Preprint Loss of Brg1 promotes seizure development via GABAergic system disruption. Pagano R, Abu Nahia K, Declève A, Stadnik D, Zmorzyńska J, A. Serwa RA, Copmans D, Jaworski J. bioRxiv. 2026 Preprint Phosphorylation of the AP2 μ2 subunit by p70S6 kinase is needed for clathrin-mediated endocytosis. Tempes A, Brzozowska A, Węgierski T, Fasemire A, Olek K, Jastrzębski K, Ewa Liszewska E, Misztal K, Machnicka K, Macias M, Szybińska A, Sitkiewicz E, Malinowska A, Gozdz A, Wyszyńska A, Łasica A, Hoffmann-Młodzianowska M, Miączyńska M, Górna MW, Pokrzywa W, Jaworski J. Malik AR. bioRxiv. 2026 Preprint β-catenin–independent regulation by TCF7L2 underlies isoform redundancy during embryonic thalamic development. Gabriel MO, Bem J, Lipiec MA, Agarwal A, Liszewska E, Baggio S, Qi H, Plewczynski D, Wisniewska MB. bioRxiv. 2025 Publication Trifluoperazine, an Antipsychotic Drug, Inhibits Viability of Cells Derived From SEGA and Cortical Tubers Cultured In Vitro. Urbanska M, Sadowski K, Stawikowska A, Liszewska E, Mlostek M, Grajkowska W, Kotulska K. J Neurochem. 2025 Publication Protocol for the visualization of pRps6-positive cells in larval zebrafish brains using whole-mount immunofluorescence and light-sheet microscopy. Doszyn O, Dulski T, Zmorzynska J. STAR Protoc. 2025 Publication Exploring the impact of MDMA and oxytocin ligands on anxiety and social responses: A comprehensive behavioural and molecular study in the zebrafish model. Maciag M, Doszyn O, Wnorowski A, Zmorzynska J, Budzynska B. J Psychopharmacol. 2025 Preprint p70S6 kinase-dependent phosphorylation of the μ2 subunit of the AP2 adaptor complex is needed for clathrin-mediated endocytosis. Tempes A, Brzozowska A, Węgierski T, Olek K, Jastrzębski K, Liszewska E, Misztal K, Machnicka K, Macias M, Szybińska A, Sitkiewicz E, Gozdz A, Wróbel AG, Miaczynska M, Pokrzywa W, Jaworski J, Malik AR. bioRxiv. 2025 Publication Protocol for microinjection of rapamycin into the zebrafish habenula. Doszyn O, Dulski T, Zmorzynska J. STAR Protoc. 2025 Publication Generation of four human induced pluripotent stem cell lines derived from patients with MPAN, subtype of NBIA, carrying the c.204_214del11 mutation in the C19orf12 gene. Krogulec E, Dobosz AM, Liszewska E, Majchrowicz L, Dobrzyń A. Stem Cell Res. 2024 Publication Study of Biological Effects Induced in Solid Tumors by Shortened-Duration Thermal Ablation Using High-Intensity Focused Ultrasound. Kaplińska-Kłosiewicz PM, Fura Ł, Kujawska T, Andrzejewski K, Kaczyńska K, Strzemecki D, Sulejczak M, Chrapusta SJ, Macias M, Sulejczak D. Cancers (Basel). 2024 Publication Hyperactive mTORC1 disrupts habenula function and light preference in zebrafish model of Tuberous sclerosis complex. Doszyn O, Kedra M, Zmorzynska J. iScience. 2024 Publication Autophagy initiation triggers p150Glued-AP-2β interaction on the lysosomes and facilitates their transport. Tempes A, Bogusz K, Brzozowska A, Weslawski J, Macias M, Tkaczyk O, Orzoł K, Lew A, Calka-Kresa M, Bernas T, Szczepankiewicz AA, Mlostek M, Kumari S, Liszewska E, Machnicka K, Bakun M, Rubel T, Malik AR, Jaworski J. Cell Mol Life Sci. 2024 Publication E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization. Fedorowicz M, Halas A, Macias M, Sledziewska-Gojska E, Woodgate R, McIntyre J. Biochim Biophys Acta Mol Cell Res. 2024 Publication Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning. Janusz-Kaminska A, Jaworski J. Autophagy Reports. 2024 Publication Targeting the EGFR pathway: An alternative strategy for the treatment of tuberous sclerosis complex? Schachenhofer J, Gruber VE, Fehrer SV, Haider C, Glatter S, Liszewska E, Höftberger R, Aronica E, Rössler K, Jaworski J, Scholl T, Feucht M. Neuropathol Appl Neurobiol. 2024 Publication Diving into the zebrafish brain: exploring neuroscience frontiers with genetic tools, imaging techniques, and behavioral insights. Doszyn O, Dulski T, Zmorzynska J. Front Mol Neurosci. 