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 ad2019

Andrzej Dziembowski, PhD, Professor

Correspondence address:
Laboratory of RNA Biology - ERA Chairs Group
International Institute of Molecular and Cell Biology in Warsaw
4 Ks. Trojdena Street, 02-109 Warsaw, Poland
Email: Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.  
www: https://mosaic.iimcb.gov.pl & crisprmice.eu    

          Mosaic logo

DEGREES:

2014 - Professor of Biological Sciences, nomination by the President of the Republic of Poland
2009 - DSc Habil in Molecular Biology, University of Warsaw, Poland
2002 - PhD in Biology, cum laude, Department of Genetics Faculty of Biology, University of Warsaw, Poland
1998 - MSc in Molecular Biology, University of Warsaw, Inter-Faculty Individual Studies in Mathematics and Natural Sciences, Poland

PROFESSIONAL EMPLOYMENT:

2019-present - Professor, Head of the Laboratory of RNA Biology - ERA Chairs Group, IIMCB, Warsaw, Poland (100% appointment)
2011-present - Associate Professor, Faculty of Biology, Department of Genetics and Biotechnology, University of Warsaw, Poland (currently 25% employment)
2014-2019 - Full Professor, Institute of Biochemistry and Biophysics PAS, Poland
2010-2014 - Associate Professor, Institute of Biochemistry and Biophysics PAS, Poland
2008-2010 - Assistant Professor, Institute of Biochemistry and Biophysics PAS, Poland
2006-2011 - Assistant Professor, Faculty of Biology, Department of Genetics and Biotechnology, University of Warsaw, Poland
2002 -2006 - Post-doctoral fellow, Centre de Génétique Moléculaire, CNRS, France

MEMBERSHIP IN SCIENTIFIC SOCIETIES, ORGANIZATIONS AND PANELS:

2020 - Corresponding Member, Polish Academy of Sciences
2018 - EMBO Member
2004 - Member, RNA society

FELLOWSHIPS AND AWARDS:

2018 - Prize for scientific achievements, Foundation for Polish Science
2014 - Master Award, Foundation for Polish Science
2013 - Ideas for Poland Award, Foundation for Polish Science
2013 - Knight's Cross of the Order of Polonia Restituta
2013 - Jakub Karol Parnas Award for the best publication in biochemistry, Polish Biochemical Society
2013 - National Science Centre Award for outstanding scientific achievements
2012 - Member, Polish Young Academy, Polish Academy of Sciences
2010 - Prime Minister Award for the habilitation thesis
2009 - Scholarship for outstanding young scientists, Minister of Science and Higher Education
2006 - EMBO Installation Grant
2002 - Postdoctoral fellowship, Foundation for Polish Science
2002 - Prime Minister Award for PhD thesis
2001 - Scholarship for Young Scientists, Foundation for Polish Science

DOCTORATES DEFENDED UNDER LAB LEADER’S SUPERVISION:

K. Drążkowska, M. Lubas, A. Siwaszek, M. Ukleja, M. Czarnocki-Cieciura, O. Gewartowska, P. Krawczyk, E. Furmańczyk, A. Pyzik, T. Kuliński.


 MOSaIC logotypy

The Laboratory of RNA Biology - ERA Chairs Group has been established thanks to the EU H2020 funding within the ERA Chairs project
entitled “MOlecular Signaling in Health and Disease - Interdisciplinary Centre of Excellence”, acronym: MOSaIC (GA no 810425)

 

group2019


Kierownik laboratorium: 

  • prof. dr hab. Andrzej Dziembowski

Starszy badacz:

  • dr hab. Seweryn Mroczek

Postdocy:

  • dr Aleksandra Brouze

  • dr Natalia Gumińska

  • dr Paweł Krawczyk

  • dr Tomasz Kuliński

  • dr Katarzyna Matylla-Kulińska

  • dr Bartosz Tarkowski

Asystenci ds. badań:

  • mgr Paula Castañeda Londoño

  • mgr Karolina Kasztelan

Starsi sepcjaliści:

  • mgr Kamila Affek

  • mgr Agnieszka Czarnocka-Cieciura

  • mgr Ewelina Patrycja Owczarek

Młodszy specjalista:

  • mgr Dominik Chwastek

  • Doktorańci:

    • mgr Wiktor Antczak

    • mgr Usman Hameed

    • mgr Zuzanna Mackiewicz

    • mgr Michał Mazur

    • mgr Tola Tame

    Wolontariusze:

    • dr Monika Kusio-Kobiałka

    • dr Ewa Poniecka

    • Julia Gilewska, student studiów magisterskich

    • Marcin Małkowski, doktorant, Uniwersytet Warszawski

    • Maria Nizik, student studiów magisterskich

    • Wiktoria Orzeł, doktorant, Uniwersytet Warszawski

    Starszy laborant:

    • lic Alina Zielińska

    Specjalista ds. wsparcia laboratorium:

    • mgr Paula Kwapisz


    MOSaIC logotypy

    The Laboratory of RNA Biology - ERA Chairs Group has been established thanks to the EU H2020 funding within the ERA Chairs project
    entitled “MOlecular Signaling in Health and Disease - Interdisciplinary Centre of Excellence”, acronym: MOSaIC (GA no 810425)

2025

Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines.

