All publications

Research groups

Laboratory of Cell Biology

Laboratory of Structural Biology

Laboratory of Bioinformatics and Protein Engineering

Laboratory of Molecular and Cellular Neurobiology

Laboratory of Neurodegeneration

Laboratory of Iron Homeostasis

Laboratory of Protein Structure

Laboratory of Protein Metabolism

Laboratory of Zebrafish Developmental Genomics

Laboratory of Biomolecular Interactions and Transport

Laboratory of RNA Biology - ERA Chairs Group

Laboratory of RNA-Protein Interactions - Dioscuri Centre

Laboratory of Prokaryotic Gene Regulation

Laboratory of Cellular Genomics

Laboratory of Cellular Proteostasis

Projects outside research groups

PolSenior Project

Aurezyna Project

Core Facilities

Core Facility

Zebrafish Core Facility

Former labs & projects

Department of Molecular Biology

Laboratory of Biomodelling

Laboratory of Cell Cortex Mechanisms

Laboratory of Mitochondrial Biogenesis

Cilia and leukemia genetics studies

Other

Other

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2014

Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry Nowak E, Miller JT, Bona MK, Studnicka J, Szczepanowski RH, Jurkowski J, Le Grice SFJ, Nowotny M Nature Structural & Molecular Biology. 2014 Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation Smietanski M, Werner M, Purta E, Kaminska KH, Stepinski J, Darzynkiewicz E, Nowotny M, Bujnicki JM Nat Commun. 2014

2013

Crystal structure of RuvC resolvase in complex with Holliday junction substrate Górecka KM, Komorowska W, Nowotny M Nucleic Acids Res. 2013 RNase H2 roles in genome integrity revealed by unlinking its activities Chon H, Sparks JL, Rychlik M, Nowotny M, Burgers PM, Crouch RJ, Cerritelli SM Nucleic Acids Res. 2013 Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M Nucleic Acids Res. 2013

2012

Sequence-specific cleavage of the RNA strand in DNA-RNA hybrids by the fusion of ribonuclease H with a zinc finger Sulej AA, Tuszynska I, Skowronek KJ, Nowotny M, Bujnicki JM Nucleic Acids Res. 2012

2011

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects Figiel M, Chon H, Cerritelli SM, Cybulska M, Crouch RJ, Nowotny M J Biol Chem. 2011 Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations Rosta E, Nowotny M, Yang W, Hummer G J Am Chem Soc.. 2011 Structure of UvrA nucleotide excision repair protein in complex with modified DNA. Jaciuk M, Nowak E, Skowronek K, Tańska A, Nowotny M Nat Struct Mol Biol. 2011

2010

Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage. Rychlik MP, Chon H, Cerritelli SM, Klimek P, Crouch RJ, Nowotny M Mol Cell. 2010

2009

Structural and functional modules in RNA interference Nowotny M, Yang W Curr Opin Struct Biol. 2009 Retroviral integrase superfamily: the structural perspective. Nowotny M EMBO Rep. 2009

2004

Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. Lee YT, Jacob J, Michowski W, Nowotny M, Kuznicki J, Chazin WJ. J Biol Chem.. 2004

2000

Characterization of the interaction of calcyclin (S100A6) and calcyclin-binding protein. Nowotny M, Bhattacharya S, Filipek A, Krezel AM, Chazin W, Kuznicki J. J Biol Chem.. 2000