Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. Koralewski R, Dymek B, Mazur M, Sklepkiewicz P, Olejniczak S, Czestkowski W, Matyszewski K, Andryianau G, Niedziejko P, Kowalski M, Gruza M, Borek B, Jedrzejczak K, Bartoszewicz A, Pluta E, Rymaszewska A, Kania M, Rejczak T, Piasecka S, Mlacki M, Mazurkiewicz M, Piotrowicz M, Salamon M, Zagozdzon A, Napiorkowska-Gromadzka A, Bartlomiejczak A, Mozga W, Dobrzański P, Dzwonek K, Golab J, Nowotny M, Olczak J, Golebiowski A. J Med Chem.. 2020 Disulfide bridge cross-linking between protein and the RNA backbone as a tool to study RNase H1. Hyjek-Składanowska M, Stasińska AR, Napiórkowska-Gromadzka A, Bartłomiejczak A, Seth PP, Chmielewski MK, Nowotny M. Bioorg Med Chem. . 2020 Evolutionary History and Activity of RNase H1-Like Proteins in Arabidopsis thaliana. Kuciński J, Chamera S, Kmera A, Rowley MJ, Fujii S, Khurana P, Nowotny M, Wierzbicki AT. Plant Cell Physiol.. 2020 Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine.. Malik D, Kobyłecki K, Krawczyk P, Poznański J, Jakielaszek A, Napiórkowska A, Dziembowski A, Tomecki R, Nowotny M. Nucleic Acids Res.. 2020 Vimentin S-glutathionylation at Cys328 Inhibits Filament Elongation and Induces Severing of Mature Filaments in Vitro. Kaus-Drobek M, Mücke N, Szczepanowski RH, Wedig T, Czarnocki-Cieciura M, Polakowska M, Herrmann H, Wysłouch-Cieszyńska A, Dadlez M. FEBS J.. 2020 Human REXO2 Controls Short Mitochondrial RNAs Generated by mtRNA Processing and Decay Machinery to Prevent Accumulation of Double-Stranded RNA. Szewczyk M, Malik D, Borowski LS, Czarnomska SD, Kotrys AV, Klosowska-Kosicka K, Nowotny M, Szczesny RJ. Nucleic Acids Res.. 2020 Origins of the increased affinity of phosphorothioate-modified therapeutic nucleic acids for proteins. Hyjek-Składanowska M, Vickers T, Napiórkowska A, Anderson B, Tanowitz M, Crooke ST, Liang XH, Seth PP, Nowotny M. J Am Chem Soc.. 2020 A combined structural and biochemical approach reveals translocation and stalling of UvrB on the DNA lesion as a mechanism of damage verification in bacterial nucleotide excision repair. Jaciuk M, Swuec P, Gaur V, Kasprzak JM, Renault L, Dobrychłop M, Nirwal S, Bujnicki JM, Costa A, Nowotny M. DNA Repair (Amst).. 2020 Crosslink and shield: protecting abasic sites from error-prone repair. Nowotny M. Nat Struct Mol Biol.. 2019 Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease. Gaur V, Ziajko W, Nirwal S, Szlachcic A, Gapińska M, Nowotny M Nucleic Acids Res.. 2019 RuvC uses dynamic probing of the Holliday junction substrate to achieve sequence specificity and efficient resolution. Górecka KM, Krepl M, Szlachcic A, Poznański J, Šponer J, Nowotny M. Nat Commun.. 2019 RNases H: Structure and mechanism. Hyjek M, Figiel M, Nowotny M. DNA Repair (Amst). 2019 Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase. Figiel M, Krepl M, Park S, Poznański J, Skowronek K, Gołąb A, Ha T, Šponer J, Nowotny M. J Biol Chem. 2018 5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. Wojtczak BA, Sikorski PJ, Fac-Dabrowska K, Nowicka A, Warminski M, Kubacka D, Nowak E, Nowotny M, Kowalska J, Jemielity J. J Am Chem Soc.. 2018 Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components. Razew M, Warkocki Z, Taube M, Kolondra A, Czarnocki-Cieciura M, Nowak E, Labedzka-Dmoch K, Kawinska A, Piatkowski J, Golik P, Kozak M, Dziembowski A, Nowotny M. Nat Commun.. 2018 The siRNA suppressor RTL1 is redox-regulated through glutathionylation of a conserved cysteine in the double-stranded-RNA-binding domain. Charbonnel C, Niazi AK, Elvira-Matelot E, Nowak E, Zytnicki M, de Bures A, Jobet E, Opsomer A, Shamandi N, Nowotny M, Carapito C, Reichheld J-P, Vaucheret H, Saez-Vasquez J. Nucleic Acids Res.. 2017 Publication mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Rydzik AM, Warminski M, Sikorski PJ, Baranowski MR, Walczak S, Kowalska J, Zuberek J, Lukaszewicz M, Nowak E, W Claridge TD, Darzynkiewicz E, Nowotny M, Jemielity J. Nucleic Acids Res. 2017 Chapter Six - Structural Studies of RNases H2 as an Example of Crystal Structure Determination of Protein–Nucleic Acid Complexes Figiel M, Nowotny M Methods in Enzymology. 2017 Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase Figiel M, Krepl M, Poznanski J, Golab A, Šponer J, Nowotny M Nucleic Acids Res.. 2017 A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans Kalisiak K, Kuliński TM, Tomecki R, Cysewski D, Pietras Z, Chlebowski A, Kowalska K, Dziembowski A Nucleic Acids Res. 2016 Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli Stracy M, Jaciuk M, Uphoff S, Kapanidis AN, Nowotny M, Sherratt DJ, Zawadzki P Nat Commun.. 2016 Structure and mechanism of nucleases regulated by SLX4 Nowotny M, Gaur V Curr Opin Struct Biol. 2016 Functional and evolutionary analyses of Helicobacter pylori HP0231 (DsbK) protein with strong oxidative and chaperone activity characterized by a highly diverged dimerization domain Bocian-Ostrzycka KM, Łasica AM, Dunin-Horkawicz S, Grzeszczuk MJ, Drabik K, Dobosz AM, Godlewska R, Nowak E, Collet J-F, Jagusztyn-Krynicka EK Frontiers in Microbiology. 2015 Helicobacter pylori HP0377, a member of the Dsb family, is an untypical multifunctional CcmG that cooperates with dimeric thioldisulfide oxidase HP0231 Roszczenko P, Grzeszczuk M, Kobierecka P, Wywial E, Urbanowicz P, Wincek P, Nowak E, Jagusztyn-Krynicka EK BMC Microbiol.. 2015 Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease Gaur V, Wyatt HDM, Komorowska W, Szczepanowski RH, de Sanctis D, Gorecka KM, West SC, Nowotny M Cell Reports. 2015 Crystal structure of RNase H3-substrate complex reveals parallel evolution of RNA/DNA hybrid recognition. Figiel M, Nowotny M. Nucleic Acids Res.. 2014 Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression. Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W. Mol Cell.. 2014 Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding Miętus M, Nowak E, Jaciuk M, Kustosz P, Studnicka J, Nowotny M Nucleic Acids Res. 2014 The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification Majorek KA, Dunin-Horkawicz S, Steczkiewicz K, Muszewska A, Nowotny M, Ginalski K, Bujnicki JM Nucleic Acids Res.. 2014 Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target Tomecki R, Drazkowska K, Kucinski I, Stodus K, Szczesny RJ, Gruchota J, Owczarek EP, Kalisiak K, Dziembowski A Nucleic Acids Res.. 2014