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  • Laboratory of Neurodegeneration: Kuznicki Laboratory

Laboratory of Neurodegeneration: Kuznicki Laboratory

 jkuznicki

Jacek Kuźnicki, PhD, Professor 

Correspondence address:
Laboratory of Neurodegeneration
International Institute of Molecular and Cell Biology
4 Ks. Trojdena Street, 02-109 Warsaw, Poland
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

DEGREES

1993 - Professor, awarded by the President of the Republic of Poland
1987 - DSc. Habil., Nencki Institute of Experimental Biology PAS, Warsaw, Poland
1980 - PhD in biochemistry, Nencki Institute of Experimental Biology PAS, Warsaw, Poland
1976 - MSc in biochemistry, Faculty of Biology, University of Warsaw, Poland

PROFESSIONAL EXPERIENCE

2001-present - Professor, Head of Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Poland
2001-2018 - Director, International Institute of Molecular and Cell Biology in Warsaw, Poland; Feb-Dec 2018 Acting Director, International Institute of Molecular and Cell Biology in Warsaw, Poland
2017-present - Deputy Chair of the Council of Provosts, 2nd Division: Biological and Agricultural Sciences, Polish Academy of Sciences
2000-2001 - Director, Centre of Excellence Phare Sci-Tech II, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
1999-2001 - Acting Director, International Institute of Molecular and Cell Biology in Warsaw, Poland; Organizer and Director, Centenarian Program
1996-2002 - Head, Laboratory of Calcium Binding Proteins, professor 2002- 2014 Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
1992-1995 - Visiting Professor, NIMH, Bethesda, MD, USA
1991-1992 - Deputy Scientific Director, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
1986-1992 - Associate Professor and Head of Laboratory of Calcium Binding Proteins, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
1984-1985 - Research Associate, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
1981-1984 - Visiting Fellow, NIH, Bethesda, MD, USA
1980-1981 - Post-doctoral Fellow, Nencki Institute
1976-1980 - PhD Student, Nencki Institute of Experimental Biology PAN, Warsaw

PROFESSIONAL TRAINING

2018 - Visiting Professor, Laboratory of H. Burgess, National Institute of Child Health and Human Development, Bethesda, MD, USA
2015 - Visiting Professor, Laboratory of W. Harris, University of Cambridge, UK 
2014 - Visiting Professor, Laboratory of B.E. Snaar-Jagalska, Leiden University, The Netherlands
1992-1995 - Visiting Professor, Laboratory of D. Jacobowitz, National Institute of Mental Health, Bethesda, MD, USA
1981-1984 - Visiting Fellow (postdoc), Laboratory of E.D. Korn, National Institute of Heart, Lung and Blood, Bethesda, MD, USA

MEMBERSHIP IN SCIENTIFIC SOCIETIES, ORGANIZATIONS, AND PANELS

2020 - Ordinary Member, Polish Academy of Sciences
2018-2022 - Member, Council of the National Science Centre and Chair of International Commission
2017-2018 - Deputy Chair, Council of Provosts, 2nd Division, Polish Academy of Sciences
2016-present - Member, International Advisory Board, Małopolska Centre of Biotechnology, Jagiellonian University
2011-present - Member, International Expert Council of the Research and Education Center, State Key Laboratory of Molecular and Cellular Biology, Ukraine
2011-2014 - Member, Science Policy Committee, and Rotating President (Jul-Dec 2012), Ministry of Science and Higher Education
2008-present - Board Member, European Calcium Society
2008-2018 - Member, Board of Directors, and Rotating President (Jul-Dec 2016, Jul-Dec 2013, Jul-Dec 2010), Biocentrum-Ochota Consortium
2006-2011 - Member, Advisory Group, 7FP HEALTH, European Commission
2004-2019 - Corresponding Member, Polish Academy of Sciences
2004-present - Honorary Chair and co-founder, BioEducation Foundation
2002-present - Head of Program Board, Centre for Innovative Bioscience Education
1993-2014 - Member, Scientific Council, Nencki Institute of Experimental Biology, Polish Academy of Sciences
1996-1998 & 2000-2002 - Vice-President, Biotechnology Committee, Polish Academy of Sciences
1989 - 1991 - General Secretary, Polish Biochemical Society

HONORS, PRIZES AND AWARDS

2018 - Commemorative medal for the 100th Anniversary of the Nencki Institute for outstanding contribution to the development of this Institute, supporting its activities, shaping the image and building a mutual success
2013 - Crystal Brussels Prize for outstanding achievements in 7th Framework Programme of the European Union for Research and Development
2013 - Award from the 2nd Division of Biological and Agricultural Sciences, Polish Academy of Sciences for series of works on β-catenin
2011 - Konorski Award for the best Polish research work in neurobiology awarded by the Polish Neuroscience Society and Committee on Neurobiology of the PAS, Warsaw
2008 - Officer's Cross of the Order of Polonia Restituta awarded by the President of Poland
2004-2007 - Professorial Subsidy Program Award from Foundation for Polish Science
2003 - Prime Minister Award for the scientific achievements, Warsaw
2001 - Award from the Division of Biological Sciences of the PAS for the work on CaBP
1998 - Knight's Cross of the Order of Polonia Restituta awarded by the President of  Poland
1987 - Polish Anatomical Society Award for the article in “Advances in Cell Biology”
1986 - Skarzynski Award from the Polish Biochemical Society for the best review article in “Advances in Biochemistry”, Warsaw
1977 - Mozolowski Award, Polish Biochem. Society for outstanding Polish young biochemist
1977 - Parnas Award from Polish Biochem. Society for the best paper in biochemical research
1976 - MSc, Magna cum laude, University of Warsaw

DOCTORATES DEFENDED UNDER LAB LEADER’S SUPERVISION

A. Filipek, J. Kordowska, U. Wojda, J. Hetman, M. Palczewska, M. Nowotny, K. Billing-Marczak, Ł. Bojarski, W. Michowski, K. Misztal, M. Figiel, K. Honarnejad, A. Jaworska, K. Gazda.

