MACIEJ ZYLICZ, PhD, Professor

Degrees
Professor, 1992
DSc.Habil. in molecular biology, Institute of Biochemistry and Biophysics, PAN, Warsaw, Poland 1986
PhD in biochemistry, Medical University of Gdansk, Poland 1979
MSc in physics, University of Gdansk, 1977 (student of physics and biology)

Post-doctoral Training
1982-1984 University of Utah, Department of Cellular, Viral and MoleŹcular Biology, Salt Lake City, UT, USA
1979-1981 University of Gdansk, Department of Biochemistry, Gdansk

Professional Employment
since Sept.1, 2005 President, Executive Director of the Fundation of Polish Science (FNP)
since 1999 Head of Department of Molecular Biology, IIMCB
1994-1999 Head of Department of Molecular and Cellular Biology, Faculty of Biotechnology, University of Gdansk
1991-1994 Head of Department of Molecular Biology, University of Gdansk
1993-1994 Visiting Professor, University of Utah, Medical Center, InstiŹtute of Oncology, Salt Lake City, UT, USA
1990-1993 Vice President, University of Gdansk
1988-1991 Associate Professor, Department of Molecular Biology, University of Gdansk
1981-1988 Assistant Professor, Department of Biochemistry, University of Gdansk

Other Professional Activities
2000-2004 Chair of Biology, Earth Sciences and EnvironŹmental Protection Commission of State CommitŹtee for Scientific Research

Membership in Scientific Societies, OrŹganizations and Panels
• Member of Polish Academy of Sciences
• Member of Polish Academy of Arts and Sciences
• Member of Academia Europaea
• Member of American Society of Biochemistry and Molecular Biology
• Member of EMBO
• Member of Advisory Editorial Board of EMBO Journal and EMBO Reports and IUBM Life
• Member of EMBO Council (2004-2009)
• Member of the Selection Committee for EMBO YIP (2001-2003)
• Polish delegate to EMBC (2001-2004)
• Member of the State Committee for Scientific Research (1997-2004)
• Polish delegate to Life Science Committee of ESF (2003-2005)
• Member of the Selection Committee for the special DFG programs (2001-2005)

Honors, Prizes, Awards
1. Prime Minister Award for Scientific Achievements, 2002
2. “L. Marchlewski” Award of Biochemistry and Biophysics Committee PAN, 2001
3. “Heweliusz” Prize for the Scientific Achievements, awarded by the President of Gdansk, 1993 4. Award of Foundation for Polish Science (FNP), 1999
5. Award of the Polish Biochemical Society for the best bioŹchemistry work performed in Polish laboratories, 1996
6. Award of Ministry of Education, 1994
7. Award of Polish Academy of Sciences, 1990
8. Individual Award of Polish Academy of Sciences for ScienŹtific Achievements, 1986

Doctorates
Liberek K, Skowyra D, Osipiuk J, Banecki B, Wojtkowiak D, Jakobkiewicz J, Puzewicz J, Barski P, King F, M. Bucko-Justyna, G. Kudla

DSc Performed in Department
Liberek K, Marszalek J, Konieczny I, Wawrzynow A, Banecki B.

Professor Titles Received:
Liberek K, Marszalek J, Konieczny I, Wawrzynow A.

Publications
81 publications in primary scientific journals including: two papers published in Cell, six in EMBO J., six in PNAS and 25 in J. Biol. Chem. These papers were cited more then 4,500 times with an average citation per paper of 60.

Selected publications since 2001
• Kudla G, Lipinski L, Caffin F, Helwak A, Zylicz M (2006) High guanine and cytosine content increases mRNA levels in mammalian cells. PLoS Biol. Jun;4(6):e180. Epub 2006 May 23.

• Jassem J, Jassem E, Jakobkiewicz-Banecka J, Rzyman W, Badzio A, Dziadziuszko R, Kobierska-Gulinda G, Szymanowska A, Skrzypski M, Zylicz M (2004) P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with non-small cell lung carcinoma. Cancer, 100: 1951-1960

• Dworakowska D, Jassem E, Jassem J, Peters B, Dziadziuszko R, Zylicz M, Jakobkiewicz-Banecka J, Kobierska-Gulida G, Szymanowska A, Skokowski J, Roessner A, Schneider-Stock R (2004) MDM2 gene amplification: a new indeŹpendent factor of adverse prognosis in non-small cell lung cancer (NSCLC). Lung Cancer 43: 285-295

• Muller L, Schaupp A, Walerych D, Wegele H, Buchner J (2004) Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. J. Biol.Chem., 279: 48846-48854
• Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M (2004) Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein. J. Biol. Chem., 279: 48836-48845

• Jassem E, Niklinski J, Rosell R, Niklinska W, Jakobkiewicz J, Monzo M, Chyczewski L, Kobierska G, Skokowski J, Zylicz M, Jassem J (2001) Types and localisation of p53 gene mutations. A report on 332 non-small cell lung canŹcer patients. Lung Cancer, 34: 47-51

• Zylicz M, Wawrzynow A (2001) Insights into the function of Hsp70 chaperones. IUBMB, 51: 283-287

• King FW, Wawrzynow A, Hohfeld J, Zylicz M (2001) Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J. 20: 6297-6305

• Zylicz M, King FW, Wawrzynow A (2001) Hsp70 inteŹractions with the p53 tumour suppressor protein. EMBO J. 20: 4634-4638

• Genevaux P, Wawrzynow A, Zylicz M, Georgopoulos C, Kelley WL (2001) DjlA is a Third DnaK Co-chaperone of Escherichia coli, and Dj1A-mediated Induction of Colanic Acid Capsule Requires Dj1A-DnaK Interaction. J. Biol. Chem. 276: 7906-7912

• Banecki B, Wawrzynow A, Puzewicz J, Georgopoulos C, Zylicz M (2001) Structure–function analysis of the zincŹbinding region of the ClpX molecular chaperone. J. Biol. Chem. 276: 18843-18848

• Kaczanowski R, Trzeciak L, Kucharczyk K (2001) MultiŹtemperature single-stranded conformation polymorphism. Electrophoresis 22: 3539-3545.