The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 25th of July, 2025; deadline for sending application is 8th August, 2025). For more information, please follow the link https://shorturl.at/mvxOR
- Reconstructing cardiovascular cell lineage evolution, one cell at a time NCN/OPUS (Laboratory of Zebrafish Developmental Genomics, 1 position)
- Dynamics of RNA-degrading complexes in bacteria NCN/SONATA BIS (Laboratory of Single-Molecule Biophysics, 1 position)
- RNA-Protein Interactions in Human Health and Disease NCN/DIOSUCRI (Laboratory of RNA-Protein Interactions - Dioscuri Centre, 1 position)
- Mechanistic and structural studies of adenoviral DNA replication NCN/OPUS (Laboratory of Protein Structure, 1 position)
Press releases:
1. From bench to bedside: the IIMCB begins a new chapter of its development (Od laboratorium do pacjenta: MIBMiK rozpoczyna nowy etap rozwoju)
The press release announces the launch of the RACE project by the IIMCB, aiming to establish a world-class Center of Excellence in RNA and cell biology, with a focus on translating research into medical applications. The project, funded by the European Commission and supported by international partners, seeks to foster innovation, attract global talent, and advance RNA-based therapies for diseases such as cancer and infections.
Media publications:
2. TVP Nauka - "Inauguracja projektu RACE. Nowy etap w polskiej nauce"
3. Forum Akademickie - "Nowy etap MIBMiK: od laboratorium do pacjenta"
4. Wprost - "Naukowcy z MIBMiK: "Chcemy zwiększyć szanse na opracowanie innowacyjnych leków w Polsce" "
5. Polskie Radio RDC - "Program RACE"
6. Jedynka. Polskie Radio - "RNA i biologia komórki. Od badań podstawowych do terapii"
7. TVP Nauka - "Polka w gronie liderów nauki w Europie"
8. Forum Akademickie - "Prof. Marta Miączyńska współprzewodniczącą EU-LIFE"
11. Forum Akademickie - "Szefowa MIBMiK: Potrzeba nowej siedziby coraz bardziej paląca"
12. Biotechnologia.pl - MIBMiK otrzyma ponad 36 mln zł na rozwój badań"
15. WNP - "Polka z prestiżowym grantem LifeArc w zakresie transferu technologii"
16. TVP Polonia - "Polka z prestiżowym grantem LifeArc w zakresie transferu technologii"
17. Forum Akademickie - "Polka z prestiżowym grantem LifeArc"
18. Nauka w Polsce - "Polka z prestiżowym grantem LifeArc w zakresie transferu technologii"
20. Executive Magazine - "Polka z prestiżowym grantem LifeArc w zakresie transferu technologii"
Additional media publications mentioning RACE:
1. Forum Akademickie - "MIBMiK wzmacnia transfer wiedzy w obszarze biotechnologii"
3. PAN - "IN-MOL-CELL - nowa jakość w badaniach biomedycznych"
5. PAN - "Nowa funkcja komórek naczyń wątroby odkryta przez naukowców z IIMCB"
Available Projects
- PhD student position in the Laboratory of Protein Structure
- PhD Student position in the Laboratory of RNA-Protein Interactions - Dioscuri Centre
- PhD student position in the Laboratory of Zebrafish Developmental Genomics
- PhD student position in the Laboratory of Single-Molecule Biophysics
Archive:
Results of the recruitment for PhD students position for projects
PhD student position in the Laboratory of Single-Molecule Biophysics
PhD student position in the Laboratory of Iron Homeostasis
PhD student position in the Laboratory of Cellular Proteostasis
Two PhD students positions in the Laboratory of Laboratory of RNA Viruses
PhD student position in the Laboratory of Protein Metabolism
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th of May 2025; deadline for sending application is 1st June, 2025. For more information, please follow the link https://shorturl.at/mvxOR
Projects available:
- Innovative Approaches to Study E3 Ligase Substrate Specificity Using C. elegans Models (Laboratory of Protein Metabolism, 1 position)
- Defining the mechanisms of gene expression control in the Hepatitis A virus (Laboratory of RNA Viruses, 1 position)
- Investigating the mechanisms of viral translation initiation (Laboratory of RNA Viruses, 1 position)
- Nuclear proteostasis in neurodegenerative diseases (Laboratory of Cellular Proteostasis, 1 position)
- Identifying unique metabolic adaptation of red pulp macrophages to iron deficiency (Laboratory of Iron Homeostasis, 1 position)
- Probing molecular mechanisms underlying neuropsychiatric disorders (Laboratory of Developmental Neurobiology (IMol), 2 positions)
- RNA biology at the phage-bacteria interface (Laboratory of Single-Molecule Biophysics, 2 positions)
- Dynamics of RNA-degrading complexes in bacteria (Laboratory of Single-Molecule Biophysics, 1 position)
- Therapeutic and endogenous mRNAs metabolism (Laboratory of RNA Biology - ERA Chairs Group, 2 positions)
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model (Laboratory of Developmental Neurobiology (IMol), 1 position)
Learn about the scientific publications recognized in the Best Papers Awards – our internal competition honoring the most outstanding papers for their merit and significance.
