ŁUKASIEWICZ – PORT POLISH CENTER FOR TECHNOLOGY DEVELOPMENT / POLISH SCIENCE FUND
HERO/WIB
1
Virtual Research Institute (WIB) - Horizon for Excellence in messenger RNA applications in immunoOncology, HERO; 28 398 800 (IIMCB), 69 160 450 (whole consortium) PLN; 2022-2027
Andrzej Dziembowski
POLISH ACADEMY OF SCIENCES
PASIFIC
1
Targeted single-cell gene expression analysis of mRNA vaccine response (PAN.BFB.S.BDN.309.022.2022); 874 878,53 PLN 2022-2025
Ewa Poniecka
EU FRAMEWORK PROGRAMME
Horizon2020
4
VERTIGO STARTS: epiMimesis “Epizode V: Shifting Identities" 2018-2019
Janusz Bujnicki
5
ERA CHAIRS - MOlecular Signaling in Health and Disease - Interdisciplinary Centre of Excellence, MOSaIC (810425); 2 498 887,50 EUR 2018-2023
Jacek Kuźnicki
6
COST - Ion Channels and Immune Response toward a global understanding of immune cell physiology and for new therapeutic approaches, IONCHAN-IMMUNRESPON (BM1406) 2015-2019
Jacek Kuźnicki
7
COST - Between Atom and Cell: Integrating Molecular Biophysics Approaches for Biology and Heltcare, MOBIEU (OC-2015-1-19651) 2016-2020
Krzysztof Skowronek
8
COST - European Epitranscriptomics Network, EPITRAN (CA 16120) 2017-2021
Janusz Bujnicki
European Research Council
1
Proof of Concept - Engineered Sequence-Specific RNases: New Reagents for RNA biotechnology, eRNAses (GA 324624); 149 970 EUR; 2013
Janusz Bujnicki
2
Starting Grant - Breaking the code of RNA sequence-structure-function relationships: New strategies and tools for modelling and engineering of RNA and RNA-protein complexes, RNA+P=123D (GA 261351); 1 500 000 EUR; 2011-2015
Janusz Bujnicki
3
Starting Grant - Structural studies of Nucleotide Excision Repair complexes, NERCOMP (GA 281500); 1 498 000 EUR; 2012-2017
Marcin Nowotny
Collaborative projects
1
Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex, EPISTOP (GA 602391); 774 818 EUR; 2013-2019
Jacek Jaworski
2
GSK-3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment, NEURO.GSK3 (GA 223276); 280 840 EUR; 2008-2011
Jacek Jaworski
3
Better Experimental Screening and Treatment for Primary Ciliary Dyskinesia, BESTCILIA (GA 305404); 321 720 EUR; 2012-2015
Michał Witt
Marie Skłodowska-Curie Actions
1
Initial Training Network - Transport and signalling mechanism in polarized cells, TRANSPOL (GA 264399); 225 523 EUR; 2010-2014
Marta Miączyńska
2
Initial Training Networks - Structural Biology of Membrane Proteins, SBMPs (GA 211800); 263 284 EUR; 2008-2012
Sławomir Filipek
ERA-NET
1
ERA-NET-RUS - Pathways of Store-Operated Calcium Entry (SOCE) as a novel therapeutic target in neurodegenerative diseases, TargetSoce (NCBR/ERA NET RUS/03/2012); 134 443 EUR; 2012-2014
Jacek Kuźnicki
2
Development of new experimental models for mental retardation and autism by iPS technology: generation of human affected and animal model neurons by reprogramming skin fibroblasts and testing gene correction using in vitro and in vivo models, AMREPACELL (ERA-NET-NEURON/06/2011); 1 419 075 PLN; 2011-2014
Jacek Jaworski
3
ERA-NET NEURON - Novel astrategies for the treatment of schizophrenia based on genetic variation of the neural cell adhesion molecule NCAM and enzymes involved in its posttranslational modifications, NeuConnect (ERA-NET NEURON/05/2011); 973 080 PLN; 2011-2014
Jacek Kuźnicki
4
ERA-NET NEURON - Imaging Neurogenesis in Neurodegenerative Disease: In vivo imaging of dopaminergic adult-born neurons in the olfactory bulb of animal models of Parkinson’s disease, ImageNinND (ERA-NET-NEURON/03/2009); 1 085 875 PLN; 2010-2013
Jacek Jaworski
EU Joint Programming
1
EU Joint Programme - Neurodegenerative Disease Research - Biomarkers for Alzheimer’s disease and Parkinson’s disease, BIOMARKAPD (2/BIOMARKAPD/JPND/2012); 240 804 PLN; 2012-2015
Jacek Kuźnicki
Research Potential
1
Proteins in Health and Disease, HEALTH-PROT (GA 229676); 954 100 EUR; 2009-2012
Jacek Kuźnicki
2
Fishing for Medicines and their targets using Zebrafish models of human diseases, FishMed (GA 316125); 3 574 100 EUR; 2012-2016
Jacek Kuźnicki
International Cooperation
1
Strengthening Cooperation in Molecular Biomedicine Between EU and Ukraine, COMBIOM (GA 80036); 973 080 EUR; 2011-2014
Jacek Kuźnicki
2
Exgenome Molecular Enzymes, EXGENOMES (GA 286556); 156 000 EUR; 2011-2013
Janusz Bujnicki
6th Framework Programme
1
Integrated Project - Abnormal proteins in the pathogenesis of neurodegenerative disorders, APOPIS (Contract No. LSHM-CT-2003-503330); 161 200 EUR; 2004-2006
Jacek Kuźnicki
2
Specific Targeted Research or Innovation Projects - Mechanisms of transgene intergration and expression in crop plant plastids: underpinning a technology for improving human health, PLASTOMICS (Contract No. LSHG-CT-2003-503238); 164 160 EUR; 2004-2007
Janusz Bujnicki
3
Network of Excellence - Genetic Testing in Europe - Network for test development harmonization, validation and standardization of services, EUROGENTEST (Contract No. LSHB-CT-2004-512148); 30 000 EUR; 2005-2010
Michał Witt
4
Network of Excellence - European Alternative Splicing Network of Excellence, EURASNET (Contract No. LSHG-CT-2005-518238); 143 000 EUR; 2008-2010
Janusz Bujnicki
5
Specific Support Action - Co-ordinated internet-linked networks for promoting innovation, exchanging knowledge and couraging good practice to enhance bioscience education in European schools, VOLVOX (Contract No. 511180); 38 354 EUR; 2005-2008
Agnieszka Chołuj
6
Integrated Project - From cell-cell recognition to memory formation. New strategies for the treatment of dysfunctional plsticity, learning and memory, PROMEMORIA (Contract No. LSHM-CT-2005-512012); 478 000 EUR; 2005-2009
Jacek Kuźnicki
7
Marie Curie Action Research Training Network - A multidisciplinary approach to the study of DNA enzymes down to the single molecule level, DNA Enzymes (Contract No. MRTN-CT-2005-019566); 254 452 EUR; 2005-2009
Janusz Bujnicki
8
Integrated Project - Tracking the Endocytic Routes of Polypeptide Growth Factor Receptor Complexes and their Modulatory Role on Signalling, ENDO TRACK (Contract No. LSHG-CT-2006-019050); 428 400 EUR; 2006-2010
Marta Miączyńska
5th Framework Programme
1
Rational engineering of lipid metabolism in flax (QLK3/CT/2000/00349); 149 000 EUR; 2001-2003
Leszek Rychlewski
2
A new Technology for Fluorescent 'Cell Chip' Immunotoxicity Testing (QLK4/CT/2000/00787); 231 703 EUR; 2001-2003
Jarosław Dastych
3
Thematic Network around Cystic Fibrosis and Related Diseases (QLK3-CT-1999-00241); 9 600 EUR; 2002-2004
Michał Witt
4
Continuing Education for European Biology Teachers (QLG7-CT-2002-00573); 23 430 EUR; 2004
Jarosław Bryk
5
Exploiting the HSP70 chaperone machine for novel therapeutic strategies in human diseases and for the engineering of productive cellular biomolecular factories (QLK3-CT-2000-00720); 64 776 EUR; 2002-2004