DESCRIPTION OF CURRENT RESEARCH

We are interested in the molecular mechanisms that are involved in neurodegeneration, with a special emphasis on the role of Ca2+ homeostasis and signaling. These processes are being studied at the genomic, proteomic, and cellular levels using mostly zebrafish, rats, and mice as model organisms. The projects are focused on proteins that are involved in store-operated Ca2+ entry (SOCE) and Ca2+ homeostasis in mitochondria, the involvement of potassium channels in the brain ventricular system, and the in vivo analysis of Ca2+ homeostasis in neurons using zebrafish models. For recent reviews, see Wegierski and Kuznicki (Cell Calcium, 2018) and Winata and Korzh (FEBS Lett, 2018).

ROLE OF STIM PROTEINS IN STORE-OPERATED Ca2+ ENTRY IN NEURONS

We previously showed that STIM1 is involved in a thapsigargin-induced SOCE-like process, whereas STIM2 is mostly active after the EGTA-driven depletion of extracellular Ca2+ (Gruszczynska-Biegala et al., PLoS One, 2011; Gruszczynska-Biegala and Kuznicki, J Neurochem, 2013). We searched for new partners of STIMs other than ORAI channels and found that endogenous STIMs associate with GluA subunits of AMPA receptors (Gruszczynska-Biegala et al., Front Cell Neurosci, 2016). STIM proteins also associate in vitro with NMDA receptors. The results suggest cross-talk between STIM proteins and NMDA receptors and their effect on Ca2+ influx through NMDA receptors (Gruszczynska-Biegala et al., Cells, 2020). Using zebrafish as a model we study STIM2 functions in vivo. We evaluated the expression of Calcium Toolkit genes in zebrafish brain and established the level of SOCE-components (Wasilewska et al., Genes, 2019). We generated stim2a, stim2b, and stim2a:2b knock-out zebrafish lines and analyze them using in vivo calcium imaging in cytosols and mitochondria, behavioral tests and scRNA-Seq.

DYSREGULATION OF Ca2+ HOMEOSTASIS IN COMMON NEURODEGENERATIVE DISEASES

We have been testing the hypothesis that brain dysfunction during aging is induced by changes in Ca2+ homeostasis, which may predispose the brain to SAD pathologies. Transgenic mice that overexpressed key SOCE proteins (STIM1, STIM2, and ORAI1) specifically in brain neurons under the Thy1 promoter were generated. Characterization of the STIM1 line (Majewski et al., BBA Mol Cell Res, 2017, Gruszczynska-Biegała et. al., Cells, 2020), STIM2/ORAI1 (Majewski et al., IJMS, 2020) and ORAI1 lines (Maciag et al., BBA Mol Cell Res, 2019; Majewski et. al., IJMS, 2019) has been reported. Strikingly, aged transgenic ORAI1 mice developed spontaneous seizure-like events that could be observed only in females, suggesting a novel, sex-dependent role of ORAI1 in neural function (Maciag, et al., BBA-MCR 2019). Furthermore, based on RNAseq gene expression profiling analysis and ddPCR conducted on hippocampus we identified a downregulation of Arx gene. The loss of function mutations of ARX are known to be implicated in human cases of epilepsy (Majewski et al., IJMS, 2019).

FAD mutations in presenilins were shown to alter both endoplasmic reticulum (ER) calcium signaling and SOCE, but the role of amyloid precursor protein (APP) and APP FAD mutants in intracellular calcium homeostasis is controversial. Our data indicate that APP and APP FAD mutants are not directly involved in SOCE (Wegierski et al., Biochem Biophys Res Commun, 2016). Instead, we found that APP knockdown resulted in an elevation of the resting levels of ER Ca2+, reduced Ca2+ leakage, and delayed the translocation of STIM1 to Orai1 upon ER Ca2+ store depletion. Our data suggest a regulatory role for APP in ER Ca2+ (Gazda et al., Sci Rep, 2017).

Using quantitative PCR, we compared microRNA (miRNA) profiles in blood plasma from mild cognitive impairment-AD patients (whose diagnoses were confirmed by cerebrospinal fluid [CSF] biomarkers) with AD patients and non-demented, age-matched controls. We adhered to standardized blood and CSF assays that are recommended by the JPND BIOMARKAPD consortium. Six miRNAs (three not yet reported in the context of AD and three reported in AD blood) were selected as the most promising biomarker candidates that can differentiate early AD from controls with the highest fold changes (Nagaraj et al., Oncotarget, 2017; patent pending: PCT/IB2016/052440).

A loss-of-function mutation of PINK1 causes early-onset Parkinson’s disease in humans. In collaboration with Oliver Bandmann (University of Sheffield), we used a pink1 mutant (pink1-/-) zebrafish line to study alterations of Ca2+ homeostasis (Flinn et al., Ann Neurol, 2013; Soman et al., Eur J Neurosci, 2016). We generated mcu knock-out fish, which is viable and fertile. The pink1-/-/mcu-/- double-knockout line shows no loss of dopaminergic neurons, suggesting that Ca2+ that enters mitochondria via the mitochondrial Ca2+ uniporter is involved in the pathology of the pink1 mutant. We expressed a mitochondrial Ca2+ probe (CEPIA2mt) under a pan-neuronal promoter (elavl3) to visualize Ca2+ levels in the mitochondrial matrix of a zebrafish (Tg[elavl3:CEPIA2mt]). Lightsheet fluorescence microscopy enabled us to visualize chemically inducible Ca2+ flux in zebrafish neurons in vivo. Inactivation of mitochondrial calcium uniporter (mcu) is protective in both genetic and chemical models of Parkinson disease (Soman et al., Biol Open. 2019). Hence, regulating the mcu function could be an effective therapeutic target in managing pathological changes in the Parkinson disease.

