Znaczenie badań z wykorzystaniem zwierząt

1 medicineBez wykorzystania zwierząt laboratoryjnych, nie jesteśmy w stanie odpowiedzieć na część pytań naukowych i medycznych. Organizmy zwierząt laboratoryjnych pod wieloma względami są podobne do ludzkich: 99% genomu myszy laboratoryjnej i 70% genomu danio pręgowanego jest identyczne z genomem człowieka. Choć alternatywne metody badawcze dynamicznie się rozwijają, wciąż nie zastępują one w pełni metody in vivo (badań na modelach zwierzęcych). 

Badania naukowe prowadzone z udziałem zwierząt laboratoryjnych pozwalają nam zrozumieć skomplikowane procesy zachodzące między różnymi typami komórek i tkanek, których nie jesteśmy w stanie obserwować w badaniach przy użyciu modeli komórkowych. Obecnie żadne ze sztucznie utworzonych systemów imitujących żywe organizmy, w tym te najnowocześniejsze jak organoidy, nie obejmują w pełni złożoności rozwoju i funkcjonowania żywego organizmu.

Wybrane wyniki badań naukowych z wykorzystaniem zwierząt, zrealizowane przez MIBMiK

Medycyna

1. Nasze badania opublikowane w czasopiśmie „Nature” wykazały, że enzym TENT5A odgrywa kluczową rolę w ochronie terapeutycznego mRNA przed degradacją w komórkach. Dzieje się tak dzięki wydłużeniu przez ten enzym ogonów poli(A), które są ochronnymi końcami cząsteczek mRNA. Odkryty mechanizm tłumaczy skuteczność działania szczepionek przeciwko COVID-19 i otwiera nowe możliwości projektowania bardziej efektywnych terapii mRNA (myszy, Krawczyk et al., 2025). 

2. Opracowaliśmy innowacyjne narzędzie o nazwie Ninetails, wykorzystujące sztuczną inteligencję do precyzyjnej analizy końców cząsteczek mRNA. Odkryliśmy, że zakończenia mRNA są bardziej zróżnicowane, niż wcześniej sądzono, co ma kluczowe znaczenie dla stabilności i skuteczności działania leków opartych na mRNA, w tym szczepionek (myszy, Gumińska et al., 2025). 

3. Wykazaliśmy, że syntetyczne RNA rozpoczynające się od specyficznego związku – adenozyny, wywołuje silniejszą reakcję układu odpornościowego u myszy, niż RNA zaczynające się od guanozyny. To odkrycie może przyczynić się do opracowania bezpieczniejszych i skuteczniejszych szczepionek RNA oraz innych terapii (myszy, Wolczyk et al., 2024). 

4. Udowodniliśmy, że określone komórki wątroby reagują na nadmiar żelaza, uruchamiając mechanizm przywracający jego prawidłowy poziom w organizmie. To odkrycie może pomóc w leczeniu chorób związanych z zaburzoną gospodarką żelazem (myszy, Żurawska et al., 2024).

5. Dowiedliśmy, że jedną z pierwszych oznak starzenia się organizmu jest zaburzone odzyskiwanie żelaza z czerwonych krwinek, spowodowane przez osłabienie funkcji specjalnych komórek w śledzionie. Badania na myszach pokazały, że ten proces można spowolnić, ograniczając ilość żelaza w diecie (myszy, Slusarczyk et al., 2023).

6. Odkryliśmy, że szczepionki mRNA są stabilizowane przez białka obecne w komórkach, i tylko dzięki nim powstaje odporność na choroby (myszy, Krawczyk et al., 2023).

7. Znaleźliśmy przyczyny wrodzonej łamliwości kości u dzieci z mutacją w genie TENT5A (myszy, Gewartowska et al., 2021).

8. Odkryliśmy w jaki sposób mutacje w genie Tent5c przyczyniają się do rozwoju szpiczaka mnogiego (rodzaj nowotworu układu krwiotwórczego) i w jaki sposób Tent5c wpływa na działanie układu odpornościowego (myszy, Mroczek et al., 2017, Bilska et al., 2020) 

9. Za pomocą techniki CRISPR-Cas9 opracowaliśmy linie danio pręgowanego z mutacjami w genach npc. Przyczyniło się do lepszego zrozumienia choroby Niemanna-Picka (powodującej uszkodzenia wielu narządów w organizmie) i może przyspieszyć rozwój terapii (danio pręgowany, Wiweger et al., 2021).

10. Poprzez badania nad mikroRNA-7 ujawniliśmy, jak mikroRNA wpływa na rozwój neuronalny, co potencjalnie może mieć zastosowania w terapiach chorób neurodegeneracyjnych, takich jak choroba Parkinsona (danio pręgowany, Adusumilli et al., 2020).

11. Poprzez badania nad rybami z niedoborem Tsc2, wykazaliśmy u nich hiperaktywność szlaku mTorC1 i nieprawidłowy rozwój połączeń między komórkami mózgu; te wyniki mogą być kluczowe dla rozwoju terapii symptomów neuropsychiatrycznych w przebiegu stwardnienia guzowatego (danio pregowany, Kedra et al., 2020 i Prentzell et al.,2021).

Biologia rozwoju 

1. Udowodniliśmy, że aktywność białek z rodziny TENT5 jest niezbędna do prawidłowego powstania i rozwoju komórek rozrodczych komórek jajowych i plemników. Lepsze zrozumienie tego procesu może wspierać diagnostykę i leczenie niepłodności (myszy, Brouze et al., 2024).

2. Dzięki zastosowaniu zintegrowanych narzędzi genomiki, poznaliśmy molekularne czynniki odpowiedzialne za wrodzone wady serca (danio pręgowany, Baranasic et al., 2022).

3. Poznaliśmy molekularne mechanizmy regeneracji serca u danio pręgowanego, co może przyczynić się do lepszego zrozumienia braku regeneracji serca u ludzi i sprofilowania terapii u pacjentów po zawale serca (danio pręgowany, Pawlak et al., 2019).

4. Odkryliśmy funkcję enzymów ADAR, które przekształcają adenozynę w inozynę, co ma kluczowe znaczenie dla prawidłowego rozwoju embrionalnego i odpowiedzi immunologicznej (danio pręgowany, Niescierowicz et al., 2022).

5. Stwierdziliśmy, że prawidłowy rozwój i działanie ucha wewnętrznego zależy od stężenia jonów potasu, z udziałem białka Kv2.1/KCNB1 (danio pregowany, Jedrychowska et al., 2021).

6. Badania białka Wnt3 dostarczyły nam wglądu w jego rozmieszczenie i funkcje w mózgu ryb, co jest istotne dla zrozumienia mechanizmów rozwojowych mózgu kręgowców (danio pręgowany, Veerapathiran et al., 2020).

Biologia komórki procesów starzenia

1. Odkryliśmy nowy mechanizm regulujący ruch lizosomów – pęcherzykowych struktur komórkowych odpowiedzialnych za usuwanie zbędnych elementów z komórek. Otrzymane wyniki mogą pomóc w zrozumieniu procesu starzenia się komórek oraz ich reakcji na stres (szczury, Tempes et al., 2024).

