Prof. Marcin Nowotny, the winner of the Foundation for Polish Science 2022 award for explaining the molecular mechanisms of DNA damage recognition and repair, recently gave an interview to the Polish Radio 1, in which he introduces the subject of his research and explains its significance.
 
"Our goal was to understand how a certain group of proteins act and interact with DNA. We used protein crystallography methods to do this. We wanted to understand at the level of individual atoms what processes take place there. We study these processes in both bacteria and higher organisms. These processes occur in a similar way, but the details of the mechanisms are different between these types of organisms," says Prof. Marcin Nowotny.
 
Thanks to the research, it was possible to identify the first spatial structure of a protein that is responsible for detecting DNA damage, regardless of its origin. - "It turned out that this protein uses a clever mechanism. Instead of checking exactly what happens to each brick, it checks for global distortions that occur in the DNA. It turns out that if this chemical structure of DNA is distorted by the presence of foreign chemical groups, the DNA becomes more flexible. And if this protein detects that this flexibility is increased, this is the first signal to the organism that something is wrong." - Prof. Nowotny adds
 
Tomorrow, November 23 at 4 pm, we also invite you to an online meeting with Prof. Marcin Nowotny, during which he will give a popular-science lecture entitled "Structural biology - how to understand processes in the cell at the level of single atoms." Details of the event - at the link

View the embedded image gallery online at:
https://www.iimcb.gov.pl/en/news-press-office#sigProId462ceabdbc

On November 21, the training on the research data management and Open Science was held at the International Institute of Molecular and Cell Biology in Warsaw. The event was attended by the IIMCB researchers who, in their daily work, produce research data and publish them. Through the Open Science policy research data are available to everyone and they can be used for further research analyses and reusage. Also, the integration of data from multiple sources allows to obtain new knowledge and ensures further progress of research. 

The costs of the traning were covered by the MOSaIC project. The full Agenda is below:

View the embedded image gallery online at:
https://www.iimcb.gov.pl/en/news-press-office#sigProId9e9dd4746a
View the embedded image gallery online at:
https://www.iimcb.gov.pl/en/news-press-office#sigProId274b445cb2

View the embedded image gallery online at:
https://www.iimcb.gov.pl/en/news-press-office#sigProId7e464a835a







On November 14-15, 2022, the annual Laboratory Leaders’ Retreat took place in Mała Wieś. The Retreat was devoted to discussions on scientific projects performed in IIMCB labs and strategic directions for the development of the Institue. Two days meeting was attended by all representatives of the laboratories and directors of the Institute. 

 

View the embedded image gallery online at:
https://www.iimcb.gov.pl/en/news-press-office#sigProIdde07cf8e12

Rare neurological diseases, ataxias, pyramidal signs indicating damage to motor neurons and manifested by a lack of proper posture - this topic concerns not only doctors and scientists but also patients affected by such conditions and their families. The search for the causes of rare diseases is a long and challenging process, as it is difficult to grasp all the molecular aspects that allow for a clear answer to the question: does a mutation detected in genetic screening really underlies the disease?

A recent study conducted using an animal model by the team of Dr. Wojciech Pokrzywa from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) indicates that specific amino acid mutation of an important enzyme involved in protein degradation can cause a neurodevelopmental disorder.

Using exome sequencing to diagnose a pediatric patient with developmental delay, pyramidal signs, and limb ataxia, the research team has identified an ultra-rare de novo Asp126His missense variant in the FEM1C gene encoding a ubiquitin ligase that promotes degradation of other proteins. - However, it was not clear yet whether this mutation was actually responsible for the patient's disease, which is crucial in making the diagnosis and the possibility of seeking personalized therapies – says Dr. Wojciech Pokrzywa, head of the Laboratory of Protein Metabolism at the IIMCB.

The bioinformatics analysis made by the team of Dr. Pokrzywa showed that the aforementioned FEM1C mutation disrupts the binding of protein substrates destined for degradation, which can lead to their accumulation in the cell and cause toxic effects. To evaluate the pathogenicity of the Asp126His variant in the FEM1C gene, the researchers used the Caenorhabditis elegans nematode as a disease model. They found that animals expressing a variant analogous to the patient's mutation had normal muscle architecture but, similarly to the patient, impaired mobility. These nematodes were sensitive to the acetylcholinesterase inhibitor, aldicarb, indicating that their impaired locomotion was due to synaptic abnormalities rather than muscle dysfunction.

As a result of the research, the first evidence from an animal model has been presented, suggesting that a mutation in the evolutionarily conserved amino acid Asp126 in the ubiquitin ligase FEM1C causes neurodevelopmental disorders in humans.

