(activity discontinued since July, 2010)

Lab Leader:
Sławomir Filipek, PhD, DSc Habil


Senior Researchers:
Michał Koliński, PhD
Dorota Latek, PhD
Szymon Niewieczerzał, PhD
Bartosz Trzaskowski, PhD


Junior Researchers:

Aleksander Dębiński, MSc
Umesh Ghoshdastider, MSc
Krzysztof Młynarczyk, MSc
Wojciech Puławski, MSc

2013

Towards Improved Quality of GPCR Models by Usage of Multiple Templates and Profile-Profile Comparison

Latek D, Pasznik P, Carlomagno T, Filipek S

PLoS One. 2013

Low-temperature molecular dynamics simulations of horse heart cytochrome c and comparison with inelastic neutron scattering data

Pulawski W, Filipek S, Zwolinska A, Debinski A, Krzysko K, Garduño-Juárez R, Viswanathan S, Renugopalakrishnan V

Eur Biophys J. 2013

Enhancing the production of galacto-oligosaccharides by mutagenesis of Sulfolobus solfataricus β-galactosidase

Wu Y, Yuan S, Chen S, Wu D, Chen J, Wu J

Food Chem. 2013

Cross-linked glucose oxidase clusters for biofuel cell anode catalysts

Dudzik J, Chang WC, Kannan AM, Filipek S, Viswanathan S, Li P, Renugopalakrishnan V, Audette GF

Biofabrication. 2013

2012

Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies

Trzaskowski B, Latek D, Yuan S, Ghoshdastider U, Debinski A, Filipek S

Curr Med Chem. 2012

The Role of Water in Activation Mechanism of Human N-Formyl Peptide Receptor 1 (FPR1) Based on Molecular Dynamics Simulations

Yuan S, Ghoshdastider U, Trzaskowski B, Latek D, Debinski A, Pulawski W, Wu R, Gerke V, Filipek S

PLoS One. 2012

Amyloid β-Peptide 25-35 Self-Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment

Naldi M, Fiori J, Pistolozzi M, Drake AF, Bertucci C, Wu R, Mlynarczyk K, Filipek S, De Simone A, Andrisano V

ACS Chem Neurosci. 2012

Ubiquitous amyloids

Pulawski W, Ghoshdastider U, Andrisano V, Filipek S

Appl Biochem Biotechnol. 2012

2011

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB(1), CB (2) and adrenergic β (2)AR.

Audette GF, Lombardo S, Dudzik J, Arruda TM, Kolinski M, Filipek S, Mukerjee S, Kannan AM, Thavasi V, Ramakrishna S, Chin M, Somasundaran P, Viswanathan S, Keles RS, Renugopalakrishnan V

Materials Today. 2011

Arginine interactions with anatase TiO(2) (100) surface and the perturbation of (49)Ti NMR chemical shifts - a DFT investigation: relevance to Renu-Seeram bio solar cell

Koch R, Lipton AS, Filipek S, Renugopalakrishnan V

J Mol Model. 2011

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB(1), CB (2) and adrenergic β (2)AR

Latek D, Kolinski M, Ghoshdastider U, Debinski A, Bombolewski R, Plazinska A, Jozwiak K, Filipek S

J Mol Model. 2011

2010

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo.

Zurawska A, Urbanski J, Matuliene J, Baraniak J, Klejman MP, Filipek S, Matulis D, Bieganowski P

Biochim Biophys Acta. 2010

Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations.

Kolinski M, Filipek S

J Mol Model. 2010

2009

Properties of Radical Anions of Triptindanones and Indanones: Electronic Communication and Stability of Ion Pairs Containing Lithium Cations

J.S. Jaworski, A. Kosson, S. Filipek, M. Kolinski, D. Kuck

J. Phys. Chem. C. 2009

Modulation of molecular interactions and function by rhodopsin palmitylation

Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K

Biochemistry. 2009

“Bioinformatyka strukturalna białek transbłonowych”

S. Filipek

Kosmos. 2009

“Nanomaterials for Energy Convertion Applications”

V. Renugopalakrishnan, A. M. Kannan, S. Srinivasan, V. Thavasi, S. Ramakrishna, P. Li, A. Mershin, S. Filipek, A. Kumar, J. Dutta, A. Jaya, L. Munukutla, S. Velumani, G. F. Audette

\"Nanomaterials for Energy Storage Applications\". 2009

Bio-batteries and bio-fuel cells: leveraging on electronic charge transfer proteins.

Kannan AM, Renugopalakrishnan V, Filipek S, Li P, Audette GF, Munukutla L

J Nanosci Nanotechnol. 2009

Study on the feasibility of bacteriorhodopsin as bio-photosensitizer in excitonic solar cell: a first report.

Thavasi V, Lazarova T, Filipek S, Kolinski M, Querol E, Kumar A, Ramakrishna S, Padrós E, Renugopalakrishnan V

J Nanosci Nanotechnol. 2009

Generation and characterization of a novel, permanently active S100P mutant.

Austermann J, Nazmi AR, Heil A, Fritz G, Kolinski M, Filipek S, Gerke V

Biochim Biophys Acta. 2009

CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1

Kilanczyk E, Filipek S, Jastrzebska B, Filipek A

Biochem Biophys Res Commun. 2009

Studies of the Activation Steps Concurrent to Ligand Binding in δOR and κOR Opioid Receptors Based on Molecular Dynamics Simulations

M. Kolinfski, S. Filipek

TOSBJ. 2009

2008

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy.