RARE AND ULTRA-RARE DISEASES WITH NEUROLOGICAL PRESENTATION

We previously showed that a mutation of huntingtin (HTT) in YAC128 mice (i.e., a model of Huntington’s disease) resulted in the higher expression of some components of the calcium signalosome, including huntingtin-associated protein 1 (HAP1) and calcyclin (S100A6) binding protein (CacyBP/SIP; Czeredys et al., Front Mol Neurosci, 2013). We detected greater activity of SOC channels in medium spiny neurons (MSNs) from YAC128 mice and found that some tetrahydrocarbazoles restored the disturbances in Ca2+ homeostasis and stabilized SOCE in YAC128 MSN cultures (Czeredys et al., Biochem Biophys Res Commun, 2017). The overexpression of HAP1 protein isoform A in MSNs from YAC128 mice was found to enhance the activity of SOC channels after the activation of IP3R1 (Czeredys at al., Front Cell Neurosci, 2018).

We also study Ca2+ homeostasis and its impact on the progression of neurodegeneration, behavioral changes, seizures, and sleep disturbances in several rare neurodegenerative diseases affecting children. Using CRISPR-Cas9 technology, we have created zebrafish lines with a mutation in the npc2, sgsh, ppp3ca, ptpn4a, and ptpn4b genes. We use those lines for identification of new diagnostic markers for early diagnosis and monitoring progression of two lysosomal storage diseases - the Niemann-Pick type C (NPC), and mucopolisaccharidosis type III (MPS-III), as well better understanding mechanisms leading to pathological changes in two ultra-rare conditions affecting just a few children world-wide (Rydzanicz et al., Eur J Hum Genet., 2018; Szczałuba et al., Clin Genet, 2019). The Zebrafish model is especially suited for drug screens. As NPC and MPS-III share many futures with Alzheimer's disease, hence drug targets that will be identified might find application in the management of a broad range of common neurodegenerative diseases.

DEVELOPMENT OF HOLLOW ORGANS

Subunits of the voltage-gated potassium channels Kcnb1 (Kv2.1) and Kcng4 (Kv6.4) are expressed in several hollow organs (e.g., brain ventricular system [BVS], ear, and eye) where they form tetrameric K+ channels and antagonize each other’s activity. The deficiency of Kcnb1 in zebrafish causes microcephaly, and the gain-of-function of Kcnb1 causes hydrocephalus. Kcng4 acts in a reverse manner (Shen et al., Sci Rep, 2016). The deficiency of BVS in human causes epilepsy (Jedrychowska and Korzh, Dev Dynam, 2019). Formation of the BVS occurs during the early neural development of vertebrates (Korzh, Cell Mol Life Sci, 2018). Deficiency of the BVS has been linked to numerous neurodegenerative diseases. Formation of the BVS depends on many factors, including the ependyma (i.e., cells that line the BVS cavity) and circumventricular organs, including the choroid plexus (Garcia-Lecea et al., Front Neuroanat, 2017; Korzh and Kondrychyn, Semin Cell Dev Biol, 2019). To study the role of K+ channels in the development of hollow organs, we generated a mutant of Kcnb1 and two mutants of kcng4b with deficiency in the BVS and ear. To distinguish the mechanism of action of KCNB1 mutations in human we initiated an analysis of developmental defects caused by mRNA of these mutants in the developing brain and ear of zebrafish

team2019

Lab Leader:

  • Jacek Kuźnicki, PhD, Professor

Senior Researchers:

  • Magdalena Czeredys, PhD

  • Vladimir Korzh, PhD

  • Łukasz Majewski, PhD

  • Tomasz Węgierski, PhD (part-time)

  • Małgorzata Wiweger, PhD

Postdoctoral Researchers:

  • Evgeny Gasanov, PhD

  • Oksana Palchevska, PhD

Research Technician:

  • Sergii Palchevskyi, PhD (part-time)

PhD Students:

  • Justyna Jędrychowska, MSc

  • Rishikesh Kumar Gupta, MSc Tech.

  • Filip Maciąg, MSc Eng.

  • Iga Wasilewska, MSc

Trainees:

  • Ewelina Latoszek

  • Joanna Oberska

Lab Technician:

  • Monika Matuszczyk (part-time)

Laboratory Support Specialist:

  • Dominika Dubicka-Boroch, MSc

 

2020

Gruszczynska-Biegala J, Strucinska K, Maciag F, Majewski L, Sladowska M, Kuznicki J.

STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.

Majewski L, Maciąg F, Boguszewski PM, Kuznicki J.

Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration.

Adusumilli L, Facchinello N, Teh C, Busolin G, Le MT, Yang H, Beffagna G, Campanaro S, Tam WL, Argenton F, Lim B, Korzh V, Tiso N.

miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation.

Dey K, Bazala MA, Kuznicki J.

Targeting mitochondrial calcium pathways as a potential treatment against Parkinson’s disease.

Babkiewicz E, Bazała M, Urban P, Maszczyk P, Markowska M, Gliwicz M.

The effects of temperature on the proxies of visual detection of Danio rerio larvae: observations from the optic tectum.

