Position for fresh postdoc
Modelling of Membrane Proteins
Laboratory of Biomodelling focuses on investigation of membrane proteins: their structures, mechanisms of action and complexes with other proteins. We are using theoretical methods such as comparative/homology modelling, molecular mechanics and molecular dynamics (also applying external forces) and quantum chemistry.
All created structures are thoroughly checked with any existing experimental data including Atomic Force Microscopy (AFM), crosslinking studies and mutagenesis. In recent years the insight into the membrane, its structure and dynamics, and also its role in many processes altered considerably:
General view of membrane structure. a. The Singer-Nicholson "fluid mosaic model". b. An updated version (Engelman, Nature 2005).
Nevertheless, despite many experimental and computational efforts, membrane proteins are still the "Wild West" of structural biology. Our work contributes to revealing the detailed picture of this membrane-protein world.