- PhD student position in the Laboratory of Single-Molecule Biophysics
- PhD student position in the Laboratory of Iron Homeostasis
- PhD student position in the Laboratory of Cellular Proteostasis
- Two PhD students positions in the Laboratory of Laboratory of RNA Viruses
- PhD student position in the Laboratory of Protein Metabolism
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th of May 2025; deadline for sending application is 1st June, 2025. For more information, please follow the link https://shorturl.at/mvxOR
Projects available:
- Innovative Approaches to Study E3 Ligase Substrate Specificity Using C. elegans Models (Laboratory of Protein Metabolism, 1 position)
- Defining the mechanisms of gene expression control in the Hepatitis A virus (Laboratory of RNA Viruses, 1 position)
- Investigating the mechanisms of viral translation initiation (Laboratory of RNA Viruses, 1 position)
- Nuclear proteostasis in neurodegenerative diseases (Laboratory of Cellular Proteostasis, 1 position)
- Identifying unique metabolic adaptation of red pulp macrophages to iron deficiency (Laboratory of Iron Homeostasis, 1 position)
- Probing molecular mechanisms underlying neuropsychiatric disorders (Laboratory of Developmental Neurobiology (IMol), 2 positions)
- RNA biology at the phage-bacteria interface (Laboratory of Single-Molecule Biophysics, 2 positions)
- Dynamics of RNA-degrading complexes in bacteria (Laboratory of Single-Molecule Biophysics, 1 position)
- Therapeutic and endogenous mRNAs metabolism (Laboratory of RNA Biology - ERA Chairs Group, 2 positions)
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model (Laboratory of Developmental Neurobiology (IMol), 1 position)
Learn about the scientific publications recognized in the Best Papers Awards – our internal competition honoring the most outstanding papers for their merit and significance.
2024
1. TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.
Authors: Brouze M, Czarnocka-Cieciura A, Gewartowska O, Kusio-Kobiałka M, Jachacy K, Szpila M, Tarkowski B, Gruchota J, Krawczyk P, Mroczek S, Borsuk E, Dziembowski A
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-024-49479-4
2. Pheromone-based animal communication influences the production of somatic extracellular vesicles in C. elegans.
Authors: Szczepańska A,* Olek K,* Kołodziejska K, Yu J, Ibrahim AT, Adamkiewicz L, Schroeder FC, Pokrzywa W, Turek M (* contributed equally)
Czasopismo: Nature Communications
Link: https://www.nature.com/articles/s41467-024-47016-x
3. Structure-functional characterization of Lactococcus AbiA phage defense system.
Authors: Gapińska M,* Zajko W,* Skowronek K, Figiel M, Krawczyk PS, Egorov AA, Dziembowski A, Johansson MJO, Nowotny M (* contributed equally)
Journal: Nucleic Acids Research
Link: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae230/7642066?login=true
3. scRNA-seq reveals the diversity of the developing cardiac cell lineage and molecular players in heart rhythm regulation.
Authors: Abu Nahia K, Sulej A, Migdał M, Ochocka N, Ho R, Kamińska B, Zagorski M, Winata CL
Journal: iScience
Link: https://www.sciencedirect.com/science/article/pii/S2589004224013087?via%3Dihub
2023
1. Mechanism of RecF–RecO–RecR cooperation in bacterial homologous recombination.
Authors: Nirwal S, Czarnocki-Cieciura M, Chaudhary A, Zajko W, Skowronek K, Chamera S, Figiel M, Nowotny M.
Journal: Nature Structural & Molecular Biology
Link: https://www.nature.com/articles/s41594-023-00967-z
2. Impaired iron recycling from erythrocytes is an early hallmark of aging.
Authors: Slusarczyk P, Mandal PK, Zurawska G, Niklewicz M, Chouhan K, Mahadeva R, Jończy A, Macias M, Szybinska A, Cybulska-Lubak M, Krawczyk O, Herman S, Mikula M, Serwa R, Lenartowicz M, Pokrzywa W, Mleczko-Sanecka K.
Journal: eLife
Link: https://elifesciences.org/articles/79196
3. Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis.
Authors: Szulc NA, Piechota M, Biriczova L, Thapa P, Pokrzywa W.
Journal: iScience
Link: https://www.sciencedirect.com/science/article/pii/S2589004223024215
2022
1. Structural basis of transposon end recognition explains central features of Tn7 transposition systems.
Authors: Kaczmarska Z, Czarnocki-Cieciura M, Górecka-Minakowska KM, Wingo RJ, Jackiewicz J, Zajko W, Poznański JT, Rawski M, Grant T, Peters JE, Nowotny M.