The findings were published in the latest issue of the British journal Human Molecular Genetics

nicień

It was two days of hard work and inspiring meetings within an international group of representatives of 15 leading research institutes in life sciences from all over Europe. That is how this year EU-LIFE Community Meeting may be summarized.

The purpose of the meeting was to integrate representatives of the EU-LIFE community and to exchange experiences in implementing best practices in the organization and management of research institutes.

The meetings were workshop-based and they were held within the framework of individual working groups, which included selected representatives of 15 member institutes. The representatives of the International Institute of Molecular and Cellular Biology in Warsaw participated in 7 working groups, namely: Core Facilities; Gender Equality, Diversity & Inclusion; Grants & Funding; IT; Training & Recruitment; Science Communication, and Tech Transfer.

"The participation in the working group such as Gender Equality, Diversity and Inclusion  was an excellent chance to get to know all its members personally. It also allowed us  to participate in interesting discussions as well as gave us an opportunity to  exchange  good practices on the implementation of gender equality plans in individual institutions. We agreed on an action plan for the near future, including the preparation of a mentoring program for women," assessed Agnieszka Faliszewska, the deputy head in the HR Unit.

In turn, the IT Working Group meeting was held to conclude the Research Data Management Policy. Among other things, the participants discussed the topic of cataloguing, storing, and sharing large data sets. An outline of the group's action plan for the next 12 months was also laid out, assuming the creation of detailed guidelines for good practice in the IT security field.

In the Technology Transfer Working Group, the action plan for 2023 was discussed. There was also an intensive exchange session on the following topics: capital and start-up policies, proof-of-concept financing and de-risking strategies, ways to protect computer software, resources, and tools used in technology transfer. The Group also talked about frequenting events to promote scientific achievements and attract business partners.

The Grant & Funding Group summarized the statistics of the EU-LIFE institutes' grants, which is an important input to science policy documents.; Its representatives also exchanged information on the Horizon Europe program rules. "The most valuable part of the meeting for me was the "Re-connect" session, during which we made tour de tables, introducing each other and the institutional grants offices. Such experiences strengthen cooperation and build a sense of community," added Dorota Libiszowska, the head of the Grants Office.

As a part of the meeting, the Science Communication Working Group held a workshop on storytelling and so-called "inclusive communication" in the area of communicating research.  Participants also discussed the topics related to upcoming 10th anniversary of EU-LIFE and the organization of events highlighting this celebration.

Last but not least, the Core Facility Working Group discussed the next steps of preparing the CF Lifecycle Guideline and CF Benchmarking Report for 2021. Activities were planned for 2023, including, among others, improving the operation of the CFs through training course opportunities and Staff exchanges. In addition, WG members agreed to continue the Tech Watch seminars, through which the EU-LIFE community can explore the scientific technologies used in the partner institutes and establish collaborations. The exchange of experiences on conducting sustainability and energy savings was also an important topic. 

The next annual EU-LIFE Community Meeting is planned for June 2023 in Lisbon.

View the embedded image gallery online at:
https://www.iimcb.gov.pl/en/news-press-office#sigProIdd14c4a5960

Awards of the Foundation for Polish Science 2022 have already been distributed! Among the winners - Prof. Marcin Nowotny, Head of the Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology in Warsaw. This is one of the most important awards of the scientific community in Poland. Our sincere congratulations!

Explanation of molecular mechanisms of DNA damage recognition and repair - this is the area of activity in the field of life and earth sciences, for which Prof. Marcin Nowotny, was honored with the most important scientific award in Poland, also known as the Polish Nobel. The prizes of the Foundation for Polish Science are awarded for special scientific achievements and discoveries that push the boundaries of cognition and open new cognitive perspectives, making an outstanding contribution to the civilizational and cultural progress of our country. They also provide Poland with a significant place in addressing the most ambitious challenges of the modern world. More about the award in the article.

The amount of the award is 200 thousand PLN. It is awarded by the FNP Council through a competition in four areas: life and earth sciences, chemical and material sciences, mathematical and physical sciences and engineering sciences, and humanities and social sciences. Candidates for this award are submitted by prominent representatives of science. The FNP Council acts as the Chapter of the competition and selects the winners based on the opinions of independent experts and reviewers - mainly from abroad - evaluating the achievements of the candidates. The FNP Prizes have been awarded since 1992.

The award ceremony will take place on December 7 and will be broadcast on line.

nowotny

 

Polish RNA Biology Meeting 2023 – International Conference at IIMCB.

New paper by IIMCB scientists in Science Advances.

Scientists from the Laboratory of Protein Structure - in Nucleic Acids Research.