Publication Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in diffuse large B cell lymphoma (DLBCL). Górniak P, Polak A, Rams A, Kupcova K, Głodkowska-Mrówka E, Pilch Z, Miączyńska M, Nowis D, Gołąb J, Davis RE, Havranek O, Juszczyński P. Cell Death Dis. 2026 Preprint Phosphorylation of the AP2 μ2 subunit by p70S6 kinase is needed for clathrin-mediated endocytosis. Tempes A, Brzozowska A, Węgierski T, Fasemire A, Olek K, Jastrzębski K, Ewa Liszewska E, Misztal K, Machnicka K, Macias M, Szybińska A, Sitkiewicz E, Malinowska A, Gozdz A, Wyszyńska A, Łasica A, Hoffmann-Młodzianowska M, Miączyńska M, Górna MW, Pokrzywa W, Jaworski J. Malik AR. bioRxiv. 2026 Publication Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance. Zurawska G, Sas Z, Jończy A, Mahadeva R, Slusarczyk P, Chwałek M, Seehofer D, Damm G, Mazgaj R, Skórzyński M, Kulecka M, Rumieńczyk I, Moulin M, Jastrzębski K, Waldron K, Mikula M, Etzerodt A, Serwa R, Miączyńska M, Rygiel TP, Mleczko-Sanecka K. EMBO Rep. 2026 Publication Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer's disease. Schmidt V, Ziemlinska E, Obrebski T, Gomes JP, Zurawska-Plaksej E, Cendrowski J, Palmfeldt J, Hempstead BL, Willnow TE, Malik AR. Nat Commun. 2025 Publication The expanding repertoire of ESCRT functions in cell biology and disease. Hurley JH, Coyne AN, Miączyńska M, Stenmark H. Nature. 2025 Publication Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin. Domagala J, Grzywa TM, Baranowska I, Justyniarska M, Tannir R, Graczyk-Jarzynka A, Kusowska A, Lecka M, Poreba M, Fidyt K, Marhelava K, Pilch Z, Picard LK, Wegierski T, Jastrzebski K, Krawczyk M, Klopotowska M, Granica M, Urlaub D, Hajduk S, Neeser A, Moros S, Kozlowski P, Bobrowicz M, Miaczynska M, Ma L, Watzl C, Winiarska M. Cancer Res. 2025 Preprint p70S6 kinase-dependent phosphorylation of the μ2 subunit of the AP2 adaptor complex is needed for clathrin-mediated endocytosis. Tempes A, Brzozowska A, Węgierski T, Olek K, Jastrzębski K, Liszewska E, Misztal K, Machnicka K, Macias M, Szybińska A, Sitkiewicz E, Gozdz A, Wróbel AG, Miaczynska M, Pokrzywa W, Jaworski J, Malik AR. bioRxiv. 2025 Publication NFκB and JNK pathways mediate metabolic adaptation upon ESCRT‑I deficiency. Cendrowski J, Wrobel M, Mazur M, Jary B, Maurya R, Wang S, Korostynski M, Dziewulska A, Rohm M, Kuropka P, Pudelko‑Malik N, Mlynarz P, Dobrzyn A, Zeigerer A, Miaczynska M. Cell Mol Life Sci. 2024 Preprint Ammonia inhibits antitumor activity of NK cells by decreasing mature perforin. Domagala J, Grzywa TM, Baranowska I, Kusowska A, Fidyt K, Marhelava K, Pilch Z, Graczyk-Jarzynka A, Picard LK, Jastrzebski K, Granica M, Justyniarska M, Urlaub D, Bobrowicz M, Miaczynska M, Watzl C, Winiarska M. bioRxiv. 2023 Preprint Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance. Zurawska G, Sas Z, Jończy A, Slusarczyk P, Mahadeva R, Chwałek M, Kulecka M, Rumieńczyk I, Moulin M, Jastrzębski K, Mikula M, Etzerodt A, Miączyńska M, Rygiel TP, Mleczko-Sanecka K. bioRxiv. 2023 Publication ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway Wróbel M, Cendrowski J, Szymańska E, Grębowicz-Maciukiewicz M, Budick-Harmelin N, Macias M, Szybińska A, Mazur M, Kolmus K, Goryca K, Dąbrowska M, Paziewska A, Mikula M, Miączyńska M.