Journal: Molecular Cell
Link: https://www.sciencedirect.com/science/article/pii/S1097276522004397?via%3Dihub
2. A heterotypic assembly mechanism regulates CHIP E3 ligase activity.
Authors: Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dąbrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W.
Journal: The EMBO Journal
Link: https://www.embopress.org/doi/full/10.15252/embj.2021109566
3. Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish.
Authors: Niescierowicz K, Pryszcz L, Navarrete C, Tralle E, Sulej A, Abu Nahia K, Kasprzyk ME, Misztal K, Pateria A, Pakuła A, Bochtler M, Winata C.
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-022-33260-6
2021
1. The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion.
Authors: Zdżalik-Bielecka D, Poświata A, Kozik K, Jastrzębski K, Schink KO, Brewińska-Olchowik M, Piwocka K, Stenmark H, Miączyńska M.
Journal: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Link: https://www.pnas.org/content/118/28/e2024596118.long
2. Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae.
Authors: Tudek A, Krawczyk PS, Mroczek S, Tomecki R, Turtola M, Matylla-Kulińska K, Jensen TH, Dziembowski A.
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-021-25251-w
3. Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.
Authors: Gewartowska O, Aranaz-Novaliches G, Krawczyk PS, Mroczek S, Kusio-Kobiałka M, Tarkowski B, Spoutil F, Benada O, Kofroňová O, Szwedziak P, Cysewski D, Gruchota J, Szpila M, Chlebowski A, Sedlacek R, Prochazka J, Dziembowski A.
Journal: Cell Reports
Link: https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00329-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124721003296%3Fshowall%3Dtrue
2020
1. Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements.
Authors: Manfredonia I, Nithin C, Ponce-Salvatierra A, Ghosh P, Wirecki TK, Marinus T, Ogando NS, Snijder EJ, van Hemert MJ, Bujnicki JM. Incarnato D.
Journal: Nucleic Acids Research
Link: https://academic.oup.com/nar/article/48/22/12436/5961787
2. Origins of the increased affinity of phosphorothioate-modified therapeutic nucleic acids for proteins.
Authors: Hyjek-Składanowska M, Vickers T, Napiórkowska A, Anderson B, Tanowitz M, Crooke ST, Liang XH, Seth PP, Nowotny M.
Journal: Journal of the American Chemical Society
Link: https://pubs.acs.org/doi/pdf/10.1021/jacs.9b13524#
3. Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.
Authors: Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M.
Journal: eLife
Link: https://elifesciences.org/articles/58504
2019
1. Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.
Authors: Szymańska E, Nowak P, Kolmus K, Cybulska M, Goryca K, Derezińska-Wołek E, Szumera-Ciećkiewicz A, Brewińska-Olchowik M, Grochowska A, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miączyńska M.
Journal: EMBO Molecular Medicine
Link: https://www.embopress.org/doi/full/10.15252/emmm.201910812
2. TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex.
Authors: Kedra M, Banasiak K, Kisielewska K, Wolinska-Niziol L, Jaworski J, Zmorzynska J.
Journal: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Link: https://www.pnas.org/doi/10.1073/pnas.1910834117
3. RuvC uses dynamic probing of the Holliday junction substrate to achieve sequence specificity and efficient resolution.
Authors: Górecka KM, Krepl M, Szlachcic A, Poznański J, Šponer J, Nowotny M.