2. Wykazaliśmy, że białko STIM2 odgrywa ważną rolę w przetwarzaniu bodźców wzrokowych oraz w produkcji insuliny przez komórki nerwowe w mózgu. Brak tego białka może prowadzić do zmian w siatkówce przypominających jaskrę. Ta wiedza otwiera nowe możliwości badania związku między sygnałami wapniowymi, insuliną i funkcjonowaniem neuronów (danio pręgowany, Baranykova et al., 2024).

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Badania naukowe z wykorzystaniem zwierząt laboratoryjnych 
Znaczenie badań
Regulacje
Badania w MIBMiK

Badania naukowe z wykorzystaniem zwierząt laboratoryjnych 

W Międzynarodowym Instytucie Biologii Molekularnej i Komórkowej w Warszawie prowadzimy badania podstawowe (eksperymentalne i teoretyczne) oraz aplikacyjne na poziomie molekularnym, organelli, komórek, tkanek i całych organizmów. Naszym celem jest poszerzenie obecnej wiedzy i przyczynienie się do rozwoju terapii medycznych. Koncentrujemy się na chorobach neurologicznych i nowotworowych, chorobach rzadkich oraz rozwoju nowej generacji leków z wykorzystaniem technologii RNA. 

Wachlarz technik i modeli badawczych jakich używamy w Instytucie jest szeroki: modelowanie komputerowe, eksperymenty biochemiczne na białkach wyprodukowanych przez bakterie, badania na liniach komórkowych, organoidach i niższych organizmach (nicieniach). Prowadzimy również badania naukowe z wykorzystaniem zwierząt laboratoryjnych: danio pręgowanego (ryba gatunku Dario rerio, ang. zebrafish), myszy i szczurów. Przy planowaniu i przeprowadzaniu badań z udziałem zwierząt kierujemy się unijnymi i krajowymi regulacjami oraz zasadą 3R (zastąpienie, ograniczenie, udoskonalenie). 

Zwierzęta laboratoryjne są wykorzystywane w badaniach wyłącznie wtedy, gdy nie jest możliwe zastosowanie innych metod i gdy uzasadnia to cel badania.

1 Olga copy– Zależy nam na prowadzeniu badań w sposób odpowiedzialny, tj. wykorzystaniu zwierząt w badaniach naukowych wyłącznie wtedy, gdy nie można zastosować innych metod badawczych oraz na transparentnej komunikacji w tym obszarze – mówi Olga Gewartowska, kierowniczka Pracowni Inżynierii Genomu w MIBMiK i członkini Krajowej Komisji Etycznej do Spraw Doświadczeń na Zwierzętach. 

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Badania naukowe z wykorzystaniem zwierząt laboratoryjnych 
Znaczenie badań
Regulacje
Badania w MIBMiK

 

IIMCB jest członkiem European Animal Research Association (EARA) – europejskiej organizacji wspierającej przejrzystość i komunikację na temat badań naukowych z wykorzystaniem zwierząt. Wśród wielu swoich inicjatyw EARA organizuje m.in. EARA Patient Day, wydarzenie łączące pacjentów, naukowców i lekarzy, mające na celu ukazanie znaczenia badań biomedycznych dla rozwoju terapii. Więcej informacji o EARA Patient Day można znaleźć tutaj: https://www.eara.eu/patient-discovery

 



 

 

The P.I. of the Laboratory of Protein Metabolism at IIMCB in Warsaw, Dr. Wojciech Pokrzywa, accompanied by doctoral students Natalia and Anwesha, had the opportunity to travel to the University of Oslo to meet with their Norwegian partner, Prof. Rafal Ciosk, and his team. The primary objective of this visit was to assess the progress of their collaborative research funded by the GRIEG grant and to strategize for forthcoming research initiatives.

A fruitful grant meeting is behind us! An interesting discussion, exchange of ideas and plans for further research. Dziembowska lab from CeNT UW, Bramham lab from UiB and Dziembowski lab from IIMCB (+Radwańska lab from Nencki Institute) have a networking session in Wierzba PAN!

The aim of the meeting was to explore RNA Biology and to inspire scientific community to undertake new research directions in this rapidly growing field of life sciences. The program broadly aligned with the RNA Biology in prokaryotic and eukaryotic systems with topics focused on transcription, RNA processing and metabolism, non-coding RNAs, RNA in therapy and medicine.

Paweł Krawczyk (member of GRIEGs project team) had a lecture druing on 28th September "SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response". Also during the Poster Session there was a poster "Cytoplasmic poly(A) polymerase TENT5A is a global positive regulator of neurohormone expression" with project results.

 

IMG 2021

IMG 2022 

 

The conference was an occasion to gain new insights across a broad range of nanopore technology. It was the opportunity to get hands-on with the technology, hear the latest from the Oxford Nanopore team, and of course network with other members of the Nanopore Community. Ms. Gumińska took a role of the representative of GRIEG project being able to discuss the new prospects of Nanopore technology following the technology changes, further consequences of that operations. The given chance of being directly with the producent, asking questions regarding possible plans for the future, provided a bit more ability for any predictions, theories that could be implemented.

CONCEPT AND OBJECTIVES

Polish science, including biomedical research, has made huge advances in the last 30 years. However, the advancement of its fundamental scientific discoveries toward medical or commercial applications still lags behind the top countries, worldwide. This gap stems from the limited experience of Polish researchers in the field of translational research. The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) aims to close this gap by building the capacity to translate basic knowledge into clinical innovations and by introducing an entrepreneurship culture in the scientific environment in Poland. Since its creation, the IIMCB has been a lighthouse of research and management excellence in Poland. Recognizing the Institute’s achievements and future potential, the Polish government awarded funding to build an expanded, modern IIMCB headquarters, which will increase our capacity to 20 research groups. The RACE project under the Teaming programme helps us achieve our goal of upgrading the IIMCB to a world-class translational research Centre of Excellence in RNA and Cell Biology. Together with our Advanced Partners we have identified five Specific Objectives that are key to achieve our goal:

  1. Expand IIMCB Research & Innovation (R&I) activities by recruiting new research groups and broadening collaborations;
  2. Train the next generation of IIMCB world-class researchers for academia and industry, aligning their expertise and skills to the best research centres across the European Research Area (ERA);
  3. Enhance IIMCB methodological capabilities through the development of modern core facilities (CFs), which will provide services to both academia and industry sectors;
  4. Facilitate the implementation of IIMCB discoveries by launching the IIMCB’s RACE Technology Incubator;
  5. Enhance overall IIMCB science management and administrative structure to fit new challenges.

Ultimately, the RACE project will make the IIMCB a reference model in translational research countrywide and elevate the Institute to the top tier of European research centres ready to engage in competitive EU and global biomedical research and innovation projects at the frontiers of science.

