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- PhD STUDENT
Laboratory of Molecular and Cellular Neurobiology
Laboratory of Molecular and Cell Neurobiology seeks PhD Student to study various aspects of mTOR contribution to regulation of retromer complex in neuronal development and neurodevelopmental diseases. The fellowship is funded in frame of National Science Centre OPUS grant (2017/27/B/NZ3/01358) entitled “Role of TBC1D5 phosphorylation in neurodevelopment and TSC-related cell pathology” High motivation, analytical skills and independent thinking as well as fluent English are required. Previous experimental experience in one or more of following areas - electrophysiology, molecular and cell biology, neurobiology or developmental biology will be an additional asset.
Research of the Laboratory of Molecular and Cell Neurobiology focuses on molecular aspects of development of neurons. We are especially interested in role of mTOR kinase regulated processes (e.g., cytoskeleton dynamics, protein translation, membrane trafficking) in neurogenesis starting from neural stem cells to the end of circuitry formation. More info can be found at IIMCB Annual Reports (http://www.iimcb.gov.pl/annual_reports.php).
Koscielny A., Malik AR., Liszewska E., Zmorzynska J., Tempes A., Tarkowski B., Jaworski J. (2018) Adaptor Complex 2 Controls Dendrite Morphology via mTOR-Dependent Expression of GluA2. Mol Neurobiol., 55(2):1590-1606.
Kononenko NL., Claßen GA., Kuijpers M., Puchkov D., Maritzen T., Tempes A., Malik AR., Skalecka A., Bera S., Jaworski J., Haucke V. (2017) Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun.:14819.
Skalecka A., Liszewska E., Bilinski R., Gkogkas C., Khoutorsky A., Malik AR., Sonenberg N., Jaworski J. (2016) mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Dev. Neurobiol., 76(12):1308-1327
Lipka J., Kapitein LC., Jaworski J., Hoogenraad CC. (2016) Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO J. 35:302-18.
Malik AR., Liszewska E., Skalecka A., Urbanska M., Iyer AM., Swiech LJ., Perycz M., Parobczak K., Pietruszka P., Zarebska MM., Macias M., Kotulska K., Borkowska J., Grajkowska W., Tyburczy ME., Jozwiak S., Kwiatkowski DJ., Aronica E., Jaworski J. (2015) Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. Acta Neuropathol. Commun. 3(1):48.
Urbanska M, Gozdz A, Swiech LJ, Jaworski J. (2012) Mammalian target of rapamycin complex 1 (MTORC1) and 2 (MTORC2) control the dendritic arbor morphology of hippocampal neurons. J Biol Chem., 287: 30240-56
Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B., Malik A., Wulf P., Hoogenraad CC., Jaworski J. (2011) CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci., 31:4555-4568.
Please include the following statement in your application: "I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”