Wasilewska I, Gupta RK, Wojtaś B, Palchevska O, Kuźnicki J.

stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae.

Gupta RK, Kuznicki J.

Biological and Medical Importance of Cellular Heterogeneity Deciphered by Single-Cell RNA Sequencing.

Korzh V, Kondrychyn I.

Origin and development of circumventricular organs in living vertebrate.

Gupta RK, Wasilewska I, Palchevska O, Kuźnicki J.

Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae.

Yang S, Emelyanov A, You MS, Sin M, Korzh V.

Camel regulates development of the brain ventricular system.

2019

Rydzanicz M, Wachowska M, Cook EC, Lisowski P, Kuźniewska B, Szymańska K, Diecke S, Prigione A, Szczałuba K, Szybińska A, Koppolu A, Murcia Pienkowski V, Kosińska J, Wiweger M, Kostrzewa G, Brzozowska M, Domańska-Pakieła D, Jurkiewicz E, Stawiński P, Gromadka A, Zielenkiewicz P, Demkow U, Dziembowska M, Kuźnicki J, Creamer TP, Płoski R.

Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.

Grzeczkowicz A, Gruszczynska-Biegala J, Czeredys M, Kwiatkowska A, Strawski M, Szklarczyk M, Koźbiał M, Kuźnicki J, Granicka LH.

Polyelectrolyte Membrane Scaffold Sustains Growth of Neuronal Cells.

Maciąg F, Majewski Ł, Boguszewski P.M, Gupta R.K, Wasilewska I, Wojtas B, Kuznicki J.

Behavioral and electrophysiological changes in female mice overexpressing ORAI1 in neurons.

Wasilewska I, Gupta RK, Palchevska O, Kuźnicki J.

Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain.

Khalil R, Lalai RA, Wiweger MI, Avramut CM, Koster AJ, Spaink HP, Bruijn JA, Hogendoorn PCW, Baelde HJ.

Glomerular permeability is not affected by heparan sulfate glycosaminoglycan deficiency in zebrafish embryos.

Jędrychowska J, Korzh V.

Kv2.1 voltage‐gated potassium channels in developmental perspective.

Soman SK, Bazała M, Keatinge M, Bandmann O, Kuznicki J.

Restriction of mitochondrial calcium overload by mcu inactivation renders neuroprotective effect in Zebrafish models of Parkinson's disease.

Majewski L, Wojtas B, Maciąg F, Kuznicki J.

Changes in Calcium Homeostasis and Gene Expression Implicated in Epilepsy in Hippocampi of Mice Overexpressing ORAI1.

2018

Wegierski T, Kuznicki J.

Neuronal calcium signaling via store-operated channels in health and disease.

Czeredys M, Vigont VA, Boeva VA, Mikoshiba K, Kaznacheyeva EV, Kuznicki J.

Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington’s Disease.

Brendel M, Jaworska A, Overhoff F, Blume T, Probst F, Gildehaus FJ, Bartenstein P, Haass C, Bohrmann B, Herms J, Willem M, Rominger A.

Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation.

De Assis GG, Gasanov EV, de Sousa MBC, Kozacz A, Murawska-Cialowicz E. Brain derived neutrophic factor, a link of aerobic metabolism to neuroplasticity.

Brain derived neutrophic factor, a link of aerobic metabolism to neuroplasticity.

Korzh V

Development of brain ventricular system

Hadar A, Milanesi E, Walczak M, Puzianowska-Kuźnicka M, Kuźnicki J, Squassina A, Niola P, Chillotti C, Attems J, Gozes I, Gurwitz D.

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.

2017

Szewczyk LM, Brozko N, Nagalski A, Rӧckle I, Werneburg S, Hildebrandt H, Wisniewska MB, Kuznicki J free access

ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons

Czeredys M, Maciag F, Methner A, Kuznicki J

Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease

Misztal K, Brozko N, Nagalski A, Szewczyk LM, Królak M, Brzozowska K, Kuznicki J, Wisniewska MB

TCF7L2 mediates the cellular and behavioral response to chronic lithium treatment in animal models

Soman S, Keatinge M, Moein M, DaCosta M, Mortiboys H, Skupin A, Sugunan S, Bazala M, Kuznicki J, Bandmann O

Inhibition of the mitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1-/- zebrafish

Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, Herms J, Haass C, Rominger A

Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

Nagaraj S, Laskowska-Kaszub K, Dębski KJ, Wojsiat J, Dąbrowski M, Gabryelewicz T, Kuźnicki J, Wojda U

Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer's disease patients from non-demented subjects

Tan SY, Teh C, Ang CY, Li M, Li P, Korzh V, Zhao Y

Responsive mesoporous silica nanoparticles for sensing of hydrogen peroxide and simultaneous treatment toward heart failure

Koh CH, Wu J, Chung YY, Liu Z, Zhang RR, Chong K, Korzh V, Ting S, Oh S, Shim W, Tian HY, Wei H

Identification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

Shen H, Shin EM, Lee S, Mathavan S, Koh H, Osato M, Choi H, Tergaonkar V, Korzh V

Ikk2 regulates cytokinesis during vertebrate development

Szybinska A, Lesniak W

P53 Dysfunction in Neurodegenerative Diseases – The Cause or Effect of Pathological Changes?

Gazda K, Kuznicki J, Wegierski T.

Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum.

Majewski Ł, Maciąg F, Boguszewski PM, Wasilewska I, Wiera G, Wójtowicz T, Mozrzymas J, Kuznicki J.

Overexpression of STIM1 in neurons in mouse brain improves contextual learning and impairs long-term depression.