RACE Work Packages:

1.       Establishment of new research groups

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WP1 Leader: IIMCB
Gracjan Michlewski, Head of Laboratory of RNA-Protein Interactions

Objective: to reach critical mass in RNA and cell biology research by establishment of 6 new groups

Main tasks:

  • Recruitment of 6 new group leaders
  • Establishment of 6 new groups, including the recruitment of group members

2.       Researcher training

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WP2 Leader: UEDIN
Javier Caceres, Head of Laboratory of RNA Processing and Gene Regulation

Objective: to train IIMCB staff in conducting world-class biomedical research with translational potential

Main tasks:

  • Identify common research possibilitiesResearch training in RNA and Cell Biology of IIMCB post-docs and PhD students
  • Training in technology transfer, leadership, science management, and research integrity
  • Knowledge transfer events

3.       Development of IIMCB Core Facilities

 A Dziembowski

WP3 Leader: IIMCB
Andrzej Dziembowski, Director's Representative for Core Facilities

Objective: to build modern and highly efficient core facilities with services for internal and external users

Main tasks:

  • Enhance the commercial potential of Genome Engineering and Preclinical Drug Development Facilities
  • Reaching competitive edge and commercial potential of existing CFs
  • Building new CFs to enhance IIMCB potential and meet the needs of fast-evolving biomedical research
  • Recruitment of CF Business Manager and training of CF staff

4.       Implementation of a RACE Incubator at IIMCB

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WP4 Leader: VIB
Erwin Sablon, Head of Business Development/Expert Scientist Diagnostics & Biomarkers

Objective: to establish comprehensive TT support to successfully commercialize the IIMCB discoveries

Main tasks:

  • Recruitments for the RACE Incubator and IIMCB Exploitation Strategy
  • Training of TT and IP managers
  • Appointment and activities of a Commercialisation Advisory Council
  • Exploitation plan – implementation and monitoring
  • Accelerator programme for IIMCB researchers
  • Training of TT managers in Poland and beyond

5.       IIMCB science management upscale

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WP5 Leader: IIMCB
Alexia Danyłow, Senior Specialist at the Grants Office/Project Assistant

Objective: to develop HR activities to attract and retain the best talent, as well as digitalise science management and administrative processes; professionalise the administration for the upscaled IIMCB  

Main tasks:

  • Attracting and developing talent through professional HR management
  • Digital transformation of IIMCB
  • Efficient IIMCB administration

6.       Dissemination and communication  

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WP6 Leader: IIMCB
Daria Goś, Senior Specialist at the Communications Office

Objective: Proper dissemination of the project’s results and communication about RACE and IIMCB

Main tasks:

  • Recruitment and activities of PR Manager
  • Dissemination and Communication Plan
  • Dissemination and communication actions
  • Dissemination and communication training

7.       Project management 

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WP7 Leader: IIMCB
Dorota Libiszowska, Heads of Grants Office/Project Manager

Objective: to coordinate and manage the project  

Main tasks:

  • Overall coordination and management
  • Administrative and financial management and reporting
  • Creation of a Data Management Plan

RACE pasek logo

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

CONTACT

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Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

NEWS

Rosa Race

Finding the perfect rhythm for focus and creativity in Edinburgh

Rosa Amini from the Laboratory of Neurodegeneration, who undertook a research stay at the Institute of Genetics and Cancer, University of Edinburgh, shared with us some new highlights from her experience: My research stay at the Institute of Genetics and Cancer in Edinburgh has been one of the most meaningful parts of my PhD. Through the RACE program, I had the opportunity to work on eEF1A2 function in neurodevelopmental disorders and to learn new techniques in functional genomics and cell-based assays. It was a chance to grow scientifically, collaborate with talented researchers, and see how ideas move from the bench toward real applications.

She also emphasized the unique atmosphere of the city of Edinburgh, which added its own kind of inspiration: The city has an atmosphere that quietly pushes you to think; the mix of history, art, and science feels alive here. Between long lab days, walks through cobbled streets, and sunsets over the sea, I found the perfect rhythm for both focus and creativity.

Rosa also had the opportunity to attend the first UK Zebrafish Meeting, where she met researchers from across the country and shared her work. I am truly grateful to the RACE program for making this possible, for opening not only a professional path but a personal one too, she added in conclusion.

Implemented under Task 2.2 (WP2): Research Training in RNA and Cell Biology for IIMCB Post-Docs and PhD Students, coordinated by the University of Edinburgh.


Race News copy copy

Technology Transfer & Commercialization Course Launched at IIMCB

The 1st Edition of the Technology Transfer & Commercialization Course took place at the IIMCB on October 20–22, 2025, bringing together researchers, entrepreneurs, and innovation experts to explore the path from scientific discovery to successful commercialization.

The three-day course featured experts from IIMCB and VIB (Flanders Institute for Biotechnology, Belgium), as well as invited guest speakers from industry, who guided participants through the key stages of transforming research into market-ready innovations.

Speakers and Guests:

  • Paweł Botwina (IIMCB)Intellectual Property Basics and Patent Databases and Search.
  • Jan Demolder (VIB)Patentability in Biotech: Hands-on Training and Lessons Learned from IP at VIB.
  • Magdalena Janczewska (Science4Beauty) — Guest Lecture: Lab to Launch: My Path on Turning Research into a Start-up Reality.
  • Ethan Kuo (VIB)Funding Startups: Perspectives from a Former Venture Capitalist, Key Ingredients for Success: Team Building, Business Models, and Scalability, Valuation & Financing: Methods to Assess Startup Value and Secure Funding, and Market Potential Analysis.
  • Kornelia Mikuła (IIMCB)Preparing Research for Industry Collaboration and co-led: Get a Taste in Negotiations – Hands-on Exercise.
  • Erwin Sablon (VIB)Diagnostic Development Journey and Get a Taste in Negotiations (co-led)

The event combined lectures, interactive exercises, and networking opportunities, offering participants practical insights into technology transfer, intellectual property management, and startup development.

The course supports RACE WP2 and WP4.


 

Join Us Post comp biology copy join us junior group leader copy

IIMCB Opens Recruitment for Junior Group Leaders

The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) invites applications for two Junior Group Leader positions — in Molecular and Cell Biology and in Computational Biology.

These are professor-level, tenure-track positions offering start-up funding, access to advanced research infrastructure, and the opportunity to build independent research groups within IIMCB’s vibrant international community.

Both positions are part of the Institute’s strategic programs RACE and RACE-PRIME, supported by the European Union under Horizon Europe and the European Funds for Smart Economy.

Application deadline: November 30, 2025
Onsite interviews: April 21–23, 2026, Warsaw

The recruitment processes support WP1 - Establishment of new research groups.


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Copyright: PIRP | Polska Izba Rzeczników Patentowych

Paweł Botwina Begins Patent Attorney Traineeship

Paweł Botwina from the Technology Transfer Unit has passed the competitive exam that qualifies him to begin a three-year patent attorney traineeship at the Polish Chamber of Patent Attorneys. Paweł emphasizes:
The test consisted of 100 questions and covered legal, technical, and language sections. After passing, I will start a three-year traineeship under the supervision of a Patron — an experienced patent attorney — and take part in group training sessions. My entire traineeship is funded by the Institute through the RACE project resources, for which I am very grateful.

The initiative supports WP4 - Implementation of a RACE Incubator at IIMCB.


 

Sunandan race news

Study visit at IGC in Edinburgh: Science Across Borders

Thanks to the support of the project RACE, Sunandan Mukherjee from the Laboratory of Bioinformatics and Protein Engineering is undertaking a study visit at the Institute of Genetics and Cancer (IGC), University of Edinburgh, under the mentorship of Prof. Grzegorz Kudla.

Sunandan’s project focuses on understanding how the three-dimensional structure of viral RNA influences the way viruses replicate and cause disease. Many viruses store their genetic information in RNA molecules (known as RNA viruses). These RNAs fold into complex shapes that play key roles in controlling infection, interaction with host cells, and virulence.

By combining computational modeling with biochemical data from experiments, he aims to build detailed 3D models of viral RNA and identify structural features critical for its function. These insights could help explain how viruses become infectious and ultimately support the development of new therapeutic strategies to target them.

