ABM

Project Title:
Identification of Biomarkers of Metabolic Dysfunction–Associated Steatotic Liver Disease

Funding:
The project is funded under the National Recovery and Resilience Plan (Krajowy Plan Odbudowy i Zwiększania Odporności), Component D – Efficiency, accessibility, and quality of the healthcare system, Investment D3.1.1 – Comprehensive development of research in the field of medical and health sciences, from KPO funds distributed through the Medical Research Agency (Agencja Badań Medycznych) under the call for scientific institutions to conduct application-oriented biomedical research (2024/ABM/03/KPO).

Funding Amount:
PLN 5,244,375.00

Study Description:
The study focuses on identifying biomarkers of metabolic dysfunction–associated steatotic liver disease (MASLD) while accounting for patient metabotypes. MASLD is a complex condition currently diagnosed mainly through imaging techniques and clinical criteria. The metabolic diversity of patients makes it challenging to pinpoint molecular indicators of the disease. Therefore, the project incorporates advanced metabolic and microbiome-based stratification to address patient heterogeneity.

Project Objectives:

  • Identification of molecular biomarkers of metabolic dysfunction–associated steatotic liver disease, considering patient metabotypes.

  • Understanding the relationship between the presence or risk of MASLD and specific metabolic states.

  • Stratification of the patient population based on metabolic status and gut microbiome composition.

  • Integration of multi-omics data (metabolomics, metagenomics, metaproteomics) to identify biomarkers specific to defined metabotypes.

Methodology:
Study population: 400 individuals aged 35–65 years, residing in Warsaw.

Study stages:

1. Information meeting and collection of data on lifestyle, diet, medication use, etc.
2. Self-collection of a stool sample by the participant (transport under controlled conditions).
3. Venous blood sampling and liver elastography.
4. Medical consultation including interpretation of test results.

Milestones:
1. Establishing collaboration with enel-med for blood sample collection and result consultations with internal medicine specialists.
2. Establishing collaboration with the Ministry of Interior and Administration Hospital (MSWiA) for liver elastography procedures.
3. Recruitment of study participants.
4. Establishing collaboration with Biogenity and Metabolon.
5. Completion of biological material collection.
6. Shipment of samples to Denmark and the USA for multi-omics analyses.

More information: https://www.zbadaj-sie.pl/

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