Maciej Żylicz
6
Novel non-antibiotic treatment of staphyloccocal diseases Euro and supplementary grant from KBN 776,000 PLN, 2002-2006 (QLK2-CT-2002-01250); 238 382 EUR; 2002-2006
Matthias Bochtler
7
Centre of Excellence in Molecular Bio-Medicine (QLK6-CT-2002-90363); 350 000 EUR; 2003-2006
Jacek Kuźnicki
Horizon Europe
1
Teaming for Excellence - RNA and Cell Biology - from Fundamental Research to Therapies (RACE) (101059801); 14 993 885 EUR 2023-2029
Marta Miączyńska
2
ERC Advanced - Principles of endogenous and therapeutic mRNA turnover in vivo (ViveRNA) (101097317); 11 570 921,43 PLN 2023-2028
Andrzej Dziembowski
3
INCYPRO: A key technology to enable the broad application of proteins in diagnostics and therapeutics (101057978); 885 500 PLN 2022-2025
Janusz Bujnicki
INTERNATIONAL GRANTS
Howard Hughes Medical Institute
1
Structural and Mechanistic Studies of Nucleic Acid Processing (55007428); 715 000 USD; 2012-2017
Marcin Nowotny
2
Molecular causes underlying the partial folding of a microtubule-associated protein domain (302.3); 5 500 USD; 2003-2004
Janusz Bujnicki
3
Bioinformatics-guided enfineering of DNA methyltransferases (742); 7 000 USD; 2003-2004
Janusz Bujnicki
4
Signaling from endosomes to the nucleus: The role of APPL proteins and their interacting partners (55005619); 494 500 USD; 2006-2010
Marta Miączyńska
European Molecular Biology Organization
1
Spatial organisation of protein quality control in neurodegenerative diseases (IG-6019-2025); 250 000 EUR 2025-2029
Lidia Wróbel
2
Role of microbiota in progression of liver disease [Installation Grant] (5685); 250 000 EUR 2024-2029
Aleksandra Kołodziejczyk
3
From dynamics of bacterial RNA degradation to gene expression manipulation tools [Installation Grant] (5730); 250 000 EUR 2024-2029
Ewelina Małecka-Grajek
4
Regulation of muscle-derived exophers (3917); 21 600 PLN 2022-2023
Wojciech Pokrzywa
5
Exploring RNA folds and remote evolutionary relationships with an improved structural similarity search method (ALTF 525-2022); 96 000 EUR 2022-2024
Eugene Baulin
6
Identification of signals coordinating the proteolytic quality control networks [Installation Grant] (3916); 250 000 EUR 2018-2023
Wojciech Pokrzywa
7
Protein biogenesis and redox homeostasis in mitochondria (1966); 250 000 EUR; 2010-2013
Agnieszka Chacińska
8
Structural and biochemical studies of UvrA DNA repair protein. (1476); 250 000 EUR; 2007-2012
Marcin Nowotny
Deutsche Forschungsgemeinschaft
1
Single-molecule fluorescence analysis of the temperature dependent structure and dynamics of an RNA thermometer: consequences for its molecular function (SE 1195/12-2); 90 450 EUR; 2010-2013
Janusz Bujnicki
International Centre for Genetic Engineering and Biotechnology
1
mTOR-driven phosphorylation of ZBP1 and Ago2 in neuronal development (CRP/12/010); 48 000 EUR; 2012-2015
Jacek Jaworski
National Institutes of Health
1
Discovering New Human DNA Repair Genes by Bioinformatics (NIH-WSU: R21 CA 097899 WSU-IIMCB: WSU03043-A1); 89 401 USD; 2003-2005
Janusz Bujnicki
2
Low-resolution Structural Genomics of Nucleases (NIH-UW: 1 R03 TW007163-01, CDFA No 93.989 UW-IIMCB: 952056); 53 365 USD; 2004-2006
Janusz Bujnicki
3
Kinetoplastid SL RNA Biogenesis (NIH-UCLA: CFDA 93.856 UCLA-IIMCB: 2301 G EN541); 100 440 USD; 2004-2009
Janusz Bujnicki
4
High-Accuracy Protein Models Derived from Lower Resolution Data (NIH-ISU: R01-GM081680 ISU-IIMCB: 430-46-22 B); 60 000 USD; 2007-2010
Janusz Bujnicki
United Nations Educational, Scientific and Cultural Organization
1
Science of modern biology - exploratory resources for biology teachers and students (27242703 POA); 20 000 USD; 2004-2005
Joanna Lilpop
INTERREG IV C
1
Effective Technology Transfer in Biotechnology (1210R4); 128 070 EUR; 2012-2014
Magda Powierża
Polish-Swiss Research Programme
1
The role of tumor susceptibility gene ; in transcriptional regulation in health and disease (PSPB-094/2010); 6 377 591 PLN; 2012-2016
Marta Miączyńska
Wellcome Trust
1
Structural and Biochemical studies of Holliday junction resolution (0988022/Z/11/Z); 3 369 854 PLN; 2012-2018
Marcin Nowotny
2
Communication between intracellular organelles in trafficking and signalling: the role of APPL proteins (076469/Z/05/Z); 4 315 706 PLN; 2005-2012
Marta Miączyńska
3
Structural and functional studies of two members of integrase superfamily – type 2 RNase H and Ruvc resolvase – from substrate recognition to catalysis (081760/Z/06/A); 4 106 806 PLN; 2007-2012
Marcin Nowotny
Polish Norwegian Research Fund
1
Screening for novel functions of endocytic and autophagic proteins in the regulation of gene expression, cell growth and carcinogenesis (PNRF-27-AI-1/07); 672 572 EUR; 2010-2011
Iwona Pilecka
2
Aberrant synaptic plasticity in epilepsy (PNRF-96-AI-1/07); 362 200 EUR; 2008-2010
Jacek Jaworski
EMBO & HHMI Young Investigator Programme Award
1
Peptidases, proteases and protein degradation (741); 78 000 USD; 2004-2006
Matthias Bochtler
2
Sequence-structure-function relationships in the evolution of RNA and DNA methyltransferases and restriction enzymes. (741(USD), 302.2 (PLN)); 150 000 (78 000) PLN (USD); 2003-2005
Janusz Bujnicki
Utrecht University fellowships (5 PhD students)
1
Utrecht University fellowships for five PhD students (none); 40 000 EUR; 2004-2007
Jacek Kuźnicki
The Max Planck Society (MPG)/ Polish Academy of Sciences
1
Joint MPG-PAN Junior Research Group Program (none); 1 500 000 EUR; 2000-2010
Matthias Bochtler
The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
1
Biochemical and microscopial characterization of APPL-positive endosomes (none); 109 000 EUR; 2006-2010
Marta Miączyńska
FOUNDATION FOR POLISH SCIENCE
MPD
1
PhD programme in Molecular Biology: Studies of nucleic acids and proteins - from basic to applied research (MPD/2009-3/2); 2 265 421 PLN; 2010-2015
Michał Witt
WELCOME
1
Biogenesis and turnover of mitochondria intermembrane space proteins (WELCOME/2009/1); 5 940 670 PLN; 2009-2014
Agnieszka Chacińska
TEAM
1
Structural biology of methylation and hydroxymethylation (TEAM/2010-6/1); 2 023 940 PLN; 2011-2015
Matthias Bochtler
2
Modeling of RNA and protein-RNA complexes: from sequence to structure to function (TEAM/2009-4/2); 2 200 000 PLN; 2010-2014
Janusz Bujnicki
HOMING
1
Structural and Functional Characterization of Photosystem II from Nicotiana tabacum (HOMING PLUS/2012-6/10); 326 000 PLN; 2013-2015
Dario Piano
2
Modeling tuberous sclrosis with induced pluripotent steam cells (HOMING PLUS/2012-5/6); 302 000 PLN; 2013-2014
Ewa Liszewska
3
Post-translational modifications and nuclear functions of endosomal APPL proteins (HOM/ed2007/126); 120 000 PLN; 2007-2010
Iwona Pilecka
REINTEGRATION
1
Role of S6-kinase interaction with µ-adaptin in clathrin-mediated endocytosis and its implications for pathology of tuberous sclerosis (POMOST/2013-7/10); 210 000 PLN; 2013-2015