Brendel M, Focke C, Blume T, Peters F, Deussing M, Probst F, Jaworska A, Overhoff F, Albert N, Lindner S, von Ungern-Sternberg B, Bartenstein P, Haass C, Kleinberger G, Herms J, Rominger A.

Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study.

Mazurek T, Kobylecka M, Zielenkiewicz M, Kurek A, Kochman J, Filipiak KJ, Mazurek K, Huczek Z, Królicki L, Opolski G.

PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesions' formation?

Gazda K, Bazała M, Węgierski T.

Mikroskopowe obrazowanie jonów wapnia za pomocą genetycznie kodowanych sond (Microscopic imaging of calcium ions with genetically encoded calcium indicators).

Woźniak A, Grześkowiak BF, Babayevska N, Zalewski T, Drobna M, Woźniak-Budych M, Wiweger M, Słomski R, Jurga S.

ZnO@Gd2O3 core/shell nanoparticles for biomedical applications: Physicochemical, in vitro and in vivo characterization.

García-Lecea M, Gasanov E, Jedrychowska J, Kondrychyn I, Teh C, You MS, Korzh V.

Development of Circumventricular Organs in the Mirror of Zebrafish Enhancer-Trap Transgenics.

2016

Nagalski A, Puelles L, Dabrowski M, Wegierski T, Kuznicki J, Wisniewska MB

Molecular anatomy of the thalamic complex and the underlying transcription factors

Wegierski T, Gazda K, Kuznicki J

Microscopic analysis of Orai-mediated store-operated calcium entry in cells with experimentally altered levels of amyloid precursor protein

Gruszczynska-Biegala J, Sladowska M, Kuznicki J

AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons

Goś D, Szymańska E, Białek-Wyrzykowska U, Wiweger M, Kuźnicki J.

Be Healthy as a Fish Educational Program at the International Institute of Molecular and Cell Biology in Warsaw, Poland.

2015

Majewski L, Kuznicki J

SOCE in neurons: Signaling or just refilling?

Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A

Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment

Vassetzky Y, Gout I, Kuznicki J.

Research reforms: Ukrainian science needs elixir of youth.

2014

Honarnejad K, Daschner A, Gehring AP, Szybinska A, Giese A, Kuznicki J, Bracher F, Herms J

Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease

Mossakowska M , Broczek K, Wieczorowska-Tobis K, Klich-Raczka A, Jonas M, Pawlik-Pachucka E, Safranow K, Kuznicki J , Puzianowska-Kuznicka M

Cognitive Performance and Functional Status Are the Major Factors Predicting Survival of Centenarians in Poland

Mills F, Bartlett TE, Dissing-Olesen L, Wisniewska MB, Kuznicki J, Macvicar BA, Wang YT, Bamji SX

Cognitive flexibility and long-term depression (LTD) are impaired following β-catenin stabilization in vivo

2013

Nagalski A, Irimia M, Szewczyk L, Ferran JL, Misztal K, Kuznicki J, Wisniewska MB

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain

Esteras N, Alquézar C, Bermejo-Pareja F, Bialopiotrowicz E, Wojda U, Martín-Requero A

Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients

Kapustian LL, Vigontina OA, Rozhko OT, Ryabenko DV, Michowski W, Lesniak W, Filipek A, Kroupskaya IV, Sidorik LL

Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy

Malik AR, Urbanska M, Gozdz A, Swiech LJ, Nagalski A, Perycz M, Blazejczyk M, Jaworski J

CYR61, a matricellular protein, is needed for dendritic arborization of hippocampal neurons

Wisniewska MB

Physiological Role of β-Catenin/TCF Signaling in Neurons of the Adult Brain

Golanska E, Sieruta M, Gresner SM, Pfeffer A, Chodakowska-Zebrowska M, Sobow TM, Klich I, Mossakowska M, Szybinska A, Barcikowska M, Liberski PP

APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians

Jaworska A, Dzbek J, Styczynska M, Kuznicki J

Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment

Golanska E, Sieruta M, Corder E, Gresner SM, Pfeffer A, Chodakowska-Zebrowska M, Sobow TM, Klich I, Mossakowska M, Szybinska A, Barcikowska M, Liberski PP

The prion protein M129V polymorphism: Longevity and cognitive impairment among Polish centenarians

Wojda U, Kuznicki J

Alzheimer's disease modeling: ups, downs, and perspectives for human induced pluripotent stem cells

Gruszczynska-Biegala J, Kuznicki J

Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons

Honarnejad K, Kirsch AK, Daschner A, Szybinska A, Kuznicki J, Herms J

FRET-Based Calcium Imaging: A Tool for High-Throughput/Content Phenotypic Drug Screening in Alzheimer Disease

Czeredys M, Gruszczynska-Biegala J, Schacht T, Methner A, Kuznicki J

Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington’s disease

Honarnejad K, Daschner A, Giese A, Zall A, Schmidt B, Szybinska A, Kuznicki J, Herms J

Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

Wegierski T

Mikroskopowe metody rejestracji wewnątrzkomórkowych odpowiedzi wapniowych

2012

Hokkanen S, Feldmann HM, Ding H, Jung CK, Bojarski L, Renner-Müller I, Schüller U, Kretzschmar H, Wolf E, Herms J

Lack of Pur-alpha alters postnatal brain development and causes megalencephaly

Buizza L, Cenini G, Lanni C, Ferrari-Toninelli G, Prandelli C, Govoni S, Buoso E, Racchi M, Barcikowska M, Styczynska M, Szybinska A, Butterfield DA, Memo M, Uberti D

Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease

Bialopiotrowicz E, Szybinska A, Kuzniewska B, Buizza L, Uberti D, Kuznicki J, Wojda U

Highly Pathogenic Alzheimer's Disease Presenilin 1 P117R Mutation Causes a specific Increase in p53 and p21 Protein Levels and Cell Cycle Dysregulation in Human Lymphocytes

Wisniewska MB, Nagalski A, Dabrowski M, Misztal K, Kuznicki J

Novel beta-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability

2011

Misztal K, Wisniewska MB, Ambrozkiewicz M, Nagalski A, Kuznicki J

WNT protein-independent constitutive nuclear localization of beta-catenin protein and its low degradation rate in thalamic neurons.

