Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels.

Idlin N, Krishnamoorthy S, Wolczyk M, Fakhri M, Lechowski M, Stec N, Milek J, Mandal PK, Cendrowski J, Spanos C, Dziembowska M, Mleczko-Sanecka K, Rappsilber J, Michlewski G.

BMC Biol. 2025

5′ terminal nucleotide determines the immunogenicity of IVT RNAs.

Wolczyk M, Szymanski J, Trus I, Naz Z, Tame T, Bolembach A, Choudhury NR, Kasztelan K, Rappsilber J, Dziembowski A, Michlewski G.

Nucleic Acids Res. 2025

Endogenous ZAP is associated with altered Zika virus infection phenotype.

Le NPK, Singh PP, Sabir AJ, Trus I, Karniychuk U.

Virol J. 2024

The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.

Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J.

Nat Commun. 2024

The molecular dissection of TRIM25‘s RNA-binding mechanism provides key insights into its antiviral activity.

Simon B, Castello A, Allain FHT, Hentze MW, Michlewski G, and 16 more authors

Research Square. 2024

The effect of infection with the entomopathogenic fungus Conidiobolus coronatus (Entomopthorales) on eighteen cytokine-like proteins in Galleria mellonella (Lepidoptera) larvae.

Wrońska AK, Kaczmarek A, Sobich J, Boguś MI.

Front Immunol. 2024

AI is a viable alternative to high throughput screening: a 318-target study.

Participants of the Atomwise AIMS Program, including IIMCB researchers Stec N, Zhu S and Michlewski G.

Sci Rep. 2024

TRIM25 mutation (p.C168*), coding for an E3 ubiquitin ligase, is a cause of early-onset autosomal dominant dementia with amyloid load and parkinsonism.

Gómez-Tortosa E, Baradaran-Heravi Y, Dillen L, Choudhury NR, Agüero Rabes P, Pérez-Pérez J, Kocoglu C, Sainz MJ, Ruiz González A, Téllez R, Cremades-Jimeno L, Cárdaba B; EU EOD Consortium, Van Broeckhoven C, Michlewski G, van der Zee J.

Alzheimers Dement.. 2023

Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain-of-function toxicity mechanism contributing to the pathogenesis of fragile X-associated premature ovarian insufficiency.

Rosario R, Stewart HL, Choudhury NR, Michlewski G, Charlet-Berguerand N, Anderson RA.

FASEB J. 2022

TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway.

*Choudhury NR, *Trus I, *Heikel G, Wolczyk M, Szymanski J, Bolembach A, Dos Santos Pinto RM, Smith N, Trubitsyna M, Gaunt E, Digard P, Michlewski G.

*joint first authors

Nucleic Acids Res. 2022

RNA pull-down confocal nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases α-synuclein levels.

Zhu S, Choudhury NR, Rooney S, Pham NT, Koszela J, Kelly D, Spanos C, Rappsilber J, Auer M, Michlewski G.

Nucleic Acids Res.. 2021