Anna Malik
2
The role of the TET proteins in zebrafish (POMOST/2013-7/4); 280 000 PLN; 2013-2015
Agnieszka Kolano
3
Huntingtin-associated Protein 1 Induces Store-Operated Calcium Entry by Activating IP3 Receptor Channels in Huntington’s Disease (POMOST/2013-8/4); 268 333 PLN; 2014-2015
Magdalena Czeredys
4
Functional characterization of the interactions between endosomal adaptor proteins APPL and Dvl proteins in the Wnt signaling pathway (POMOST/2010-1/1); 420 000 PLN; 2010-2013
Magdalena Banach-Orłowska
5
Characterization of selected endocytic proteins as novel regulators of AP-1 mediated transcription (POMOST/2011-3/11); 430 000 PLN; 2012-2014
Ewelina Szymańska
SKILLS
1
Enzymatic chimeras with bacteriolytic activity (87/UD/SKILLS/2014); 100 000 PLN; 2014-2015
Izabela Sabała
2
Commercialization of the 'eRNases' technology - development of restriction enzymes for RNA (41/UD/SKILLS/2014); 120 000 PLN; 2014-2015
Janusz Bujnicki
3
Gene Hackers (38/UD/SKILLS/2014); 43 750 PLN; 2014-2015
Anna Olchowik
4
Lead optimisation of novel antiviral drugs: influenza virus nuclease inhibitors (25/UD/SKILLS/2014); 80 000 PLN; 2014-2015
Katarzyna Kamińska
Subventions
1
mTOR kinase and protein sorting by retromer and trans-Golgi network (Mistrz5./2014); 300 000 PLN; 2015-2017
Jacek Jaworski
2
Functional studies on human and viral methyltransferases involved in RNA cap biosynthesis: from in silico docking and in vitro validation, to RNA methylation inhibition in human cells (Mistrz1./2014); 300 000 PLN; 2015-2017
Janusz Bujnicki
3
Structural studies of Nucleotide Excision Repair complexes (SUB.5/2013); 100 000 PLN; 2014-2016
Marcin Nowotny
4
Molecular Chaperones in cancer cells (FNP-15/2000); 225 000 PLN; 2000-2002
Maciej Żylicz
Structural Funds 2021-2027
1
RNA and Cell Biology Platform for Research and Innovation in Medicine (RACE-PRIME) (FENG.02.01-IP.05-T003/23); 36 293 600 PLN 2024-2029
Marta Miączyńska
NATIONAL CENTRE FOR RESEARCH AND DEVELOPMENT
Structural Funds (NCBR)
1
Centre of Pre-clinical Research and Technology ; (POIG.02.02.00-14-024/08-00); 14 625 545 PLN; 2008-2013
Jacek Kuźnicki
2
Biocentrum Ochota - IT infrastructure for development of strategic directions of the biology and medicine (POIG.02.03.00-00-003/09); 4 834 300 PLN; 2009-2013
Janusz Bujnicki Sławomir Filipek
Polish Funds
1
Application of novel diagnostic and therapeutical methods in epilepsy and neurodevelopmental abnormalities in children based on the clinical and cellular model of mTOR dependent epilepsy (STRATEGMED//306306/4/NCBR/2017); 3088120 PLN 2017-2022
Jacek Jaworski
2
Development of new cancer therapies based on selective antitumor immunomodulators (265503); 982 500 PLN; 2015-2017
Marcin Nowotny
3
Development of new biotechnology products based on innovative technique of ribonucleic acid cleavage (245550); 2 829 000 PLN; 2015-2018
Janusz Bujnicki
4
Polish Reference Genome for Genomic Diagnostics and Personalized Medicine (181852); 732 347 PLN; 2013-2016
Małgorzata Mossakowska
5
New drugs for targeted therapy of multiple myelomas (176911); 368 880 PLN; 2012-2016
Marcin Nowotny
6
Biotechnological applications of bacteriolytic protein ; IIMCB budget: 2059000 PLN; (177126); 2 443 260 PLN; 2013-2016
Izabela Sabała
7
The study of genetic variation at the cellular level – new opportunities for forensic identification (OR00002712); 9 904 670 PLN; 2010-2013
Jacek Kuźnicki
NATIONAL SCIENCE CENTRE
POLONEZ
1
Deciphering the role of RNA editing in zebrafish development (2015/19/P/NZ2/03655); 921 064 PLN; 2017-2018
Leszek Pryszcz
2
Deciphering BMP6 regulatory mechanisms using CRISPR/Cas9-based screening approach (2015/19/P/NZ2/03278); 893 104 PLN; 2017-2018
Katarzyna Mleczko-Sanecka
3
Genomic profiling of zebrafish cardiac pacemaker cells (2015/19/P/NZ3/03613); 921 064 PLN; 2016-2018
Rashid Minhas
4
Regulation of genome activity in plastids (2015/19/P/NZ1/03619); 402 932 PLN; 2016-2017
Andrzej Wierzbicki
MAESTRO
2
Andrzej Dziembowski
4
Integrative modeling and structure determination of macromolecular complexes comprising RNA and proteins (2017/26/A/NZ1/01083); 3 500 000 PLN; 2018-2025
Janusz M. Bujnicki
5
Cross-talk between the transport of mitochondrial proteins and cellular protein homeostasis (2015/18/A/NZ1/00025); 4 271 581 PLN; 2016-2021
Agnieszka Chacińska
6
Molecular mechanisms of pro-survival processes in breast cancer (2012/06/A/NZ1/00089); 3 000 000 PLN; 2013-2019
Maciej Żylicz
7
Structural RNomics (2012/04/A/NZ2/00455); 3 000 000 PLN; 2012-2018
Janusz Bujnicki
8
Transgenic mice with elevated basal level of calcium ions in neurons as a model of aged-induced neurodegeneration of sporadic Alzheimer’s disease (2011/02/A/NZ3/00144); 2 989 800 PLN; 2012-2019
Jacek Kuźnicki
9
New functions of endocytic proteins in transcriptional regulation (2011/02/A/NZ3/00149); 2 875 000 PLN; 2012-2018
Marta Miączyńska
SYMFONIA
1
Mitochondrial RNA decay and surveillance - comprehensive interdisciplinary studies (2014/12/W/NZ1/00463); 2 953 248 PLN; 2014-2020
Marcin Nowotny
SONATA BIS
1
Dynamics of RNA degrading complexes in bacteria (2022/46/E/NZ1/00462); 3 218 840 PLN 2023-2028
Ewelina Małecka-Grajek
2
Adaptation of Proteins to Evade Premature Degradation by the Ubiquitin- Proteasome System (2021/42/E/NZ1/00190); 3 686 840 PLN 2022-2027
Wojciech Pokrzywa
3
Identifying unique adaptive responses of red pulp macrophages to iron deficiency (2020/38/E/NZ4/00511); 3 613 374 PLN 2021-2026
Katarzyna Mleczko-Sanecka
4
STIM proteins as new regulators of NMDA receptor trafficking in neurons (2017/26/E/NZ3/01144); 1 999 191 PLN; 2018-2023
Joanna Gruszczyńska-Biegała
5
Role of Rap proteins in regulation of mTOR function (2012/07/E/NZ3/00503); 1 500 000 PLN; 2013-2018
Jacek Jaworski
HARMONIA
1
Structural biology of mixed lineage leukemia proteins (2014/14/M/NZ5/00558); 1 255 000 PLN; 2015-2019
Matthias Bochtler
2
The relationship between GSK3α and GSK3β activities and neuronal plasticity in chronic stress (2011/01/M/NZ3/05413); 499 964 PLN; 2011-2014
Iwona Cymerman
DAINA
1
CRISPR tools for the study of embryonic development in zebrafish (2017/27/L/NZ2/03234); 1634500 PLN 2018-2023
Matthias Bochtler
DIOSCURI
1
The Dioscuri Centre for RNA-Protein Interactions in Human Health and Disease (2019/02/H/NZ1/00002); 1 495 000 EUR 2021-2025
Gracjan Michlewski
OPUS
1
Targeting Proteinopathies: Understanding and Mitigating the Effects of Pathogenic Mutations in Cullin-RING Ubiquitin Ligase Receptor (2024/53/B/NZ3/02882); 3 295 220 PLN 2025-2029
Wojciech Pokrzywa
2
“Stealth” asparaginases as improved protein drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) (2024/53/B/NZ1/01841); 2 875 400 PLN 2025-2029
Matthias Bochtler
3
