All publications
2021
Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and Chemoresistance.
Herok M, Wawrzynow B, Maluszek MJ, Olszewski MB, Zylicz A, Zylicz M.
Cancers (Basel). 2021
2020
HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells.
Cancers (Basel). 2020
Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells.
Chen L, Olszewski MB, Kruithof-de MJ, Snaar-Jagalska BE.
Cells. 2020
2019
Heat shock proteins create a signature to predict the clinical outcome in breast cancer.
Klimczak M, Biecek P, Zylicz A, Zylicz M.
Sci Rep. . 2019
Function, evolution, and structure of J-domain proteins.
Kampingaa HH et al. …. (Zylicz A, Zylicz M)
Cell Stress Chaperones.. 2019
Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness.
Olszewski MB, Pruszko M, Snaar-Jagalska E, Zylicz A, Zylicz M.
Int. J. Oncol.. 2019
2018
Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism.
Walerych D, Pruszko M, Zyla L, Wezyk M, Gaweda-Walerych K, Zylicz A.
Oncotarget. 2018
Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.
Donzelli S, Milano E, Pruszko M, Sacconi A, Masciarelli S, Iosue I, Melucci E, Gallo E, Terrenato I, Mottolese M, Zylicz M, Zylicz A, Fazi F, Blandino G, Fontemaggi G.
Breast Cancer Res.. 2018
Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action.
Wawrzynow B, Zylicz A, Zylicz M.
BBA-Rev Cancer. 2018
Novel role for the testis-enriched HSPA2 protein in regulating epidermal keratinocyte differentiation.
Gogler-Pigłowska A, Klarzyńska K, Sojka DR, Habryka A, Głowala-Kosińska M, Herok M, Kryj M, Halczok M, Krawczyk Z, Scieglinska D.
J Cell Physiol.. 2018
2017
TRIM28 epigenetic corepressor is indispensable for stable induced pluripotent stem cell formation
Klimczak M, Czerwińska P, Mazurek S, Sozańska B, Biecek P, Mackiewicz A, Wiznerowicz M
Stem Cell Research. 2017
Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation
Tracz-Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosinski M, Olszewski MB, Czerwińska P, Wiech M, Wiznerowicz M, Zylicz A, Zylicz M, Wawrzynow B
Oncotarget. 2017
The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1
Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S, De Panfilis S, Fazi F, Bates DO, Bicciato S, Zylicz M, Zylicz A, Blandino G, Fontemaggi G
EMBO Rep. 2017
2016
Białka z rodziny ID w inicjacji i progresji nowotworów (Białka z rodziny ID w inicjacji i progresji nowotworów).
Pruszko M, Żylicz A.
Postępy Biochemii. 2016
2015
NeuroMorph: A Toolset for the Morphometric Analysis and Visualization of 3D Models Derived from Electron Microscopy Image Stacks.
Jorstad A, Nigro B, Cali C, Wawrzyniak M, Fua P, Knott G.
Neuroinformatics. 2015
2013
2012
Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Wiech M, Olszewski MB, Tracz-Gaszewska Z, Wawrzynow B, Zylicz M, Zylicz A
PLoS One. 2012
2011
The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities
Hageman J, van Waarde MA, Zylicz A, Walerych D, Kampinga HH
Biochem J. 2011
2010
Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms
Zubrienė A, Gutkowska M, Matulienė J, Chaleckis R, Michailovienė V, Voroncova A, Venclovas C, Zylicz A, Zylicz M, Matulis D
Biophys Chem. 2010
The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin
Kvardova V, Hrstka R, Walerych D, Muller P, Matoulkova E, Hruskova V, Stelclova D, Sova P, Vojtesek B
Mol Cancer. 2010
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.
Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, Moilanen I, Zylicz A, Knudsen J, Sandhoff K, Arenz C, Kinnunen PK, Nylandsted J, Jäättelä M
Nature. 2010
Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo.
Zurawska A, Urbanski J, Matuliene J, Baraniak J, Klejman MP, Filipek S, Matulis D, Bieganowski P
Biochim Biophys Acta. 2010
ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein.
Walerych D, Gutkowska M, Klejman MP, Wawrzynow B, Tracz Z, Wiech M, Zylicz M, Zylicz A
J Biol Chem. 2010
2009
Mathematical modelling of the influence of heat shock proteins on cancer invasion of tissue.
Szymańska Z, Urbański J, Marciniak-Czochra A.
J Math Biol. 2009
Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions.
Walerych D, Olszewski MB, Gutkowska M, Helwak A, Zylicz M, Zylicz A
Oncogene. 2009
Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery
Narayan V, Eckert M, Zylicz A, Zylicz M, Ball KL
J Biol Chem. 2009
A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.
Wawrzynow B, Pettersson S, Zylicz A, Bramham J, Worrall E, Hupp TR, Ball KL
J Biol Chem. 2009
2008
Fhit proteins can also recognize substrates other than dinucleoside polyphosphates.
