All publications
2025
Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin.
Domagala J, Grzywa TM, Baranowska I, Justyniarska M, Tannir R, Graczyk-Jarzynka A, Kusowska A, Lecka M, Poreba M, Fidyt K, Marhelava K, Pilch Z, Picard LK, Wegierski T, Jastrzebski K, Krawczyk M, Klopotowska M, Granica M, Urlaub D, Hajduk S, Neeser A, Moros S, Kozlowski P, Bobrowicz M, Miaczynska M, Ma L, Watzl C, Winiarska M.
Cancer Res. 2025
p70S6 kinase-dependent phosphorylation of the μ2 subunit of the AP2 adaptor complex is needed for clathrin-mediated endocytosis.
Tempes A, Brzozowska A, Węgierski T, Olek K, Jastrzębski K, Liszewska E, Misztal K, Machnicka K, Macias M, Szybińska A, Sitkiewicz E, Gozdz A, Wróbel AG, Miaczynska M, Pokrzywa W, Jaworski J, Malik AR.
bioRxiv. 2025
2024
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT‑I deficiency.
Cendrowski J, Wrobel M, Mazur M, Jary B, Maurya R, Wang S, Korostynski M, Dziewulska A, Rohm M, Kuropka P, Pudelko‑Malik N, Mlynarz P, Dobrzyn A, Zeigerer A, Miaczynska M.
Cell Mol Life Sci. 2024
2023
Ammonia inhibits antitumor activity of NK cells by decreasing mature perforin.
Domagala J, Grzywa TM, Baranowska I, Kusowska A, Fidyt K, Marhelava K, Pilch Z, Graczyk-Jarzynka A, Picard LK, Jastrzebski K, Granica M, Justyniarska M, Urlaub D, Bobrowicz M, Miaczynska M, Watzl C, Winiarska M.
bioRxiv. 2023
Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance.
Zurawska G, Sas Z, Jończy A, Slusarczyk P, Mahadeva R, Chwałek M, Kulecka M, Rumieńczyk I, Moulin M, Jastrzębski K, Mikula M, Etzerodt A, Miączyńska M, Rygiel TP, Mleczko-Sanecka K.
bioRxiv. 2023
2022
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
Wróbel M, Cendrowski J, Szymańska E, Grębowicz-Maciukiewicz M, Budick-Harmelin N, Macias M, Szybińska A, Mazur M, Kolmus K, Goryca K, Dąbrowska M, Paziewska A, Mikula M, Miączyńska M.
Life Sci Alliance. 2022
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Sekar R, Motzler K, Kwon Y, Novikoff A, Jülg J, Najafi B, Wang S, Warnke AL, Seitz S, Hass D, Gancheva S, Kahl S, Yang B, Finan B, Schwarz K, Okun JG, Roden M, Blüher M, Müller TD, Krahmer N, Behrends C, Plettenburg O, Miaczynska M, Herzig S, Zeigerer A.
Cell Metab. 2022
The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells.
Oroń M, Grochowski M, Jaiswar A, Legierska J, Jastrzębski K, Nowak-Niezgoda M, Kołos M, Kaźmierczak W, Olesiński T, Lenarcik M, Cybulska M, Mikula M, Żylicz A, Miączyńska M, Zettl K, Wiśniewski JR, Walerych D.
Cell Rep. 2022
Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide.
Wolińska-Nizioł L, Romaniuk K, Wojciechowska K, Surga K, Kamaszewski M, Szudrowicz H, Miączyńska M.
FEBS Open Bio. 2022
Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation.
Poświata A, Kozik K, Miączyńska M, Zdżalik-Bielecka D.
Cell Mol Life Sci. 2022
Bemcentinib and gilteritinib inhibit cell growth and impair the endo-lysosomal and autophagy systems in an AXL-independent manner.
Zdzalik-Bielecka D, Kozik K, Poswiata A, Jastrzebski K, Jakubik M, Miaczynska M.
Mol Cancer Res. . 2022
2021
Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors.
Poźniak M, Porębska N, Jastrzębski K, Krzyścik MA, Kucińska M, Zarzycka W, Barbach A, Zakrzewska M, Otlewski J, Miączyńska M, Opaliński Ł.