2025
1. Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines
Authors: S. Krawczyk P, Mazur M, Orzeł W, Gewartowska O, Jeleń S, Antczak W, Kasztelan K, Brouze A, Matylla-Kulińska K, Gumińska N, Tarkowski B, P. Owczarek E, Affek K, Turowski P, Tudek A, Sroka M, Śpiewla T, Kusio-Kobiałka M, Wesołowska A, Nowis D, Golab J, Kowalska J, Jemielity J, Dziembowski A*, Mroczek S*
Journal: Nature
Link: Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines | Nature
2. Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Authors: Zurawska Z, Sas Z, Jończy A, Mahadeva R, Slusarczyk P, Chwałek M, Seehofer D, Georg Damm, Mazgaj R, Skórzyński M, Kulecka M, Rumieńczyk I, Moulin M, Jastrzębski K, Waldron K, Mikula M, Etzerodt A, Serwa R, Miączyńska M, P Rygiel T*, Mleczko-Sanecka K*
Jurnal: EMBO Reports
Link: Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance | EMBO Reports | Springer Nature Link
3. Activity and structure of human (d)CTP deaminase CDADC1
Authors: Slyvka A*, Rathore I, Yang R, Gewartowska O, Kanai T, T. Lountos G, Skowronek K, Czarnocki-Cieciura M, Wlodawer A*, Matthias Bochtler*
Journal: PNAS
Link:Activity and structure of human (d)CTP deaminase CDADC1 | PNAS
3. Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA
Authors: Nirwal S, Czarnocki-Cieciura M, Zajko W, Skowronek K, H. Szczepanowski R, Nowotny M*
Journal: Nature Communications
Link: Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA | Nature Communications
Authors marked in bold are affiliated with IIMCB.
2024
1. TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.
Authors: Brouze M, Czarnocka-Cieciura A, Gewartowska O, Kusio-Kobiałka M, Jachacy K, Szpila M, Tarkowski B, Gruchota J, Krawczyk P, Mroczek S, Borsuk E, Dziembowski A
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-024-49479-4
2. Pheromone-based animal communication influences the production of somatic extracellular vesicles in C. elegans.
Authors: Szczepańska A,* Olek K,* Kołodziejska K, Yu J, Ibrahim AT, Adamkiewicz L, Schroeder FC, Pokrzywa W, Turek M (* contributed equally)
Czasopismo: Nature Communications
Link: https://www.nature.com/articles/s41467-024-47016-x
3. Structure-functional characterization of Lactococcus AbiA phage defense system.
Authors: Gapińska M,* Zajko W,* Skowronek K, Figiel M, Krawczyk PS, Egorov AA, Dziembowski A, Johansson MJO, Nowotny M (* contributed equally)
Journal: Nucleic Acids Research
Link: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae230/7642066?login=true
3. scRNA-seq reveals the diversity of the developing cardiac cell lineage and molecular players in heart rhythm regulation.
Authors: Abu Nahia K, Sulej A, Migdał M, Ochocka N, Ho R, Kamińska B, Zagorski M, Winata CL
Journal: iScience
Link: https://www.sciencedirect.com/science/article/pii/S2589004224013087?via%3Dihub
2023
1. Mechanism of RecF–RecO–RecR cooperation in bacterial homologous recombination.
Authors: Nirwal S, Czarnocki-Cieciura M, Chaudhary A, Zajko W, Skowronek K, Chamera S, Figiel M, Nowotny M.
