Preprint Structures and enzymatic mechanisms of DRT7/UG10 antiphage reverse transcriptases. Figiel M, Viswanath VK, Czarnocki-Cieciura M, Šoltysová M, Rybakowska J, Egorov AA, Hauryliuk V, Johansson MJO, Nowotny M. bioRxiv. 2026 Publication Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA. Nirwal S, Czarnocki-Cieciura M, Zajko W, Skowronek K, Szczepanowski RH, Nowotny M. Nat Commun. 2025 Publication Genome-wide in vivo and ex vivo mapping of R-loops using engineered N-terminal hybrid-binding domain of RNase H3 (enDR3). Jedynak-Slyvka M, Kaczmarska Z, Graczyk D, Jurkiewicz A, Figiel M, Borowski LS, Szczesny RJ, Nowotny M. Nucleic Acids Res. 2025 Preprint Structural insights into DNA annealing and recombination by herpesviral DNA-binding proteins ICP8 and BALF2. Apte GR, Patra S, Czarnocki-Cieciura M, Jabeen A,
Jackiewicz J, Poznański J, Nowotny M, Figiel M. bioRxiv. 2025 Publication The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ. Sołtys K, Skowronek K, Bystranowska D, Wycisk K, Ożyhar A. Cell Commun Signal. 2025 Publication From discovery to potential application: engineering a novel M23 peptidase to combat Listeria monocytogenes. Kaus-Drobek M, Nowacka M, Gewartowska M, Korzeniowska Nee Wiweger M, Jensen MR, Møretrø T, Heir E, Nowak E, Sabała I. Sci Rep. 2025 Publication Activity and structure of human (d)CTP deaminase CDADC1. Slyvka A, Rathore I, Yang R, Gewartowska O, Kanai T, Lountos GT, Skowronek K, Czarnocki-Cieciura M, Wlodawer A, Bochtler M. Proc Natl Acad Sci U S A. 2025 Publication Tailoring Alkyl Side Chains of Ionizable Amino-Polyesters for Enhanced In Vivo mRNA Delivery. López Espinar A, Mulder LM, Elkhashab M, Khan Z, Czarnocki-Cieciura M, Aburto MR, Vucen S, Kowalski PS. ACS Appl Bio Mater. 2025 Publication Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines. Krawczyk PS, Mazur M, Orzeł W, Gewartowska O, Jeleń S, Antczak W, Kasztelan K, Brouze A, Matylla-Kulińska K, Gumińska N, Tarkowski B, Owczarek EP, Affek K, Turowski P, Tudek A, Sroka M, Śpiewla T, Kusio-Kobiałka M, Wesołowska A, Nowis D, Golab J, Kowalska J, Jemielity J, Dziembowski A, Mroczek S. Nature. 2025 Publication Structural and biochemical characterization of the 3'-5' tRNA splicing ligases. Chamera S, Zajko W, Czarnocki-Cieciura M, Jaciuk M, Koziej Ł, Nowak J, Wycisk K, Sroka M, Chramiec-Głąbik A, Śmietański M, Gołębiowski F, Warmiński M, Jemielity J, Glatt S, Nowotny M. J Biol Chem. 2025 Publication Data storage based on the absence of nucleotides using a bacteriophage abortive infection system reverse transcriptase. Bajc G, Pavlin A, Figiel M, Zajko W, Nowotny M, Butala M. Lab Chip. 2025 Publication Structural and biochemical characterization of cauliflower mosaic virus reverse transcriptase. Prabaharan C, Figiel M, Szczepanowski RH, Skowronek K, Zajko W, Thangaraj V, Chamera S, Nowak E, Nowotny M. J Biol Chem. 2024 Publication Structure-functional characterization of Lactococcus AbiA phage defense system. Gapińska M, Zajko W, Skowronek K, Figiel M, Krawczyk PS, Egorov AA, Dziembowski A, Johansson MJO, Nowotny M. Nucleic Acids Res. 2024 Publication Despite the odds: formation of the SARS-CoV-2 methylation complex. Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A. Nucleic Acids Res. 2024 Publication Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex. Kuzikov M, Reinshagen J, Wycisk K, Corona A, Esposito F, Malune P, Manelfi C, Iaconis D, Beccari A, Tramontano E, Nowotny M, Windshügel B, Gribbon P, Zaliani A. Virus Res.. 2024 Publication Cryo-EM structure of rotavirus B NSP2 reveals its unique tertiary architecture. Chamera S, Wycisk K, Czarnocki-Cieciura M, Nowotny M. J Virol. 