Finding molecular mechanisms behind the activation of stellate cells (2023/51/B/NZ2/02649); 4 191 920 PLN 2024-2028
Aleksandra Kołodziejczyk
4
How inactivation of Mitochondrial Calcium Uniporter protects dopaminergic neurons (2023/49/B/NZ4/02744); 2 917 239 PLN 2024-2028
Jacek Kuźnicki
5
Biological control and pharmacological regulation of RNAs implicated in aetiology of Parkinson’s disease (2023/49/B/NZ1/02456); 2 999 834 PLN 2024-2028
Gracjan Michlewski
6
Elucidating the contribution of non-coding genomic elements to heart development and disease at single-cell resolution (2022/47/B/NZ2/02926); 3 040 240 PLN 2023-2027
Cecilia Winata
7
Structural studies of herpesvirus proteins involved in DNA replication (2022/45/B/NZ1/02456); 2 047 255 PLN 2023-2027
Małgorzata Figiel
8
Building a genomic atlas of human inner ear malformations: focus on novel genes and functional non-coding regions (2021/41/B/NZ5/04390 ); 845460 PLN 2022-2026
Vladimir Korzh
9
Structural and mechanistic studies of (+)RNA virus replicatio (2021/41/B/NZ1/03620); 2 684 000 PLN 2022-2027
Marcin Nowotny
10
AXL receptor signaling in cancer cell growth and drug resistance (2020/39/B/NZ3/03429); 2 482 764 PLN 2021-2025
Marta Miączyńska
11
The new methodology for better understanding of ligand-RNA interactions. (2020/39/B/NZ2/03127); 671 000 PLN 2021-2024
Filip Stefaniak
12
Experimental analysis of molecular determinants involved in epilepsy (2020/39/B/NZ3/02729); 1 780 590 PLN 2021-2025
Vladimir Korzh
13
Rac1 contribution to brain connectivity impairments and neuropsychiatric disorders in Tuberous Sclerosis Complex. (2020/37/B/NZ3/02345); 2 251 260 PLN 2021-2025
Justyna Zmorzyńska
14
Unraveling the influence of posttranscriptional modifications on RNA 3D structure formation and its dynamics, with the integrated use of theoretical and experimental approaches (2020/37/B/NZ2/02456); 1 650 000 PLN 2021-2026
Janusz Bujnicki
15
Identification of novel vulnerabilities of VPS4B-deficient cancers cells (2020/37/B/NZ3/02991); 1 878 854 PLN 2021-2025
Ewelina Szymańska
16
Reconstructing cardiovascular cell lineage evolution, one cell at a time (2019/35/B/NZ2/02548); 2 631 552 PLN 2020-2024
Cecilia Winata
17
Analysis of the role of cytoplasmic polyadenylation in the regulation of the innate immune response (2019/33/B/NZ2/01773); 2 324 800 PLN 2020-2023
Andrzej Dziembowski
18
Linking abnormal Ca2+ signaling and the unfolded protein response with Huntington’s disease pathology in both YAC128 mouse model and iPSCderived neurons from HD patients (2019/33/B/NZ3/02889); 1 857 550 PLN 2020-2024
Magdalena Czeredys
19
Mechanism of RNA ligation in maturation of transfer RNAs (2019/33/B/NZ1/02839 ); 1 985 200 PLN 2020-2023
Marcin Nowotny
20
Shedding new light on genome's dark matter: identification of novel long non-coding RNAs in zebrafish (2018/31/B/NZ2/01940 ); 1896000 PLN 2019-2022
Barbara Uszczyńska-Ratajczak
21
Deciphering novel mechanisms that control iron sensing and iron accumulation in the liver (2018/31/B/NZ4/03676); 1 778 635 PLN 2019-2022
Katarzyna Mleczko-Sanecka
22
Approaching integrative genomics to identify molecular drivers of congenital heart disease (2018/29/B/NZ2/01010); 1 880 050 PLN 2019-2023
Michał Pawlak
23
Role of TBC1D5 phosphorylation in neurodevelopment and TSC-related cell pathology (2017/27/B/NZ3/01358); 1 795 700 PLN; 2018-2022
Jacek Jaworski
24
The impact of intracellular distribution and endocytic transport of lymphotoxin beta receptor (LTbetaR) on its signaling (2016/21/B/NZ3/03637); 996 125 PLN; 2017-2020
Magdalena Banach-Orłowska
25
mTOR kinase impact on cellular functions of selected molecular motors (2016/21/B/NZ3/03639 ); 1 336 250 PLN; 2017-2020
Jacek Jaworski
26
Finding novel determinants of the brain ventricular system (2016/21/B/NZ3/00354); 1 294 885 PLN; 2017-2021
Vladimir Korzh
27
Biochemical and structural studies of retroviral reverse transcriptases evolution (2016/21/B/NZ1/02757); 1 145 000 PLN; 2017-2022
Elżbieta Nowak
28
Exploring Baltic Sea cyanobacteria for small-molecule inhibitors of microRNA function (2017/25/B/NZ9/00202); 1 410 100 PLN; 2018-2022
Filip Stefaniak
29
Enabling routine and reliable analysis of transport tunnels in proteins (2017/25/B/NZ1/01307 ); 1 375 050 PLN; 2018-2021
Jan Brezovsky
30
Developement of new methods for designing RNA molecules that fold into desired spatial structures and their use for development of new functional RNAs and for prediction of noncoding RNAs in transcriptome sequences (2017/25/B/NZ2/01294); 1 494 250 PLN; 2018-2021
Janusz M. Bujnicki
31
Role of STIM2 isoforms in regulation of neuronal calcium channels in Danio rerio (2016/23/B/NZ3/03142); 2 085 031 PLN; 2017-2021
Jacek Kuźnicki
32
A coarse-grained method for RNA 3D structure modeling, with emphasis on noncanonical base pairing. (2016/23/B/ST6/03433); 741 250 PLN; 2017-2021
Michał Boniecki
33
The role of E3 ligase complexes in integration of protein homeostasis and aging. (2016/23/B/NZ3/00753); 1 116 875 PLN; 2017-2021
Wojciech Pokrzywa
34
Identification of genes controlling brain development through genomic analysis of patients (2015/19/B/NZ2/01824); 162 960 PLN; 2016-2020
Cecilia Winata
35
Mechanisms protecting from oxidative damage during aging (2015/19/B/NZ1/03444); 1 200 800 PLN; 2016-2019
Urlike Topf
36
Characterization of the TIM23 pathway of protein import into mitochondria in mammalian cells (2015/19/B/NZ3/03272); 1 198 600 PLN; 2016-2019
Michał Wasilewski
37
Elucidating the gene regulatory network of zebrafish heart development using genomics (2014/13/B/NZ2/03863); 955 500 PLN; 2015-2018
Cecilia Winata
38
New 5-hydroxymethylcytosine binding proteins (2014/13/B/NZ1/03991); 1 283 750 PLN; 2015-2019
Matthias Bochtler
39
Coupling of synthesis and transport for proteins targeted to the mitochondia (2013/11/B/NZ3/00974); 1 165 520 PLN; 2014-2018
Agnieszka Chacińska
40
Interplay between MIA pathway and reactive oxygen species in mitochondrial homeostasis (2012/05/B/NZ3/00781); 663 500 PLN; 2013-2016
Michał Wasilewski
41
Nuclear functions of mTOR in neurons (2012/05/B/NZ3/00429); 750 000 PLN; 2013-2016
Jacek Jaworski
42
The role of Amyloid Precursor Protein in the regulation of store-operated calcium entry (2011/03/B/NZ3/01760); 504 000 PLN; 2012-2016
Tomasz Węgierski
43
Regulation of clathrin-dependent endocytosis by mTOR kinase in neuronal development (2011/03/B/NZ3/01970); 813 125 PLN; 2012-2016
Jacek Jaworski
44
Oxidation landscape of mitochondrial proteins upon ROS production and in ageing (2011/03/B/NZ2/01402); 997 500 PLN; 2012-2016
Agnieszka Chacińska
45
Sequence specificity and its determinants in dsRNA endoribonucleases (2011/01/B/NZ1/00209); 350 000 PLN; 2011-2015
Krzysztof Skowronek
46