The IGC provides access to advanced computational tools, expertise in RNA biology, and an inspiring environment that encourages collaboration and innovation. Sunandan notes that this experience not only broadens his scientific perspective but also strengthens the links between the IIMCB and the University of Edinburgh.

Sundandan adds the following: “Outside the lab, Edinburgh’s unique blend of history, culture, and creativity makes it an exceptional place to reflect and find inspiration. The atmosphere is welcoming, intellectually vibrant, and full of opportunities for discussion and discovery. I look forward to deepening this collaboration, sharing knowledge between our institutes, and contributing to the growing understanding of RNA viruses and their role in human disease.”

The study visit is part of the broader mission of RACE to promote scientific exchange, training, and collaboration between the IIMCB and its international partners (WP2 – Researcher training).

Read more about Sunandan's experience in his blog. 


news o race

Promoting RACE at the IIMCB Reporting Session

On 22 September 2025, the IIMCB held its reporting session. One of the main highlights for the research staff was the poster session, during which scientists presented key information about their research projects. After the session, participants voted for the best poster, and the authors of the top three received small prizes.

The poster session also featured the project managers of the RACE, who presented a poster highlighting the project’s main goals and assumptions, strategic partners, and its impact. They also promoted research exchanges to the University of Edinburgh, RACE Advanced Partner,  within the community of IIMCB researchers and provided all necessary information how to arrange such visits.

See the poster:

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NSzulc SPP Cambridge

Highlights from SPP Cambridge 2025

On 15 September 2025, at the University of Cambridge, the meeting titled Science: Polish Perspectives (SPP) Cambridge 2025 — “From Discovery to Disruption: Polish Innovation in the UK” took place. Natalia Szulc from the Laboratory of Protein Metabolism participated in the event. During the Science Spotlight pitch session, she presented how her basic-science PhD research evolved into a science-popularization initiative. She admitted the following: “The event was an excellent opportunity to meet the Polish scientific diaspora in the UK and to learn from talks spanning cutting-edge research, science policy, and career stories from senior scientists.”

SPP Cambridge 2025 focused on showcasing how Polish science, business, and innovation can develop and grow in the UK. During the event, participants could approach the topic from two perspectives: research and entrepreneurship. The organizers provided attendees with opportunities for networking, taking part in lively discussions, and meeting professionals not only from research but also from startups, investment, and policymaking.

Participation in the event supported the RACE project (WP6 – Dissemination and Communication).


 

Research stay Nathalie

Another Research Stay in Edinburgh: Nathalie Shares Her Research Insights

Nathalie Idlin from the Laboratory of RNA-Protein Interactions is another participant in the research stay at the Institute of Genetics and Cancer at the University of Edinburgh, carried out within the framework of the Race project.

She shared the following about her research: “We aim to develop an efficient and reliable experimental model to investigate the role of HuR (ELAVL1) in modulating the RIG-I/type I interferon (IFN) signaling pathway which is essential for antiviral responses. Our study will involve testing a wide range of compounds designed to disrupt HuR-RNA complexes, investigate their molecular mechanisms and cellular consequences. Our final step will be to identify novel therapeutic strategies targeting viral infections and autoimmune disorders. To achieve rapid and acute depletion of HuR we plan to use the dTag system that offers advantages over traditional knockout methods (e.g., minimizing cellular adaptation of the cell to the knockout).”

She also emphasized that the research stay in Edinburgh is particularly valuable to her, since Dr Andrew Wood, the group leader at IGC, specializes in genome editing and targeted protein degradation.

The main objective of Nathalie’s visit is to learn how to efficiently generate a homozygous population of cells using CRISPR- HOT strategy. This system increases genome editing efficiency by using homology-independent-based strategy. Nathalie explained that during her first years of work, she had been able to obtain a homozygous population of HeLa cells containing the insertion of FKBP12 at the C-terminus of HuR. She added that she had been using a conventional HDR approach at that time, wchich was not very efficient and required a considerable amount of time.

The research stays in Edinburgh support the objectives of the RACE project (WP2 – Researcher training).


VIB zdjecie copy
Photos copyright: VIB Training & Conferences

IIMCB Researchers at VIB Innovation & Business Summer School: From Science to Real-World Impact

Five days of interactive workshops, debates, a pitching competition, and brilliant minds willing to turn science into impact. The VIB Innovation & Business Summer School took place in Ghent between 25–29 August 2025, and thanks to the RACE project, implemented as part of the Horizon Europe “Teaming for Excellence” program, four of our staff members – Olga Gewartowska (Technology Development Unit), Vanessa Linke (Mass Spectrometry Facility), Raghunandan Mahadeva (Laboratory of Iron Homeostasis), and Ryhor Nikalayeu (Laboratory of Bioinformatics and Protein Engineering) – participated in this event.

It was a unique opportunity to step outside the lab and gain a deeper understanding of how scientific ideas can be transformed into real-world products and ventures. Among the highlights, Olga Gewartowska, Head of the Technology Development Unit, was one of the winners of the Pitching Competition. Reflecting on her experience, she said:

“(...)I was impressed by the cross-disciplinary insights and practical takeaways, and how collaboration with experts from different fields and my peers enriched every session.”

Participation in the VIB Innovation & Business Summer School supports the objectives of the RACE project (WP2 – Researcher training).


RACE news 2025 07 14

Building Bridges Beyond Research: Uniting Science, People & Purpose
IIMCB welcomes delegation from the Embassy of Belgium and Flanders representation in Poland

Fantastic how our Teaming of Excellence RACE project unites people! On 14.07.2025, the IIMCB had the honor of hosting a distinguished delegation from the Embassy of Belgium to Poland and Lithuania and Flanders representation in Poland. The delegation included: Mr. Matthias De Moor, Diplomatic Representative of Flanders to Poland and the Baltic States, Mr. Kris Put, Trade and Economic Representative of Flanders in Poland and Mr. Tijs Verstraete, Policy Officer. Given that VIB Belgium is a key partner in the RACE consortium, it was a privilege to welcome the Belgian diplomatic and economic representatives to IIMCB. The visit proves that the RACE project not only fosters collaboration within its consortium but also generates opportunities to build wider networks and partnerships beyond it, including with diplomatic and trade missions.

During the visit, Prof. Marta Miączyńska, Director of IIMCB, presented the history of the institute, its scientific achievements to date, and its ambitious vision for future development — a vision that is deeply embedded in and supported by the RACE project. Our guests were then given a guided tour of the institute, during which they saw some of IIMCB’s most recent infrastructure investments, including state-of-the-art equipment purchased to advance cutting-edge biomedical research. We extend our sincere thanks to the Belgian delegation for their interest in IIMCB and look forward to continued engagement and strengthening of ties between the Polish and Flemish scientific and innovation communities.

This visit was of particular significance in the context of IIMCB’s implementation of the Teaming for Excellence RACE project, funded by the European Union under Horizon Europe. The RACE project is a strategic initiative aimed at strengthening excellence in research and innovation at IIMCB, implemented together with two outstanding advanced partners: the Flanders Institute of Biotechnology (VIB, Belgium) and the University of Edinburgh (UK).


