Director: Prof. Bożena Kamińska-Kaczmarek
phone: 022 58 92 209
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Administrative office:
Postgraduate School of Molecular Medicine
61 Żwirki i Wigury Street
02-091 Warsaw
room 216 Didactic Centre
phone: (+48) 22 57 20 558
mobile. 728 960 626
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Website: https://smm.wum.edu.pl/en
Head of the PhD Studies: Prof. Daniel K. Wójcik
PhD Studies Office:
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mgr Karolina Wysowska
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mgr Diana Szymańska
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
phone: +48 22 5892554
Website: http://en.nencki.edu.pl/phd-general-information
Head of the PhD Studies:
Prof. Anna Muszewska
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
PhD Studies Office:
Adrian Iwaniuk
Monika Wiczuk
phone: 22 592 2162
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Website: https://www.ibb.waw.pl/pl/struktura/szkola-biologii-molekularnej
A person pursuing a degree of doctor in the external course submits an application to appoint a PhD thesis supervisor which initiates the proceedings of awarding a degree of doctor.
IIMCB contact:
Human Resources Unit
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
International Institute of Molecular and Cell Biology in Warsaw
4 Ks. Trojdena Street, 02-109 Warsaw, Poland
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May 25, 2020 - recruitment opens
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June 7, 2020 - deadline for applications
Research projects for admissions 2020/2021-1:
Linking abnormal Ca2+ signaling and the unfolded protein response with Huntington’s disease pathology in both YAC128 mouse model and iPSC-derived neurons from HD patients.
Prof. Jacek Kuźnicki, PhD; Magdalena Czeredys, PhD, Laboratory of Neurodegeneration
Description: Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by the aggregation of mutant huntingtin and degeneration of medium spiny neurons (MSNs) in the striatum. Abnormal Ca2+ signaling is considered as an early event in HD pathology since disturbances in Ca2+ homeostasis were found in HD models and postmortem samples from HD patients. One of the pathways for Ca2+ signaling is store-operated calcium entry (SOCE). The activation of inositol-(1,4,5)triphosphate receptor 1 (IP3R1) results in Ca2+ release, which decreases ER Ca2+ content and activates Ca2+ influx through SOC channels. Elevated SOCE and increased IP3R1 activity was previously reported in MSNs from the transgenic model of HD, YAC128. The project is based on the hypothesis that neurodegeneration in HD is induced by disturbances in Ca2+ signaling in neurons. Previously we found that huntingtin-associated protein 1 (HAP1) that is overexpressed in striatal neurons and binds to mutant huntingtin causes dysregulation of Ca2+ signaling by increased activation of both SOCE and IP3R1 receptors. We intend to examine the link between dysregulated Ca2+ signals and neuronal cell death in HD. The experiments will be performed in YAC128 MSNs cultures and neurons delivered by the reprogramming of fibroblasts from HD patients with the application on CRISPR/Cas9-based editing strategies and Ca2+ signaling inhibitors.
Aim: The project aims to investigate whether and how the disturbed Ca2+ homeostasis affects HD pathology. A Ph.D. project related to this issue will be done using different HD models. One position is available in the project. We are looking for a person interested in neurobiology, with experience in working with animal models (mice, zebrafish), cell cultures, and biochemical techniques (immunoprecipitation, western blot). Knowledge/experience in iPSCs cultures is welcome.
Number of positions available: 1
Source of funding: NCN/OPUS grant
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
Cytoplasmic polyadenylation as a central regulator of physiological processes
Prof. Andrzej Dziembowski, PhD, Laboratory of RNA Biology
Description: Poly(A) tails generated by canonical poly(A) polymerases during mRNA 3’ formation are essential for mRNA stability and translation. It is now appreciated that poly(A) tail dynamics is more complex than previously suspected; deadenylated mRNAs in the cytoplasm can be degraded, uridylated or stored in a dormant state to be later re adenylated to activate protein synthesis. Cytoplasmic polyadenylation was mostly studied in the context of gametogenesis and in synapses, where the transcriptional activity is limited. Surprisingly, mouse lines devoid of the well known cytoplasmic poly(A) polymerase GLD2 display no apparent phenotypes. We recently described a novel family of cytoplasmic poly(A) polymerases, TENT5 (FAM46), comprising four members in vertebrates (Mroczek et al. & Bilska et al. Nat Comm 2017,2020). TENT5C acts as a tumor suppressor in multiple myeloma, while mutations in TENT5A lead to a rare disease osteogenesis imperfecta. We have generated KO mouse models for all TENT5 genes and detected a variety of different phenotypes affecting several organs and biological processes: gametogenesis, growth, skeletal development, hematopoiesis, immune response, and behavior. Moreover, analysis of the KO of worm TENT5 orthologue revealed dysfunction of innate immunity. Thus, TENT5 proteins contribute significantly to metazoan physiology and, more generally, that cytoplasmic polyadenylation plays a much broader role than previously anticipated, opening a new area of important research.
Aim: The project aims is to dissect functions and mechanisms of cytoplasmic polyadenylation by TENT5 in innate immunity, erythropoiesis, and neuronal physiology. Unique animal models constructed using CRISPR/Cas9, combined with advanced transcriptomic and proteomic approaches, will be used to achieve our goals. Several positions are available in the lab. The exact PhD project will depend on the particular skills and preferences of the student. We are looking for students with experience in work with animal modes (mouse, C. elegans), RNA biology, or bioinformatics.
Number of positions available: 4
Source of funding: NCN/Norway grants/FNP/Horizon2020 era chairs
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
See also:
School of Molecular Biology
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Head of the PhD Studies: |
PhD Studies Office: Adrian Iwaniuk Monika Wiczuk e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. phone: +48 22 592 21 64 |
PhD studies of the Nencki Institute of Experimental
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Head of the PhD Studies: |
PhD Studies Office: mgr Karolina Wysowska mgr Diana Szymańska e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. phone: +48 22 589 25 54 |
Postgraduate School of Molecular Medicine WUM |
Director: Prof. Bożena Kamińska-Kaczmarek e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. phone: +48 22 589 22 09 |
Administrative office: Postgraduate School of Molecular Medicine 61 Żwirki i Wigury Street, 02-091 Warsaw room 216 Didactic Centre e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. phone: +48 22 57 20 558 mobile. 728 960 626 |
Warsaw PhD School of Natural and BioMedical Sciences [Warsaw-4-PhD] was established on May 16, 2019. The School is operated by nine research institutions: 1. Nencki Institute of Experimental Biology PAS (leader of the School); 2.Institute of Organic Chemistry PAS; 3. Institute of Physical Chemistry PAS; 4. Institute of Physics PAS; 5.Center for Theoretical Physics PAS; 6. Institute of High Pressure Physics PAS; 7. Maria Sklodowska-Curie Institute - Oncology Center; 8. Institute of Psychiatry and Neurology; 9. International Institute of Molecular and Cell Biology in Warsaw. The School educates doctoral students in four scientific disciplines: biology, chemistry, physics and medicine.The School commenced its activity on October 1, 2019.
IIMCB contact:
Zuzanna Mackiewicz (Laboratory of RNA Biology)
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Human Resources Unit
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
International Institute of Molecular and Cell Biology in Warsaw
4 Ks. Trojdena Street, 02-109 Warsaw, Poland