All publications
2025
p70S6 kinase-dependent phosphorylation of the μ2 subunit of the AP2 adaptor complex is needed for clathrin-mediated endocytosis.
Tempes A, Brzozowska A, Węgierski T, Olek K, Jastrzębski K, Liszewska E, Misztal K, Machnicka K, Macias M, Szybińska A, Sitkiewicz E, Gozdz A, Wróbel AG, Miaczynska M, Pokrzywa W, Jaworski J, Malik AR.
bioRxiv. 2025
A novel MAPK1 variant in a family with complex psychiatric and neurodegenerative clinical phenotype.
Dubey AA, Rydzanicz M, Barczak A, Szulc NA, Surpeta B, Kuzniewska B, Gaweda-Walerych K, Wężyk M, Berdyński M, Fichna JP, Kostrzewa G, Gasperowicz P, Stępniak I, Szymańska K, Szczałuba K, Brezovsky J, Dziembowska M, Pokrzywa W, Ploski R.
Research Square. 2025
DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies.
Szulc NA, Olchowik A, Jaszczak P, Janiak B, Cup M, Tomaszewski J, Pokrzywa W.
J Chem Educ. 2025
2024
HSP70 inhibits CHIP E3 ligase activity to maintain germline function in Caenorhabditis elegans.
Thapa P, Chikale RV, Szulc NA, Pandrea MT, Sztyler A, Jaggi K, Niklewicz M, Serwa RA, Hoppe T, Pokrzywa W.
J Biol Chem. 2024
Optogenetic induction of mechanical muscle stress identifies myosin regulatory ubiquitin ligase NHL-1 in C. elegans.
Kutzner CE, Bauer KC, Lackmann JW, Acton RJ, Sarkar A, Pokrzywa W, Hoppe T.
Nat Commun. 2024
Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans.
Dubey AA, Sarkar A, Milcz K, Szulc NA, Thapa P, Piechota M, Serwa RA, Pokrzywa W.
PLoS Genet. 2024
SARS-CoV-2 inhibitory potential of fish oil-derived 2-pyrone compounds by acquiring linoleic acid binding site on the spike protein.
Duragkar N, Chikhale R, Piechota M, Danta CC, Gandhale P, Itankar P, Chikhale S, Gurav N, Khan MS, Pokrzywa W, Thapa P, Bryce R, Gurav S.
Int J Biol Macromol. 2024
Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans
Szczepańska A, Olek K, Kołodziejska K, Yu J, Ibrahim AT, Adamkiewicz L, Schroeder FC, Pokrzywa W, Turek M.
Nat Commun. 2024
DEGRONOPEDIA: a web server for proteome-wide inspection of degrons.
Szulc NA, Stefaniak F, Piechota M, Soszyńska A, Piórkowska G, Cappannini A, Bujnicki JM, Maniaci C, Pokrzywa W.
Nucleic Acids Res. 2024
2023
SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model.
Thapa P, Olek K, Kowalska A, Serwa RA, Pokrzywa W.
NPJ Aging. 2023
Sterility-Independent Enhancement of Proteasome Function via Floxuridine-Triggered Detoxification in C. elegans.
Dubey AA, Szulc NA, Piechota M, Serwa RA, Pokrzywa W.
bioRxiv. 2023
Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis.
Szulc NA, Piechota M, Biriczova L, Thapa P, Pokrzywa W.
iScience. 2023
In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers.
Paul AA, Szulc NA, Kobiela A, Brown SJ, Pokrzywa W, Gutowska-Owsiak D.
Front. Mol. Biosci.. 2023
Impaired iron recycling from erythrocytes is an early hallmark of aging.
Slusarczyk P, Mandal PK, Zurawska G, Niklewicz M, Chouhan K, Mahadeva R, Jończy A, Macias M, Szybinska A, Cybulska-Lubak M, Krawczyk O, Herman S, Mikula M, Serwa R, Lenartowicz M, Pokrzywa W, Mleczko-Sanecka K.
eLife. 2023
Lysine-deficient proteome can be regulated through non-canonical ubiquitination and ubiquitin-independent proteasomal degradation.
Szulc N, Piechota M, Thapa P, Pokrzywa W.
bioRxiv. 2023
Preparation of Caenorhabditis elegans for Scoring of Muscle-derived Exophers.