RACE news workshop

RACE Workshop in Edinburgh: Two Days of Science, Skills, and Exchange Opportunities

On June 12–13, 2025, 20 PhD students and postdocs from IIMCB participated in a two-day Research Training in RNA and Cell Biology Workshop, hosted by the Institute of Genetics and Cancer (IGC), University of Edinburgh. 

The workshop brought together early-career researchers from both institutions for a programme packed with short talks, keynote lectures, poster sessions, and networking opportunities. Scientific sessions covered a wide range of topics – from protein function and RNA biology to disease mechanisms and gene regulation – with presentations delivered by students and postdocs from IIMCB and IGC. Highlights included keynote lectures by Prof. Pleasantine Mill (“Exploring cilia diversity – patient-driven gene discovery leads the way”) and Prof. Andrzej Dziembowski (“Complex metabolic pathways of mRNA therapeutics”), as well as a tour of IGC research facilities and vibrant poster discussions. 

Beyond science, the workshop created space for informal exchange and future planning. IIMCB participants learned more about the RACE mobility programme, which offers fully funded research stays at the University of Edinburgh for periods ranging from 1 to 24 months – including travel, accommodation, and research costs. 

View the photo gallery from the event here: RACE Workshop Photo Gallery

We warmly thank our hosts and organizers from the IGC and University of Edinburgh for creating such a welcoming, inspiring and collaborative environment – and look forward to future exchanges across the RACE network.
 

The workshop was implemented under Task 2.2 (WP2) of the RACE project: Research Training in RNA and Cell Biology for IIMCB Post-Docs and PhD Students.


RACE news new preprint

New Preprint from IIMCB–Edinburgh Collaboration:
Understanding Tissue-Specific Effects of Degron Tags

We are pleased to share the results of a collaborative study (bioRxiv link) between researchers from the IIMCB and the MRC Human Genetics Unit at the University of Edinburgh, conducted as part of the RACE consortium, funded under the Horizon Europe Teaming for Excellence programme.

The study reveals that degron tags — widely used in functional genomics — can cause tissue-specific differences in protein stability in vivo. Using the DEGRONOPEDIA platform and CRISPR-engineered mouse models, the authors identify two opposing mechanisms that shape protein turnover in different tissues. These findings highlight the need for careful, tissue-aware design of degron-based experiments and contribute to the development of more refined preclinical models.

This collaborative work exemplifies the RACE project’s goal of building scientific excellence through collaboration in RNA and cell biology. It was implemented within the strategic framework of the RACE partnership between IIMCB and the University of Edinburgh.


RACE Travel Postcard from Rose

“Not just a research exchange – a life experience”
Rosa shares her story from the University of Edinburgh

As part of the RACE project, Rosa from the Laboratory of Neurodegeneration is currently undertaking a research stay at the Institute of Genetics and Cancer, University of Edinburgh. Her project focuses on eEF1A2 modulation in neurodevelopmental disorders and high-throughput drug screening, where she gains hands-on experience with functional genomics and cell-based assays. She highlights the supportive and dynamic lab environment, full of researchers who inspire and challenge her daily. “This city blends culture, nature, and innovation beautifully. It’s not just a research exchange; it’s a life experience.” – says Rosa.

This mobility is part of the RACE project’s mission to support early-career researchers through international training, mentoring, and networking. Research stays at the University of Edinburgh last from 1 to 24 months, offering access to advanced research infrastructure, academic and industry collaboration, and the chance to live in one of Europe’s most beautiful cities.

One message stands out for prospective candidates: “To any PhD student or postdoc thinking about an international exchange: do it. You’ll gain skills, perspective, and unforgettable memories.” The RACE project is not only about research excellence — it’s about personal and professional transformation through mobility.

Implemented under Task 2.2 (WP2): Research Training in RNA and Cell Biology for IIMCB Post-Docs and PhD Students, coordinated by the University of Edinburgh.


RACE news CTLS

Krzysztof Skowronek presents IN-MOL-CELL workflows at CTLS 2025

At the Core Technologies for Life Sciences Congress 2025 in Brno, Dr. Krzysztof Skowronek, Head of the Biophysics and Bioanalytics Facility took part in the session "Cross-facility workflows and cooperation", co-chaired by Aleš Benda and Josh Rappoport. Dr. Skowronek presented a talk titled: “Cross-Platform Collaboration to Develop New Models for Rare Diseases in IN-MOL-CELL infrastructure”, co-authored with Olga Gewartowska and Andrzej Dziembowski. 

He presented a comprehensive pipeline that begins with gene candidate identification in collaboration with pediatric clinical partners and extends through the creation of advanced disease models in human cells, mice, zebrafish, and C. elegans. These models undergo detailed behavioral, physiological, transcriptomic, proteomic, and structural analyses. The goal is to deliver highly relevant disease models with multi-layered characterization — enabling breakthrough insights into rare disorders.


RACE news Ambasada

IIMCB at the German Embassy’s Open Day – Inspiring the Next Generation Through RNA Science

Members of the Laboratory of RNA–Protein Interactions – Dioscuri Centre, led by Dr. Gracjan Michlewski, participated in the event, engaging with many visitors — including children and their families – to share the wonders of molecular biology. Through hands-on activities and interactive demonstrations, they introduced the basics of gene expression, RNA biology, and cell function, showing how molecular processes relate to human health and disease. The IIMCB team booth invited curiosity and inspired young minds to explore the world of science.

During the event, visitors could also take home copies of our Annual Report 2023, the educational booklet “Be Healthy as a Fish”, and the 25th Anniversary Brochure of IIMCB. The printing of all materials was funded by the RACE project.

We thank the German Embassy for the opportunity to take part in this unique event celebrating Polish–German friendship, science diplomacy, and public engagement in research.

This outreach initiative supports the goals of the RACE project (WP6: Dissemination and Communication) – promoting public awareness of RNA and cell biology, strengthening science–society dialogue, and encouraging the next generation of researchers.


RACE news brochure

25 Years of IIMCB – Celebrating the Past, Building the Future with RACE

We are proud to present the official 25th Anniversary Brochure of the IIMCB, titled “Let’s Build a Great Institute.” This special publication reflects on the bold vision, challenges, and achievements that shaped IIMCB into one of Poland’s leading research institutions — from its founding in 1995 to its transformation into a globally recognized center of scientific excellence.

As the brochure illustrates, RACE (RNA and Cell Biology – from Fundamental Research to Therapies) is not only the most ambitious project in the Institute’s history — it is the natural next step in the journey outlined over the past 25 years. With support from the Horizon Europe Teaming for Excellence programme, RACE enables IIMCB to scale up its scientific impact, expand its Core Facilities, and strengthen collaborations with top-tier international partners.

The brochure also explores how RACE, RACE-PRIME, and IN-MOL-CELL form the three strategic pillars shaping IIMCB’s dynamic development toward 2029 — a vision rooted in excellence, driven by innovation, and powered by people.

Read the full story of IIMCB’s past and future in our anniversary brochure


The brochure is part of Work Package 6 (WP6): Dissemination and Communication activities of the RACE project.


RACE news

EMBO Delegation Visits IIMCB to Strengthen Research Excellence and European Collaboration

We had the pleasure of hosting representatives from the European Molecular Biology Organization EMBO - excellence in life sciences: Prof. Fiona Watt – EMBO Director; Dr. Karin Dumstrei – Head of the EMBO Fellowship Programme; Marina Giampietro – Head of Communications. The visit aligns with the RACE project goals of empowering talent, expanding international partnerships, and raising IIMCB’s profile as a leader in translational RNA and cell biology research. Notably, 5 out of 18 EMBO Members from Poland work at IIMCB, highlighting our strong presence in the European scientific community.


