This is the latest publication on the key protein quality control ubiquitin ligase CHIP. Its co-author is Wojciech Pokrzywa, PhD, Dsc Habil, who heads the Protein Metabolism Laboratory. We sincerely congratulate you and recommend your attention.
Another publication on the key protein quality control ubiquitin ligase CHIP. CHIP regulates the degradation of chaperone-dependent and chaperone-independent proteins. Our studies have better understood how CHIP mediates substrate selection and processing. We revealed that CHIP exists as a dimer and a monomer with different substrate-specific functions. The CHIP dimer mediates the degradation of damaged proteins. The CHIP monomer regulates insulin receptor turnover and longevity. Dimer-monomer switching is controlled by CHIP auto-ubiquitylation and chaperone binding. In summary, we identified a conserved molecular switch mechanism that controls substrate specificity of CHIP and that may be related to the pathophysiology of age-related diseases.
Link to the article