Investigation of Arc Protein Role in Synaptic Plasticity of Hippocampal and Cortical Neurons and Mechanisms Regulating Arc Expression with the Special Focus on GSK3-Dependent Degradation (2011/01/B/NZ3/05397); 450 000 PLN; 2011-2014
Agata Góźdź
SONATA
1
Nuclear protein quality control in neurodegeneration (2023/51/D/NZ3/01939); 2 514 102 PLN 2024-2027
Lidia Wróbel
2
The role of gut-liver axis in Amanita species mushroom poisoning (2022/47/D/NZ5/03438); 2 544 840 PLN 2023-2026
Aleksandra Kołodziejczyk
3
A framework for de novo modeling of RNA structures using restraints derived from experimental data (2021/43/D/NZ1/03360); 691252 PLN 2022-2025
Sunandan Mukherjee
4
3D Structure determination of key regulatory regions at the 5' and 3' termini of pathogenic Flaviviruses RNA (2020/39/D/NZ6/02528); 895 358 PLN 2021-2024
Tales Rocha de Moura
5
Discovery and characterization of RNA structure motifs conserved in positive-sense single-stranded RNA viruses and in other functional RNAs (2020/39/D/NZ2/02837); 825 330 PLN 2021-2025
Tomasz Wirecki
6
Elucidating the role of TENT5C-mediated polyadenylation in erythropoiesis (2019/35/D/NZ3/04253); 1 482 000 PLN 2020-2024
Monika Kusio-Kobiałka
7
Endocytosis of AXL receptor and its role in AXL-mediated signaling (2015/19/B/NZ3/03270); 762 929 PLN; 2016-2020
Daria Zdżalik-Bielecka
8
Bridging the gap: DNA catalysis explained (2018/31/D/NZ2/01883); 1247150 PLN 2019-2022
Maria Almudena Ponce Salvatierra
9
Role of Tollip protein in embryonic development and protein homeostasis in the model of zebrafish (Danio rerio) (2016/21/D/NZ4/00494); 583 750 PLN; 2017-2022
Lidia Wolińska-Nizioł
10
Endocytosis of AXL receptor and its role in AXL-mediated signaling ( 2015/19/D/NZ3/03270); 762 929 PLN; 2016-2020
Daria Zdżalik-Bielecka
11
Uncovering the molecular mechanisms of heart regeneration in zebrafish through profiling of contributing genomic factors (2016/21/D/NZ2/03843); 556 708 PLN; 2017-2020
Katarzyna Nieścierowicz
12
Architecture and evolution of protein-RNA networks and their relevance in the process of virulence regulation (2011/03/D/NZ8/3011); 720 000 PLN; 2012-2016
Stanisław Dunin-Horkawicz
13
The contribution of STIM proteins and the role of store-operated calcium entry (SOCE) in calcium homeostasis of neurons (2011/01/D/NZ3/02051); 684 000 PLN; 2011-2018
Joanna Gruszczyńska-Biegała
14
Characterizing the functions and molecular mechanisms of VPS4B action in biology of colorectal cancer (CRC) cells and in CRC pathogenesis (2016/21/D/NZ3/00637); 791 850 PLN; 2017-2020
Ewelina Szymańska
15
Modeling 3D structures and dynamics of RNA complexes with metal ions, with particular emphasis on the formation of non-canonical base pairs: extension of he SimRNA coarse-grained model towards hish-resolution (2015/17/D/NZ1/01560); 465 400 PLN; 2016-2019
Dorota Niedziałek
16
The role of Zebrafish mTOR in neuronal development in vivo as a key regulator of neuronal circuit formation (2015/17/D/NZ3/03735); 689 000 PLN; 2016-2019
Justyna Zmorzyńska
17
Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel Biomarker of Liver Fibrosis (2014/15/D/NZ5/03421); 541 875 PLN; 2015-2019
Michał Pawlak
18
Role of CacyBP/SIP in the dysregulation of beta-catenin ubiquitination in YAC128 mouse model of Huntington's disease (2014/15/D/NZ3/05181); 650 000 PLN; 2015-2019
Magdalena Czeredys
19
Modulation of mitochondrial calcium traffic in pink1 mutant Zebrafish model of Parkinson's disease (2014/15/D/NZ3/05176); 583 437 PLN; 2015-2018
Smijin Soman
20
Extramitochondrial factors regulating turnover of mitochondrial intermembrane (2013/11/D/NZ1/02294); 796 100 PLN; 2014-2017
Piotr Brągoszewski
21
Patient-specific iPS cells as a novel approach to study patophysiology of mTOR related neurodvelopmental disorders (2013/11/D/NZ3/01079); 700 000 PLN; 2014-2018
Ewa Liszewska
22
Identification of post-transcriptional modifications in RNA sequences through mass Spectrometry (2012/05/D/ST/6/03282); 493 125 PLN; 2013-2014
Bogusław Kluge
23
Determination of composition structure and substrate specificity of the mRNA_m6A methyltransferase protein complex (2011/03/D/NZ1/03247); 750 000 PLN; 2012-2016
Elżbieta Purta
24
Structural and functional characterization of novel non-coding RNAs from Helicobacter pylori (2011/01/D/NZ1/00212); 550 000 PLN; 2011-2015
Grzegorz Chojnowski
PRELUDIUM
1
Decoding the molecular mechanisms behind indole-3-acetic acid's influence on liver cells (2024/53/N/NZ2/03338); 209 960 PLN 2025-2028
Aleksandra Uryga
2
Looking for mechanisms responsible for the retinal ganglion cell loss in zebrafish stim2 knockout (2023/49/N/NZ3/02921); 209 352 PLN 2024-2027
Sofiia Baranykova
3
Exploring the role of Ferroportin-mediated Ca2+ influx in the functional rewiring of macrophages (2023/49/N/NZ3/04232); 69 540 PLN 2024-2025
Pratik Kumar Mandal
4
Deciphering the molecular mechanism of activity switch of the ubiquitin ligase CHIP (2021/41/N/NZ1/03086); 132 126 PLN 2022-2025
Pankaj Thapa
5
Living on the edge: evolutionary adaptation of substrate-recruiting subunits of the cullin-RING ubiquitin ligase complexes to avoid premature degradation (2021/41/N/NZ1/03473); 190 770 PLN 2022-2025
Natalia Szulc
6
Regulation of the human cap methyltransferase CMTr1 by an RNA helicase (2015/19/B/NZ1/03449); 49 800 PLN; 2016-2017
Magdalena Zielińska
7
The role of mu2-adaptin serine 45 and serine 309 phosphorylation in clathrin mediated endocytosis (2017/25/N/NZ3/01280); 120 000 PLN; 2018-2021
Aleksandra Tempes
8
Is endocytosis disrupted in tuberous sclerosis complex? Novel studies on human neural stem cells. (2016/23/N/NZ3/00108); 100 000 PLN; 2017-2019
Alicja Kościelny
9
RNA structure prediction based on modeling the target sequence and homologous sequences (2015/17/N/NZ2/03360); 49 400 PLN; 2016-2017
Marcin Magnus
10
Bioinformatic analysis of GmrSD, a Type IV Modification-Dependent Restriction Systems (2012/07/N/NZ2/01562); 100 000 PLN; 2013-2016
Magdalena Machnicka
11
Regulation of mTOR kinase signaling pathway by ESCRT-II complex in dendritogenesis (2012/07/N/NZ3/01661); 140 000 PLN; 2013-2017
Marcelina Pieprzyk
12
Genome wide high throughput analysis of 5-hydroxymethyl cytosine in Danio rerio (2012/05/N/NZ2/02233); 150 000 PLN; 2013-2017
Karolina Mierzejewska
13
Structural basis of the recognition of postreplicative DNA modifications (2012/05/N/NZ1/01912); 100 000 PLN; 2013-2015
Wojciech Siwek
14
Analysis role of the PsbS subunit from photosystem II in the non-photochemical quenching (2012/05/N/NZ1/01922); 99 200 PLN; 2013-2015
Patrycja Haniewicz
15
Modeling of charge transport in RNA structural motifs (2012/05/N/NZ1/02970); 75 000 PLN; 2013-2015
Juliusz Stasiewicz
16
The interplay between the processes of inner membrane formation and protein transport in mitochondria (2011/03/N/NZ3/01614); 318 750 PLN; 2012-2015
Paulina Kwiatkowska