2024 Publication Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner. Janusz-Kaminska A, Brzozowska A, Tempes A, Urbanska M, Blazejczyk M, Miłek J, Kuzniewska B, Zeng J, Wesławski J, Kisielewska K, Bassell GJ, Jaworski J. Mol Biol Cell.. 2024 Publication Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior. Szewczyk LM, Lipiec MA, Liszewska E, Meyza K, Urban-Ciecko J, Kondrakiewicz L, Goncerzewicz A, Rafalko K, Krawczyk TG, Bogaj K, Vainchtein ID, Nakao-Inoue H, Puscian A, Knapska E, Sanders SJ, Jan Nowakowski T, Molofsky AV, Wisniewska MB. Mol Psychiatry. 2024 Publication Dendritic arbor dynamics and stability in health and disease. Mlostek M, Zeng J, Urbanska M, Jaworski J. Acta Neurobiol Exp (Wars). 2023 Publication Molecular EPISTOP, a comprehensive multi-omic analysis of blood from Tuberous Sclerosis Complex infants age birth to two years. Huschner F, Głowacka-Walas J, Mills JD, Klonowska K, Lasseter K, Asara JM, Moavero R, Hertzberg C, Weschke B, Riney K, Feucht M, Scholl T, Krsek P, Nabbout R, Jansen AC, Petrák B, van Scheppingen J, Zamecnik J, Iyer A, Anink JJ, Mühlebner A, Mijnsbergen C, Lagae L, Curatolo P, Borkowska J, Sadowski K, Domańska-Pakieła D, Blazejczyk M, Jansen FE, Janson S, Urbanska M, Tempes A, Janssen B, Sijko K, Wojdan K, Jozwiak S, Kotulska K, Lehmann K, Aronica E, Jaworski J, Kwiatkowski DJ. Nat Commun.. 2023 Preprint Dynactin interaction with AP-2 adaptor complex requires CLIP-170 and autophagy. Tempes A, Bogusz K, Brzozowska A, Weslawski J, Macias M, Lew A, Calka-Kresa M, Bernas T, Szczepankiewicz AA, Bakun M, Rubel T, Malik AR, Jaworski J. bioRxiv. 2022 Publication Mitofusin 2 Integrates Mitochondrial Network Remodelling, Mitophagy and Renewal of Respiratory Chain Proteins in Neurons after Oxygen and Glucose Deprivation. Wojtyniak P, Boratynska-Jasinska A, Serwach K, Gruszczynska-Biegala J, Zablocka B, Jaworski J, Kawalec M. Mol Neurobiol. 2022 Publication MicroRNA Expression Profile in TSC Cell Lines and the Impact of mTOR Inhibitor. Pawlik B, Grabia S, Smyczyńska U, Fendler W, Dróżdż I, Liszewska E, Jaworski J, Kotulska K, Jóźwiak S, Młynarski W, Trelińska J. Int J Mol Sci. 2022 Publication Generation of three human iPSC lines from patients with Huntington’s disease with different CAG lengths and human control iPSC line from a healthy donor. Latoszek E, Piechota M, Liszewska E, Hansíkova ́H, Klempír J,
Mühlback A, Landwehrmeyer GB, Kuznicki J, Czeredys M. Stem Cell Res. 2022 Publication miRNAs and isomiRs: Serum-Based Biomarkers for the Development of Intellectual Disability and Autism Spectrum Disorder in Tuberous Sclerosis Complex. Scheper M, Romagnolo A, Besharat ZM, Iyer AM, Moavero R, Hertzberg C, Weschke B, Riney K, Feucht M, Scholl T, Petrak B, Maulisova A, Nabbout R, Jansen AC, Jansen FE, Lagae L, Urbanska M, Ferretti E, Tempes A, Blazejczyk M, Jaworski J, Kwiatkowski DJ, Jozwiak S, Kotulska K, Sadowski K, Borkowska J, Curatolo P, Mills JD, Aronica E, Epistop Consortium Members. Biomedicines. 2022 Publication SRF depletion in early life contributes to social interaction deficits in the adulthood. Roszkowska M, Krysiak A, Majchrowicz L, Nader K, Beroun A, Michaluk P, Pekala M, Jaworski J, Kondrakiewicz L, Puścian A, Knapska E, Kaczmarek L, Kalita K. Cell Mol Life Sci. 2022 Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial. Kotulska K, Kwiatkowski DJ, Curatolo P, Weschke B, Riney K, Jansen F, Feucht M, Krsek P, Nabbout R, Jansen AC, Wojdan K, Sijko K, Głowacka-Walas J, Borkowska J, Sadowski K, Domańska-Pakieła D, Moavero R, Hertzberg C, Hulshof H, Scholl T, Benova B, Aronica E, de Ridder J, Lagae L, Jóźwiak S; EPISTOP Investigators (Jaworski J, Błażejczyk M, Tempes A, Urbańska M.) Ann Neurol. 2021 G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Prentzell MT et al. (Jaworski J, Kedra M, Kopach A, Macias M, Zmorzynska J.) Cell. 2021 mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types. Koscielny A, Liszewska E, Machnicka K, Wezyk M, Kotulska K, Jaworski J. Cell Mol Biol Lett.. 2021 Establishment of two hiPSC lines (IIMCBi001-A and IIMCBi002-A) from dermal fibroblasts of healthy donors and characterization of their cell cycle. Liszewska E, Majchrowicz L, Krogulec E, Kotulska K, Kaczmarek L, Kalita K, Dobrzyń A, Jaworski J. Stem Cell Res.. 2021