Steinbeck JA, Henke N, Opatz J, Gruszczynska-Biegala J, Schneider L, Theiss S, Hamacher N, Steinfarz B, Golz S, Brüstle O, Kuznicki J, Methner A

Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy

Bialopiotrowicz E, Kuzniewska B, Kachamakova-Trojanowska N, Barcikowska M, Kuznicki J, Wojda U

Cell cycle regulation distinguishes lymphocytes from sporadic and familial Alzheimer's disease patients

Sobczak A, Debowska K, Blazejczyk M, Kreutz MR, Kuznicki J, Wojda U

Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth

Gruszczynska-Biegala J, Pomorski P, Wisniewska MB, Kuznicki J

Differential Roles for STIM1 and STIM2 in Store-Operated Calcium Entry in Rat Neurons

2010

Bojarski L, Debowska K, Wojda U.

In vitro findings of alterations in intracellular calcium homeostasis in schizophrenia.

Uberti D, Cenini G, Bonini SA, Barcikowska M, Styczynska M, Szybinska A, Memo M.

Increased CD44 gene expression in lymphocytes derived from Alzheimer disease patients.

Spooren A, Rondou P, Debowska K, Lintermans B, Vermeulen L, Samyn B, Skieterska K, Debyser G, Devreese B, Vanhoenacker P, Wojda U, Haegeman G, Van Craenenbroeck K.

Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation.

Nagalski A, Kiersztan A.

Fizjologia i molekularny mechanizm działania glikokortykoidów.

Wisniewska MB, Misztal K, Michowski W, Szczot M, Purta E, Lesniak W, Klejman ME, Dabrowski M, Filipkowski RK, Nagalski A, Mozrzymas JW, Kuznicki J.

LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain.

Michowski W, Ferretti R, Wisniewska MB, Ambrozkiewicz M, Beresewicz M, Fusella F, Skibinska-Kijek A, Zablocka B, Brancaccio M, Tarone G, Kuznicki J.

Morgana/CHP-1 is a novel chaperone able to protect cells from stress.

Klemba A, Kowalewska M, Kukwa W, Tonska K, Szybinska A, Mossakowska M, Scinska A, Golik P, Koper K, Radziszewski J, Kukwa A, Czarnecka AM, Bartnik E

Mitochondrial genotype in vulvar carcinoma - cuckoo in the nest

Adler G, Parczewski M, Czerska E, Loniewska B, Kaczmarczyk M, Gumprecht J, Grzeszczak W, Szybinska A, Mossakowska M, Ciechanowicz A

An age-related decrease in factor V Leiden frequency among Polish subjects

Polosak J, Roszkowska-Gancarz M, Kurylowicz A, Owczarz M, Dobosz P, Mossakowska M, Szybinska A, Puzianowska-Kuznicka M

Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity

Czarnecka AM, Krawczyk T, Plak K, Klemba A, Zdrozny M, Arnold RS, Kofler B, Golik P, Szybinska A, Lubinski J, Mossakowska M, Bartnik E, Petros JA

Mitochondrial genotype and breast cancer predisposition

2009

Puzianowska-Kuznicka M, Kuznicki J.

The ER and ageing II: calcium homeostasis.

Blazejczyk M, Sobczak A, Debowska K, Wisniewska MB, Kirilenko A, Pikula S, Jaworski J, Kuznicki J, Wojda U.

Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling.

Bojarski L, Pomorski P, Szybinska A, Drab M, Skibinska-Kijek A, Gruszczynska-Biegala J, Kuznicki J

Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease.

Skibinska-Kijek A, Wisniewska MB, Gruszczynska-Biegala J, Methner A, Kuznicki J

Immunolocalization of STIM1 in the mouse brain.

Klejman ME, Gruszczynska-Biegala J, Skibinska-Kijek A, Wisniewska MB, Misztal K, Blazejczyk M, Bojarski L, Kuznicki J.

Expression of STIM1 in brain and puncta-like co-localization of STIM1 and ORAI1 upon depletion of Ca(2+) store in neurons.

2008

Sbroggiò M, Ferretti R, Percivalle E, Gutkowska M, Zylicz A, Michowski W, Kuznicki J, Accornero F, Pacchioni B, Lanfranchi G, Hamm J, Turco E, Silengo L, Tarone G, Brancaccio M.

The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1.

Blazejczyk M, Wojda U

Factfile: Calmyrin 1 (review)

Filipek A, Michowski W, Kuznicki J

Involvement of S100A6 (calcyclin) and its binding partners in intracellular signaling pathways

Zabka M, Leśniak W, Prus W, Kuźnicki J, Filipek A

Sgt1 has co-chaperone properties and is up-regulated by heat shock.

Lanni C, Racchi M, Mazzini G, Ranzenigo A, Polotti R, Sinforiani E, Olivari L, Barcikowska M, Styczynska M, Kuznicki J, Szybinska A, Govoni S, Memo M, Uberti D

Conformationally altered p53: a novel Alzheimer's disease marker?