17
Development of a new scoring function for models of protein-small molecule complexes and its use for studying the mechanism of protein-ligand recognition (2011/03/N/NZ2/3241); 230 000 PLN; 2012-2015
Irina Tuszyńska
18
The role of HSP70 in the stabilization of p53 mutants in cancer cells (2011/01/N/NZ1/00202); 192 000 PLN; 2011-2014
Milena Wiech
19
Generation of knockouts of HMTR1 and HMTR2 genes in human somatic cells and functional analysis of cap1 and cap2 methyltransferases encoded by these genes (2011/01/N/NZ1/00211); 100 000 PLN; 2011-2014
Maria Werner
20
Role of transcription factor TCF7L2 in establishment of thalamocortical connectivity and identity of thalamic neurons (2011/01/N/NZ3/05345); 96 000 PLN; 2011-2013
Andrzej Nagalski
21
Characterization of mTOR-dependent phosphorylation of ZBP1 and CLIP-170 and description of its contribution to dendritic arbor development (2011/01/N/NZ3/05405); 180 000 PLN; 2011-2014
Anna Urbańska
22
Defining the mechanism of GSK3 dependent regulation of mTOR kinase activity in neurons in physiology and pathology (2011/01/N/NZ3/05409); 150 000 PLN; 2011-2014
Małgorzata Urbańska
FUGA
1
Analysis of the mitochondrial proteins translocase TIM22 in human cells (2016/20/S/NZ1/00423); 612 000 PLN; 2016-2019
Katarzyna Chojnacka
2
Does the hyperactivation of mTOR kinase interfere with cell differentiation into neurons? (2012/04/S/NZ3/00264); 608 100 PLN; 2012-2016
Bartosz Tarkowski
3
A code for RNA recognition in RNA–RRM interactions (2012/04/S/NZ1/00729); 612 000 PLN; 2012-2016
Martyna Nowacka
MINIATURA
1
Study of functional variability of the Lactobacillus strains and their impact on hepatocytes (2024/08/X/NZ2/01013); 49 500 PLN 2024-2025
Krzysztof Szczepaniak
2
Study of the function and regulation of the key molecular chaperone UNC-45 in the development of CIM myopathy (2019/03/X/NZ3/00824); 49 401 PLN 2019-2021
Małgorzata Piechota
3
Status oksydacyjny białka STIM2 i jego partnerów interakcyjnych w mózgu myszy (2019/03/X/ZN3/00628); 49 500 PLN 2019-2020
Oksana Palchevska
4
Photoswitchable Ligands for Riboswitches (2018/02/X/NZ1/01468); 21670 PLN 2018-2019
Filip Stefaniak
5
The influence of surface net charge on the activity of new peptidoglycan hydrolases from Staphylococcus pettenkoferi (2017/01/X/NZ1/00512); 47 740 PLN; 2017-2018
Elżbieta Jagielska
GRIEG
1
Cellular adaptation to cold (2019/34/H/NZ3/00691); 3 834 426 PLN 2021-2024
Wojciech Pokrzywa
2
The impact of cytoplasmic polyadenylation on local translation in neurons (2019/34/H/NZ3/00733); 1 935 625 PLN 2020-2023
Andrzej Dziembowski
SONATINA
1
Targeting nucleic acid-protein complexes with small molecules using a deep- learning framework (2023/48/C/NZ1/00122); 645 136 PLN 2023-2026
Ryhor Nikalayeu
2
How dysfunction in the nuclear, RNA degrading enzyme DIS3 leads to mitotic defects creating a possible therapeutic strategy for Multiple Myeloma (2019/32/C/NZ2/00558); 832 059 PLN 2019-2023
Tomasz Kuliński
Research Components
1
Regulation of microRNAs for the treatment and understanding the etiology of Parkinson’s disease (2021/01/1/NZ1/00001); 200 000 PLN 2021-2023
Gracjan Michlewski
2
Gut-liver axis in liver cirrhosis (2023/02/1/NZ5/00003); 200 000 PLN 2023-2024
Aleksandra Kołodziejczyk
PRELUDIUM BIS
1
Chilling resilience: Decoding phosphatases in cold adaptation (2023/50/O/NZ4/00179); 688 080,00 PLN 2024-2028
Wojciech Pokrzywa
POLISH NATIONAL AGENCY FOR ACADEMIC EXCHANGE
International Academic Partnership
1
Molecular basis of enzyme specificity and applications (PPI/APM/2018/1/00034); 2000000 PLN 2018-2022
Izabela Sabała Matthias Bochtler
Foreign Promotion Programme (en-GB)
1
Excellent Institute for excellent Scientists - international promotion of the IIMCB (PPI/PZA/2019/1/00079); 99 900 PLN 2019-2021
Agata Skaruz
STER
1
Internationalisation of the Warsaw Doctoral School in Natural and BioMedical Sciences (BPI/STE/2021/1/00034/U/00001); 2 186 700 PLN 2022-2024
Urszula Białek-Wyrzykowska
Polish Returns
1
Gut-liver axis in liver cirrhosis (BPN/PPO/2022/1/00023); 1 143 200 PLN 2023-2026
Aleksandra Kołodziejczyk
2
Regulation of microRNAs for the treatment and understanding the etiology of Parkinson’s disease (PPN/PPO/2020/1/00006/U/00001); 1 870 000 PLN 2021-2025
Gracjan Michlewski
IMPRESS-U
1
IMPRESS-U DCL: Supplement: Structure and function of plastid nucleoid (BPN/NSF/2023/1/00011 ); 967 180,00 PLN 2024-2026
Marcin Nowotny
MINISTRY OF SCIENCE AND HIGHER EDUCATION
Ministerial Commissioned Grants
1
New bioinformatic tools for proteomics and structural genomics (PBZ-KBN-088/P04/2003); 1 850 000 PLN; 2004-2007
Janusz Bujnicki
2
Molecular and Genetic Mechanisms of Neurodegeneration and Neuroprotection (PBZ-KBN-002/CD/P05/2000); 260 000 PLN; 2001-2002
Michał Hetman
3
Molecular and Genetic Mechanisms of Neurodegeneration and Neuroprotection (PBZ-KBN-002/CD/P05/2000); 300 000 PLN; 2001-2002
Jacek Kuźnicki
4
Addiction: Neurobiological Basis, Mechanisms, Methods of Prophylaxis and Treatment (PBZ-KBN-033/P05/2000); 3 400 000 PLN; 2001-2004
Ryszard Przewłocki
5
The transduction of neuronal Ca2+ -signals via EF-hand Calcium-Binding Proteins Caldendrin and Calmyrin in Alzheimer's disease and psychotic disorders (PBZ-MN-001/P05/09); 955 400 PLN; 2003-2006
Urszula Wojda
6
Role of Hsp90 in regulation of gene expression involved in tumorgenic transformation (PBZ-KBN-107/P04/2004); 985 000 PLN; 2004-2007
Maciej Żylicz
7
Advanced molecular methods in haematology. Development and implementation of standardized research procedures for minimal residual disease, posttransplantation chimerism and marker translocations (PBZ-KBN-120/P05/2004); 3 027 500 PLN; 2005-2009
Michał Witt
8
Structural studies of restriction endonucleases generating unusual cleavage patterns (PBZ/MEiN/01/2006/24); 160 000 PLN; 2007-2009
Honorata Czapińska
9
Search for diagnostic methods of Alzheimer’s disease and identification of pathogenic mechanisms as potential targets of therapies based on proteomic research in human lymphocytes (PBZ-KBN-124/P05/2004); 400 000 PLN; 2005-2008
Urszula Wojda
10
Mechanism of biosynthesis of unusual protein-glycosaminoglycan linkage that plays key role in inflammatory processes (PBZ/MEiN/01/2006/50); 106 560 PLN; 2007-2008
Aneta Kaczmarczyk
11
Ageing of the Polish population - medical, psychological, sociological and economic aspects (PBZ-MEiN-9/2/2006); 12 178 420 PLN; 2007-2010
Małgorzata Mossakowska
12
Novel computer programs for homology modelling and fold recognition of RNA (PBZ/MNiSW/07/2006); 240 000 PLN; 2007-2010
Michał Boniecki
Ministerial Doctoral Grants
1
Automated creation and implementation of data flow schemes between bioinformatics tools (N N301 297337); 49 680 PLN; 2009-2011
Janusz Bujnicki Jerzy Orłowski
2
