Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A.

EMBO Mol Med.. 2019

Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins.

Monteuuis G, Miścicka A, Świrski M, Zenad L, Niemitalo O, Wrobel L, Alam J, Chacinska A, Kastaniotis AJ, Kufel J.

Nucleic Acids Res.. 2019

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.

Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A.

Mol Biol Cell.. 2019

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Sokol AM, Uszczynska-Ratajczak B, Collins MM, Bazala M, Topf U, Lundegaard PR, Sugunan S, Guenther S, Kuenne C, Graumann J, Chan SSL, Stainier DYR, Chacinska A.

PLoS Genet.. 2018

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins.

Kowalski L, Bragoszewski P, Khmelinskii A, Glow E, Knop M, Chacinska A.

BMC Biol. . 2018

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.

Topf U, Suppanz I, Samluk L, Wrobel L, Böser A, Sakowska P, Knapp B, Pietrzyk MK, Chacinska A, Warscheid B.

Nat Commun. . 2018

Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography.

Gold VA, Chroscicki P, Bragoszewski P, Chacinska A.

EMBO Rep.. 2017

Cell biology: Sort and destroy

Chacinska A.

Nature. 2017

Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system

Bragoszewski P, Turek M, Chacinska A.

Open Biol. 2017

Protein trafficking at the crossroads to mitochondria

Wasilewski M, Chojnacka K, Chacinska A

Biochim Biophys Acta. 2016

Białka mitochondrialne – import, eksport, degradacja

Wasilewski M, Chojnacka K, Chacinska A

Postępy Biochemii. 2016

TIM29 is a subunit of the human carrier translocase required for protein transport

Callegari S, Richter F, Chojnacka K, Jans DC, Lorenzi I, Pacheu-Grau D, Jakobs S, Lenz C, Urlaub H, Dudek J, Chacinska A, Rehling P

FEBS Lett. 2016

Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential

Turakhiya U, von der Malsburg K, Gold VA, Guiard B, Chacinska A, van der Laan M, Ieva R

J Mol Biol. 2016

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly

Wrobel L, Sokol AM, Chojnacka M, Chacinska A

Sci Rep. 2016

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis

Topf U, Wrobel L, Chacinska A

Trends Cell Biol. 2016

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O

Hum Mol Genet. 2015

The oxidation status of Mic19 regulates MICOS assembly

Sakowska P, Jans DC, Mohanraj K, Riedel D, Jakobs S, Chacinska A

Mol Cell Biol. 2015

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Wrobel L, Topf U, Bragoszewski P , Wiese S, Sztolsztener ME , Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B, Chacinska A

Nature. 2015

Retro-translocation of mitochondrial intermembrane space proteins

Bragoszewski P, Wasilewski M, Sakowska P, Gornicka A, Böttinger L, Qiu J, Wiedemann N, Chacinska A

Proc Natl Acad Sci U S A. 2015

Cox17 is an auxiliary factor involved in the control of the mitochondrial contact site and cristae organizing system

Chojnacka M, Gornicka A, Oeljeklaus S, Warscheid B, Chacinska A

J Biol Chem. 2015

Mitochondrial translocation of APE1 relies on the MIA pathway

Barchiesi A, Wasilewski M, Chacinska A, Tell G, Vascotto C

Nucleic Acids Res. 2015

Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane

Ieva R, Schrempp SG, Opaliński L Wollweber F, Höß P, Heißwolf AK, Gebert M, Zhang Y, Guiard B, Rospert S, Becker T, Chacinska A, Pfanner N, van der Laan M

Mol Cell.. 2014

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria

Gornicka A, Bragoszewski P, Chroscicki P, Wenz LS, Schulz C, Rehling P, Chacinska A

Mol Biol Cell. 2014

Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix

Melin J, Schulz C, Wrobel L, Bernhard O, Chacinska A, Jahn O, Schmidt B, Rehling P

Mol Cell Biol. 2014

Mitochondrial protein translocases for survival and wellbeing

Sokol AM, Sztolsztener ME, Wasilewski M, Heinz E, Chacinska A

FEBS Lett. 2014

Uniform nomenclature for the mitochondrial contact site and cristae organizing system

Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J

J Cell Biol.. 2014

Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation

Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T

Cell. 2013

Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1

Varabyova A, Topf U, Kwiatkowska P, Wrobel L, Kaus-Drobek M, Chacinska A

FEBS J. 2013

The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins

Bragoszewski P, Gornicka A, Sztolsztener ME, Chacinska A

Mol Cell Biol. 2013

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria

Wrobel L, Trojanowska A, Sztolsztener ME, Chacinska A

Mol Biol Cell. 2013

Mitochondrial protein homeostasis

Varabyova A, Stojanovski D, Chacinska A

IUBMB Life. 2013

Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40

Sztolsztener ME, Brewinska A, Guiard B, Chacinska A

Traffic. 2013

In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins

Böttinger L*, Gornicka A*, Czerwik T, Bragoszewski P, Loniewska-Lwowska A, Schulze-Specking A, Truscott KN, Guiard B, Milenkovic D, Chacinska A, *equally contributing first author

Mol Biol Cell. 2012

Intermembrane space proteome of yeast mitochondria

Voegtle FN, Burkhart JM, Rao S, Gerbeth C, Hinrichs J, Martinou JC, Chacinska A, Sickmann A, Zahedi RP, Meisinger C

Mol Cell Proteomics. 2012

Role of MINOS in protein biogenesis of the mitochondrial outer membrane

Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Müller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M

Mol Biol Cell.. 2012

The MIA pathway: A tight bond between protein transport and oxidative folding in mitochondria

Stojanovski D, Bragoszewski P, Chacinska A

BBA-MOL CELL RES. 2012

A high density consensus map of rye (Secale cereale L.) based on DArT markers

Milczarski P, Bolibok-Brągoszewska H, Myśków B, Stojałowski S, Heller-Uszyńska K, Góralska M, Brągoszewski P, Uszyński G, Kilian A, Rakoczy-Trojanowska M

PLoS One. 2011

Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex

Schulz C, Lytovchenko O, Melin J, Chacinska A, Guiard B, Neumann P, Ficner R, Jahn O, Schmidt B, Rehling P

J Cell Biol.. 2011

Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis

von der Malsburg K, Müller JM, Bohnert M, Oeljeklaus S, Kwiatkowska P, Becker T, Loniewska-Lwowska A, Wiese S, Rao S, Milenkovic D, Hutu DP, Zerbes RM, Schulze-Specking A, Meyer HE, Martinou JC, Rospert S, Rehling P, Meisinger C, Veenhuis M et all

Dev Cell.. 2011

The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins

Becker T, Wenz LS, Krüger V, Lehmann W, Müller JM, Goroncy L, Zufall N, Lithgow T, Guiard B, Chacinska A, Wagner R, Meisinger C, Pfanner N

J Cell Biol.. 2011