Journal: Nature Structural & Molecular Biology
Link: https://www.nature.com/articles/s41594-023-00967-z
2. Impaired iron recycling from erythrocytes is an early hallmark of aging.
Authors: Slusarczyk P, Mandal PK, Zurawska G, Niklewicz M, Chouhan K, Mahadeva R, Jończy A, Macias M, Szybinska A, Cybulska-Lubak M, Krawczyk O, Herman S, Mikula M, Serwa R, Lenartowicz M, Pokrzywa W, Mleczko-Sanecka K.
Journal: eLife
Link: https://elifesciences.org/articles/79196
3. Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis.
Authors: Szulc NA, Piechota M, Biriczova L, Thapa P, Pokrzywa W.
Journal: iScience
Link: https://www.sciencedirect.com/science/article/pii/S2589004223024215
2022
1. Structural basis of transposon end recognition explains central features of Tn7 transposition systems.
Authors: Kaczmarska Z, Czarnocki-Cieciura M, Górecka-Minakowska KM, Wingo RJ, Jackiewicz J, Zajko W, Poznański JT, Rawski M, Grant T, Peters JE, Nowotny M.
Journal: Molecular Cell
Link: https://www.sciencedirect.com/science/article/pii/S1097276522004397?via%3Dihub
2. A heterotypic assembly mechanism regulates CHIP E3 ligase activity.
Authors: Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dąbrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W.
Journal: The EMBO Journal
Link: https://www.embopress.org/doi/full/10.15252/embj.2021109566
3. Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish.
Authors: Niescierowicz K, Pryszcz L, Navarrete C, Tralle E, Sulej A, Abu Nahia K, Kasprzyk ME, Misztal K, Pateria A, Pakuła A, Bochtler M, Winata C.
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-022-33260-6
2021
1. The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion.
Authors: Zdżalik-Bielecka D, Poświata A, Kozik K, Jastrzębski K, Schink KO, Brewińska-Olchowik M, Piwocka K, Stenmark H, Miączyńska M.
Journal: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Link: https://www.pnas.org/content/118/28/e2024596118.long
2. Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae.
Authors: Tudek A, Krawczyk PS, Mroczek S, Tomecki R, Turtola M, Matylla-Kulińska K, Jensen TH, Dziembowski A.
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-021-25251-w
3. Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.
Authors: Gewartowska O, Aranaz-Novaliches G, Krawczyk PS, Mroczek S, Kusio-Kobiałka M, Tarkowski B, Spoutil F, Benada O, Kofroňová O, Szwedziak P, Cysewski D, Gruchota J, Szpila M, Chlebowski A, Sedlacek R, Prochazka J, Dziembowski A.
Journal: Cell Reports
Link: https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00329-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124721003296%3Fshowall%3Dtrue
2020
1. Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements.
Authors: Manfredonia I, Nithin C, Ponce-Salvatierra A, Ghosh P, Wirecki TK, Marinus T, Ogando NS, Snijder EJ, van Hemert MJ, Bujnicki JM. Incarnato D.
Journal: Nucleic Acids Research
Link: https://academic.oup.com/nar/article/48/22/12436/5961787
2. Origins of the increased affinity of phosphorothioate-modified therapeutic nucleic acids for proteins.
Authors: Hyjek-Składanowska M, Vickers T, Napiórkowska A, Anderson B, Tanowitz M, Crooke ST, Liang XH, Seth PP, Nowotny M.
Journal: Journal of the American Chemical Society
Link: https://pubs.acs.org/doi/pdf/10.1021/jacs.9b13524#
3. Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.
Authors: Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M.
Journal: eLife
Link: https://elifesciences.org/articles/58504
2019
1. Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.
Authors: Szymańska E, Nowak P, Kolmus K, Cybulska M, Goryca K, Derezińska-Wołek E, Szumera-Ciećkiewicz A, Brewińska-Olchowik M, Grochowska A, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miączyńska M.
Journal: EMBO Molecular Medicine
Link: https://www.embopress.org/doi/full/10.15252/emmm.201910812
2. TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex.
Authors: Kedra M, Banasiak K, Kisielewska K, Wolinska-Niziol L, Jaworski J, Zmorzynska J.
Journal: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Link: https://www.pnas.org/doi/10.1073/pnas.1910834117
3. RuvC uses dynamic probing of the Holliday junction substrate to achieve sequence specificity and efficient resolution.