MvaI restriction-modification system: different ways to recognize the same DNA sequence (NN301030634); 31 080 PLN; 2008-2009
Matthias Bochtler Magdalena Kaus-Drobek
3
New method to predict both local and global quality of theoretical models of protein structure (N30110632/3600); 36 600 PLN; 2007-2009
Janusz Bujnicki Marcin Pawłowski
4
Sequence-structure-function relationships in apoptotic nuclease DNase II (N40110731/2409); 30 080 PLN; 2006-2007
Janusz Bujnicki Iwona Cymerman
5
Evolutionary, structural and functional methyltransferase classification (N30110532/3599); 49 000 PLN; 2007-2009
Janusz Bujnicki Karolina Tkaczuk
6
Investigation of the structure of arrestin-rhodopsin complex by theoretical methods (2PO4A06030); 33 000 PLN; 2006-2007
Sławomir Filipek
7
Modelling of the structure and the process of formation of the complex of oligomeric rhodopsin and trimeric G protein (N30110731/3154); 33 200 PLN; 2006-2007
Sławomir Filipek
Ministerial Research and Development Grants
1
New tools for analysis and manipulations of nucleic acids: restriction enzymes acting on RNA and DNA-RNA hybrids (R12 002 02); 1 000 000 PLN; 2007-2010
Janusz Bujnicki
Ministerial Habilitation Grants
1
Variation of restriction enzymes sequence specificities by combination of different methods of bioinformatics and protein engineering (N30110031/3043); 278 000 PLN; 2006-2009
Krzysztof Skowronek
Ideas Plus
1
Cytosolic chaperone systems for mitochondrial precursor proteins (0002/ID1/2014/63); 3 156 000 PLN; 2014-2018
Agnieszka Chacińska
Iuventus Plus
1
Molecular determinants of sequence-specific DNA-RNA hybrid recognition (IP2012 065672); 180 000 PLN; 2013-2015
Agata Sulej
2
mTOR compex 2 role in the regulation of actin cytoskeleton and neuronal dendritogenesis (IP2012 037872); 288 750 PLN; 2013-2015
Małgorzata Urbańska
3
Zinc finger Com-RNA complex as an example of specific protein-RNA interaction (IP2012 049072); 200 000 PLN; 2013-2015
Martyna Nowacka
4
Bioinformatics search and analysis of protelomerase and its DNA recognition sites (IP2012 030172); 152 000 PLN; 2013-2014
Łukasz Kozłowski
5
Analysis of the relationship between sequence and structure in coiled-coil protein domains (IP2011011071); 178 000 PLN; 2012-2014
Stanisław Dunin-Horkawicz
6
Bioinformatics analysis of sequence-structure-function relationships in the GIY-YIG nuclease superfamily (IP2011021871); 100 000 PLN; 2012-2013
Katarzyna Kamińska
7
Structural biology of anti-cancer DNA methyltransferase inhibitors (IP2011060971); 200 000 PLN; 2012-2014
Marek Wojciechowski
8
Coordinating proteasome subunit expression: structural biology of the master regulator Rpn4 (IP2011050971); 400 000 PLN; 2012-2014
Monika Sokołowska
9
Casimir-Polder effect in scattering of atoms on liquid surfaces (IP2011030771); 150 000 PLN; 2012-2013
Grzegorz Łach
10
Practical algorithms for graph isomorphism testing in the computational biology (IP2011058671); 160 000 PLN; 2012-2014
Tomasz Waleń
11
Structural analysis of the RNA-RNA and RNA-protein interactions (IP2011006671); 145 000 PLN; 2012-2014
Grzegorz Chojnowski
12
Structural studies of mechanism of action of UvrC protein from bacterial DNA repair system called nucleotide excision repair system (IP2011018671); 150 000 PLN; 2012-2013
Marcin Jaciuk
13
Development and application of new methods for protein-RNA and protein-DNA complexes modeling (IP2011057071); 175 000 PLN; 2012-2014
Irina Tuszyńska
14
Structural analysis of RNase H3 in complex with a substrate - the mechanism of action and substrate specificity in the context of an enzyme family (IP2011012171); 150 000 PLN; 2012-2013
Małgorzata Figiel
Ministerial Research Grants
1
Changes in cell cycle and apoptosis as a basis for diagnosis and potential therapeutic targets in Alzheimer’s disease (N N401 596840); 408 000 PLN; 2011-2014
Urszula Wojda
2
A new type of antibacterial drugs: a search for inhibitors of Arm methyltransferases that confer resistance to aminoglycosides (0160/H03/2010/70); 100 000 PLN; 2010-2011
Katarzyna Kamińska
3
The Elmo1 function of regulated by mTOR kinase activity in neuronal plasticity. (N N301 779040); 250 000 PLN; 2010-2014
Magdalena Błażejczyk
4
Is there a “universal” RNA-guided DNA endonuclease? (N N302 654640); 400 000 PLN; 2011-2014
Matthias Bochtler
5
Searching for compounds abolishing bacterial resistance for MLSb antibiotics (0337/P01/2010/70); 150 000 PLN; 2010-2011
Elżbieta Purta
6
Function of STIM proteins in capacitative calcium entry to the ER of healthy neurons and of cells with calcium dyshomeostasis in Alzheimer’s disease (N N301 190039); 340 740 PLN; 2010-2013
Jacek Kuźnicki
7
Searching for Beta-catenin regulators in thalamic neurons (N N301 191739); 48 000 PLN; 2010-2012
Katarzyna Misztal
8
Functional analysis of proteins responsible for processing of mRNA 3' termini. Identification of domains and intrinsically disordered regions (N N301 190139); 37 600 PLN; 2010-2012
Janusz Bujnicki
9
Identification of a genetic program regulated by Lef1/B-katenina complex in mature neurons (N N301 424538); 372 000 PLN; 2010-2013
Marta Wiśniewska
10
Structural studies of ββα-Me restriction endonucleases (N N301 425038); 400 000 PLN; 2010-2012
Honorata Czapińska
11
Experimental characterization of hMTcap1 and hMTcap2 – last missing enzymes taking part in biosynthesis of the cap structure of human mRNA (N N301 425338); 500 000 PLN; 2010-2013
Janusz Bujnicki
12
Biochemical and structural studies of lentiviral reverse transcriptases (NN301439738); 599 800 PLN; 2010-2014
Marcin Nowotny
13
Towards a new drug against influenza: Identification and characterization of compounds witch abolish the activity of the influenza virus mRNA polymerase by the inhibition of virus endonuclease (NN401585738); 150 000 PLN; 2010-2013
Katarzyna Kamińska
14
The role of multifunctional adaptor proteins APPL1 and APPL2 in the regulation of cell growth and tumorigenic potential (N N301 189839); 336 000 PLN; 2010-2013
Beata Pyrzyńska
15
Function of calmyrin 2 in Ca2+-dependent egzocytosis (N N301 335239); 60 000 PLN; 2010-2012
Urszula Wojda
16
Mechanism of oncogenic activities of mutated TP53 (NN302621838); 600 000 PLN; 2010-2013
Alicja Żylicz
17
The role of mitochondria in biogenesis and pathogenesis of superoxide dismutase Sod1 (N N301 298337); 476 000 PLN; 2009-2012
Agnieszka Chacińska
18
Sturctural and biochemical studies of restriction enzymes specific for pseudopalindromic sequences. (NN301 029534); 344 400 PLN; 2008-2011
Matthias Bochtler
19
Identification and characteristics of endosomal proteins involved in the regulation of gene transcription (N N301 296437); 340 740 PLN; 2009-2013
Iwona Pilecka
20
Functional characterization of Exonuclease G - the role in the apoptosis and diabetes (NN401 061535); 290 400 PLN; 2008-2011
Iwona Cymerman
21