J Biomed Sci.. 2021
The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion.
Zdżalik-Bielecka D, Poświata A, Kozik K, Jastrzębski K, Schink KO, Brewińska-Olchowik M, Piwocka K, Stenmark H, Miączyńska M.
Proc Natl Acad Sci USA. 2021
Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1.
Porebska N, Pozniaka M, Krzyscik MA, Knapika A, Czyrek A, Kucinska M, Jastrzebski K, Zakrzewska M, Otlewski J, Opalinski L.
Int J Biol Macromol.. 2021
Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses.
Kolmus K, Erdenebat P, Szymańska E, Stewig B, Goryca K, Derezinska-Wolek E, Szumera-Cieckiewicz A, Brewinska-Olchowik M, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miaczynska M.
J Cell Sci.. 2021
2020
Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor.
Maksymowicz M, Miączyńska M, Banach-Orłowska M.
Cell Commun Signal.. 2020
Splicing variants of an endocytic regulator, BMP2K, differentially control autophagic degradation in erythroid cells.
Autophagy. 2020
Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.
Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M.
eLife . 2020
FGFR1 Clustering With Engineered Tetravalent Antibody Improves the Efficiency and Modifies the Mechanism of Receptor Internalization.
Pozniak M, Sokolowska-Wedzina A, Jastrzebski K, Szymczyk J, Porebska N, Krzyscik MA, Zakrzewska M, Miaczynska M, Otlewski J, Opalinski L.
Mol Oncol. . 2020
Membrane Trafficking: Vesicle Formation, Cargo Sorting and Fusion.
Miaczynska M, Munson M.
Mol Biol Cell. . 2020
Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.
Szymańska E, Nowak P, Kolmus K, Cybulska M, Goryca K, Derezińska-Wołek E, Szumera-Ciećkiewicz A, Brewińska-Olchowik M, Grochowska A, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miączyńska M.
EMBO Mol Med.. 2020
2019
Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling.
Banach-Orłowska M, Wyszyńska R, Pyrzyńska B, Maksymowicz M, Gołąb J, Miączyńska M.
Cell Commun Signal.. 2019
2018
Integration of the Endocytic System into the Network of Cellular Functions.
Budick-Harmelin N, Miaczynska M.
Prog Mol Subcell Biol.. 2018
The topology of lymphotoxin β receptor accumulated upon endolysosomal dysfunction dictates the NF-κB signaling outcome.
Banach-Orłowska M, Jastrzębski K, Cendrowski J, Maksymowicz M, Wojciechowska K, Korostyński M, Moreau D, Gruenberg J, Miaczynska M.
J Cell Sci.. 2018
2017
Endosomal "sort" of signaling control: The role of ESCRT machinery in regulation of receptor-mediated signaling pathways.
Szymanska E, Budick-Harmelin N, Miaczynska M.
Semin Cell Dev Biol.. 2017
Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling
Jastrzębski K, Zdżalik-Bielecka D, Mamińska A, Kalaidzidis Y, Hellberg C, Miaczynska M
J Cell Sci.. 2017
2016
Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes
Tudek B, Zdżalik-Bielecka D, Tudek A, Kosicki K, Fabisiewicz A, Speina E
Free Radic Biol Med. 2016
Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy.
Mikula M, Skrzypczak M, Goryca K, Paczkowska K, Ledwon JK, Statkiewicz M, Kulecka M, Grzelak M, Dabrowska M, Kuklinska U, Karczmarski J, Rumienczyk I, Jastrzebski K, Miaczynska M, Ginalski K, Bomsztyk K, Ostrowski J.