Authors: Górecka KM, Krepl M, Szlachcic A, Poznański J, Šponer J, Nowotny M.
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-019-11900-8
Additional information
Order 5.2023 on adopting regulations of the Best Papers Awards Competition
Additional information “Best Papers Awards” Competition 2025
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- Degradacja RNA w ludzkim patogenie Acinetobacter baumannii. - 1 miejsce w Laboratorium Laboratorium Biofizyki Pojedynczych Cząsteczek
- Dynamika kompleksów degradujących RNA u bakterii. (NCN/SONATA) - 1 miejsce w Laboratorium Biofizyki Pojedynczych Cząsteczek
- Metabolizm terapeutycznych i endogennych mRNA. - 1 miejsce w Laboratorium Biologii RNA – Grupa ERA Chairs
- Badanie inicjacji translacji u pikornawirusów, jako potencjalnego celu terapeutycznego. - 1 miejsce w Laboratorium Wirusów RNA
- Wpływ czynników środowiskowych związanych z infekcją matki podczas ciąży na rozwój zaburzeń neuropsychiatrycznych u potomstwa ze stwardnieniem guzowatym w modelu danio pręgowanego. (NCN/SONATA BIS) - 1 miejsce w Laboratorium Neurobiologii Rozwoju(IMoL)
- Ewolucja kariotypów oraz obecność mutacji w ostrej białaczce szpikowej. - 1 miejsce w Laboratorium Biologii Strukturalnej
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- Data-driven methodology for predicting, explaining and understanding of RNA and small molecule ligand binding. - PhD student in Laboratory of Bioinformatics and Protein Engineering
- RNA targeting and degradation in human pathogen, Acinetobacter baumannii. - PhD student in Laboratory of Single-Molecule Biophysics
- Dynamics of RNA-degrading complexes in bacteria. (NCN/SONATA) - PhD Student in Laboratory of Single-Molecule Biophysics
- Therapeutic and endogenous mRNAs metabolism. - PhD Student in Laboratory of RNA Biology – ERA Chairs Group
- Investigating picornavirus translation initiation as a potential therapeutic target. - PhD Student in Laboratory of RNA Viruses
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model. (NCN/SONATA BIS) - PhD Student in Laboratory of Developmental Neurobiology(Zmorzyńska Group | IMoL)
- Design of “strealth” asparaginases for the treatment of acute lympoblastic leukemia (ALL). - PhD Student in Laboratory of Structural Biology
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- Data-driven methodology for predicting, explaining and understanding of RNA and small molecule ligand binding. - PhD student in Laboratory of Bioinformatics and Protein Engineering
- RNA targeting and degradation in human pathogen, Acinetobacter baumannii. - PhD student in Laboratory of Single-Molecule Biophysics
- Dynamics of RNA-degrading complexes in bacteria. (NCN/SONATA) - PhD Student in Laboratory of Single-Molecule Biophysics
- Therapeutic and endogenous mRNAs metabolism. - PhD Student in Laboratory of RNA Biology – ERA Chairs Group
- Investigating picornavirus translation initiation as a potential therapeutic target. - PhD Student in Laboratory of RNA Viruses
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model. (NCN/SONATA BIS) - PhD Student in Laboratory of Developmental Neurobiology(Zmorzyńska Group | IMoL)
- Design of “strealth” asparaginases for the treatment of acute lympoblastic leukemia (ALL). - PhD Student in Laboratory of Structural Biology
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- RNA targeting and degradation in human pathogen, Acinetobacter baumannii. - PhD student in Laboratory of Single-Molecule Biophysics
- Dynamics of RNA-degrading complexes in bacteria. (NCN/SONATA) - PhD Student in Laboratory of Single-Molecule Biophysics
- Therapeutic and endogenous mRNAs metabolism. - PhD Student in Laboratory of RNA Biology – ERA Chairs Group
- Investigating picornavirus translation initiation as a potential therapeutic target. - PhD Student in Laboratory of RNA Viruses
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model. (NCN/SONATA BIS) - PhD Student in Laboratory of Developmental Neurobiology(Zmorzyńska Group | IMoL)
- Design of “stealth” asparaginases for the treatment of acute lympoblastic leukemia (ALL). - PhD Student in Laboratory of Structural Biology