closes
20
September

POSTDOCTORAL FELLOW

Laboratory of Molecular and Cellular Neurobiology

Post
Laboratory of Molecular and Cell Neurobiology seeks a Postdoctoral fellow (within 5 years after receiving PhD) to study molecular mechanism of dendritic arbor stability and its relation to mood disorders. The fellowship is funded in frame of Foundation for Polish Science TEAM grant. Strong background in neurobiology, practical skills in brain surgery, histochemistry and animal behavior analysis, high motivation, analytical skills and independent thinking as well as fluent English are required. Previous experimental experience in advanced light microscopy and molecular and cell biology will be an additional asset.

Laboratory interest
Research of the Laboratory of Molecular and Cell Neurobiology focuses on molecular aspects of development and stability of neuron morphology. We are especially interested in role of mTOR and GSK3 kinases. More info can be found at IIMCB Annual Reports (http://www.iimcb.gov.pl/annual_reports.php). Within the TEAM grant we aim to identify RNAs and proteins underlying mature dendritic arbors' stability. Because dendritic arbors destabilize in mood disorders the second objective of the proposal is to identify chemicals or drugable targets which support dendrite stability under stress conditions. In order to reach these aims combination of molecular biology, cell biology, high-throughput screening and behavioral studies will be used.

Selected publications
Urbanska M., Gozdz A., Macias M., Cymerman IA., Liszewska E., Kondratiuk I., Devijver H., Lechat B., Van Leuven F., Jaworski J. (2017) GSK3β Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol. doi: 10.1007/s12035-017-0823-9. [Epub ahead of print]

Gozdz A., Nikolaienko O., Urbanska M., Cymerman IA., Sitkiewicz E., Blazejczyk M., Dadlez M., Bramham CR., Jaworski J.* (2017) GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation. Front Mol Neurosci., 10:192. doi: 10.3389/fnmol.2017.00192.

Kononenko NL., Claßen GA., Kuijpers M., Puchkov D., Maritzen T., Tempes A., Malik AR., Skalecka A., Bera S., Jaworski J., Haucke V. (2017) Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun.:14819.

Lipka J., Kapitein LC., Jaworski J., Hoogenraad CC. (2016) Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO J. 35:302-18.

Malik AR., Liszewska E., Skalecka A., Urbanska M., Iyer AM., Swiech LJ., Perycz M., Parobczak K., Pietruszka P., Zarebska MM., Macias M., Kotulska K., Borkowska J., Grajkowska W., Tyburczy ME., Jozwiak S., Kwiatkowski DJ., Aronica E., Jaworski J. (2015) Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. Acta Neuropathol. Commun. 3(1):48.

Urbanska M, Gozdz A, Swiech LJ, Jaworski J. (2012) Mammalian target of rapamycin complex 1 (MTORC1) and 2 (MTORC2) control the dendritic arbor morphology of hippocampal neurons. J Biol Chem., 287: 30240-56

Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B., Malik A., Wulf P., Hoogenraad CC., Jaworski J. (2011) CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci., 31:4555-4568.

Interested candidates are kindly asked to contact Dr. Jaworski by e-mail only (This email address is being protected from spambots. You need JavaScript enabled to view it.) and provide short motivation letter, CV, the name of at least to referees by 20.09.2018. Please include in your application the following statement:I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena Str., 02-109 Warsaw, for the purpose of carrying out the current recruitment process.” Your personal data will be processed for the purpose of the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw. Full information is available under the link https://www.iimcb.gov.pl/pl/information-clause

The shortlisted candidates will be contacted regarding further selection procedures.