Wojda U, Salinska E, Kuznicki J

Calcium ions in neuronal degeneration

Bojarski L, Herms J, Kuznicki J

Calcium dysregulation in Alzheimer's disease

Mossakowska M, Barcikowska M, Broczek K, Grodzicki T, Klich-Raczka A, Kupisz-Urbanska M, Podsiadly-Marczykowska T, Sikora E, Szybinska A, Wieczorowska-Tobis K, Zyczkowska J, Kuznicki J

Polish Centenarians Programme. Multidisciplinary studies of successful ageing: aims, methods, and preliminary results

Winiarska M, Bil J, Wilczek E, Wilczynski GM, Lekka M, Engelberts PJ, Mackus WJ, Gorska E, Bojarski L, Stoklosa T, Nowis D, Kurzaj Z, Makowski M, Glodkowska E, Issat T, Mrowka P, Lasek W, Dabrowska-Iwanicka A, Basak GW, Wasik M, Warzocha K, Sinski M, Gaciong Z, Jakobisiak M, Parren PW, Golab J.

Statins impair antitumor effects of rituximab by inducing conformational changes of CD20.

Erickson RP, Larson-Thomé K, Weberg L, Szybinska A, Mossakowska M, Styczynska M, Barcikowska M, Kuznicki J

Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population

2007

Wollmer MA, Sleegers K, Ingelsson M, Zekanowski C, Brouwers N, Maruszak A, Brunner F, Huynh KD, Kilander L, Brundin RM, Hedlund M, Giedraitis V, Glaser A, Engelborghs S, De Deyn PP, Kapaki E, Tsolaki M, Daniilidou M, Molyva D, Paraskevas GP, Thal DR, Barcikowska M, Kuznicki J, Lannfelt L, Van Broeckhoven C, Nitsch RM, Hock C, Papassotiropoulos A.

Association study of cholesterol-related genes in Alzheimer's disease

Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J,Filipek A

Hsp70 is a new target of Sgt1-an interaction modulated by S100A6

Schneider G, Nieznanski K, Kilanczyk E,Bieganowski P, Kuznicki J, Filipek A

CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies

Leśniak W, Słomnicki ŁP, Kuźnicki J

Epigenetic control of the S100A6 (calcyclin) gene expression

Bojarski L, Lewandowicz A, Blazejczyk M, Sobczak A, Kuznicki J, Wojda U

Biochemical properties of endogenous presenilin 1 and presenilin 2 in cultured human B-lymphocytes

2006

Blazejczyk M, Wojda U, Sobczak A, Spilker C, Bernstein HG, Gundelfinger ED, Kreutz MR, Kuznicki J

Ca2+-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of Ca2+-signals to Alzheimer's disease-related presenilin 2 in forebrain

Bik W, Baranowska-Bik A, Wolinska-Witort E, Martynska L, Chmielowska M, Szybinska A, Broczek K, Baranowska B

The relationship between adiponectin levels and metabolic status in centenarian, early elderly, young and obese women

Baranowska B, Bik W, Baranowska-Bik A, Wolinska-Witort E, Szybinska A, Martynska L, Chmielowska M

Neuroendocrine control of metabolic homeostasis in Polish centenarians

Spiechowicz M, Bernstein HG, Dobrowolny H, Leśniak W, Mawrin C, Bogerts B, Kuźnicki J, Filipek A

Density of Sgt1-immunopositive neurons is decreased in the cerebral cortex of Alzheimer's disease brain.

Leśniak W, Kuźnicki J

Binding and functional characteristics of two E-box motifs within the S100A6 (calcyclin) gene promoter.

Groves P, Palczewska M, Kuznicki J

Calretinin, an EF-hand calcium-binding proteins, binds zinc and Cooper

Zekanowski C, Golan MP, Krzyśko KA, Lipczyńska-Łojkowska W, Filipek S, Kowalska A, Rossa G, Pepłońska B, Styczyńska M, Maruszak A, Religa D, Wender M, Kulczycki J, Barcikowska M, Kuźnicki J.

Two novel presenilin 1 gene mutations connected with frontotemporal dementia-like clinical phenotype: genetic and bioinformatic assessment.

2005

Zekanowski C, Religa D, Safranow K, Maruszak A, Dziedziejko V, Styczyńska M, Gacia M, Golan M, Pepłońska B, Chlubek D, Kuźnicki J, Barcikowska M

The -22c/t polymorphism in presenilin 1 gene is not connected with late-onset and early-onset familial Alzheimer's disease in Poland

Sobczak A, Blazejczyk M, Piszczek G, Zhao G, Kuznicki J, Wojda U.

Calcium-binding calmyrin forms stable covalent dimers in vitro, but in vivo is found in monomeric form.

Puzianowska-Kuznicka M, Kuznicki J.

Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?

Palczewska M, Batta G, Groves P, Linse S, Kuznicki J

Characterization of calretinin I-II as an EF-hand, Ca2+, H+-sensing domain

Leśniak W, Szczepańska A, Kuźnicki J.

Calcyclin (S100A6) expression is stimulated by agents evoking oxidative stress via the antioxidant response element.

Bhattacharya S, Lee YT, Michowski W, Jastrzebska B, Filipek A, Kuznicki J, Chazin WJ

The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies

Bernstein HG, Blazejczyk M, Rudka T, Gundelfinger ED, Dobrowolny H, Bogerts B, Kreutz MR, Kuznicki J, Wojda U

The Alzheimer disease-related calcium-binding protein Calmyrin is present in human forebrain with an altered distribution in Alzheimer's as compared to normal ageing brains

2004

Brzezińska A, Magalska A, Szybińska A, Sikora E

Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging

Zekanowski C, Religa D, Graff C, Filipek S, Kuźnicki J

Genetic aspects of Alzheimer's disease

Zekanowski C, Pepłońska B, Styczyńska M, Religa D, Pfeffer A, Czyzewski K, Gabryelewicz T, Szybińska A, Kijanowska-Haładyna B, Kotapka-Minc S, Łuczywek E, Barczak A, Wasiak B, Chodakowska-Zebrowska M, Przekop I, Kuźnicki J, Barcikowska M

The E318G substitution in PSEN1 gene is not connected with Alzheimer's disease in a large Polish cohort.