RACE 2025 IAB

International Advisory Board Endorses Progress of RACE and RACE-PRIME Projects

World-leading scientists from IIMCB’s International Advisory Board visited Warsaw to support the Institute’s scientific growth. Over three days, they conducted evaluations, met with our community, and provided strategic recommendations. Importantly, both RACE and RACE-PRIME projects received positive assessments, with the Board endorsing their effective implementation and alignment with IIMCB’s long-term vision. This visit reflects our commitment under RACE to world-class science management, talent development, and research excellence.


RACE training on AI for GO and SCU

RACE Training on Generative AI Empowers IIMCB Staff in Science Management

As part of RACE Work Package 5, IIMCB hosted a practical workshop on how Generative AI tools can streamline research administration and coordination. On March 18–19, 2025, IIMCB Grants Office and Scientific Coordination Unit teams hosted a training session titled “How can Generative AI help in our daily tasks?”. Led by experts from the Centre for Genomic Regulation (CRG), the session explored the use of tools like Microsoft Copilot and ChatGPT in everyday institutional tasks. The training supports RACE goals to digitalize science management and upskill administrative teams at IIMCB.


Meeting Brussels

IIMCB Director Engages in High-Level Dialogue on Future of European Research

Prof. Marta Miączyńska, IIMCB Director and EU-LIFE Co-Chair, joined a delegation in Brussels to meet with EU Commissioner for Startups, Research, and Innovation, Ekaterina Zaharieva. The meeting focused on key priorities for European science, including FP10, the ERA Act, scientific mobility, and collaboration. It underscored the critical role of independent research institutes in shaping Europe’s innovation landscape. This engagement reflects RACE goals to strengthen IIMCB’s international partnerships and strategic presence in European science policy. Click here to read more about the meeting and EU-LIFE’s science policy priorities.


Pawel IIMCB

Fellowship at VIB Strengthens IIMCB’s Innovation Capacity

Paweł Botwina, Innovation Specialist at IIMCB’s Technology Transfer Office, has completed a one-year training at the Flanders Institute of Biotechnology (VIB) in Belgium. Conducted within the RACE project, this training supports IIMCB’s goals to develop strong technology transfer practices, modern research infrastructure, and science management. Paweł’s experience at VIB will contribute directly to building a vibrant innovation ecosystem at IIMCB.


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IIMCB Hosts UK Delegation to Foster Horizon Europe Collaboration

As part of the UUKi high-level visit to Poland, IIMCB welcomed representatives from UK universities and the UK Science & Innovation Network. Discussions focused on strengthening scientific cooperation and exploring joint opportunities within the Horizon Europe programme. This aligns with RACE objectives to broaden international partnerships and boost IIMCB’s engagement in European research networks.


New CFs Heads

New Facility Heads Join IIMCB to Expand Core Research Infrastructure

We are excited to welcome Vanessa Linke as Head of the newly established Mass Spectrometry Facility and Michał Brouze as Head of the Genome Engineering Facility. Their expertise in molecular biology and genomics will significantly strengthen IIMCB’s core research capabilities — in line with RACE goals to develop cutting-edge infrastructure and provide high-level services for academia and industry.


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Celebrating Women in Science: Meet IIMCB Researchers Leading Innovation

On February 11, we joined the global celebration of the International Day of Women and Girls in Science, recognizing the vital role of female researchers in advancing molecular and cell biology."

At IIMCB, women make up half of our research staff, leading scientific groups, core facilities, and innovation projects. As part of this year’s celebration, we proudly highlight the work of:
- Olga Gewartowska, currently the head of the Technology Development Unit, devoted to the management of the IIMCB's Core Facilities, the IN-MOL-CELL research infrastructure. In this role, Olga closely collaborates with the Flanders Institute for Biotechnology (VIB), IIMCB’s advanced partner in the RACE project;
- Agnieszka Czarnocka-Cieciura, bioinformatician at the Laboratory of RNA Biology - ERA Chairs Group, studying mRNA stability using nanopore sequencing;
- Małgorzata Figiel, structural biologist exploring viral replication mechanisms.
These outstanding scientists exemplify RACE goals to empower talent, foster gender balance, and drive innovation through excellent research infrastructure. Click here to read their full stories and career paths.


RACE news Bresson Lab

New Group at IIMCB: Laboratory of RNA Viruses Led by Dr. Stefan Bresson

In January 2025, IIMCB launched a new research group – the Laboratory of RNA Viruses, headed by Dr. Stefan Bresson, formerly at the University of Edinburgh. The lab aims to uncover how RNA viruses manipulate host RNA metabolism and how host cells detect and respond to viral RNA.

Dr. Bresson’s team applies a multidisciplinary approach combining RNA biology, biochemistry, and transcriptomic techniques to explore virus-host interactions and mechanisms of innate immunity.

This group was established within the framework of the RACE WP1 entitled: “Establishment of new research groups.”


2024 IIMCB Key Discoveries

2024 at a Glance: A Year of Growth, Innovation and International Collaboration

From launching new laboratories and core facilities, to securing strategic funding and advancing the RACE initiative — 2024 marked a transformative year at IIMCB. Our community published over 70 scientific articles, organized 70+ events, and deepened partnerships across Europe, supporting our mission to become a top-tier Centre of Excellence in RNA and Cell Biology. Click here to read the full visual summary (PDF).


O Gewartowska new role RACE

New Leadership for Technology Development at IIMCB Core Facilities

Olga Gewartowska has been appointed Head of the newly established Technology Development Unit at IIMCB. The Unit will strengthen the operation of our Core Facilities and complement the role of Prof. Andrzej Dziembowski, Director’s Representative for Core Facilities. This strategic step supports RACE goals to enhance research infrastructure, professionalize facility management, and boost IIMCB’s capacity to serve both academia and industry.


K Mikula Kobiera RP Nauka

LifeArc Fellow Dr. Kornelia Mikuła on Bringing Global Best Practices to IIMCB

Dr. Kornelia Mikuła, recipient of the prestigious LifeArc Fellowship, shares her perspectives in a recent interview. She reflects on her scientific journey and her role in the RACE project, where she focuses on implementing international standards in research management and innovation practices at IIMCB. This work supports RACE’s mission to elevate institutional excellence and align IIMCB with global research leadership. Click here to read the interview (in Polish).


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IIMCB Showcases RACE Project at Mazovia Development Forum

IIMCB took part in the 14th edition of the Mazovia Development Forum, presenting the RACE project as a model of research excellence and innovation in biomedical science. The event provided an opportunity to share our vision of translating molecular and cell biology into real-world applications — in line with RACE’s mission to build strong links between science, society, and the regional innovation ecosystem.


Degradator International Educational Games Competition

DEGRADATOR Game Wins 3rd Prize at ECGBL 2024 — IIMCB at the Forefront of Science Education

DEGRADATOR, an educational game developed by IIMCB PhD student Natalia Szulc, won 3rd place in the fully developed games category at the 12th International Educational Games Competition, part of ECGBL 2024 at Aarhus University. Participation in ECGBL 2024 was funded by the RACE project, supporting IIMCB’s mission to promote innovation and communicate science on the European stage.
The game creatively explains the ubiquitin-proteasome system and targeted protein degradation therapies, placing players in the role of an E3 ubiquitin ligase. Designed for learners aged 12+, DEGRADATOR bridges science and engagement to fight misinformation and promote understanding of cutting-edge biomedical topics. Learn more and play the game: https://degradator-game.com/.


