cM region on chromosome 15q24-25
J Med Genet 2006; 43: e1. doi: 10.1136/jmg.2005.031526

Moore A, Escudier E, Roger G, Tamalet A, Pelosse B, Marlin S, Clement A, Geremek M, Delaisi B, Bridoux AM, Coste A, Witt M, Duriez B, Amselem S.
RPGR is mutated in patients with a complex X-linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa.
J Med Genet 2006, 43: 326-33. Epub 2005 Jul 31

Jolkowska J, Pieczonka A, Strabel T, Boruczkowski D, Wachowiak J, Bader P, Witt M.
Comparison of methods for quantitative analysis of hematopoietic chimerism after allogeneic stem cell transplantation using automated DNA sizing technology and fluorescent in situ hybridization
BMC Blood Disorders 2005; 5: 1

Witt M.
DNAI1 and DNAH5 and Primary Ciliary Dyskinesia or Kartagener Syndrome
W: Molecular Basis of Inborn Errors of Development, Epstein CJ, Erickson RP, Wynshaw-Boris A (eds.), Oxford University Press, New York, 2004, pp. 934-945

Lubka M, Wojda A, Witt M.
Mikrojadra w komorkach czlowieka – powstawanie, zawartoscoraz wykorzystanie diagnostyczne i prognostyczne
Post Biol Kom 2004; 31: 299-311

Jolkowska J, Witt M.
Chimeryzm komórkowy po transplantacji szpiku kostnego
Acta Haematol Polon 2004; 35: 321-328

Geremek M, Witt M.
Primary ciliary dyskinesia: genes, candidate genes and chromosomal regions.
J Appl Genet 2004; 45: 347-362

Krawczynski MR, Dmenska, H, Witt M.
Aparrent X-linked primary ciliary dyskinesia associated with retinitis pigmentosa and a hearing loss
J Appl Genet 2004; 45: 107-110

Krawczynski MR, Witt M.
PCD and RP: X-linked inheritance of both disorders
Pediatr Pulmonol 2004; 38:88-89

Wojda A, Witt M.
Manifestations of ageing at the cytogenetic level
J Appl Genet 2003; 44: 383-399

Majka L, Gozdzik J, Witt M.
Cystic fibrosis – a probable cause of Frederic Chopin’s suffering and death
J Appl Genet 2003; 44: 77-84

Wojda A, Wolnik-Brzozowska D, Lubka M, Mossakowska M, Witt M.
The 102-year old woman with translocation (7;12) and infertility in anamnesis
J Appl Genet 2003; 44: 425-427

Walkowiak J, Nousia-Arvanitakis S, Agguridaki C, Fotoulaki M, Strzykala K, Balassopoulou A, Witt M, Herzig K-H.
Longitudinal follow-up of exocrine pancreatic function in pancreatic sufficient cystic fibrosis patients with the use of fecal elastase-1 test
J Pediatr Gastroenterol Nutr 2003; 36: 474-478

Witt M, Rutkiewicz E, Wang Y-F, Sun C, Wyszynski DF, Diehl SR, Pawlik J, Zebrak J.
Identifying the genes for primary ciliary dyskinesia and Kartagener syndrome.
W: Cilia, Mucus and Mucus. From Development to Respiratory Defense, Salathe M (ed.), Marcel Dekker, Inc., New York, pp. 99-108, 2001

Ladon D, Pieczonka A, Jolkowska J, Wachowiak J, Witt M.
Molecular follow-up of donor lymphocyte infusion in CML children after allogeneic bone marrow transplantation
J Appl Genet 2001; 42: 547-552

Walkowiak J, Herzig K-H, Witt M, Pogorzelski A, Piotrowski R, Sobczynska-Tomaszewska A, Trawinska-Bartnicka M, Cichy W, Ksiezyk J, Krawczynski M.
One mild CFTR mutation does not exclude exocrine pancreatic insufficiency in cystic fibrosis patients.
Eur J Clin Invest 2001; 31: 798-801

Majka L, Pogorzelski A, Mlynarczyk W, Zebrak J, Rutkiewicz E, Nowicka A, Witt M.
Effect of genotype on selected clinical features of Polish cystic fibrosis adults
J Appl Genet 2001; 42: 367-377

Leda M, LadonD, Pieczonka A, Boruczkowski D, Jolkowska J, Witt M, Wachowiak J.
Donor lymphocyte infusion followed by interferon-alpha plus low dose cyclosporine A for modulation of donor CD3 cells activity with monitoring of minimal residual disease and cellular chimerism in a patient with first hematologic relapse of chronic myelogenous leukemia after allogeneic bone marrow transplantation.
Leukemia Res 2001; 25: 353-357

Witt M.
Mechanism, detection and significance of some chromosomal rearrangements in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).
J Appl Genet 2000; 41: 187-197

Jolkowska J, Witt M.
The Evi-1 gene - its role in pathogenesis of human leukemias.
Leukemia Res 2000; 24: 553-558

Jolkowska J, LadonD, Wachowiak J, Witt M.
Monitoring of cellular chimerism in patients after sex-mismatched bone marrow transplantation: technical report.
J Appl Genet 2000; 41: 209-212

Dörk T, Macek M Jr, Mekus F, Tümmler B, Tzountzouris J, Casals T, Krebsova A, Koudova M, Sakmaryova I, Macek M Sr, Vavrova V, Zemkova D, Ginter E, Petrova NV, Ivaschenko T, Baranov V, Witt M, Pogorzelski A, Bal J, Zekanowski C, Wagner K et al.
Characterisation of a novel 21-kb deletion, CFTRdele2,3(21kb), in the CFTR gene: a cystic fibrosis mutation of Slavic origin common in Central and East Europe.
Hum Genet 2000; 106: 259-268

Zebrak J, Skuza B, Pogorzelski A, Ligarska R, Kopytko E, Pawlik J, Rutkiewicz E, Witt M.
Partial CFTR genotyping and characterization of cystic fibrosis patients with myocardial fibrosis and necrosis.
Clin Genet 2000; 57: 56-60

Jolkowska J, Wachowiak J, Lange A, Kwissa M, Witt M.
Molecular assessment of post-BMT chimerism with the use of various biological specimens and automated DNA sizing technology.
J Hematother Stem Cell Res 2000; 9: 263-268