Banasiak K, Turek M, Pokrzywa W.
bio-protocol Journal. 2023
A novel de novo FEM1C variant is linked to neurodevelopmental disorder with absent speech, pyramidal signs, and limb ataxia.
Dubey AA, Krygier M, Szulc NA, Rutkowska K, Kosińska J, Pollak A, Rydzanicz M, Kmieć T, Mazurkiewicz-Bełdzińska M, Pokrzywa W, Płoski R.
Hum Mol Genet.. 2023
2022
Pheromone-dependent olfaction bidirectionally regulates muscle extracellular vesicles formation.
Banasiak K, Szczepańska A, Kołodziejska K, Ibrahim AT, Pokrzywa W, Turek M.
bioRxiv. 2022
A Dimer-Monomer Switch Controls CHIP-Dependent Substrate Ubiquitylation and Processing.
Mol Cell. 2022
Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.
Pekec T, Lewandowski J, Komur AA, Sobańska D, Guo Y, Świtońska-Kurkowska K, Małecki JM, Dubey AA, Pokrzywa W, Frankowski M, Figiel M, Ciosk R.
Nat Commun. 2022
CHIP ubiquitin ligase is involved in the nucleolar stress management.
Piechota M, Biriczova L, Kowalski K, Szulc NA, Pokrzywa W.
bioRxiv preprint. 2022
A heterotypic assembly mechanism regulates CHIP E3 ligase activity.
Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dabrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W.
EMBO J. . 2022
2021
Muscle-derived exophers promote reproductive fitness.
Turek M, Banasiak K, Piechota M, Shanmugam N, Macias M, Śliwińska MA, Niklewicz M, Kowalski K, Nowak N, Chacinska A, Pokrzywa W.
EMBO Rep.. 2021
The Dose-Dependent Pleiotropic Effects of the UBB+1 Ubiquitin Mutant.
Banasiak K, Szulc NA, Pokrzywa W.
Front. Mol. Biosci. . 2021
2020
Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.
Donkervoort S, Kutzner CE, Hu Y, Lornage X, Rendu J, Stojkovic T, Baets J, Neuhaus SB, Tanboon J, Maroofian R, Bolduc V, Mroczek M, Conijn S, Kuntz NL, Töpf A, Monges S, Lubieniecki F, McCarty RM, Chao KR, Governali S, Böhm J, Boonyapisit K, Malfatti E, Sangruchi T, Horkayne-Szakaly I, Hedberg-Oldfors C, Efthymiou S, Noguchi S, Djeddi S, Iida A, di Rosa G, Fiorillo C, Salpietro V, Darin N, Faure´ J, Houlden H, Oldfors A, Nishino I, de Ridder W, Straub V, Pokrzywa W, Laporte J, Foley R, Romero NB, Ottenheijm C, Hoppe T, Bönnemann CG.
Am. J. Hum. Genet.. 2020
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.
Albert M-C, Brinkmann K, Pokrzywa W, Günther SD, Krönke M, Hoppe T, Kashkar H.
Cell Death & Disease. 2020
Nutritional status and fecundity are synchronised by muscular exopheresis.
Turek M, Piechota M, Shanmugam N, Niklewicz M, Kowalski K, Chacińska A, Pokrzywa W.
bioRxiv. 2020
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.
Fatima A, Irmak D, Noormohammadi A, Rinschen MM, Das A, Leidecker O, Schindler C, Sánchez-Gaya V, Wagle P, Pokrzywa W, Hoppe T, Rada-Iglesias A, Vilchez D.
Commun Biol.. 2020
Article BioShell 3.0: Library for Processing Structural Biology Data.
Macnar JM, Szulc N, Kryś JD, Badaczewska-Dawid AE, Gront D.
Biomolecules. 2020
Ubiquitin Signaling Regulates RNA Biogenesis, Processing, and Metabolism.
Thapa P, Shanmugam N, Pokrzywa W.
BioEssays. 2020
2018
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
Koyuncu S, Saez I, Lee HJ, Gutierrez-Garcia R, Pokrzywa W, Fatima A, Hoppe T, Vilchez D.
Nat Commun.. 2018
Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis.
Balaji V, Pokrzywa W, Hoppe T.
Bioessays. 2018
2017