Wojda U.

Gene therapy of hematopoietic cells: development of strategies and vectors. (in Polish)

Lee YT, Jacob J, Michowski W, Nowotny M, Kuznicki J, Chazin WJ.

Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain.

Billing-Marczak K, Ziemińska E, Leśniak W, Łazarewicz JW, Kuźnicki J

Calretinin gene promoter activity is differently regulated in neurons and cancer cells. Role of AP2-like cis element and zinc ions

2003

Zekanowski C

Molecular diagnostics of Alzheimer's disease (in Polish)

Zekanowski C

The sun, the genome, the internet… eugenics?

Tighe O, Dunican D, O'Neill C, Bertorelle G, Beattie D, Graham C, Zschocke J, Cali F, Romano V, Hrabincova E, Kozak L, Nechyporenko M, Livshits L, Guldberg P, Jurkowska M, Zekanowski C, Perez B, Desviat LR, Ugarte M, Kucinskas V, Knappskog P, Treacy E, N

Genetic diversity within the R408W phenylketonuria mutation lineages in Europe

Zekanowski C, Przyluska-Fiszer A, Barcikowska M

Alzheimer's disease: between diagnostic, economy and ethic (in Polish)

Zekanowski C, Pepłońska B, Styczyńska M, Gustaw K, Kuźnicki J, Barcikowska M

Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia

Zekanowski C, Styczyńska M, Pepłońska B, Gabryelewicz T, Religa D, Ilkowski J, Kijanowska-Haładyna B, Kotapka-Minc S, Mikkelsen S, Pfeffer A, Barczak A, Łuczywek E, Wasiak B, Chodakowska-Zebrowska M, Gustaw K, Łaczkowski J, Sobów T, Kuźnicki J, Barcikowsk

Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland

Pepłońska B, Zekanowski C, Religa D, Czyzewski K, Styczyńska M, Pfeffer A, Gabryelewicz T, Gołebiowski M, Luczywek E, Wasiak B, Barczak A, Chodakowska M, Barcikowska M, Kuźnicki J

Strong association between Saitohin gene polymorphism and tau haplotype in the Polish population

Palczewska M, Groves P, Batta G, Heise B, Kuźnicki J

Calretinin and calbindin D28k have different domain organizations

Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J

Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins

2002

Billing-Marczak K, Buzanska L, Winsky L, Nowotny M, Rudka T, Isaacs K, Belin MF, Kuznicki J.

AP2-like cis element is required for calretinin gene promoter activity in cells of neuronal phenotype differentiated from multipotent human cell line DEV.

Filipek A, Jastrzebska B, Nowotny M, Kuznicki J

CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family

Zekanowski C

Genetic aspects of Alzheimer’s disease

Zekanowski C, Gizewska M, Nowacka M, Cabalska B

Novel PKU treatment methods

Cabalska B, Nowacka M, Nowaczewska I, Zekanowski C, Zorska K

Atypical PKU - treatment effectiveness

Filipek A, Jastrzebska B, Nowotny M, Kwiatkowska K, Hetman M, Surmacz L, Wyroba E,Kuznicki J

Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells

Filipek A, Jastrzebska B, Nowotny M, Kuznicki J

CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family

Billing-Marczak K, Buzanska L, Winsky L, Nowotny M, Rudka T, Isaacs K, Belin MF, Kuznicki J

AP2-like cis element is required for calretinin gene promoter activity in cells of neuronal phenotype differentiated from multipotent human cell line DEV

2001

Palczewska M, Groves P, Ambrus A, Kaleta A, Kövér KE, Batta G, Kuźnicki J.

Structural and biochemical characterization of neuronal calretinin domain I-II (residues 1-100). Comparison to homologous calbindin D28k domain I-II (residues 1-93)

2000

Leśniak W, Swart GW, Bloemers HP, Kuźnicki J.

Regulation of cell specific expression of calcyclin (S100A6) in nerve cells and other tissues.

Leśniak W, Jezierska A, Kuźnicki J.

Upstream stimulatory factor is involved in the regulation of the human calcyclin (S100A6) gene.

Jastrzebska B, Filipek A, Nowicka D, Kaczmarek L, Kuznicki J.

Calcyclin (S100A6) binding protein (CacyBP) is highly expressed in brain neurons.

Nowotny M, Bhattacharya S, Filipek A, Krezel AM, Chazin W, Kuznicki J.

Characterization of the interaction of calcyclin (S100A6) and calcyclin-binding protein.

Mossakowska M, Puzianowska-Kuznicka M, Barcikowska M, Chiron-Jouan S, Czyzewski K, Derejczyk J, Franceschi C, Gabryelewicz T, Galus K, Grodzicki T, Gross R, Klich-Raczka A, Luczywek E, Passeri G, Pfeffer A, Pruszynski J, Radziszewska E, Sikora E, Sosnowski M, Styczynska M, Wasiak B, Wieczorowska-Tobis K, Zyczkowska J, Kuznicki J

Polish Centenarians Program “PolStu99” – search for longevity promoting factors (in Polish)

Zekanowski C

Cloning - the crossroads of biology and culture