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Publications
All publications
Research groups:
Laboratory of Structural Biology
Laboratory of Bioinformatics and Protein Engineering
Laboratory of Molecular and Cellular Neurobiology
Laboratory of Neurodegeneration
Laboratory of Iron Homeostasis
Laboratory of Protein Structure
Laboratory of Protein Metabolism
Laboratory of Zebrafish Developmental Genomics
Laboratory of Biomolecular Interactions and Transport
2022
Szulc NA, Stefaniak F, Piechota M, Cappannini A, Bujnicki JM, Pokrzywa W.
DEGRONOPEDIA - a web server for proteome-wide inspection of degrons.
bioRxiv preprint
Piechota M, Biriczova L, Kowalski K, Szulc NA, Pokrzywa W.
CHIP ubiquitin ligase is involved in the nucleolar stress management.
bioRxiv preprint
Dubey AA, Krygier M, Szulc NA, Rutkowska K, Kosinska J, Pollak A, Rydzanicz M, Kmiec T, Mazurkiewicz-Beldzinska M, Pokrzywa W, Ploski R.
A novel de novo FEM1C variant as a potential cause of neurodevelopmental disorder with absent speech, pyramidal signs, and limb ataxia.
bioRxiv preprint
Slusarczyk P, Mandal PK, Zurawska G, Niklewicz M, Chouhan KK, Macias M, Szybinska A, Cybulska M, Krawczyk O, Herman S, Mikula M, Serwa R, Lenartowicz M, Pokrzywa W, Mleczko-Sanecka K.
Impaired iron recycling from erythrocytes is an early hallmark of aging.
bioRxiv preprint
Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dabrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W.
A heterotypic assembly mechanism regulates CHIP E3 ligase activity.
EMBO J.
2021
Maintaining proteostasis under mechanical stress.
EMBO Rep.
Turek M, Banasiak K, Piechota M, Shanmugam N, Macias M, Śliwińska MA, Niklewicz M, Kowalski K, Nowak N, Chacinska A, Pokrzywa W.
Muscle-derived exophers promote reproductive fitness.
EMBO Rep.
Banasiak K, Szulc NA, Pokrzywa W.
The Dose-Dependent Pleiotropic Effects of the UBB+1 Ubiquitin Mutant.
Front. Mol. Biosci.
2020
Donkervoort S, Kutzner CE, Hu Y, Lornage X, Rendu J, Stojkovic T, Baets J, Neuhaus SB, Tanboon J, Maroofian R, Bolduc V, Mroczek M, Conijn S, Kuntz NL, Töpf A, Monges S, Lubieniecki F, McCarty RM, Chao KR, Governali S, Böhm J, Boonyapisit K, Malfatti E, Sangruchi T, Horkayne-Szakaly I, Hedberg-Oldfors C, Efthymiou S, Noguchi S, Djeddi S, Iida A, di Rosa G, Fiorillo C, Salpietro V, Darin N, Faure´ J, Houlden H, Oldfors A, Nishino I, de Ridder W, Straub V, Pokrzywa W, Laporte J, Foley R, Romero NB, Ottenheijm C, Hoppe T, Bönnemann CG.
Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.
Am. J. Hum. Genet.
Albert M-C, Brinkmann K, Pokrzywa W, Günther SD, Krönke M, Hoppe T, Kashkar H.
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.
Cell Death & Disease
Turek M, Piechota M, Shanmugam N, Niklewicz M, Kowalski K, Chacińska A, Pokrzywa W.
Nutritional status and fecundity are synchronised by muscular exopheresis.
bioRxiv
Fatima A, Irmak D, Noormohammadi A, Rinschen MM, Das A, Leidecker O, Schindler C, Sánchez-Gaya V, Wagle P, Pokrzywa W, Hoppe T, Rada-Iglesias A, Vilchez D.
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.
Commun Biol.
Macnar JM, Szulc N, Kryś JD, Badaczewska-Dawid AE, Gront D.
Article BioShell 3.0: Library for Processing Structural Biology Data.
Biomolecules
Thapa P, Shanmugam N, Pokrzywa W.
Ubiquitin Signaling Regulates RNA Biogenesis, Processing, and Metabolism.
BioEssays
2018
Koyuncu S, Saez I, Lee HJ, Gutierrez-Garcia R, Pokrzywa W, Fatima A, Hoppe T, Vilchez D.
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
Nat Commun.
Balaji V, Pokrzywa W, Hoppe T.
Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis.
Bioessays
2017
Pokrzywa W, Hoppe T.
CHIPped balance of proteostasis and longevity.
Oncotarget
Pokrzywa W, Lorenz R, Hoppe T
Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity.
Worm
Kevei É, Pokrzywa W, Hoppe T
Repair or Destruction: An Intimate Liaison Between Ubiquitin Ligases and Molecular Chaperones in Proteostasis
FEBS Lett. doi:10.1002/1873-3468.12750.