Nucleic Acids Res. 2016
Endocytic regulation of cytokine receptor signaling
Cendrowski J, Mamińska A, Miaczynska M
Cytokine Growth Factor Rev. 2016
APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain
Song J, Mu Y, Li C, Bergh A, Miaczynska M, Heldin CH, Landström M
Oncotarget. 2016
ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors
Mamińska A, Bartosik A, Banach-Orłowska M, Pilecka I, Jastrzębski K, Zdżalik-Bielecka D, Castanon I, Poulain M, Neyen C, Wolińska-Nizioł L, Toruń A, Szymańska E, Kowalczyk A, Piwocka K, Simonsen A, Stenmark H, Fürthauer M, González-Gaitán M, Miaczynska M
Sci Signal. 2016
Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway
Szymanska E, Skowronek A, Miaczynska M
Cell Signal. 2016
2015
APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments
Kalaidzidis I, Miaczynska M, Brewińska-Olchowik M, Hupalowska A, Ferguson C, Parton RG, Kalaidzidis Y, Zerial M
J Cell Biol. 2015
APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription
Banach-Orlowska M, Szymanska E, Miaczynska M
FEBS Lett. 2015
Endocytic adaptor protein Tollip inhibits canonical Wnt signaling
Torun A, Szymańska E, Castanon I, Wolińska-Nizioł L, Bartosik A, Jastrzębski K, Miętkowska M, González-Gaitán M, Miaczynska M
PLoS One. 2015
Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome
Kolanczyk M, Krawitz P, Hecht J, Hupalowska A, Miaczynska M, Marschner K, Schlack C, Emerich D, Kobus K, Kornak U, Robinson PN, Plecko B, Grangl G, Uhrig S, Mundlos S, Horn D
Eur J Hum Genet. 2015
2014
Labeling of platelet-derived growth factor by reversible biotinylation to visualize its endocytosis by microscopy
Sadowski Ł, Jastrzębski K, Purta E, Hellberg C, Miaczynska M
Methods Enzymol.. 2014
2013
Effects of membrane trafficking on signaling by receptor tyrosine kinases
Miaczynska M
Cold Spring Harb Perspect Biol.. 2013
Dynamin Inhibitors Impair Endocytosis and Mitogenic Signaling of PDGF
Sadowski L, Jastrzębski K, Kalaidzidis Y, Heldin CH, Hellberg C, Miaczynska M
Traffic. 2013
Multifunctional protein APPL2 contributes to survival of human glioma cells
Pyrzynska B, Banach-Orlowska M, Teperek-Tkacz M, Miekus K, Drabik G, Majka M, Miaczynska M
Mol Oncol.. 2013
2012
Prenyltransferases Regulate CD20 Protein Levels and Influence Anti-CD20 Monoclonal Antibody-mediated Activation of Complement-dependent Cytotoxicity
Winiarska M, Nowis D, Bil J, Glodkowska-Mrowka E, Muchowicz A, Wanczyk M, Bojarczuk K, Dwojak M, Firczuk M, Wilczek E, Wachowska M, Roszczenko K, Miaczynska M, Chlebowska J, Basak GW, Golab J
J Biol Chem. 2012
P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3
Zerrouqi A, Pyrzynska B, Febbraio M, Brat DJ, Van Meir EG
J Clin Invest.. 2012
APPL1 regulates basal NF-κB activity by stabilizing NIK
Hupalowska A, Pyrzynska B, Miaczynska M
J Cell Sci. 2012
2011
Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment
Urbanska A, Sadowski L, Kalaidzidis Y, Miaczynska M
Traffic. 2011
Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment
Pilecka I, Sadowski L, Kalaidzidis Y, Miaczynska M
Exp Cell Res. 2011
2010
2009
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.
Ohya T, Miaczynska M, Coskun U, Lommer B, Runge A, Drechsel D, Kalaidzidis Y, Zerial M
Nature. 2009
[Effectors of GTPase Rab5 in endocytosis and signal transduction]
Olchowik M, Miaczyńska M
Postepy Biochem. 2009
Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex
Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M
Biochem J. 2009
Signaling from endosomes: location makes a difference.
Sadowski L, Pilecka I, Miaczynska M
Exp Cell Res. 2009
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M
J Biol Chem. 2009
Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis
Pyrzynska B, Pilecka I, Miaczynska M
Mol Oncol. 2009
2008
On the transition from the meiotic to mitotic cell cycle during early mouse development.
Kubiak JZ, Ciemerych MA, Hupalowska A, Sikora-Polaczek M, Polanski Z
Int J Dev Biol. 2008
2007