Guranowski A, Wojdyła AM, Pietrowska-Borek M, Bieganowski P, Khurs EN, Cliff MJ, Blackburn GM, Błaziak D, Stec WJ
FEBS Lett. 2008
The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1.
Sbroggiò M, Ferretti R, Percivalle E, Gutkowska M, Zylicz A, Michowski W, Kuznicki J, Accornero F, Pacchioni B, Lanfranchi G, Hamm J, Turco E, Silengo L, Tarone G, Brancaccio M.
FEBS Lett. 2008
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.
Stevens C, Pettersson S, Wawrzynow B, Wallace M, Ball K, Zylicz A, Hupp TR
FEBS J. 2008
Hsp90n - An accidental product of a fortuitous chromosomal translocation rather than a regular Hsp90 family member of human proteome
Zurawska A, Urbanski J, Bieganowski P
Biochim Biophys Acta. 2008
2007
Hsp70 is a new target of Sgt1-an interaction modulated by S100A6.
Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J,Filipek A.
Biochem Biophys Res Commun. 2007
Potentiated antitumor effects of the combination treatment with statins and pamidronate in vitro and in vivo.
Issat T, Nowis D, Legat M, Makowski M, Klejman MP, Urbanski J, Skierski J, Koronkiewicz M, Stoklosa T, Brzezinska A, Bil J, Gietka J, Jakóbisiak M, Golab J
Int J Oncol. 2007
MDM2 chaperones the p53 tumor suppressor.
Wawrzynow B, Zylicz A, Wallace M, Hupp T, Zylicz M.
J Biol Chem. 2007
Potentiated antitumor effects of the combination treatment with statins and pamidronate in vitro and in vivo.
Issat T, Nowis D, Legat M, Makowski M, Klejman MP, Urbanski J, Skierski J, Koronkiewicz M, Stoklosa T, Brzezinska A, Bil J, Gietka J, Jakóbisiak M, Golab J
Int J Oncol. 2007
2006
Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.
Bieganowski P, Seidle HF, Wojcik M, Brenner C
J Biol Chem. 2006
Glutamine-dependent NAD+ synthetase. How a two-domain, three-substrate enzyme avoids waste.
Wojcik M, Seidle HF, Bieganowski P, Brenner C
J Biol Chem. 2006
High guanine and cytosine content increases mRNA levels in mammalian cells.
Kudla G, Lipinski L, Caffin F, Helwak A, Zylicz M.
PLoS Biol. 2006
Brain-derived heat shock protein 70-peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis.
Galazka G, Stasiolek M, Walczak A, Jurewicz A, Zylicz A, Brosnan CF, Raine CS, Selmaj KW
J Immunol. 2006
2005
Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants.
Klejman MP, Zhao X, van Schaik FM, Herr W, Timmers HT
Nucleic Acids Res. 2005
Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms.
Ilyushik E, Pryce DW, Walerych D, Riddell T, Wakeman JA, McInerny CJ, McFarlane RJ
Biol Chem. 2005
Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling.
Bucko-Justyna M, Lipinski L, Burgering BM, Trzeciak L
FEBS J. 2005
2004
Hsp90 chaperones wild-type p53 tumor suppressor protein.
Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M.
J Biol Chem. 2004
Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II.
Mycko MP, Cwiklinska H, Szymanski J, Szymanska B, Kudla G, Kilianek L, Odyniec A, Brosnan CF, Selmaj KW.
J Immunol. 2004
Gene conversion and GC-content evolution in mammalian Hsp70.
Kudla G, Helwak A, Lipinski L
Mol Biol Evol. 2004
Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
Müller L, Schaupp A, Walerych D, Wegele H, Buchner J
J Biol Chem. 2004
P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.
Jassem J, Jassem E, Jakóbkiewicz-Banecka J, Rzyman W, Badzio A, Dziadziuszko R, Kobierska-Gulida G, Szymanowska A, Skrzypski M, Zylicz M.
Cancer. 2004
MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).
Dworakowska D, Jassem E, Jassem J, Peters B, Dziadziuszko R, Zylicz M, Jakóbkiewicz-Banecka J, Kobierska-Gulida G, Szymanowska A, Skokowski J, Roessner A, Schneider-Stock R
Lung Cancer. 2004
2001
Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.
King FW, Wawrzynow A, Höhfeld J, Zylicz M.
EMBO J. 2001
Types and localisation of p53 gene mutations: a report on 332 non-small cell lung cancer patients.
Jassem E, Nikliński J, Rosell R, Niklińska W, Jakóbkiewicz J, Monzo M, Chyczewski L, Kobierska G, Skokowski J, Zylicz M, Jassem J
Lung Cancer. 2001
DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.
Genevaux P, Wawrzynow A, Zylicz M, Georgopoulos C, Kelley WL
J Biol Chem. 2001
Multitemperature single-strand conformation polymorphism.
Kaczanowski R, Trzeciak L, Kucharczyk K
Electrophoresis. 2001
Hsp70 interactions with the p53 tumour suppressor protein.
Zylicz M, King FW, Wawrzynow A.
EMBO J. 2001