Krawczyk PS, Mazur M, Orzeł W, Gewartowska O, Jeleń S, Antczak W, Kasztelan K, Brouze A, Matylla-Kulińska K, Gumińska N, Tarkowski B, Owczarek EP, Affek K, Turowski P, Tudek A, Sroka M, Śpiewla T, Kusio-Kobiałka M, Wesołowska A, Nowis D, Golab J, Kowalska J, Jemielity J, Dziembowski A, Mroczek S.

Nature. 2025

Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with Ninetails.

Gumińska N, Matylla-Kulińska K, Krawczyk PS, Maj M, Orzeł W, Mackiewicz Z, Brouze A, Mroczek S, Dziembowski A.

Nat Commun. 2025

Terminal nucleotidyltransferase Tent2 microRNA A-tailing enzyme regulates excitatory/inhibitory balance in the hippocampus.

Wardaszka-Pianka P, Kuzniewska B, Guminska N, Hojka-Osinska A, Puchalska M, Milek J, Stawikowska A, Krawczyk P, Pauzin FP, Wojtowicz T, Radwanska K, Bramham CR, Dziembowski A, Dziembowska M.

RNA. 2025

DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.

Brouze M, Szpila M, Czerwińska AM, Antczak W, Mroczek S, Kuliński T, Hojka-Osińska AM, Cysewski D, Gewartowska O, Adamska D, Gruchota J, Borsuk E, Dziembowski A.

RNA. 2025

Comprehensive analysis of poly(A) tails in mouse testes and ovaries using Nanopore Direct RNA Sequencing.

Czarnocka-Cieciura A, Brouze M, Gumińska N, Mroczek S, Gewartowska O, Krawczyk PS, Dziembowski A.

Sci Data. 2025

5′ terminal nucleotide determines the immunogenicity of IVT RNAs.

Wolczyk M, Szymanski J, Trus I, Naz Z, Tame T, Bolembach A, Choudhury NR, Kasztelan K, Rappsilber J, Dziembowski A, Michlewski G.

Nucleic Acids Res. 2025

Zygotic activin a is dispensable for the mouse preimplantation embryo development and for the derivation and pluripotency of embryonic stem cells.

Winek E, Wolińska-Nizioł L, Szczepańska K, Szpakowska A, Gewartowska O, Wysocka I, Grzesiak M, Suwińska A.

Biol Reprod. 2025

Ecological interactions in glacier environments: a review of studies on a model Alpine glacier

Crosta A, Valle B, Caccianiga M, Gobbi M, Ficetola FG, Pittino F, Franzetti A, Azzoni RS, Lencioni V, Senese A, Corlatti L, Buda J, Poniecka E, Novotná Jaroměřská T, Zawierucha K, Ambrosini R.

Biol Rev. 2025

2024

Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay.

Czarnocka-Cieciura A, Poznański J, Turtola M, Tomecki R, Krawczyk PS, Mroczek S, Orzeł W, Saha U, Jensen TH, Dziembowski A, Tudek A.

EMBO J. 2024

Transcriptome-Wide Analysis of mRNA Adenylation Status in Yeast Using Nanopore Sequencing.

Krawczyk PS, Tudek A, Mroczek S, Dziembowski A.

Methods Mol Biol. 2024

TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.

Brouze M, Czarnocka-Cieciura A, Gewartowska O, Kusio-Kobiałka M, Jachacy K, Szpila M, Tarkowski B, Gruchota J, Krawczyk P, Mroczek S, Borsuk E, Dziembowski A.

Nat Commun. 2024

Structure-functional characterization of Lactococcus AbiA phage defense system.

Gapińska M, Zajko W, Skowronek K, Figiel M, Krawczyk PS, Egorov AA, Dziembowski A, Johansson MJO, Nowotny M.

Nucleic Acids Res. 2024

Mutation in the mitochondrial chaperone TRAP1 leads to autism with more severe symptoms in males.

Rydzanicz M, Kuzniewska B, Magnowska M, Wójtowicz T, Stawikowska A, Hojka A, Borsuk E, Meyza K, Gewartowska O, Gruchota J, Miłek J, Wardaszka P, Chojnicka I, Kondrakiewicz L, Dymkowska D, Puścian A, Knapska E, Dziembowski A, Płoski R, Dziembowska M.