 Zrzut ekranu 2024 10 14 110719

First Industry Day at IIMCB Sparks Dialogue Between Science and Business

On October 8, 2024, IIMCB hosted the first Industry Day, bringing together representatives from leading biotech companies and the scientific community to explore pathways for innovation, technology transfer, and collaboration. Speakers from Adamed Pharma, Selvita S.A., BacterOMIC, and ExploRNA Therapeutics shared insights into their R&D strategies and expectations from academic partnerships. The event featured a dynamic discussion on AI in life sciences, startup challenges, and the role of basic research in industrial innovation. Organized as part of IIMCB’s broader RACE project activities, the event underscored the Institute’s mission to create meaningful synergies between academic excellence and market application. Click here to explore the Industry Day photo gallery and more highlights.


RACE in Encounters

RACE Project Featured in EMBO Encounters Magazine

The RACE project was highlighted in issue #48 of EMBO Encounters, showcasing its ambitious goal to transform IIMCB into a global Centre of Excellence in RNA and Cell Biology. The article outlines how IIMCB, in partnership with MRC-HGU (Edinburgh) and VIB (Ghent), is expanding its research teams, launching core facilities, and establishing a technology transfer incubator. Just one year in, RACE has already delivered new groups, training at partner institutes, and digitalization progress. With strong leadership from EMBO Council Co-Chair Prof. Marta Miączyńska and Prof. Wendy Bickmore, RACE bridges fundamental research and therapeutic innovation. Click here to read the full article (on page 26).


2024 09 23 Workshop

World-Class Biophysical Methods Workshop Co-Hosted by IIMCB and NIH Experts

From September 23–27, IIMCB and the University of Warsaw jointly hosted a prestigious workshop on advanced biophysical techniques, delivered by leading researchers from the US National Institutes of Health and the University of Texas Medical Center. Participants from across Europe and Asia explored techniques such as AUC, ITC, SPR, MP, and associated software (e.g. SEDFIT, SEDPHAT, NITPIC). Combining theory and hands-on training, the workshop equipped scientists at all career stages with tools vital to preclinical research, drug development, and nanotechnology. This internationally recognized training supports RACE project objectives to empower IIMCB researchers with cutting-edge skills and prepare for implementation of new biophysical methods at the Institute. Click here to read more about the workshop.


RACE news Wrobel Lab

New Group at IIMCB: Laboratory of Cellular Proteostasis Led by Dr. Lidia Wróbel

As of September 2024, a new research group has been established at IIMCB: the Laboratory of Cellular Proteostasis, led by Dr. Lidia Wróbel, previously affiliated with the University of Cambridge. The lab investigates how cells maintain protein homeostasis and how cellular stress responses can be harnessed to understand and treat diseases such as neurodegeneration.

Dr. Wróbel’s group focuses on protein folding and quality control mechanisms, including mitochondrial proteostasis and the unfolded protein response, using proteomic, biochemical, and cell biology approaches.

This group was established within the framework of the RACE WP1 entitled: “Establishment of new research groups.”


news LifeArc

Kornelia Mikuła Awarded Prestigious LifeArc Innovation Fellowship

Kornelia Mikuła, Head of IIMCB’s Technology Transfer Office, has been selected as the first fellow from a Polish institution to receive the LifeArc Knowledge Transfer Innovation Fellowship — a prestigious international program that builds top-level expertise in research commercialization. The TTO at IIMCB was established under the RACE project as a cornerstone of its innovation strategy, supported by international partners including VIB and the University of Edinburgh. Click here to read more about the Fellowship.


RACE 2nd Work Package Leaders Meeting

2nd RACE Work Package Leaders Meeting: Coordinating Excellence Across All Pillars

The second coordination meeting of all RACE Work Package Leaders brought together IIMCB teams and advanced partners to review project milestones, share updates, and plan next steps across all strategic areas — from research expansion and training, to infrastructure, innovation, and communication. This cross-WP dialogue strengthens integration and ensures effective implementation of the project’s mission: transforming IIMCB into a leading European Centre of Excellence in RNA and Cell Biology.


RACE 1st anniversary 

RACE Turns One: Celebrating a Year of Ambition, Growth and Collaboration

On September 1, 2023, IIMCB launched the RACE project to become a leading Centre of Excellence in RNA and Cell Biology. To celebrate, we invite you to watch a short video capturing highlights from this exciting first year. Thank you to our partners at UEDIN and VIB for their ongoing support. Let’s keep racing forward — together! Click here to watch the short video.


Join US CFs Heads

Join IIMCB as Head of a Core Facility – Apply Now!

We are hiring! IIMCB is looking for talented leaders to head its newly established Core Facilities, developed as part of the RACE project. Watch our short recruitment video https://youtu.be/08ixe7TVczU and explore the open positions


Dorota RACE

Grants Office Behind IIMCB’s Strategic Growth: From RACE to Future-Ready Funding

In 2023, the IIMCB’s Grants Office (GO) played a central role in securing major institutional grants — including the prestigious RACE project, co-authored and coordinated by GO staff alongside directors and scientists. Led by Dorota Libiszowska, the GO team of eight professionals continues to streamline funding processes, support researchers, and navigate complex grant requirements — from strategic planning to daily operations. Their mission: to empower science through funding excellence and ensure long-term impact for IIMCB. Click here to read the full interview with Dorota Libiszowska.


CFs RACE

PLN 71.7 Million for IIMCB Core Facilities – Expanding RACE Vision through the National Recovery Plan

The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) has secured PLN 71.7 million (€16.75M) under the National Recovery Plan to develop its cutting-edge Molecular and Cell Research Infrastructure — a key step in advancing the goals of the RACE project. Together with the infrastructure upgrades introduced under RACE, this funding brings IIMCB closer to its goal of becoming a world-class Centre of Excellence in RNA and Cell Biology, offering top-tier services to both academia and industry. The initiative also includes specialized training for research staff, technology transfer support, and IP management — all integral to RACE Work Package 3 (WP3), focused on enhancing methodological capacity and translational potential.


IAB 2024 RACE

International Advisory Board Convenes at IIMCB to Guide Future Growth

From April 24–26, IIMCB hosted the annual meeting of its International Advisory Board (IAB) — a key event shaping the Institute’s strategic direction and research priorities. Renowned scientists from across Europe and the U.S. engaged in evaluations, discussions with Institute councils, and the final stage of the Junior Lab Leader selection process. The IAB also formally approved the Director’s annual report and provided expert feedback to Lab Leaders during thematic Q&A sessions. This high-level consultation reinforces the goals of the RACE project, supporting IIMCB’s transformation into a Centre of Excellence through structured leadership, global collaboration, and continued scientific excellence.


AR2023 RACE

IIMCB Annual Report 2023 Now Online

The 2023 edition of the IIMCB Annual Report is now available! It features a conversation with Director Prof. Marta Miączyńska on the Institute’s future, presentations of research groups and core facilities, an interview with Dr. Aleksandra Kołodziejczyk, and insights into the work of the Grants Office and HR team. It also includes a dedicated section on the RACE project, outlining its vision, structure, and first achievements. Click here to read the full report (PDF).