Life Sci Alliance. 2022 Publication Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes. Sekar R, Motzler K, Kwon Y, Novikoff A, Jülg J, Najafi B, Wang S, Warnke AL, Seitz S, Hass D, Gancheva S, Kahl S, Yang B, Finan B, Schwarz K, Okun JG, Roden M, Blüher M, Müller TD, Krahmer N, Behrends C, Plettenburg O, Miaczynska M, Herzig S, Zeigerer A. Cell Metab. 2022 Publication The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells. Oroń M, Grochowski M, Jaiswar A, Legierska J, Jastrzębski K, Nowak-Niezgoda M, Kołos M, Kaźmierczak W, Olesiński T, Lenarcik M, Cybulska M, Mikula M, Żylicz A, Miączyńska M, Zettl K, Wiśniewski JR, Walerych D. Cell Rep. 2022 Publication Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide. Wolińska-Nizioł L, Romaniuk K, Wojciechowska K, Surga K, Kamaszewski M, Szudrowicz H, Miączyńska M. FEBS Open Bio. 2022 Publication Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation. Poświata A, Kozik K, Miączyńska M, Zdżalik-Bielecka D. Cell Mol Life Sci. 2022 Publication Bemcentinib and gilteritinib inhibit cell growth and impair the endo-lysosomal and autophagy systems in an AXL-independent manner. Zdzalik-Bielecka D, Kozik K, Poswiata A, Jastrzebski K, Jakubik M, Miaczynska M. Mol Cancer Res. . 2022 Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors. Poźniak M, Porębska N, Jastrzębski K, Krzyścik MA, Kucińska M, Zarzycka W, Barbach A, Zakrzewska M, Otlewski J, Miączyńska M, Opaliński Ł. J Biomed Sci.. 2021 The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion. Zdżalik-Bielecka D, Poświata A, Kozik K, Jastrzębski K, Schink KO, Brewińska-Olchowik M, Piwocka K, Stenmark H, Miączyńska M. Proc Natl Acad Sci USA. 2021 Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1. Porebska N, Pozniaka M, Krzyscik MA, Knapika A, Czyrek A, Kucinska M, Jastrzebski K, Zakrzewska M, Otlewski J, Opalinski L. Int J Biol Macromol.. 2021 Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses. Kolmus K, Erdenebat P, Szymańska E, Stewig B, Goryca K, Derezinska-Wolek E, Szumera-Cieckiewicz A, Brewinska-Olchowik M, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miaczynska M. J Cell Sci.. 2021 Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor. Maksymowicz M, Miączyńska M, Banach-Orłowska M. Cell Commun Signal.. 2020 Splicing variants of an endocytic regulator, BMP2K, differentially control autophagic degradation in erythroid cells. Cendrowski J, Miaczynska M. Autophagy. 2020 Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M. eLife . 2020 FGFR1 Clustering With Engineered Tetravalent Antibody Improves the Efficiency and Modifies the Mechanism of Receptor Internalization. Pozniak M, Sokolowska-Wedzina A, Jastrzebski K, Szymczyk J, Porebska N, Krzyscik MA, Zakrzewska M, Miaczynska M, Otlewski J, Opalinski L. Mol Oncol. . 2020 Membrane Trafficking: Vesicle Formation, Cargo Sorting and Fusion.  Miaczynska M, Munson M. Mol Biol Cell. . 2020 Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer. Szymańska E, Nowak P, Kolmus K, Cybulska M, Goryca K, Derezińska-Wołek E, Szumera-Ciećkiewicz A, Brewińska-Olchowik M, Grochowska A, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miączyńska M. EMBO Mol Med.. 2020 Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling. Banach-Orłowska M, Wyszyńska R, Pyrzyńska B, Maksymowicz M, Gołąb J, Miączyńska M. Cell Commun Signal.. 2019 Integration of the Endocytic System into the Network of Cellular Functions. Budick-Harmelin N, Miaczynska M. Prog Mol Subcell Biol.. 2018 The topology of lymphotoxin β receptor accumulated upon endolysosomal dysfunction dictates the NF-κB signaling outcome. Banach-Orłowska M, Jastrzębski K, Cendrowski J, Maksymowicz M, Wojciechowska K, Korostyński M, Moreau D, Gruenberg J, Miaczynska M. J Cell Sci.. 2018 Endosomal "sort" of signaling control: The role of ESCRT machinery in regulation of receptor-mediated signaling pathways. Szymanska E, Budick-Harmelin N, Miaczynska M. Semin Cell Dev Biol.. 2017