EMBO Mol Med. 2024

Circular extrachromosomal DNA in Euglena gracilis under normal and stress conditions.

Gumińska N, Hałakuc P, Zakryś B, Milanowski R.

Protist. 2024

2023

Multiple Myeloma associated DIS3 mutations drive AID-dependent IgH Translocations.

Kulinski TM, Gewartowska O, Mahe M, Kasztelan K, Durys J, Seraphin B, Dziembowski A.

bioRxiv. 2023

Identification of cardiac-related serum miRNA in patients with type 2 diabetes mellitus and heart failure: Preliminary report.

Wrzosek M, Hojka-Osińska A, Klimczak-Tomaniak D, Żarek-Starzewska AK, Dyrla W, Rostek-Bogacka M, Wróblewski M, Kuch M, Kucia M.

Adv Clin Exp Med.. 2023

mRNA decay can be uncoupled from deadenylation during stress response.

Czarnocka-Cieciura A, Turtola M, Tomecki R, Krawczyk P, Mroczek S, Orzeł W, Saha U, Jensen TH, Dziembowski A, Tudek A.

bioRxiv. 2023

Measuring the tail: Methods for poly(A) tail profiling.

Brouze A, Krawczyk PS, Dziembowski A, Mroczek S.

Wiley Interdiscip Rev RNA.. 2023

2022

TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals.

Liudkovska V, Krawczyk PS, Brouze A, Gumińska N, Wegierski T, Cysewski D, Mackiewicz Z, Ewbank JJ, Drabikowski K, Mroczek S, Dziembowski A.

Sci Adv. 2022

Disrupting interaction between miR-132 and Mmp9 3'UTR improves synaptic plasticity and memory in mice.

Kuzniewska B, Rejmak K, Nowacka A, Ziółkowska M, Milek J, Magnowska M, Gruchota J, Gewartowska O, Borsuk E, Salamian A, Dziembowski A, Radwanska K, Dziembowska M.

Front Mol Neurosci. 2022

A long noncoding RNA promotes parasite differentiation in African trypanosomes.

Guegan F, Rajan KS, Bento F, Pinto-Neves D, Sequeira M, Gumińska N, Mroczek S, Dziembowski A, Cohen-Chalamish S, Doniger T, Galili B, Estévez AM, Notredame C, Michaeli S, Figueiredo LM.

Sci Adv. 2022

2021

Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae.

Turtola M, Manav MC, Kumar A, Tudek A, Mroczek S, Krawczyk PS, Dziembowski A, Schmid M, Passmore LA, Casañal A, Jensen TH.

Genes Dev.. 2021

The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis.

Scheer H, de Almeida C, Ferrier E, Simonnot Q, Poirier L, Pflieger D, Sement FM, Koechler S, Piermaria C, Krawczyk P, Mroczek S, Chicher J, Kuhn L, Dziembowski A, Hammann P, Zuber H, Gagliardi D.

Nat Commun.. 2021

Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae.

Tudek A, Krawczyk PS, Mroczek S, Tomecki R, Turtola M, Matylla-Kulińska K, Jensen TH, Dziembowski A.

Nat Commun. . 2021

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.

Gewartowska O, Aranaz-Novaliches G, Krawczyk PS, Mroczek S, Kusio-Kobiałka M, Tarkowski B, Spoutil F, Benada O, Kofroňová O, Szwedziak P, Cysewski D, Gruchota J, Szpila M, Chlebowski A, Sedlacek R, Prochazka J, Dziembowski A.

Cell Rep.. 2021

Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases.

Liudkovska V, Dziembowski A.

Wiley Interdiscip Rev RNA.. 2021

2020

Immunoglobulin Expression and the Humoral Immune Response Is Regulated by the Non-Canonical poly(A) Polymerase TENT5C.

Bilska A, Kusio-Kobiałka M, Krawczyk PS, Gewartowska OTarkowski B, Kobyłecki K, Nowis D, Golab J, Gruchota J, Borsuk E, Dziembowski A, Mroczek S.

Nat Commun.. 2020

Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine..

Malik D, Kobyłecki K, Krawczyk P, Poznański J, Jakielaszek A, Napiórkowska A, Dziembowski A, Tomecki R, Nowotny M.

Nucleic Acids Res.. 2020

Mitochondrial protein biogenesis in the synapse is supported by local translation.

Kuzniewska B, Cysewski D, Wasilewski M, Sakowska P, Milek J, Kulinski TM, Winiarski M, Kozielewicz P, Knapska E, Dadlez M, Chacinska A, Dziembowski A, Dziembowska M.

EMBO Rep.. 2020