closes
30
June

POSTDOCTORAL POSITIONS AVAILABLE

Laboratory of Molecular and Cell Neurobiology

Post
Laboratory of Molecular and Cell Neurobiology seeks a highly motivated Postdoctoral Fellows to study to study various aspects of mTOR contribution to regulation of retromer complex in neuronal development and neurodevelopmental diseases. These positions are funded in frame of National Science Centre OPUS grant (2017/27/B/NZ3/01358) entitled “Role of TBC1D5 phosphorylation in neurodevelopment and TSC-related cell pathology” and available for a period of up to 12 and 32 months, respectively. The candidates should be highly motivated and independent young researchers with a good publication track record, speaking fluent English and having practical skills in neurobiology (work with primary neuronal cultures and living animals), biochemistry (especially analysis of mass spectrometry results), molecular and cell biology, advanced high resolution and live imaging techniques (e.g. Airyscan microscopy, spinning disc microscopy).

Laboratory interest
Research of the Laboratory of Molecular and Cell Neurobiology focuses on molecular aspects of development of neurons. We are especially interested in role of mTOR kinase regulated processes (e.g., cytoskeleton dynamics, protein translation, membrane trafficking) in neurogenesis starting from neural stem cells to the end of circuitry formation. More info can be found at IIMCB Annual Reports (http://www.iimcb.gov.pl/annual_reports.php).

Selected publications
Koscielny A., Malik AR., Liszewska E., Zmorzynska J., Tempes A., Tarkowski B., Jaworski J. (2018) Adaptor Complex 2 Controls Dendrite Morphology via mTOR-Dependent Expression of GluA2. Mol Neurobiol., 55(2):1590-1606.

Kononenko NL., Claßen GA., Kuijpers M., Puchkov D., Maritzen T., Tempes A., Malik AR., Skalecka A., Bera S., Jaworski J., Haucke V. (2017) Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun.:14819.

Skalecka A., Liszewska E., Bilinski R., Gkogkas C., Khoutorsky A., Malik AR., Sonenberg N., Jaworski J. (2016) mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Dev. Neurobiol., 76(12):1308-1327

Lipka J., Kapitein LC., Jaworski J., Hoogenraad CC. (2016) Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO J. 35:302-18.

Malik AR., Liszewska E., Skalecka A., Urbanska M., Iyer AM., Swiech LJ., Perycz M., Parobczak K., Pietruszka P., Zarebska MM., Macias M., Kotulska K., Borkowska J., Grajkowska W., Tyburczy ME., Jozwiak S., Kwiatkowski DJ., Aronica E., Jaworski J. (2015) Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. Acta Neuropathol. Commun. 3(1):48.

Urbanska M, Gozdz A, Swiech LJ, Jaworski J. (2012) Mammalian target of rapamycin complex 1 (MTORC1) and 2 (MTORC2) control the dendritic arbor morphology of hippocampal neurons. J Biol Chem., 287: 30240-56

Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B., Malik A., Wulf P., Hoogenraad CC., Jaworski J. (2011) CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci., 31:4555-4568.

Interested candidates are kindly asked to contact Dr. Jaworski by e-mail only (This email address is being protected from spambots. You need JavaScript enabled to view it.) and provide short motivation letter, CV and the name of a referee by 30th of June at the latest.
Candidates are also asked to specify whether they are interested in 12 or 32 month and to include the following statement in the application: "I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.” The shortlisted candidates will be contacted regarding further selection procedures.