All publications

Research groups

Laboratory of Cell Biology

Laboratory of Structural Biology

Laboratory of Bioinformatics and Protein Engineering

Laboratory of Molecular and Cellular Neurobiology

Laboratory of Neurodegeneration

Laboratory of Iron Homeostasis

Laboratory of Protein Structure

Laboratory of Protein Metabolism

Laboratory of Zebrafish Developmental Genomics

Laboratory of Biomolecular Interactions and Transport

Laboratory of RNA Biology - ERA Chairs Group

Laboratory of RNA-Protein Interactions - Dioscuri Centre

Laboratory of Prokaryotic Gene Regulation

Laboratory of Cellular Genomics

Laboratory of Cellular Proteostasis

Projects outside research groups

PolSenior Project

Aurezyna Project

Core Facilities

Core Facility

Zebrafish Core Facility

Former labs & projects

Department of Molecular Biology

Laboratory of Biomodelling

Laboratory of Cell Cortex Mechanisms

Laboratory of Mitochondrial Biogenesis

Cilia and leukemia genetics studies

Other

Other

2026 2025 2024 2023 2022 2021 2020 2018 2017

2022

Publication Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Pekec T, Lewandowski J, Komur AA, Sobańska D, Guo Y, Świtońska-Kurkowska K, Małecki JM, Dubey AA, Pokrzywa W, Frankowski M, Figiel M, Ciosk R. Nat Commun. 2022 Preprint CHIP ubiquitin ligase is involved in the nucleolar stress management. Piechota M, Biriczova L, Kowalski K, Szulc NA, Pokrzywa W. bioRxiv preprint. 2022 Publication A heterotypic assembly mechanism regulates CHIP E3 ligase activity. Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dabrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W. EMBO J. . 2022

2021

Maintaining proteostasis under mechanical stress. Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B. EMBO Rep.. 2021 Muscle-derived exophers promote reproductive fitness. Turek M, Banasiak K, Piechota M, Shanmugam N, Macias M, Śliwińska MA, Niklewicz M, Kowalski K, Nowak N, Chacinska A, Pokrzywa W. EMBO Rep.. 2021 The Dose-Dependent Pleiotropic Effects of the UBB+1 Ubiquitin Mutant. Banasiak K, Szulc NA, Pokrzywa W. Front. Mol. Biosci. . 2021

2020

Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores. Donkervoort S, Kutzner CE, Hu Y, Lornage X, Rendu J, Stojkovic T, Baets J, Neuhaus SB, Tanboon J, Maroofian R, Bolduc V, Mroczek M, Conijn S, Kuntz NL, Töpf A, Monges S, Lubieniecki F, McCarty RM, Chao KR, Governali S, Böhm J, Boonyapisit K, Malfatti E, Sangruchi T, Horkayne-Szakaly I, Hedberg-Oldfors C, Efthymiou S, Noguchi S, Djeddi S, Iida A, di Rosa G, Fiorillo C, Salpietro V, Darin N, Faure´ J, Houlden H, Oldfors A, Nishino I, de Ridder W, Straub V, Pokrzywa W, Laporte J, Foley R, Romero NB, Ottenheijm C, Hoppe T, Bönnemann CG. Am. J. Hum. Genet.. 2020 CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Albert M-C, Brinkmann K, Pokrzywa W, Günther SD, Krönke M, Hoppe T, Kashkar H. Cell Death & Disease. 2020 Nutritional status and fecundity are synchronised by muscular exopheresis. Turek M, Piechota M, Shanmugam N, Niklewicz M, Kowalski K, Chacińska A, Pokrzywa W. bioRxiv. 2020 The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Fatima A, Irmak D, Noormohammadi A, Rinschen MM, Das A, Leidecker O, Schindler C, Sánchez-Gaya V, Wagle P, Pokrzywa W, Hoppe T, Rada-Iglesias A, Vilchez D. Commun Biol.. 2020 Article BioShell 3.0: Library for Processing Structural Biology Data. Macnar JM, Szulc N, Kryś JD, Badaczewska-Dawid AE, Gront D. Biomolecules. 2020 Ubiquitin Signaling Regulates RNA Biogenesis, Processing, and Metabolism. Thapa P, Shanmugam N, Pokrzywa W. BioEssays. 2020

2018

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Koyuncu S, Saez I, Lee HJ, Gutierrez-Garcia R, Pokrzywa W, Fatima A, Hoppe T, Vilchez D. Nat Commun.. 2018 Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis. Balaji V, Pokrzywa W, Hoppe T. Bioessays. 2018

2017

CHIPped balance of proteostasis and longevity. Pokrzywa W, Hoppe T. Oncotarget. 2017 Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity. Pokrzywa W, Lorenz R, Hoppe T Worm. 2017 Repair or Destruction: An Intimate Liaison Between Ubiquitin Ligases and Molecular Chaperones in Proteostasis Kevei É, Pokrzywa W, Hoppe T FEBS Lett. doi:10.1002/1873-3468.12750.. 2017