Modultion of activity of transription factors involved in tumorigenesis, by MDM2 and other E3 ubiquitin ligases (NN301 032534); 750 000 PLN; 2008-2011
Maciej Żylicz
22
Investigation of mechanisms regulating expression of calmyrin 2, a novel EF-hand Ca2+-binding protein and elucidation of calmyrin 2 role in Ca2+ signal transduction in physiology and death of neurons. (N30110932/3854); 303 000 PLN; 2007-2010
Urszula Wojda
23
Experimental characterization of the complete set of RNA methyltransferases in the model organisms and identification of their counterparts in sequenced genomes (NN301239633); 460 000 PLN; 2007-2010
Janusz Bujnicki
24
Studies of agonist and antagonist binding modes in opioid receptors (NN401140133); 50 000 PLN; 2007-2009
Sławomir Filipek
25
Structural and biochemical characterization of two restriction enzymes: BcnI recognizing asymmetric DNA and AvaII cutting RNA-DNA hybrids. (NN301028934); 30 600 PLN; 2008-2009
Matthias Bochtler
26
Role of mTOR-regulated proteins in development of dendritic tree of hippocampal and cortical neurons (2P04A01530); 220 800 PLN; 2006-2009
Jacek Jaworski
27
Modification of the substrate specificity of Bsp6I restriction endonuclease with novel methods of directed evolution (N30204532/3598); 50 020 PLN; 2007-2009
Janusz Bujnicki
28
Role of dendrtic mRNA transport and local protein syntheis in development of dendritic arobor of neurons (NN301314733); 300 000 PLN; 2007-2010
Jacek Jaworski
29
Investigation of activation processes of GPCRs by theoretical methods. (NN301203833); 205 000 PLN; 2007-2010
Sławomir Filipek
30
Proteins S-nitrosylation and Cdk5 kinase-dependent phosphorylation. Proteomic studies of synaptosomal fractions from transgenic mice - Alzheimer's disease models. (NN301254333); 70 000 PLN; 2007-2010
Aleksandra Szybińska
31
Polish-German Special Grant “Relationship between dysregulated calcium homeostasis and synaptic pathology in Alzheimer’s disease as a target for therapy (P-N/001/2006); 1 050 000 PLN; 2007-2010
Jacek Kuźnicki
32
The role of cell cortex contractility in the establishment and positioning of the cleavage furrow" The Max Planck Society; – the Polish Academy of Sciences ; MPI-CBG Junior Research Program - Laboratory (JRGP/37/2005); 3 024 200 PLN; 2006-2009
Ewa Paluch
33
Polish-Spanish Special Grant “Computer prediction and simulation of RNA tertiary structure formation (HISZPANIA/152/2006); 553 600 PLN; 2007-2010
Janusz Bujnicki
34
Development and implementation of methods for improving protein’s crystals quality by engineering of protein-protein contacts (DWM/N2/DFG/2008); 940 000 PLN; 2008-2011
Janusz Bujnicki
35
International Project Grant ; “The role of cell cortex mechanics in cell motility (454/N-MPG/2009/0); 4 692 929 PLN; 2009-2013
Ewa Paluch
36
Identification of natural substrates for enzymes from the HINT family of phosphoroamidases and identification of enzymes that synthesize these substrates (2 P04A 05029); 352 000 PLN; 2005-2008
Paweł Bieganowski
37
Investigation of structure of presenilin protein and significance of its mutations in Alzheimer’s disease development (2 P05A 129 29); 220 000 PLN; 2005-2008
Krzysztof Jóźwiak
38
STRUF- the novel software for classification and prediction of proteins functions (3T11C04029); 105 000 PLN; 2005-2007
Joanna Sasin
39
Biochemical and microscopical characterization of APPLpositive endosomes (2 P04A 038 28); 390 040 PLN; 2005-2008
Marta Miączyńska
40
Differences in action of stress-induced and constitutively synthesized Hsp70 (2 P04A 010 27); 550 200 PLN; 2004-2007
Maciej Żylicz
41
Combating bacterial resistance against MLSb antibiotics by design of a novel type of inhibitors against Erm methyltransferases (2 P05A 108 27); 93 000 PLN; 2004-2006
Marcin Feder
42
Interaction of chaperones with p53 protein (6 P04A 042 19); 447 000 PLN; 2000-2002
Maciej Żylicz
43
Influence of 3'UTR sequences of IL-4 gene on stability of mRNA (6 P04A 039 19); 18 200 PLN; 2000-2001
Dominika Trzaska
44
Cloning and Characterisation of a Novel Human Protein Kinase (6 P04B 006 19); 386 500 PLN; 2000-2003
Lech Trzeciak
45
Hsp90 in Cancerogenesis (3 P04B 021 22); 462 000 PLN; 2002-2005
Alicja Wawrzynow
46
Calcium binding proteins interaction with presenilin ; in lymphocytes of Alzheimer's disease patients and healthy controls (6 P04A 039 20); 325 000 PLN; 2001-2004
Jacek Kuźnicki
47
Application of bioinformatic tools to characterization of enzymes involved in DNA repair (3 P05A 020 24); 30 800 PLN; 2003-2004
Michał Kurowski
48
Role of glycogen synthase kinase 3 beta in neuronal death (6 P04A 004 21); 270 000 PLN; 2001-2003
Michał Hetman
49
Modelling of G Protein-Coupled Receptor and their interactions with drugs in case of opioid receptors (3 P05F 026 25); 120 000 PLN; 2003-2006
Sławomir Filipek
50
Genetic and Environmental Longevity Factors in a Group of Polish Centenarians (PBZ-KBN-022/P05/1999); 1 500 000 PLN; 2001-2004
Jacek Kuźnicki
51
The Role of TNF-Alpha Propeptide in the Process of Storage of this Cytokine in Mast Cell Cytoplasmatic Granules (6 P04A 005 21); 20 000 PLN; 2001-2002
Maciej Olszewski
52
Characterisation of Promoter Sequences, Transcription Factors and Signal Transduction Pathways involved in the Activation of IL-4 Gene Expression by Heavy Metal Ions (4 P05A 051 18); 180 000 PLN; 2000-2002
Jarosław Dastych
53
Engineering of DNA Methytransferases (KBN-6/P04B/00519); 400 000 PLN; 2000-2003
Janusz Bujnicki
54
Analysis of sequence-structure-function relationships in the evolution of RNA methyltransferases (8 T11F 010 19); 19 000 PLN; 2000
Janusz Bujnicki
55
Identification of specificity determinants of restriction endonucleases by bioinformatics and mutagenesis (3 P04A 011 24); 300 000 PLN; 2003-2006
Janusz Bujnicki
Diamond Grant
1
Elucidating the mechanism of translational control of maternal transcripts through cytoplasmic polyadenylation (DI2014 008644); 199 980 PLN; 2015-2019
Maciej Łapiński
OPI
Operational Programme Infrastructure and Environment
1
Support for patent procedure of the invention: Tools and methods useful in characterising the immunotoxic activity of xenobiotic substances (UDA POIG.01.03.02-00-063/10-00); 230315 PLN 2011-2015
Magdalena Powierża
KPO – The National Recovery and Resilience Plan
1
Molecule and Cell Research Infrastructure (IBMiK) (KPOD.01.18-IW.03-0006/23); 100 251697,12 PLN 2024-2025
Marta Miączyńska
MJWPU
Operational Programme Human Capital
1
Support for bio tech med. scientists in technology transfer (UDA-POKL.08.02.01-14-041/09-00); 2 586 221 PLN; 2010-2013
Magda Powierża
MINISTRY OF EDUCATION AND SCIENCE
Medical Research Agency
ABM Projects
1
Identyfikacja markerów metabolicznej stłuszczeniowej choroby wątroby (4/ABM/03/KPO/ KPOD.07.07-IW.07-0158/24-00); 5 244 375,00 PLN 2025-2026
Aleksandra Kołodziejczyk