Characterization of molecular interactions of macromolecules with ligands or other biomolecules

The VP-ITC system is an ultrasensitive isothermal titration calorimeter designed for ease-of-use. All functions are operated through software to minimize operator involvement and facilitate fast and accurate analyses without the need for expertise in thermodynamics. The capabilities of ITC as a technique, combined with the unique performance features of the VP-ITC have made this system the best selling ultrasensitive isothermal titration calorimeter in the world. Applications include: Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. Lead optimization. Enzyme kinetics. Assessment of the effect of molecular structure changes on binding mechanisms. Assessment of biological activity.
Why VP-ITC?
More than just affinities: Simultaneous determination of all binding parameters in a single experiment - information unobtainable from more limited binding assays. Directly measure sub-millimolar to nanomolar binding constants (10² to 10⁹ M^-1). Measure nanomolar to picomolar binding constants (10⁹ to 10¹² M^-1) using the competitive binding technique. Application versatility: Investigate any biomolecular interaction with high sensitivity. True in-solution technique: No labeling or immobilization required. No buffer restrictions. Easily handles turbid solutions. Easy to use: Unattended operation after sample loading. Complete system: No additional accessories to purchase. No reagents are required. Info from: VP-DSC Microcal web page www.microcalorimetry.com. Contact: Roman Szczepanowski, This email address is being protected from spambots. You need JavaScript enabled to view it.