Majewski T, Lee S, Jeong J, Yoon DS, Kram A, Kim MS, Tuziak T, Bondaruk J, Lee S, Park WS, Tang KS, Chung W, Shen L, Ahmed SS, Johnston DA, Grossman HB, Dinney CP, Zhou JH, Harris RA, Snyder C, Filipek S, Narod SA, Watson P, Lynch HT, Gazdar A, Bar-Eli M,

Lab Invest. 2008

Ca2+ -dependent regulation of phototransduction.

Stephen R, Filipek S, Palczewski K, Sousa MC

Photochem Photobiol. 2008

Determination and modelling of stereoselective interactions of ligands with drug transporters: a key dimension in the understanding of drug disposition

Bhatia P, Kolinski M, Moaddel R, Jozwiak K, Wainer IW

Xenobiotica. 2008

Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs

Jozwiak K, Krzysko KA, Bojarski L, Gacia M, Filipek S

ChemMedChem. 2008

Molecular dynamics of mu opioid receptor complexes with agonists and antagonists

Kolinski M, Filipek S.

The Open Struct. Biol. J.. 2008

2007

Stabilizing effect of Zn2+ in native bovine rhodopsin

Park PS, Sapra KT, Koliński M, Filipek S, Palczewski K, Muller DJ

J Biol Chem. 2007

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.

Lee S, Jeong J, Majewski T, Scherer SE, Kim MS, Tuziak T, Tang KS, Baggerly K, Grossman HB, Zhou JH, Shen L, Bondaruk J, Ahmed SS, Samanta S, Spiess P, Wu X, Filipek S, McConkey D, Bar-Eli M, Issa JP, Benedict WF, Czerniak B

Proc Natl Acad Sci U S A. 2007

Molecular modelling of the complex of oligomeric rhodopsin and its G protein.

Krzysko KA, Kolinski M, Filipek S.

J Phys Condens Matter. 2007

Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene

Golan MP, Styczyńska M, Jóźwiak K, Walecki J, Maruszak A, Pniewski J, Lugiewicz R, Filipek S, Zekanowski C, Barcikowska M

Exp Neurol. 2007

2006

Electrostatic model of bond dissociation energies in polyhalogen methanes

Jaworski JS, Cembor M, Koliński M

J Phys Org Chem. 2006

Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene.

Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K

J Biol Chem. 2006

Two novel presenilin 1 gene mutations connected with frontotemporal dementia-like clinical phenotype: genetic and bioinformatic assessment.

Zekanowski C, Golan MP, Krzyśko KA, Lipczyńska-Łojkowska W, Filipek S, Kowalska A, Rossa G, Pepłońska B, Styczyńska M, Maruszak A, Religa D, Wender M, Kulczycki J, Barcikowska M, Kuźnicki J.

Exp Neurol.. 2006

Detecting molecular interactions that stabilize native bovine rhodopsin

Tanuj Sapra K, Park PS, Filipek S, Engel A, Müller DJ, Palczewski K

J Mol Biol. 2006

Arrestin interaction with rhodopsin: conceptual models.

Modzelewska A, Filipek S, Palczewski K, Park PS

Cell Biochem Biophys. 2006

Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction

Jozwiak K, Zekanowski C, Filipek S

J Neurochem. 2006

Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment.

Cieplak M, Filipek S, Janovjak H, Krzyśko KA

Biochim Biophys Acta. 2006

2005

A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)

Sokal I, Dupps WJ, Grassi MA, Brown J Jr, Affatigato LM, Roychowdhury N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W

Invest Ophthalmol Vis Sci. 2005

Functional oligomers of rhodopsin – a G protein-coupled receptor template

Filipek S, Modzelewska A, Krzysko KA

Joint Meeting on Medical Chemistry. 2005

Organization of rhodopsin molecules in native membranes of rod cells--an old theoretical model compared to new experimental data.

Filipek S

J Mol Model. 2005

2004

Genetic aspects of Alzheimer's disease

Zekanowski C, Religa D, Graff C, Filipek S, Kuźnicki J

Acta Neurobiol Exp (Wars). 2004

A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor.

Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K

J Biol Chem. 2004

The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes.

Suda K, Filipek S, Palczewski K, Engel A, Fotiadis D

Mol Membr Biol. 2004

Oligomerization of G protein-coupled receptors: past, present, and future.

Park PS, Filipek S, Wells JW, Palczewski K

Biochemistry. 2004

Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice

Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein DA, Engel A, Palczewski K

J Biol Chem. 2004

Functional characterization of rhodopsin monomers and dimers in detergents

Jastrzebska B, Maeda T, Zhu L, Fotiadis D, Filipek S, Engel A, Stenkamp RE, Palczewski K

J Biol Chem. 2004

Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (

Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W

J Mol Evol. 2004

The G protein-coupled receptor rhodopsin in the native membrane

Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K

FEBS Lett. 2004

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

Filipek S, Krzysko KA , Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K

Photochem Photobiol Sci. 2004

2003

Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins

Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J

J Biol Chem.. 2003

Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin.

Schadel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP

J Biol Chem. 2003

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa.

Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S

J Biol Chem. 2003

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin.

Mirzadegan T, Benkö G, Filipek S, Palczewski K

Biochemistry. 2003

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo.

Maeda T, Van Hooser JP, Driessen CA, Filipek S, Janssen JJ, Palczewski K

J Neurochem. 2003

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A

J Biol Chem. 2003

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes.

Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A

J Biol Chem. 2003

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.

Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP

Proc Natl Acad Sci U S A. 2003

Atomic-force microscopy: Rhodopsin dimers in native disc membranes

Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K

Nature. 2003

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.

Filipek S, Teller DC, Palczewski K, Stenkamp R

Annu Rev Biophys Biomol Struct. 2003

2002

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals.

Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, Van Hooser JP, Liang Y, Filipek S, Gelb MH, Hofmann KP, Palczewski K

J Biol Chem. 2002