PhD, MSc Projects (ongoing and future):
The applicants interested in working in our group are welcomed to contact us
- G-Protein Coupled Receptors - Activation
- Interactions of G-Protein (Transducin) with Rhodopsin
- Structures of complexes and process of activation
- The role of membrane in activation
- G-Protein Coupled Receptors - Deactivation
- Interactions of Rhodopsin Kinase and Arrestin with Rhodopsin
- Modelling of structures and processes
- Internalization of GPCRs
- Opioid receptors
- Modelling of structures of mu, delta and kappa opioid receptors
- Analysis of binding of agonists and antagonists
- Drug Design
- Formyl Peptide receptors
- Modelling of structures of these receptors
- Docking of peptide agonists and antagonists
- Drug Design by peptide modifications
- Neurodegeneration in Alzheimer and Parkinson Diseases
- Modelling of structures of membrane proteins - presenilins. Wild type and mutants
- Interactions of presenilins with Amyloid Precursor Protein
- Complexes of presenilins with other membrane proteins
- Minimal requirements for candidates:
- Practical knowledge of at least one protein visualizing/modelling program (e.g. YASARA, VMD, PyMol, MolMol, SPDBviewer)
- Knowledge of types of protein structures
- Practical usage of biological web servers (e.g. SwissProt, Blaster, Protein Data Bank)
- Basic programming skills (Unix or MSWindows)
- Good knowledge of English