Journal: Nature Communications
Link: https://www.nature.com/articles/s41467-019-11900-8
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- Degradacja RNA w ludzkim patogenie Acinetobacter baumannii. - 1 miejsce w Laboratorium Laboratorium Biofizyki Pojedynczych Cząsteczek
- Dynamika kompleksów degradujących RNA u bakterii. (NCN/SONATA) - 1 miejsce w Laboratorium Biofizyki Pojedynczych Cząsteczek
- Metabolizm terapeutycznych i endogennych mRNA. - 1 miejsce w Laboratorium Biologii RNA – Grupa ERA Chairs
- Badanie inicjacji translacji u pikornawirusów, jako potencjalnego celu terapeutycznego. - 1 miejsce w Laboratorium Wirusów RNA
- Wpływ czynników środowiskowych związanych z infekcją matki podczas ciąży na rozwój zaburzeń neuropsychiatrycznych u potomstwa ze stwardnieniem guzowatym w modelu danio pręgowanego. (NCN/SONATA BIS) - 1 miejsce w Laboratorium Neurobiologii Rozwoju(IMoL)
- Ewolucja kariotypów oraz obecność mutacji w ostrej białaczce szpikowej. - 1 miejsce w Laboratorium Biologii Strukturalnej
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- Data-driven methodology for predicting, explaining and understanding of RNA and small molecule ligand binding. - PhD student in Laboratory of Bioinformatics and Protein Engineering
- RNA targeting and degradation in human pathogen, Acinetobacter baumannii. - PhD student in Laboratory of Single-Molecule Biophysics
- Dynamics of RNA-degrading complexes in bacteria. (NCN/SONATA) - PhD Student in Laboratory of Single-Molecule Biophysics
- Therapeutic and endogenous mRNAs metabolism. - PhD Student in Laboratory of RNA Biology – ERA Chairs Group
- Investigating picornavirus translation initiation as a potential therapeutic target. - PhD Student in Laboratory of RNA Viruses
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model. (NCN/SONATA BIS) - PhD Student in Laboratory of Developmental Neurobiology(Zmorzyńska Group | IMoL)
- Design of “strealth” asparaginases for the treatment of acute lympoblastic leukemia (ALL). - PhD Student in Laboratory of Structural Biology
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- Data-driven methodology for predicting, explaining and understanding of RNA and small molecule ligand binding. - PhD student in Laboratory of Bioinformatics and Protein Engineering
- RNA targeting and degradation in human pathogen, Acinetobacter baumannii. - PhD student in Laboratory of Single-Molecule Biophysics
- Dynamics of RNA-degrading complexes in bacteria. (NCN/SONATA) - PhD Student in Laboratory of Single-Molecule Biophysics
- Therapeutic and endogenous mRNAs metabolism. - PhD Student in Laboratory of RNA Biology – ERA Chairs Group
- Investigating picornavirus translation initiation as a potential therapeutic target. - PhD Student in Laboratory of RNA Viruses
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model. (NCN/SONATA BIS) - PhD Student in Laboratory of Developmental Neurobiology(Zmorzyńska Group | IMoL)
- Design of “strealth” asparaginases for the treatment of acute lympoblastic leukemia (ALL). - PhD Student in Laboratory of Structural Biology
The admissions process is conducted through the Doctoral School website system. The PhD student can apply to this specific project carried out as part of the Warsaw-4-PhD doctoral school via website https://shorturl.at/cJKQY (the application system will be activated from 19th December 2024; deadline for sending application is 6th January 2025). For more information, please follow the link https://shorturl.at/mvxOR
Projects available to apply:
- RNA targeting and degradation in human pathogen, Acinetobacter baumannii. - PhD student in Laboratory of Single-Molecule Biophysics
- Dynamics of RNA-degrading complexes in bacteria. (NCN/SONATA) - PhD Student in Laboratory of Single-Molecule Biophysics
- Therapeutic and endogenous mRNAs metabolism. - PhD Student in Laboratory of RNA Biology – ERA Chairs Group
- Investigating picornavirus translation initiation as a potential therapeutic target. - PhD Student in Laboratory of RNA Viruses
- Influence of environmental factors related to maternal infection during pregnancy on the development of neuropsychiatric disorders in offspring with Tuberous Sclerosis Complex in the zebrafish model. (NCN/SONATA BIS) - PhD Student in Laboratory of Developmental Neurobiology(Zmorzyńska Group | IMoL)
- Design of “stealth” asparaginases for the treatment of acute lympoblastic leukemia (ALL). - PhD Student in Laboratory of Structural Biology
The Final Symposium on GRIEG Projects, which took place online on 17th September 2024, gave us an insights into two GRIEG projects funded by the Norwegian Financial Mechanism 2014-2021:
"Cellular adaptation to cold" (CellCOLD), led by Wojciech Pokrzywa, PhD, DSc Habil.
"The impact of cytoplasmic polyadenylation on local translation in neurons", led by Prof. Andrzej Dziembowski.
Wojciech Pokrzywa presented focus of his project - investigating the mechanisms of cold stress adaptation using C. elegans as a model organism. Natalia Gumińska, PhD presented the focus of the second project - understanding how cytoplasmic polyadenylation regulates neuronal functions related to memory and learning.
The progress and research achievements made under the GRIEG projects highlight the power of local and international collaboration, as the projects were implemented with a strong contribution from Polish partner at the University of Warsaw, and Norwegian partners located at the University of Oslo and the University of Bergen.
Key Achievements of both projects are:
9 peer-reviewed publications
20 presentations at international conferences
25 researchers supported in basic research
9 mentor-mentee relationships across both projects established
2 joint grant applications