2024 Publication Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1. Czestkowski W, Krzemiński Ł, Piotrowicz MC, Mazur M, Pluta E, Andryianau G, Koralewski R, Matyszewski K, Olejniczak S, Kowalski M, Lisiecka K, Kozieł R, Piwowar K, Papiernik D, Nowotny M, Napiórkowska-Gromadzka A, Nowak E, Niedziałek D, Wieczorek G, Siwińska A, Rejczak T, Jędrzejczak K, Mulewski K, Olczak J, Zasłona Z, Gołębiowski A, Drzewicka K, Bartoszewicz A. J Med Chem. 2024 Publication Structure of human TRPM8 channel. Palchevskyi S, Czarnocki-Cieciura M, Vistoli G, Gervasoni S, Nowak E, Beccari AR, Nowotny M, Talarico C. Commun Biol.. 2023 Publication Rep protein accommodates together dsDNA and ssDNA which enables a loop-back mechanism to plasmid DNA replication initiation. Wegrzyn K, Oliwa M, Nowacka M, Zabrocka E, Bury K, Purzycki P, Czaplewska P, Pipka J, Giraldo R, Konieczny I. Nucleic Acids Res.. 2023 Publication Mechanism of RecF–RecO–RecR cooperation in bacterial homologous recombination. Nirwal S, Czarnocki-Cieciura M, Chaudhary A, Zajko W, Skowronek K, Chamera S, Figiel M, Nowotny M. Nat Struct Mol Biol.. 2023 Publication Arginase 1/2 inhibitor OATD-02: from discovery to first-in-man setup in cancer immunotherapy. Borek B, Nowicka J, Gzik A, Dziegielewski M, Jedrzejczak K, Brzezinska J, Grzybowski M, Stanczak P, Pomper P, Zagozdzon A, Rejczak T, Matyszewski K, Golebiowski A, Olczak J, Lisiecki K, Tyszkiewicz M, Kania M, Piasecka S, Cabaj A, Dera P, Mulewski K, Chrzanowski J, Kusmirek D, Sobolewska E, Magdycz M, Mucha L, Masnyk M, Golab J, Nowotny M, Nowak E, Napiorkowska-Gromadzka A, Pikul S, Jazwiec R, Dzwonek K, Dobrzanski P, Meyring M, Skowronek K, Iwanowski P, Zaslona Z, Blaszczyk R. Mol Cancer Ther.. 2023 Publication Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding. Hyjek-Składanowska M, Anderson BA, Mykhaylyk V, Orr C, Wagner A, Poznański JT, Skowronek K, Seth P, Nowotny M. Nucleic Acids Res.. 2023 Publication Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Figiel M, Gapińska M, Czarnocki-Cieciura M, Zajko W, Sroka M, Skowronek K, Nowotny M. Nucleic Acids Res. 2022 Publication Structural basis of transposon end recognition explains central features of Tn7 transposition systems. Kaczmarska Z, Czarnocki-Cieciura M, Górecka-Minakowska KM, Wingo RJ, Jackiewicz J, Zajko W, Poznański JT, Rawski M, Grant T, Peters JE, Nowotny M. Mol Cell.. 2022 Publication Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities. Corona A, Wycisk K, Talarico C, Manelfi C, Milia J, Cannalire R, Esposito F, Gribbon P, Zaliani A, Iaconis D, Beccari AR, Summa V, Nowotny M, Tramontano E. ACS Pharmacol Transl Sci. 2022 Publication The Pet127 protein is a mitochondrial 5'-to-3' exoribonuclease from the PD-(D/E)XK superfamily involved in RNA maturation and intron degradation in yeasts. Labedzka-Dmoch K, Razew M, Gapinska M, Piatkowski J, Kolondra A, Salmonowicz H, Wenda JM, Nowotny M, Golik P. RNA. 2022 Publication A heterotypic assembly mechanism regulates CHIP E3 ligase activity. Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dabrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W. EMBO J. . 2022 Structures of substrate complexes of foamy viral protease-reverse transcriptase. Nowacka M, Nowak E, Czarnocki-Cieciura M, Jackiewicz J, Skowronek K, Szczepanowski R, Wöhrl BM, Nowotny M. J Virol.. 2021 Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. Warminski  M, Kowalska  J, Nowak E, Kubacka  D, Tibble  R, Kasprzyk  R, Sikorski  PJ, Gross  JD, Nowotny  M, Jemielity J. ACS Chem Biol.. 2021 The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase. Cieśla M, Turowski TW, Nowotny M, Tollervey D, Boguta M. Nucleic Acids Res.. 2020