TEDxPUT

Prof. Marta Miączyńska at TEDx: What Can Cells Teach Us About Cities and Ourselves?

In her recent TEDx talk at Poznań University of Technology, Prof. Marta Miączyńska, Director of IIMCB and Coordinator of the RACE project, reflects on the value of science, the surprising parallels between cells and cities, and whether cell biology might be viewed as modern-day alchemy. Click here to watch the full talk.


Minister Szeptycki at IIMCB

Deputy Minister Andrzej Szeptycki Visits IIMCB to Discuss the Future of Polish Science

Deputy Minister of Science and Higher Education, Andrzej Szeptycki, visited IIMCB to explore challenges and opportunities in strengthening the international profile of Polish science. Director Prof. Marta Miączyńska presented IIMCB’s 25-year track record as a model international research institute, highlighting its unique legal structure, the role of the International Advisory Board, and strategic plans — including those developed under the RACE project. The visit concluded with a tour of the Institute and open discussion with scientists and administrative leaders.


2024 Marta Miaczynska Kongres Umiedzynarodowienia NAWA

Prof. Marta Miączyńska Moderates Panel on Scientific Careers at NAWA Congress

At the 2nd Internationalization Congress organized by NAWA, IIMCB Director Prof. Marta Miączyńska moderated a panel titled “Scientific Career in the International Space – How to Build It?”. The event gathered leaders from academia, government, and education to discuss strategies for global cooperation in science and higher education. The discussion echoed the mission of the RACE project, which supports researcher development and international visibility of Polish science.


RACE PRIME RACE

Over PLN 36 Million for IIMCB’s RACE-PRIME Project from FNP

The IIMCB has received PLN 36.3 million in funding from the Foundation for Polish Science under the International Research Agendas programme to implement the RACE-PRIME project — a continuation and complement to the Horizon Europe–funded RACE project. RACE-PRIME will develop innovative research on infectious and rare diseases, supported by international partners from UEDIN and VIB, and coordinated by Prof. Gracjan Michlewski and Prof. Marta Miączyńska. The initiative will enable the recruitment of six new research teams, strengthen Core Facilities, and support the Institute’s long-term development strategy.


RACE IIMCB in Edinburgh

IIMCB Administrative Team Visits RACE Partner in Edinburgh

As part of the RACE project, a delegation from the IIMCB administration visited the MRC Human Genetics Unit at the University of Edinburgh — one of the Institute’s key strategic partners. The study visit focused on exchanging best practices in research administration, management, and support structures, contributing to the professionalization goals set out in RACE Work Package 5.


2024 IIMCB at VIB

IIMCB Delegation Visits VIB to Share Best Practices within RACE

A delegation from IIMCB visited the Flanders Institute for Biotechnology (VIB) as part of the RACE project, strengthening collaboration between partners. The visit focused on exchanging best practices in areas such as HR, finance, and science management, reinforcing the shared commitment to institutional excellence. Thank you, VIB, for the warm welcome and continued partnership!


20 02 2024 RACE 1st Work Package Leaders meeting

1st RACE Work Package Leaders Meeting Kicks Off Project Coordination

Leaders of all RACE Work Packages gathered for the first coordination meeting to align goals, share implementation plans, and strengthen collaboration across the project. The meeting marked an important step in establishing a shared strategic framework for transforming IIMCB into a Centre of Excellence in RNA and Cell Biology.


RACE Project Featured on Polskie Radio’s EUREKA Programme

The RACE project was recently presented in the popular science broadcast EUREKA on Polskie Radio Jedynka. The episode explored how RNA and cell biology research at IIMCB is being translated into future therapies, highlighting the vision behind the RACE project. Clik here to listen to the full interview with Marta Miączyńska, RACE Coordinator.


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RACE Project Officially Inaugurated – View the Photo Gallery

The official inauguration of the RACE project marked the beginning of IIMCB’s journey toward becoming a Centre of Excellence in RNA and Cell Biology. Relive the key moments and explore highlights from the event in our photo gallery.


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VIB Representatives Visit IIMCB: Strengthening the Foundation of RACE

Representatives of the Flanders Institute for Biotechnology (VIB) visited IIMCB for the first in-person partner meeting following the RACE project’s kick-off. The study visit focused on getting to know the teams, planning collaborative work across all Work Packages, and aligning strategies to ensure smooth and impactful implementation of the project. This milestone marks the start of close operational cooperation between IIMCB and its advanced partners.


RDC RACE 

RACE Project on RDC Radio – Interview with Prof. Marta Miączyńska

Prof. Marta Miączyńska, Director of IIMCB and Coordinator of the RACE project, presented the vision and goals of the initiative in an interview for RDC Radio. The conversation highlighted how IIMCB aims to translate RNA and cell biology research into future therapies and how international collaboration drives this transformation. Click here to listen to the interview (in Polish).


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The official inauguration of the Horizon Europe Teaming for Excellence: RACE project

On January 10, 2024, IIMCB held the official kick-off of the RACE project, launching its path toward becoming a Centre of Excellence in RNA and Cell Biology. The event gathered representatives from the European Commission, FNP, the Embassies of the UK and Belgium, the City of Warsaw, and strategic partners from VIB and the University of Edinburgh. RACE, ranked #1 in Europe under Horizon Europe Teaming, will drive cutting-edge research, build modern infrastructure, and foster international collaboration — bringing science from bench to bedside.


 

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RACE Project Officially Inaugurated at IIMCB

On January 10, 2024, IIMCB held the official kick-off of the RACE project, launching its path toward becoming a Centre of Excellence in RNA and Cell Biology. The event gathered representatives from the European Commission, FNP, the Embassies of the UK and Belgium, the City of Warsaw, and strategic partners from VIB and the University of Edinburgh. RACE, ranked #1 in Europe under Horizon Europe Teaming, will drive cutting-edge research, build modern infrastructure, and foster international collaboration — bringing science from bench to bedside. 


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Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

 GENERAL INFORMATION

Title:

RNA and Cell Biology - from Fundamental Research to Therapies

Acronym:

RACE

Main goal:

Elevate the IIMCB to a world-class Centre of Excellence in RNA and Cell Biology that will translate cutting-edge fundamental research into clinical applications and innovations

Coordinator:

Prof. Marta Miączyńska

Implementation period:

1 September 2023 - 31 August 2029

Budget:

14 993 885 EUR

Funding:

Horizon Europe Widening participation and spreading excellence and UK Research and Innovation

   Advanced Partners:

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Medical Research Council, Human Genetics Unit, University of Edinburgh (UEDIN), Great Britain – combines scientific and clinical expertise to study human genetic disease and normal development. UEDIN supports the IIMCB in broadening its scientific scope by training its researchers. It also engages in enhancing the IIMCB methodological capabilities through the development of modern core facilities and upgrading IIMCB science management.

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Flanders Institute of Biotechnology (VIB), Belgium is an entrepreneurial research institute that is a European leader in translational research. VIB supports the IIMCB in creating a Technology Transfer Office and training researcher staff. It also helps the IIMCB in developing modern core facilities and science management and administration. The partnership between the IIMCB and VIB is boosted by the supportive culture of excellence within the EU-LIFE alliance.


RACE pasek logo

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.